Training Manual Word Format PART 2

…to provide innovative quality products
for the betterment of people from all walks

of life…
-WERT Mission Statement excerpts
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PEDIATRIC BRANDS
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Multivitamins I NUTRI10 SYRUP & DROPS
Vitamins C I DAYZINC FAMILY
Multivitamins I NUTRIGROW
Vitamins C I DAYCEE
Cefixime I ZEFAXIM
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Multivitamins I NUTRI10 DROPS
OBJECTIVE:
To define basic nutrition concepts such as malnutrition, nutrition, health, wellness and nutrients and
principles.
 What Is Malnutrition
 What is Nutrition
 What is Health
 What is Wellness
 What are nutrients and their functions
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What is Malnutrition?
Malnutrition is a state of nutrition in which a deficiency or excess (or imbalance) of energy, protein and
other nutrients causes measurable adverse effects on tissue / body form (body shape, size and
composition) and function and clinical outcome
Malnutrition is a condition that results from eating a diet in which nutrients are either not enough or are
too much such that the diet causes health problems. It may involve calories, protein, carbohydrates,
vitamins or minerals.
Consequences of malnutrition in children and adolescents
⇒ Growth failure and stunting
⇒ Poor concentration
⇒ Poor growth in children
⇒ Loss of appetite
⇒ Reduced muscle mass and strength
⇒ Impaired intellectual development
⇒ Rickets
⇒ Delayed sexual development
⇒ Increased lifetime risk of osteoporosis
⇒ Tiredness, loss of energy
⇒ Altered mood – malnutrition can be associated with depression
⇒ Consequences of specific micronutrient deficiencies
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Nutrients Deficiency
The commonest are given below:
 Iron deficiency can cause anaemia
 Zinc deficiency causes skin rashes and decreased ability to fight infection
 Vitamin B12 deficiency can cause anaemia and problems with nerves
 Vitamin D deficiency causes rickets in children and osteomalacia in adults
 Vitamin C deficiency causes scurvy
 Vitamin A deficiency causes night blindness
Preventing Malnutrition
Malnutrition is caused mainly by not consuming what the Nutritional Guide for Filipinos (NGF).
• Carbohydrates
• Fruit and vegetables
• Protein
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• Dairy - vegans are able to find abundant nutrients from non-animal sources Fats.
The average human should drink at least 1.2 liters of fluid per day.
What does RENI stand for?
RENI stands for Recommended Energy and Nutrient Intake (nutrition)
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IMPORTANCE OF NUTRITION
Toddlers and preschoolers (1-6 years )
 Several developmental changes in brain, body and organ occur at this time.
 Best time for Visual development.
 Vitamins and minerals are very important for bone health, brain development and to strengthen the
immune system.
School going children (6-12 years )
 It is a growth spurt time where nutritional needs are high but fairly small appetite.
 Food choices largely depends a lot on family food choices, peer groups, media.
 Important for good development for cognitive skills, bone mineralization and life long eating
patterns
 Apparently healthy looking children have sub-clinical or biochemical deficiencies of vitamin A,

vitamins B2, B6, folate and vitamin C.
NUTRITION
 Nutrition is about eating a healthy and balanced diet. Food and drink provide the energy and
nutrients you need to be healthy.
 Nutrition is the science that interprets the interaction of nutrients and other substances in food in
relation to maintenance, growth, reproduction, health and disease of an organism.
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FOOD
Any nutritious substance that people or animals eat or drink, or that plants absorb, in order to
maintain life and growth.
Refers to any edible material which when taken into the body can provide nutrients needed to
support the various body functions.
CALORIE
 Calorie - is the amount of heat produced or released when food is burned by the body cells.
 Calorie also refers to the amount of energy required to “do work” or to perform certain physical
activities.
ENERGY
Energy is the ability to do work and is measured in terms of calories.
Food and drinks are made up of different amounts of protein, fat, carbohydrate (and sometimes
alcohol); known collectively as macronutrients. The amount of each macronutrient in the food will
determine its energy content.
NUTRIENTS
 Chemical substances derived from food which the body uses to build and repair tissues, generate
energy and regulate body processes.
Substance that provides nourishment essential for growth and the maintenance of life.
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Macronutrients are eaten in large amounts and include the primary building blocks of your diet
— protein, carbohydrates, and fat — which provide your body with energy.
Vitamins and minerals are micronutrients, and small doses go a long way.
ESSENTIAL NUTRINIENTS
Carbohydrates
Carbohydrates are the main energy source for the brain. Without carbohydrates, the body could not
function properly.
Protein
Protein is the major structural component of cells and is responsible for the building and repair of body
tissues.
Fat
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Fat is an energy source that when consumed, increases the absorption of fat-soluble vitamins including
vitamins A, D, E and K.
Vitamins
Vitamin C is necessary for the synthesis of collagen, which provides structure to blood vessels, bone and
ligaments. Rich sources include citrus fruits, strawberries and peppers.
Vitamin D helps to maintain calcium homeostasis.
Minerals
Sodium helps to maintain fluid volume outside of the cells and helps cells to function normally.
Potassium maintains fluid volume inside and outside of cells and prevents the excess rise of blood
pressure with increased sodium intake. Calcium helps to maintain and build strong bones and teeth.
Include three servings of calcium-rich foods per day including milk, low-fat cheese and yogurt.
Water
 Water helps to maintain homeostasis in the body and transports nutrients to cells.
 Water also assists in removing waste products from the body.
 All beverages and high-moisture foods such as soup and watermelon contain water and count
towards your daily water requirement. Adults should consume 25 to 35 milliliters of fluids per kilogram
body weight or 2 to 3 liters per day.
VITAMIN DEFICIENCY
Vitamin A are essential for eye health, immunity and cell growth. Vitamin A deficiency is the leading
cause of preventable blindness, disease and death from severe infections in children and cause night
blindness and increases risk of death in pregnant women.
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 Thiamine (vitamin B1) deficiency is associated with beriberi.
⇒ Beriberi in infants can present as cardiomegaly, tachycardia, a loud piercing, cyanosis, dyspnea, and
vomiting, all culminating in fulminant cardiac syndrome.
 Riboflavin (vitamin B2) deficiency presents with relatively non-specific signs, such as sore throat,
hyperemia and edema of mucous membrane, stomatitis, glossitis and seborrheic dermatitis.
 Pyridoxine (vitamin B6) deficiency is not commonly encountered as an isolated nutritional deficiency.
If encountered, it is often associated with isoniazid treatment or in infants older than six months who are
exclusively breast-fed.
Deficiencies of cobalamin (vitamin B12) in infants, cobalamin deficiency is usually due to cobalamin
deficiencies of breast-feeding mothers who follow strict vegan or moderate vegetarian diets. Infants
often present with growth, movement, developmental, and hematologic problems, but if identified and
treated early with supplementation, children can avoid long term consequences of this nutritional
deficiency.
VITAMIN C DEFICIENCY
Deficiency are quite low, but when patients’ diets are deficient in this vitamin, they present with
symptoms such as:
 bleeding gums,
 ecchymoses,
 petechiae,
 hyperkeratosis,
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 impaired wound healing
It is needed for the health and repair of various tissues in your body, including skin, bone, teeth and
cartilage. Persistent lack of vitamin C in your diet can lead to a condition called scurvy.
VITAMIN E DEFICIENCY
It is essential to the central nervous system. It is among the body's main antioxidants
and a deficiency results in oxidative stress.
Vitamin E deficiency may cause disorientation and vision problems.
Low levels of vitamin E can lead to muscle weakness.
ZINC DEFICIENCY
Zinc deficiency can cause growth failure and impaired immune system functioning.
Zinc Deficiency cause severe infections.
HEALTH AND WELLNESS
Health - is “a state of complete physical, mental, and social well-being and not merely the absence of
disease and infirmity”
A more recent definition states that health is the dynamic, ever-changing process of achieving potential
in the physical, social, emotional, mental, spiritual, and environmental dimensions.
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Wellness - It is defined as “the achievement of the highest level of health possible in each of several
dimensions.
To achieve high-level wellness, a person needs to move progressively on a

