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15
SRI VENKATESWARA COLLEGE OF ENGINEERING
Session
Topics to be covered Ref Teaching Aids
No *
4. Class notes
Chargaff’s rule LCD & BB
Quadruple helix
Reversible denaturation
Requirements for Renaturation TB1-CH-4-(96-
Mechanism of Renaturation 103)
Unit : II
Session
Topics to be covered Ref Teaching Aids
No *
TB1-CH-8-(207-
Overview of Central dogma 208)
1. LCD & BB
Organization of prokaryotic and eukaryotic chromosomes TB1-CH-7-(178-
180, 181-188)
DNA replication:
2. Meselson & Stahl experiment TB1-CH-9-(226- LCD & BB
227)
TB1-CH-9-(262-
Bi–directional DNA replication 264)
3. LCD & BB
Okazaki fragments TB1-CH-9-(244-
245, 248-250)
TB1-CH-9-(223-
243)
Proteomics of DNA replication
TB1-CH-9-(233-
4. Fidelity of DNA replication 243) LCD & BB
Unit : III
Objective: The objective of this unit is to impart the students the deep knowledge on transcription process and protein
synthesis of both Prokaryotes and Eukaryotes
Session
Topics to be covered Ref Teaching Aids
No *
Structure and function of
mRNA TB1-CH-12-
The Lifetime of Prokaryotic mRNA (334-336
1. LCD & BB
rRNA 336-341
tRNA 379)
The clover structure of tRNA
TB1-CH-12-
2. Characteristics of promoter and enhancer sequences (321-325, 349- LCD & BB
342)
Transcription in Eukaryote
RNA polymerases:
Transcription factors
Eukaryotic promoter
Enhancer
Proteins of RNA synthesis TB1-CH-12-
Auxiliary proteins (325-327)
4. LCD & BB
Fidelity of RNA synthesis TB1-CH-12-
(346-351)
Internet
5. Inhibitors of transcription material LCD & BB
FT/GN/68/00/21.04.15
SRI VENKATESWARA COLLEGE OF ENGINEERING
Internet
6. Differences in prokaryotic and eukaryotic transcription material LCD & BB
TB1-CH-12-
8. Splicing-Alternative splicing (355-363) LCD & BB
TB1-CH-12-
Poly ‘A’ tail addition and base modification.
9. (353-355) LCD & BB
Unit : IV
Objective: The objective of this unit is to impart the students the knowledge on genetic codon, translation and post
translational modifications in prokaryote and eukaryotes.
Session
Topics to be covered Ref Teaching Aids
No *
Introduction to Genetic code: TB1-CH-12,
1. 13- (355-377) LCD & BB
Elucidation of genetic code
TB1-CH-13-
2. Codon degeneracy (377-387) LCD & BB
TB1-CH-13-
Wobble hypothesis
3. (388-391) LCD & BB
Redundancy as a Response of one Anticodon to Several Codons
TB1-CH-13-
4. Importance of Wobble hypothesis (388-391) LCD & BB
TB1-CH-14-
Prokaryotic ribosomes
5. (415-419) LCD & BB
Unit : V
TB1-CH-8-
2. Organization of genes in prokaryotic chromosomes (178-188) LCD & BB
TB1-CH-8-
3. Organization of eukaryotic chromosomes (178-188) LCD & BB
TB1-CH-15-
4. Hierarchical levels of gene regulation I (453-456) LCD & BB
TB1-CH-16-
5. Hierarchical levels of gene regulation II (501-504) LCD & BB
TB1-CH-15-
6. Prokaryotic gene regulation –lac operon (456-460) LCD & BB
OUTCOMES:
By the end of this course, students should be able to:
To understand the basics of nucleic acids and proteins
To study the details of bacterial molecular mechanism
To apply the molecular biology of microorganisms in the Research work
.
REFERENCES:
TEXT BOOKS:
1. Friefelder, David. “Molecular Biology” Narosa Publications, 1999.
2. Weaver, Robert F. “Molecular Biology” 2nd Edition, Tata McGraw-Hill,2003.
3. Karp, Gerald “Cell & Molecular Biology”: Concepts & Experiments” 4th Edition, John Wiley, 2005.
4. Friefelder, David & George M. Malacinski “Essentials of Molecular Biology” 2nd Edn, Panima Publishing, 1993.
5. Lewin’s GENES XI, Published by Jones & Bartlett Learning; 11 edition (January 15, 2013).
REFERENCES:
1. Tropp, Burton E. “ Molecular Biology: Genes to Proteins”. 3rd Edition. Jones and Bartlett, 2008.
2. Glick , B.R. and J.J. Pasternak. “Molecular Biotechnology: Principles and Applications of Recombinant DNA” 4th
Edition. ASM, 2010.
Prepared by Approved by
Signature
* If the same lesson plan is followed in the subsequent semester/year it should be mentioned and signed
by the Faculty and the HOD
FT/GN/68/00/21.04.15
SRI VENKATESWARA COLLEGE OF ENGINEERING
Department of Biotechnology
CO: Sub Code
B.E/B.Tech/M.E/M.Tech : B.Tech - Biotechnology BT6504
Regulation : 2013 Rev. No: 01
PG Specialisation : NA
Date:
Sub. Code / Sub. Name : BT6504 / Molecular Biology
13/06/2017
Module Coordinator
CO Statements RBT*
Level
CO-1 To understand the concepts of nucleic acids and proteins 2
CO-2 To study the details of Bacterial molecular mechanism 3
CO-3 To apply the molecular biology of microorganisms in the Research work 3
Mapping CO – PO - PSO:
PO1 PO2 PO3 PO4 PO5 PO6 PO7 PO8 PO9 PO1 PO1 PO1 PSO-1 PSO-2
0 1 2
CO1 A B C B B C B C
A
CO2 B A A A B A B A B A A B
A
CO3 A B A B A B A A A B A B A
Course Requirements
1. Scientific Calculator
2. Interest Tables
Assessment Methods
1. Assignment 1 + CAT 1
2. Assignment 2 + CAT 2 Internals - 20 Marks
3. Assignment 3 + CAT 3
4. Attendance (Not applicable for R2013)
5. End semester exam - 80 Marks