22. Which of the following NSAIDs is a propionic acid derivative?

a. indomethacin
b. mefenamic acid
c. ibuprofen
d. diclofenac
e. phenacetin
Key: c

23. Among NSAIDs only aspirin (and other salicylates) can:

a. selectively inhibit the COX-2 enzyme.
b. reduce pain and fever effectively.
c. reduce the risk of colon cancer.
d. prevent episodes of gouty arthritis with long term use.
e. irreversibly inhibit COX enzyme.
Key: e

24. Incorrect statement among the following regarding acetaminophen toxicity

is:
a) acetaminophen is the principal metabolic product of phenacetin.
b) an overdose of 10 grams or more may produce hepatic necrosis in adults.
c) acetaminophen overdose may produce transient azotemia or renal failure.
d) forced diuresis may be a useful form of therapy for acetaminophen overdose.
e) liver pathology is centrilobular and midzonal necrosis.

Key: d