continuum of positive health indicators.
EFFECTS OF POOR NUTRITION IN CHILDREN
A. Physical Growth
A study published in the "New England Journal of Medicine" by doctors H. Peter Chase and Harold P.
Martin measured children who were hospitalized for undernutrition during their first year of life. The
doctors found that these children were consistently smaller than children who had not experienced
undernutrition, even three and four years later. At the other end of the spectrum, the Academy of
Nutrition and Dietetics suggests that poor nutrition in the form of overfeeding can contribute to weight
issues later in a child's life.
B. Intellectual Development and Education
A 2010 study from "The Journal of Nutrition" found that undernourished 2-year-olds were 16 percent
more likely to fail at least one grade in school and entered school later than their well-nourished
counterparts. The scientists behind the study determined that this could decrease the child's lifetime
income by about 10 percent. The United Nations Standing Committee on Nutrition says that even in
mild or moderate situations, stunted growth resulting from poor nutrition is correlated with poor
academic performance and lowered mental capacity.
C. Emotional and Psychological Development
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Poor nutrition can pave the road to emotional or psychological development issues. Dr. Lawrence
Wilson from the Center for Development has studied psychiatric issues in relationship to hair sample
mineral analysis in children. Some minerals, such as calcium, have proved to be extremely important for
emotional development. Wilson's research has shown developmental emotional issues related to
autism, hyperactivity, depression, bipolar disorder, schizophrenia and anxiety are associated with some
nutritional imbalances.
D. Behavioral Development
Dr. David E. Barrett, a Harvard Medical School psychologist, and Dr. Marian Radke-Yarrow, a National
Institutes of Health child development psychologist, performed research focused on behavioral issues in
6- to 8-year-old children. Their research showed that social behaviors were even more susceptible to
the negative effects of poor nutrition than learning functions were. The children in the study who had
poor nutrition during the critical two-year period after birth appeared withdrawn, less active and were
less helpful than their well-nourished counterparts.
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Early Childhood Development
 A child's most formative years are their youngest, from birth to age 5.
 About 90 percent of a child's brain develops in that time, according to studies. And 85 percent of a
child's intellect, personality and social skills are developed by that age.
The period of childhood between ages 6 and 13 years is characterized by continued physical growth
and rapid cognitive, emotional, and social development.
Due to increased growth and metabolism, the nutritional requirements of children are higher in
proportion to body weight compared with adults.
Good nutrition throughout childhood is important not only to support normal growth and cognitive
development but also to establish healthy eating patterns.
Inadequate intake of nutrients can impair growth and development in children.
Children should get their vitamins from a balanced, healthy diet that includes:
 Milk and dairy products like cheese and yogurt (preferably low-fat products for kids over age 3).
 Plenty of fresh fruits and leafy, green vegetables
 Protein like chicken, fish, meat, and eggs
 Whole grains like steel-cut oats and brown rice
INDICATION:
 Picky Eaters
 Kids who aren't eating regular, well-balanced meals made from fresh, whole foods
 Kids on a vegetarian diet, a dairy-free diet, or other restricted diet
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 Kids with chronic medical conditions such as asthma or digestive problems.
 Particularly active kids who play physically demanding sports
Kids who drink a lot of carbonated sodas, which can leach vitamins and minerals
from their bodies.
Home-cooked meals are not always possible. That's why pediatricians may recommend a daily
multivitamin or mineral supplement.
Multivitamins I NUTRI10 SYRUP & PLUS
 Nutri10Plus is a multivitamin composed of CGF, Taurine, Lysine and Zinc.
⇒ With added benefits of Ascorbic Acid for better nutrients absorption .
⇒ Plus Vitamins A,D and E and Vitamin B complex
2018 KEY MESSAGE - SYRUP
“Nutri10 Plus has the Highest content of Lysine, that makes a Child Aktibo’t Malakas”
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 Doctor, good nutrition throughout childhood is important not only to support normal growth
and cognitive development but also to establish healthy eating patterns. Inadequate intake of
nutrients can impair growth and development in children.
 Doctor, Moms want to provide healthy and nutritious food to their kids but unfortunately it is not
always possible.
 With Nutri10Plus, your patient will be "magana at di picky eater sa pagkain“ because Nutri10Plus
has 300mg content of Lysine that boost child's appetite.
Nutri10Plus with Lysine ensures the good appetite of your kids and have the energy to sustain the
whole day of activities.
 The foods are converted to energy and used to fuel for your patient’s muscle to run, to swim, to
jump and for the brain to concentrate.
2018 KEY MESSAGE - DROPS
“Nutri10Plus Drops helps promote overall immunity, maximize physical growth and
enhance brain development.”
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NUTRI10PLUS – DROPS
Nutritional Information
Each mL
ACTIVE INGREDIENTS contains
% RENI
CGF (Chorella Growth Factor) 5 mg *

Taurine 15 mg *
Lysine 50mg *
Vitamin C (Ascorbic Acid) 35 mg 117%
Zinc, elemental (as Zinc Sulfate) 4.2 mg 100%
Vitamin A (as Palmitate) eq. to 420 RE 764 IU 105%
Vitamin D3 (Cholecalciferol) eq. to 5.25 mcg 210 IU 105%
Vitamin E (as Acetate) eq. to 9mg TE 6 IU 100%
Vitamin B1 (Thiamin HCl) 0.5 mg 125%
Vitamin B2 (Riboflavin) 0.5 mg 125%
Vitamin B3 (Niacinamide) 6 mg 120%
Vitamin B6 (Pyridoxine HCI) 0.4 mg 133%
Vitamin B12 (Cyanocobalamin) 0.6 mg 150%
* No Established RENI (Recommended Energy and Nutrients Intakes per day)
Recommended Dosage:
⇒ 6 months - 2 yeas old: 1 mL
⇒ Less than 6 months : 0.5mL or as directed by a pediatrician.
NUTRI10PLUS - SYRUP
Nutritional Information
Each 5mL
ACTIVE INGREDIENTS contains
% RENI
CGF (Chorella Growth Factor) 100 mg *

Taurine 25 mg *
Lysine 300 mg * 20
Vitamin C (Ascorbic Acid) 60 mg 100%
Zinc, elemental (as Zinc Sulfate) 6.8 mg 133%
Vitamin A (as Palmitate) eq. to 420 RE 764 IU 105%
P195.00 P335.00 P135.00
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Features & Benefits
 Superior in Formulation
Complete and high in composition of multivitamins with added Ascorbic Acid of

