TUTORIAL 1

ENZYMES

1. What are enzymes? What is the importance of enzymes for living beings?

2. Explain the mechanism of enzyme activity that able to speed up a chemical

reaction.

3. Define the following terms:

i) Enzyme-substrate complex

ii) Active site

iii) Allosteric site

iv) Cofactors

4. What happens to a denatured enzyme regarding its functionality? How can

that result be explained with the help of the lock and key model?

5. Differentiate the enzymatic activity between induced fit and key and lock
model.

6. Give two classes of enzymes and state the functions according to the types of
reaction they catalyze.

7. Explain four factors that affecting enzyme activity.

8. Differentiate between competitive inhibition and non-competitive irreversible

inhibition

9. Explain the allosteric regulation of metabolic pathway by end product inhibition.

10.List and briefly describe three types of enzyme cofactors.

11.Define negative feedback inhibition.