60mg for better nutrients absorption.
 Effective, Safe and Assured Quality
Nutri10Plus is manufactured by an FDA accredited and cGMP certified healthcare

manufacturing company, Novagen, Inc.
 More Value for Money
The most affordable 120mL preparation with added Ascorbic Acid formulation.
 Conveniently Available
Major Drugstores Nationwide
Easy Patient Compliance
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 Preparations and Savings
Nutri10Plus Oral Drops 30mL – P135.00
Nutri10Plus Syrup 120mL – P195.00
Nutri10Plus Syrup 250mL – P335.00
COMMUNICATION
I. TARGET AUDIENCE
a) PEDIATRICIAN
b) FM & GP (Practicing pedia)
c) END CONSUMER
II. POSITIONING STATEMENT
a) For Syrup:
“Nutri10 Plus has the Highest content of Lysine, that makes a Child Aktibo’t Malakas”
b) For Drops:
“Nutri10Plus Drops helps promote overall immunity, maximize physical growth

and enhance brain development.”
Chlorella Growth Factor (CGF)
CGF causes children to grow at an accelerated rate and increased healing of damaged tissue.
Taurine
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 Plays an important role in brain development
 Anti-anxiety agent
 Is necessary for normal skeletal muscle functioning
 Protect cells from the harmful effects of ultraviolet light
Lysine
Evidence has shown that taking lysine with other vitamins helps to boost appetite in most children.
Zinc elemental (as Zinc Sulfate)
 An essential component of a large number (>300) of enzymes participating in the synthesis and
degradation of carbohydrates, lipids, proteins, and nucleic acids as well as in the metabolism of
other micronutrients.
 Stabilizes the molecular structure of cellular components and membranes and in this way
contributes to the maintenance of cell and organ integrity.
Zinc elemental (as Zinc Sulfate)
Has an essential role in polynucleotide transcription and thus in the process of genetic expression.
Its involvement in such fundamental activities probably accounts for the essentiality of zinc for all
life forms.
Zinc plays a central role in the immune system, affecting a number of aspects of cellular and
humoral immunity.
Vitamin A (as Palmitate)
Is a vitamin that is needed by the retina of the eye in the form of a specific metabolite, the
light-absorbing molecule retinal that is absolutely necessary for both low-light (scotopic vision) and
color vision.
Vitamin B1 (Thiamine HCl)
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A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with
antioxidant, erythropoietic, mood modulating, and glucose-regulating activities.
Vitamin B2 (Riboflavin)
It plays a key role in energy metabolism, and for the metabolism of fats, ketone bodies,
carbohydrates, and proteins.
Vitamin B3 (Niacinamide)
 One of the eight B complex vitamins that help the body convert food in to energy.
 Niacin also helps improve blood circulation and cholesterol levels.
Vitamin B6 (Pyroxidine HCl)
It is essential for normal brain development and function, and helps the body make the hormones
serotonin and norepinephrine (which influence mood) and melatonin (which helps regulate the
body clock).
Vitamin B6 (Pyroxidine HCl)
Along with vitamins B12 and B9 (folic acid), B6 helps control levels of homocysteine in the blood.
Homocysteine is an amino acid that may be associated with heart disease. B6 is also necessary for
proper absorption of vitamin B12 and for the production of red blood cells and cells of the immune
system.
Vitamin B12 (Cyanocobalamin)
 Is a water soluble vitamin with a key role in the normal functioning of the brain and nervous
system, and for the formation of blood.
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 It is normally involved in the metabolism of every cell of the human body, especially affecting
DNA synthesis and regulation, but also fatty acid synthesis and energy production.
As the largest and most structurally complicated vitamin, it can be produced industrially only
through bacterial fermentation-synthesis.
Vitamin C (Ascorbic Acid)
 Required for the growth and repair of tissues in all parts of the body.
Necessary to form collagen, an important protein used to make skin, scar tissue, tendons,
ligaments, and blood vessels.
Essential for healing of wounds and for the repair and maintenance of cartilage, bones and teeth.
Vitamin D3 (Cholecalciferol)
 Vitamin D without a subscript refers to either D2 or D3 or both.
 One of the most important roles of vitamin D is to maintain skeletal calcium balance by
promoting calcium absorption in the intestines, promoting bone resorption by increasing
osteoclast number, maintaining calcium and phosphate levels for bone formation, and allowing
proper functioning of parathyroid hormone to maintain serum calcium levels.
Vitamin E (as Acetate)
Protects red blood cells and may play a role in immune function, DNA repair and other metabolic
functions.
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Sodium Ascorbate / Ascorbic Acid / Zinc
DAYZINC FAMILY
(drops/chewable tablet/syrup/capsule)
Sodium Ascorbate / Ascorbic Acid / Zinc I DAYZINC FAMILY
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Sodium Ascorbate is a natural and non-acidic (alkaline) form of Ascorbic Acid that has been
buffered (neutralized) with sodium to avoid acidity for persons with sensitive stomach.
It minimizes the negative effects of highly acidic Vitamin C like bloating, gastric and intestinal
irritations. It dissolves faster for quicker absorption and stay on the body tissue longer.
Powerful antioxidant!
Necessary for collagen which is required for the health and repair of various tissues in the body,
including:
 Skin
 Bone
 Cartilage
 Ligamen
MINERAL ZINC
Zinc is a trace element that is necessary for a healthy immune system. A lack of zinc can make a
person more susceptible to disease and illness.
 Boosts immunity and energy level
 Treats Common Cold
 Zinc for treating diarrhea
 Role in would healing
 Preventing age-related macular degeneration AMD
 Zinc and Fertility
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SOURCES MINERAL ZINC
Dayzinc drops
FORMULATION:
Each mL contains:
Sodium Ascorbate 56.24mg [ equivalent to Ascorbic Acid 50mg ]
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Ascorbic Acid 50mg
Zinc Sulfate Monohydrate 27.5mg
DOSAGE:
Children:
3 – 12 months: 0.6 mL
Less than 3 months: 0.3mL
To be taken once daily or as prescribed by the physician
INDICATION
For prevention and treatment of Vitamin C and/or Zinc deficiencies
Dayzinc Syrup
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FORMULATION:
Each 5mL [teaspoonful]
Sodium Ascorbate 56.24mg [equivalent to Ascorbic Acid 50mg]
Ascorbic Acid 50mg
Zinc Sulfate Monohydrate 27.5mg [equivalent to elemental Zinc 10mg]
DOSAGE:
Children:
Under 2 years old: 2.5mL [½ tsp.]
2 – 6 years old: 2.5 – 5mL [½ -1tsp.]
7 – 12 years old: 5 – 10mL [1 – 2 tsp.]
To be taken once daily or as prescribed by the physician
INDICATION:
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Dayzinc Chewable Tablet
FORMULATION:
Sodium Ascorbate 225mg [equivalent to Ascorbic Acid 200mg]
Ascorbic Acid 50mg
DOSAGE:
Adult and children above 15 years: 2tablets daily
Children 4 – 15 years: ½: 1 tablet or as prescribed by the physician
INDICATION:
PRECAUTION:
Ascorbic Acid should be given with care to patients with hyperoxaluria
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Dayzinc Capsule
FORMULATION:
Each 5mL [teaspoonful]
Sodium Ascorbate 562.4mg [equivalent to Ascorbic Acid 500mg]
DOSAGE:
1 capsule daily or as prescribed by the physician
INDICATION:
For prevention and treatment of Vitamin C and Zinc deficiencies
PRECAUTION:
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2018 KEY MESSAGE
“Dayzinc has Triple Defense Action of Sodium Ascorbate, Ascorbic Acid and Zinc para sa
proteksyong C-guradong Zinc-gurado”
Doctor, Sodium Ascorbate defends against the negative effects of highly acidic Vitamin C like
bloating, gastric and intestinal irritations.
SUPPORTING MESSAGE
 Dayzinc is a natural and non-acidic alkaline form of Vitamin C
Doctor, Sodium Ascorbate is a natural and non-acidic (alkaline) form of Ascorbic Acid that avoid
acidity for persons with sensitive stomach. It dissolves faster for quicker absorption and stay on the
body tissue longer.
 Dayzinc has a strong defense actions against common colds and illnesses.
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Doctor, Vitamin C is a strong defense against common colds and illnesses. Its anti-oxidant
properties and its key role in the formation of collagen, which is the most abundant protein in the
human body present in all types of connective tissues such as bones, cartilage, ligaments, and
tendons are added major benefits of Dayzinc.
 Dayzinc strengthens immune system and has superior defense against infection which ultimately
promotes good health and quality of life.
Doctor, our Dayzinc also contains Zinc, which is an immunity booster that also helps and promotes
fast recovery from infections.
Vitamin C and Zinc work in synergy with each other and will save you money in the long run if
purchased in one combined preparation.(drops/syrup/tablet/capsule)
Features & Benefits
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 Effective, Safe and Assured Quality
Dayzinc Oral Drops preparation is an Approved FDA under Drug Category and manufactured by
NOVAGEN with cGMP.
Dayzinc Chewable has the highest content of 250 mg combined Sodium Ascorbate and Ascorbic
Acid vs leading brand.
 Conveniently available
Major Drugstores Nationwide & Easy Patient compliance
 Value for Money
Dayzinc Oral Drops 30mL - P115.00
Dayzinc Syrup 120mL - P130.00
Dayzinc Syrup 250mL - P240.00
Dayzinc Chewable Tablet - P180.00
Dayzinc Capsule - P225.00
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Chlorella Growth Factor (CGF)
CGF causes children to grow at an accelerated rate and increased healing of damaged tissue.
Taurine
• Plays an important role in brain development
• Helps regulate minerals like calcium in your cells
• Essential in the formation of bile salts, which is need for digestion
• Supports your overall central nervous system function
• Regulates your immune system health and antioxidant function
Lysine
 One of nine essential amino acids in humans required for growth and tissue repair
 Strengthens your immunity in fighting diseases and increases your appetite
Zinc
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Young children are at greater risk of zinc deficiency because of increased zinc requirements during
growth.
 Important aspect of nutrition
 Controls and regulates immune response
 Helps reduce diarrhea
 Improves mental awareness and achieve higher performance
 Treats the common cold
 Maintains skin integrity and structure
VITAMIN C (Ascorbic Acid)
Vital to your body's healing process
Water soluble,
Plays an important role in a number of bodily functions including:
 Formation of collagen
 Iron absorption
 Wound healing
 Antioxidant action
 Creation of neurotransmitters like dopamine and epinephrine
VITAMIN A (Palmitate)
Vitamin A is a fat-soluble vitamin that is good for healthy vision, skin, bones and other tissues in the
body.
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Vitamin B-Complex
Vitamin B1 (Thiamine)
Vit B2 (Riboflavin)
Vitamin B3 ( Niacinamide)
Vit B6 (Pyridoxine)
Vit B12 (Cynacobalamin)
> Play a significant role in nerve function and formation of red blood cells
KEY MESSAGE
Basta Multivitamins Go with
DOSAGE for 1-12 years old:
1 - 3 years old - 2.5 – 5 mL
4 – 12 years old - 5 mL
Price - P 155.00 for 120mg
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Sodium Ascorbate I DAYCEE SYRUP
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Sodium Ascorbate I DAYCEE SYRUP
 Description:
Sodium Ascorbate = Syrup
 Indication:
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Daycee is used for the treatment and prevention of Vitamin C deficiencies.
 Benefits:
1. Immune system - proteksyon laban sa pneumonia, diarrhea at iba pang

impeksyon. Binabawasn nito ang tagal at paglala ng sipon.
2. 2. Non-acidic vitamin C
 Precaution:
SODIUM ASCORBATE
Sodium ascorbate is a form of ascorbic acid (Vitamin C) which is more bioavailable and “alkaline”
Benefits of Sodium Ascorbate
1. Cardiovascular health
2. Good Eye Health
3. Immune Function
4. Wound healing
5. Vitamin E Regeneration
COMPOSTION AND STRENGTH
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DOSAGE - 2-12 years old = 5mL
7-12 years old = 10mL
PRICE - Php 120.00
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Cefixime I ZEFAXIM
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Cefixime I ZEFAXIM
Zefaxim is a 3rd generation oral cephalosporin, effective against wide spectrum of sensitive gram
positive, gram negative and anaerobic bacterial pathogens including beta-lactamase producing
strains.
Each 5mL or reconstituted suspension contains 100mg of Cefixime.
ACTION
It has high affinity for penicillin binding proteins with varying site of activity. It acts by inhibition of
bacterial cell-wall synthesis.
PHARMACOKINETICS
Absorption: 40%-50%
Peak Plasma Concentration 2-3 mcg/mL in 2 hours
Half Life 3-4 hours
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Protein Binding 65%
Excretion 50% active in the urine
INDICATION
For treatment of infections due to sensitive gram-positive and gram-negative bacteria.
 Focused on UTI and GITI (majority of the infections are gram negative).
Used to treat acute bronchitis, secondary infections of chronic respiratory tract diseases,
pneumonia, cystitis, and gonococcal urethritis.
DOSAGE
AVAILABILITY AND PRICE
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POINTS OF DISCUSSION
 Taste- Palatable strawberry flavor
 Ease of administration- measuring cup and spoon
 Quality- Assay Analysis
 Efficacy- Study or cure rate versus another anti- infective
 Price- 113% lower than leading brand
COMPETITORS:
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PRODUCT POSITIONING
Zefaxim will be promoted to all Pedia doctors stated in TML.
It will serve as the P1 product of the TOP identified Cefixime user.
ATTENTION GETTING
Doctor, we want your patients to look happy and healthy. However, no matter how we protect
them, it’s inevitable that kids still get sick. Speaking of sickness, isn’t it that infection is one of the
common causes of kid’s hospital visits?
Be it respiratory, GI, and UTI.
KEY MESSAGE
“Zefaxim tastes delicious due to its palatable strawberry flavor but it also does its job of killing the
bacteria in our body.”
FEATURES I ADVANTAGE I BENEFITS
When we talk of infection, here’s a sweet treat from Wert, ZEFAXIM :
 Zefaxim tastes delicious due to its palatable strawberry flavor but it also does it job of killing
the bacteria in our body.
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F: Zefaxim comes in palatable strawberry flavor
A: Kids will not spit out, at “ walang habulan blues”
B: Treatment success is assured
F: Zefaxim has broad range of activity and stable even against b-lactamase producing organism
A: We’re assured of lesser chances of bacterial resistance
B: Remission of symptoms will be faster “at balik sigla ang kids”
F: Zefaxim comes with kid-friendly measuring cup and spoon
A: Ease of administration
B: Walang tapon at accurate and dosage
F: Zefaxim passed the Assay analysis conducted at CeDRES
A: Quality is not compromise
B: Both Doctor and Moms will be confident with the treatment success!
F: Zefaxim’s price is lower by 113% compared to innovator brand
A: Treatment will not be compromised
B: Moms can save as much as 541 pesos/bottle!
COMMITMENT SEEKING
Doctor, Zefaxim’s value and patient’s benefits will never be realized, unless you will try this. Here’s a
good start of trying Zefaxim, a stock size sample from Wert Philippines Inc.
Available Mercury Drugstore mention specific branch.
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POINTS OF DISCUSSION
 Taste- Palatable strawberry flavor
 Ease of administration- measuring cup and spoon
 Quality- Assay Analysis
 Efficacy- Study or cure rate versus another anti- infective
 Price- 113% lower than leading brand
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ETHICAL/ADULT BRANDS
Eperisone HCl I PERISPA
Vitamin B Complex I CRAMIN FORTE
Calcium Carbonate + Vitamin D3 I CALCIDAY

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Ampalaya / Banaba / Camote / Duhat I ALPHABETIC
OB Multivitamins I NUTRI10 OB
Adult Multivitamins I NUTRI10 EXCEL
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Eperisone HCL I PERISPA 50mg
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Eperisone HCL I PERISPA
The Muscular System
- Specialized tissue that enable the body and its parts to move.
Anterior View
Posterior View
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TRIVIA:
How many muscles are there in the human body?
 Answer: 640 Muscles
 The muscles make up about 40 % of the body mass.
What is the longest muscle in the body?
 Answer: The Sartorius
 The Sartorius runs from the outside of the hip, down and across to the inside of the knee. It twists
and pulls the thigh outwards.
What is the smallest muscle in the body?
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 Answer: The Stapedius
 The Stapedius is located deep in the ear. It is only 5mm long and thinner than cotton thread. It is
involved in hearing.
What is the biggest muscle in the body?
 Answer: The Gluteus Maximus
 The Gluteus Maximus is located in the buttock. It pulls the leg backwards powerfully for
walking and running.
Functions of the Muscles
 Movement
 Maintenance of posture and muscle tone
 Heat production
 Protects the bones and internal organs.
Muscle Classification
• Functionally
Voluntarily – can be moved at will
Involuntarily – can’t be moved intentionally
• Structurally
Striated – have stripes across the fiber
Smooth – no striations
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The 3 Types of Muscles
 SMOOTH MUSCLE
 CARDIAC MUSCLE
 SKELETAL MUSCLE
Smooth Muscle
 Fibers are thin and spindle shaped.
 No striations
 Single nuclei
 Involuntary
 Contracts slowly
• They fatigue… but very slowly and found in the circulatory system
• Lining of the blood vessels helps in the circulation of the blood
• Found in the digestive system - Esophagus, stomach, intestine
• Controls digestion - Found in the respiratory system
• Controls breathing - Found in the urinary system, Urinary bladder, Controls urination
Cardiac Muscle
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 Cells are branched and appear fused with one another
 Has striations
 Each cell has a central nuclei
 Involuntary
• Found ONLY in the heart
• Contractions of the heart muscles pump blood throughout the body and account for the heartbeat.
• Healthy cardiac muscle NEVER fatigues or else…
Skeletal Muscle
 Fibers are long and cylindrical
 Has many nuclei
 Has striations
 Have alternating dark and light bands
 Voluntary
• Attached to skeleton by tendons and causes movement of bones at the joints.
• And yes… they do fatigue
• Muscle fatigue activity
- what substance forms causing muscle fatigue???
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Functions of Skeletal Muscle
1. Movement – muscle move bones by pulling not pushing.
 Synergists – any movement is generally accomplished by more than one muscle. All of the
muscles responsible for the movement are synergists.
The one that is most responsible for the movement is the Prime Mover (agonist).
 Antagonists – muscles and muscle groups usually work in pairs
– example the biceps flex your arm and its partner the triceps extend your arm. The two
muscles are antagonists, i.e. cause opposite actions.
– when one contracts the other relaxes.
 Levators – muscle that raise a body part.
2. Maintenance of posture or muscle tone
We are able to maintain our body position because of tonic contractions in our skeletal muscles.
These contractions don’t produce movement yet hold our muscles in position.
3. Heat production – contraction of muscles produces most of the heat required to maintain body
temperature.
Structure of Skeletal Muscle
1. Composed of striated muscle cells (=muscle fibers) and connective tissue.
 Most muscles attach to 2 bones that have a moveable joint between them.
 The attachment to the bone that does not move is the origin.
 The attachment to the bone that moves is the insertion.
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Tendons anchor muscle firmly to bones. Tendons are made of dense fibrous
connective tissue.
 Ligaments connect bone to bone at a joint.
2. Bursae – small fluid filled sacs that lie between some tendons and the bones beneath them. They
are made of connective tissue and are lined with synovial membrane that secretes synovial fluid.
3. Contribution of the nervous system
 Electrochemical impulses travel from the frontal lobes of the cerebrum via motor nerves to the
muscle fibers and cause them to contract.
 Sensation is a function of the brain – impulses are integrated in the parietal lobes of the
cerebrum (conscious muscle sense) and in the cerebellum (unconscious). These activities promote
coordination.
4. Microscopic anatomy
Muscle cells (fibers) are grouped in a highly organized way in the muscle. The membrane that
surrounds the muscle cell is called the sarcolemma.
 Muscle cells are filled with 2 types of fine threadlike proteins called myofilaments: myosin (thick)
and actin (thin). These structures slide past each other causing the muscle cell to contract or shorten.
 The myofilaments are arranged in the cells in small units called sarcomeres.
5. Neuromuscular junction
Spot where the axon of a motor nerve nears the muscle fiber.
The axon terminal does not touch the muscle but comes close. The space between the axon and the
muscle cell is called the synapse.
Within the terminal end of the axon are small sacs filled with a neurotransmitter called acetylcholine.
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Muscle Contraction
SEQUENCE
 Electrical impulse travels down a motor neuron. When it reaches the end, acetylcholine (chemical) is
released into the synapse.
Acetylcholine bind to special receptors on the muscle cell and causes an electrical impulse to spread
over the cell.
 The sarcomeres shorten and the muscle cell contracts.
Movement of Muscles
⇒ Origin: the attachment of the muscle to the bone that remains stationary
⇒ Insertion: the attachment of the muscle to the bone that moves
⇒ Belly: the fleshy part of the muscle between the tendons of origin and/or insertion
Movement of skeletal muscle
 These muscles move when the brain sends messages to the muscle
 Always work in pairs
 2 movements of skeletal muscle
 Contraction (shorten)
 Extension (lengthen)
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Practice these Movements
1. Bend arm
- biceps contract
- triceps extend
2. Straighten arm
- biceps extend
- triceps contract
3. Bend knee
- quadriceps extend
- hamstrings contract
4. Straighten knee
- quadriceps contract
- hamstrings extend
5. Crunches
- abdomen contract
- back muscles extend
6. Point toes
- calf muscle contract
- shin muscle extend
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The Nervous System
How is the Nervous System Organized?
Neurons within our nervous system must take in sensory information from the outside world and then
decide what to do with the information.
What is the Nervous System?
 The Nervous System is the body’s main processing system for information.
This consists of structures and organs that facilitate electrical and chemical communication in the
body.
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Central Nervous System (CNS)
 The brain
 The spinal cord
Peripheral Nervous System (PNS)
 The main function of the PNS is to connect the CNS to the limbs and organs
Nervous System (master controller of the body)
Central Nervous System
 Command center of the body

 Interprets incoming sensory information, then sends out instructions on how body should react.
Peripheral Nervous System
 Consist mainly of nerves that extend from the brain and spinal cord to areas in the rest of the body.
CENTRAL NERVOUS SYSTEM
I. BRAIN
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-Mushroom shaped structure encased with in the skull
-One trillion nerve cells
-Gray & white matter
-Glucose, O2 & certain ions pass easily through blood
-Four major parts,
1-Diencephalon
2-Brain stem
3-Cerebrum
4-Cerebellum
II. SPINAL CORD
-Transmits impulses to and from the brain & controls some reflex actions
-Vertebral column encloses the spinal cord
-13.5 M neurons
-31 pairs of spinal nerves
8 (neck area)+12(chest area)+11 (lower part)
PERIPHERAL NERVOUS SYSTEM
I. SENSORY / AFFERENT DIVISION
 Consists of nerve fibers that convey impulses to the central nervous system from sensory
receptors located throughout the body.
II. MOTOR / EFFERENT DIVISION
 It transmits impulses from the CNS to effector organs, the muscles and glands
Makes up :
⇒ Somatic Nervous System
⇒ Autonomic Nervous System
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SOMATIC NERVOUS SYSTEM
• Controls activities of voluntary movements of skeletal muscles.
• Transmits sensory messages to the central nervous system.
• Carries messages from the voluntary muscles and sense organs.
• Activated by touch, pain, changes in temperature, and changes in body position.
AUTONOMIC NERVOUS SYSTEM
• Controls activities of involuntary movements of skeletal muscles
• Regulates the body’s vital functions, such as heartbeat, breathing, digestion, and blood pressure
• It has two divisions
• The sympathetic nervous system reacts to stress.
• The parasympathetic nervous system restores peace to the body’s systems
AUTONOMIC NERVOUS SYSTEM
I. PARASYMPATHETIC NERVOUS SYSTEM
 Is concerned especially with preparing the body to react to situations of stress or emergency.
II. SYMPATHETIC NERVOUS SYSTEM
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 Is concerned especially with preparing the body to react to situations of stress or emergency.
Two parts that have opposite effects on the organs they control:
Sympathetic (“gas pedal”)
Parasympathetic (“brake”)
How much do you know about YOUR brain and the spinal cord?
Spinal Cord
 The spinal cord transmits signals from the sensory organs, muscles and glands to the brain.
 Controls reflexive responses
 Conveys signals from the rest of the body
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The spinal cord is like a communication superhighway between the brain and the rest of the body.
Spinal cord communication
 Communicates with the body below the head through sensory and motor neurons
 Sensory neurons (afferent neurons)
Carry information about touch, pain, and other senses from the periphery of the body to the
spinal cord
 Motor neurons (efferent neurons)
Transmit impulses from the central nervous system to the muscles and glands
DID YOU KNOW THAT?
⇒ There are about 3 million miles of axons in the human brain
⇒ Information travels in the nerves at speeds up to 268 miles per hour
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Does bigger mean smarter?
NO… larger brains have nothing to do with intelligence.
True or False?
We Only Use 10% of Our Brain ⇒ FALSE
- This is a Psychology Myth…we use all of the brain most of the time.
Three Types of Muscles Found in the Human Body
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• Skeletal (muscles that move voluntarily)
• Smooth (involuntary muscles in organs)
• Cardiac (only found in the heart)
The Function of Muscles
• To help us move and maintain posture
• Create heat (the calories burned for energy tend to have an output of 75% heat, therefore on a cold
day running is an effective way to warm up).
• Regulate organs
• Move substances around the body (blood from the heart and food through the digestive system.
SPASTICITY
Spasticity was described in 1980 as a motor disorder with increased muscle tone and involuntary jerking
of tendons (the flexible cords that connect joints).
Nine years later, Robert R. Young, MD introduced the term ‘‘spastic paresis, which includes weakness,
loss of dexterity, and trouble controlling muscles.
Spasticity is a common phenomenon seen in neurologic disorders that result in loss of mobility and may
produce pain due to muscle spasms. It is a state of sustained increase in tone of a muscle when it is
passively lengthened.
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In simple terms of clinical neurology, spasticity is defined as increased resistance to passive movement
due to a lowered threshold of tonic and phasic stretch reflexes.
Spasticity
It is a disorder of the body's motor system in which certain muscles are continuously contracted. This
contraction causes stiffness or tightness of the muscles. It may interfere with gait, movement, and
speech.
In MS, ‘spasticity’ ( muscle spasm & stiffness) is thought to be due to nerve conduction being affected
by lesions located in the brain or spinal cord.
This means that the upper motor neurones struggle to regulate messages to the lower motor neurones.
The lower motor neurones can then become overactive and hypersensitive, causing stiffness or spasms
in the muscles.
Spasticity occurs as a result of an imbalance between the excitatory and inhibitory signals from the brain
and/or spinal cord.
Why worry ?
Pain is the most common symptom of most musculoskeletal disorders.
Pain ranges from mild to severe and from acute and short-lived to chronic and of long duration and
may be local or widespread.
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MUSCULOSKELETAL DISORDER
An MSD is an injury or illnesses of:
 Muscle
 Nerves
 Tendons
 Ligaments
 Joints
 Cartilages
 Spinal Discs
Interventions for muscle stiffness and spasm
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Active movement exercise:
Recent research showed this to be the most effective form of exercise for spasm / stiffness.
Muscle relaxant medication –
all (except dantrolene) affect neurotransmitters, promoting increase of inhibitory transmitters like GABA.
Pharmacological Intervention
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Spasmolytics (antispasmodic)
⇒ pharmaceutical drug or other agent that suppresses muscle spasms
2 Types :
smooth muscle spasm
skeletal muscle spasm
Smooth muscle spasm
- Type of antispasmodic used for smooth
muscle relaxation, especially in tubular
organs of the gastrointestinal tract.
- The effect is to prevent spasms of the stomach, intestine or urinary bladder
- Dicyclomine / Hyoscyamine
Skeletal muscle spasm
- Spasm may also be seen in movement
disorders featuring spasticity in neurologic
conditions such as cerebral palsy, multiple
sclerosis, and spinal cord disease
- Eperisone / Baclofen / Tizanidine / Dantrolene
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Eperisone HCL I PERISPA
GENERIC NAME:
EPERISONE Hydrochloride 50mg
BRAND NAME:
PERISPA 50mg
As a Muscle Relaxant :
- widely used to treat spasms and sensitive reflexes
- alleviate pain in the muscles brought about by various activities, pressures, or stimuli.
The main component of the drug is Eperisone hydrochloride. The drug is used for cerebral palsy, SVD
or spinal vascular disease, headaches, and spastic paralysis
Mode of Action :
 Primarily acts on spinal cord level to depress spinal reflex and produced skeletal muscle relaxation.
Increases blood circulation by exhibiting muscular sympatholitic action on the vascular smooth
muscle.
Target Indications :
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 Spasticity
 Cervical spondylosis
 Shoulder arm neck syndrome
 Muscle spasm
 Back Pain
 Muscle stiffness
Dosage :
⇒ 150 mg per day in three divided doses taken with full stomach (after meals)
⇒ Dose may be adjusted according to patient’s age & symptoms.
FEATURES
 Cost-effective / Lowest Eperisone preparation in the market
 Safe to be given with CV & CNS drugs
 It does not impair quality of life due to non-sedative action
 The best Anti-Spasmodic drug proven
 Sugar-coated tablet
ADVANTAGE
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 Economic alternative for muscular spasm & neurological disorders
 Patient compliance
 Less drowsiness / dizziness that will hinder daily activities
 Quality and efficacy confirmed
 Mask the bitter taste
BENEFITS
 Savings assured
 Convenience for use
 Leads a normal life
 Pain – free life
 Better compliance
Precautions / Contraindications :
⇒ Hypersensitivity to any ingredient of the drug
⇒ Patients with hepatic function disorder
(it aggravate hepatic function)
⇒ It has not been established to be safe for the use of pregnant women
⇒ Avoid administration in nursing mothers
COMPETITORS:
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1.
COMPANY: HI-EISAI (Innovator Brand)
BRAND NAME: MYONAL 50mg
PRICE: P 26.75 / tab
PREPARATION: BOX OF 100’s
2.
COMPANY: WERT PHILIPPINES, INC.
BRAND NAME: PERISPA 50mg
COMPANY: CATHAY DRUG
BRAND NAME: MYELAX 50mg
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Vitamin B Complex
 Vitamin B1: Essential nutrient needed for the normal functioning of several organ
systems.
 Vitamin B6: Important for normal brain development and for keeping the nervous
system and immune system healthy.
 Vitamin B12: Helps keep the body’s nerve and blood cells healthy and helps make
DNA, the genetic material in all cells.
B Complex helps…
⇒ Increase metabolism
⇒ Maintain healthy skin
⇒ Enhance immunity
⇒ Prevent anemia
Risk of decreased Vitamin B absorption due to…
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• Smoking
• Excessive alcohol intake
• Old age
• Medications
• Strict vegetarian diet
Vitamin B1 Deficiency
 Beriberi
 Weak limbs
 Edema
 Loss of appetite
 Numbness of arms and legs
 Fatigue
 Anemia
 Dermatitis
 Depression
 High blood pressure
 Neuropathy
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 Infertility
 Hyperthyroidism
 Cognitive Decline
 Fatigue/Low Energy
 Neuropathy
 Hair problems
RENI (Recommended Energy Nutrient Intake)
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ACTION
Vitamin B1
 A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with
antioxidant, erythropoietic, mood modulating, and glucose-regulating activities.
 Plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and
insulin on arterial smooth muscle cell proliferation.
 May also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.
Vitamin B6
 Helps the body make several neurotransmitters, chemicals that carry signals from one nerve cell
to another. It is essential for normal brain development and function, and helps the body make the
hormones serotonin and norepinephrine (which influence mood) and melatonin (which helps
regulate the body clock).
 B6 is also necessary for proper absorption of vitamin B12 and for the production of red blood
cells and cells of the immune system.
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Vitamin B12
 Is a water soluble vitamin with a key role in the normal functioning of the brain and nervous
system, and for the formation of blood.
 It is normally involved in the metabolism of every cell of the human body, especially affecting
DNA synthesis and regulation, but also fatty acid synthesis and energy production.
As the largest and most structurally complicated vitamin, it can be produced industrially only
through bacterial fermentation-synthesis.
Pharmacokinetics
After oral administration, cyanocobalamin absorbed from the gastrointestinal tract. Metabolized in
the tissues, becoming a co-enzyme form - adenosylcobalamin which is the active form of
cyanocobalamin. Excreted in bile and urine.
INDICATION
Treatment and prevention of Vitamin B deficiencies.
High potency formulation = therapeutic
Neuropathy - Peripheral neuropathy, a result of damage to your peripheral nerves, often causes
weakness, numbness and pain, usually in your hands and feet. It can also affect other areas of your
body.
Neuralgia - is a stabbing, burning, and often severe pain due to an irritated or damaged nerve.
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Neuritis - is inflammation of a nerve or the general inflammation of the peripheral nervous system.
Symptoms depend on the nerves involved but may include pain, paresthesia (pins-and-needles),
paresis (weakness), hypoesthesia (numbness), anesthesia, paralysis, wasting, and disappearance of
the reflexes.
Indication – Vitamin B1
 In treatment of mild thiamine deficiency , dosage of 30mg daily in single or divided dosage have
been recommended.
 In severe thiamine deficiency, doses up to 300mg daily may be given.
 Doses of 150mg daily have been used in general deficiency states
 Higher doses of up to 400mg daily have been used in the treatment of anemia, metabolic
disorders, and seizures.
In the absence of neurological involvement, cyanocobalamin may be administered in doses of

250mcg to 1000mcg.
Dosage, Availability, and Price
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Prophylaxis : 1-2 capsules daily
Therapeutic : 2-4 capsules daily
Chronic cases: a longer therapy may be required and dosage may be adjusted upon
the physician’s recommendation.
Capsule : Aluminum Foil Strip x 4’s (Box of 100’s)
Price : P15.00/Capsule or P1,500.00/box of 100’s
Precaution
Administration of doses greater than 10mcg of Vitamin B12 daily may produce a hematological
response in patients with folate deficiency.
Side Effects
 Vitamins contained in Cramin Forte are completely non-toxic even in high doses and usually,
no side effects occur.
 Sensitivity to Vitamin B may sometimes be encountered if administration is at prolonged

intervals, irregular, or if initial dose is low and suddenly increased.
 Liver dysfunction also predisposes patients to hypersensitivity reactions.
 It must be stressed that hypersensitivity to Vitamin B1, is very rare when orally given unlike if
administered by intravenous injections where hypersensitivity is more often encountered.
Major Competitors
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Calcium Carbonate + Vitamin D3 CALCIDAY
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Calcium Carbonate + Vitamin D3 I CALCIDAY
Experiencing…
 Weak muscles (Muscle pain and spasms)
 Low Energy
 Declining in hormone production (Estrogen, Parathyroid)
 Slow blood clotting
 Weak Bones
 Weak Teeth
CALCIUM - The most essential mineral for bone health.
⇒ An important component of a healthy diet and a mineral necessary for life.
⇒ Calcium plays an important role in building stronger, denser bones early in life and
keeping bones strong and healthy later in life.
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⇒ Approximately 99 percent of the body's calcium is stored in the bones and teeth. The
rest of the calcium in the body has other important uses, such as some exocytosis,
especially neurotransmitter release, and muscle contraction.
CALCIUM
⇒ Long-term calcium deficiency can lead to rickets and poor blood clotting and in case of a
menopausal woman, it can lead to osteoporosis, in which the bone deteriorates and there is
an increased risk of fractures.
⇒ Lifelong deficit can affect bone and tooth formation, over-retention can cause hypercalcemia
(elevated levels of calcium in the blood), impaired kidney function and decreased absorption
of other minerals.
⇒ High calcium intakes or high calcium absorption were previously thought to contribute to
the development of kidney stones.
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BIOLOGICAL FUNCTIONS OF CALCIUM
• Bone and teeth mineralization
• Regulate neuromuscular excitability
• Blood coagulation
• Secretory processes
• Membrane integrity
• Plasma membrane transport
• Enzyme reactions
• Release of hormones and neurotransmitters
• Intracellular second messenger
CALCIUM OCCURENCE
• Calcium is not naturally found in its elemental state.
• Occurs most commonly in sedimentary rocks in the minerals calcite, dolomite and
gypsum. It also occurs in igneous and metamorphic rocks chiefly in the silicate minerals:
plagioclase, amphiboles, pyroxenes and garnets.
VITAMIN D
• Is added to some calcium supplements.
• Proper vitamin D status is important because vitamin D is converted to a hormone in the

body which then induces the synthesis of intestinal proteins responsible for calcium absorption.
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RISK FACTORS OF CALCIUM DEFICIENCY
Lifestyle: inactivity, stress, diet, aging
Behaviour: sex, smoking, alcohol, drugs
Fatal Four: obesity, cholesterol, diabetes, hypertension
Diseases: HIV, heart, cancer, autoimmune, immuno-compromise
Infection: animals, birds, insects, water, travel
Exposure: environment, occupation, sunlight, radiation, chemicals
Medications: medications, contraceptives, steroids
Womens: pregnancy, childbirth, menopause
Who needs more Calcium?
 Smokers
 Pregnant women
 People who love to drink Caffeinated drinks
 Elders
 Menopausal Women
 People with sedentary lifestyles
Calcium Supplementation
 Post Menopausal Women
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 Women of childbearing age whose menstrual periods stop
 Lactose intolerants
 Absorption problems due to GI illness
 On a vegan diet
WHAT ARE THE SOLUTIONS?
• Take in food rich in Calcium
• Expose to healthy sunlight and take in Vitamin D which helps absorb Calcium and keep bones
healthy and strong.
• Eliminate bad habits and do a lifestyle change
*Our body doesn’t produce Calcium by its own. Therefore, we supply Calcium from food/ products
we consume.
*Too much calcium intake can cause problems such as constipation, hypercalcemia, calcium
buildup in soft tissues and trouble absorbing iron and zinc.
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This is what CALCIDAY does:
 Strengthens bones and teeth
 Helps prevents Osteoporotic fractures
 Strengthens muscles
 Enhances Calcium Absorption
 Supply calcium during amenorrhea and during childbearing
 Helps indigestion and heartburn (surge of acid in lower part of esophagus)
CALCIUM FACTS:
 1 tablet of Calciday = 2 glasses of milk
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 Calcium supplement is best absorbed when taken in amounts of 500 - 600mg or less, preferably
with a meal
COMPOSITION:
Elemental Calcium
Refers to the supplemental label to determine how many milligrams (mg) of elemental calcium it
contains. This is the amount of pure calcium contained in the supplement and the amount that
your body can use to help prevent bone density.
Composition Benefits
 Calcium Carbonate
• Most inexpensive form of calcium
• Equivalent to 40% elemental calcium compared to Calcium Citrate which is only

equivalent to 21% elemental calcium
 Vitamin D3
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• Helps the body absorb calcium
Dosage
Availability and Price
Who should not use Calciday?
⇒ Patients with allergy to calcium carbonate or any other components of the product.
⇒ Hypercalcemia
⇒ Severe hypercalciuria
What should the patient tell to the doctor before taking Calciday?
 Mild hypercalciuria
 Impaired kidney function
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 Kidney stones
What should be avoided when taking Calciday?
*Do not breast-feed. It is not known if Calciday will pass through the milk of the mother.
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DIABETES MELLITUS
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Review of Anatomy and Physiology
PANCREAS - Secretes hormones called:
- Insulin by Beta Cells
- Glucagon by Alpha Cells
Pancreas secretes 40-50 units of insulin daily in two steps:
 Secreted at low levels during fasting ( basal insulin secretion)
 Increased levels after eating (prandial)
⇒ An early burst of insulin occurs within 10 minutes of eating then proceeds with increasing
release as long as hyperglycemia is present.
INSULIN
 Insulin allows glucose to move into cells to make energy
 Inhibits glucagon activity
Physiology
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DIABETES MELLITUS
 Is a chronic disorder of carbohydrate, protein, and fat metabolism resulting from insulin
deficiency or abnormality in the use of insulin.
Types of DIABETES
1. Type I
• Formerly known as Insulin – Dependent Diabetes Mellitus (IDDM)
• Autoimmune (Islet cell antibodies)
• Early introduction of cow’s milk and cereals
• Intake of medicine during pregnancy
• Indoor smoking of family members
• Destruction of beta cells of the pancreas / little or no insulin production
• Requires daily insulin admin.
• May occur at any age, usually appears below age 15
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2. Type II
• Formerly known as Non Insulin–Dependent Diabetes Mellitus (NIDDM)
probably caused by:
• disturbance in insulin reception in the cells
• Number of insulin receptors
• Loss of beta cell responsiveness to glucose leading to slow or insulin release by the pancreas.
• Occurs over age 40 but can occur in children
• Common in overweight or obese
• W/ some circulating insulin present, often do not require insulin
Who are at risk?
Obesity
Race
History of CVD
HTN
Physical inactivity
Familial history
Polycystic Ovary Syndrome
Gestational Diabetes
Clinical Manifestations ( Signs and Symptoms)
106
- Polyuria - weakness
- Polydipsia - fatigue
- Polyphagia - blood sugar / glucose level
- weight loss - (+) glucose in urine (glycosuria)
- nausea / vomiting
- changes in LOC (severe hyperglycemia)
(sleepiness, drowsiness coma)
- recurrent infection, prolonged wound healing
- altered immune and inflammatory response, prone to infection (glucose inhibits the phagocytic
action of WBC resistance)
- genital pruritus – (hyperglycemia and glycosuria favor fungal growth : candidal infection –
resulting in pruritus, common presenting symptom in women)
107
What is diabetes?
 Diabetes means that your blood sugar (glucose) is too high
 Your blood always has some sugar in it because the body needs sugar for energy
 But too much sugar in the blood can cause damage to your health
 Diabetes can be controlled but not cured
108
Alternative Treatment with Food Supplements:
109
Ampalaya, Banaba, Camote, Duhat - ALPHABETIC
Ampalaya
Ayon sa mga pananaliksik, ang ampalaya ay mabisang panglunas sa sakit na diyabetes.

Sa wastong pagkain at dosi ng ampalaya, ito ay makatutulong sa pagtaas ng produksyon
ng beta cells ng lapay (pancreas). Bilang resulta, pinagbubuti ang abilidad ng ating katawan na
gumawa ng insulin, ang pumipigil sa pagtaas ng blood sugar ng mga diyabetiko.
Banaba
Kilalang nakakapagpababa sa blood sugar ng mga pasyenteng may diyabetes ang banaba.
May sangkap ito na mataas sa corosolic acid, isang triterpenoid compound na tumutulong sa
pagkarga at tamang pagdaloy ng glucose. Bukod pa rito, ayon sa mga klinikal na pagsusuri
ang corosolic acid ay nakakatulong sa pagbawas ng fat tissue, pagtaas ng timbang, poor glucose
control at blood sugar level
Camote
Ang Camote ay kilala bilang may mababang Glycemic Index (GI) na angkop sa mga
diyabetiko sa pag regulate ng blood-sugar levels sa katawan. Ang mababang glycemic index ang
sanhi para ang tiyan ay bumagal sa pag breakdown ng food into glucose, na nagpipigil sa
pangangailangan para sa insulin.
110
Duhat
Ayon sa mga pag-aaral sa laboratoryo, nagagawa ng katas ng duhat na paramihin ang mga
selyula na tumutugon sa insulin mula sa lapay kaya ito ay mainam para sa sakit na diyabetes.
Today many people are looking for natural supplements to be more healthy. Even Doctors are
recommending that people take these supplements.
Supplements have become the alternative way to combat diabetes.
ALPHABETIC is…
Is an all natural, herbal, food supplement contains the miracle vegetables and herbs Ampalaya,
Banaba, Camote, & Duhat.
Together, these components combat blood sugar related diseases
It was produced to address the growing rate of obesity that increases the risk of developing type 2
Diabetes with poor intake of vegetables and those with sedentary lifestyle.
COMPOSITION
Each tablet contains:
(Momordica charantia) Ampalaya Leaf Powder 225mg
(Lagerstroemia speciosa Linn.) Banaba Leaf Powder 225mg
(Ipomoea batatas) Camote Leaf Powder 25mg
111
(Syzygium cumini) Duhat Leaf Powder 25mg
INDICATION
 Controls the blood glucose level in a diabetic patient
 Supportive drug regimen in the management of diabetes mellitus type II
DOSAGE
Adults:
One (1) Tablet three times a day or as prescribed by a physician.
AVAILABILITY & PRICE
11 / tablet box of 30’s
MANUFACTURER & DISTRIBUTOR:
LA CROESUS PHARMA, INC. In Brgy. Sto. Tomas, Binan, Laguna for WERT PHILIPPINES, INC.
112
113
Folic Acid + Iron + Zinc + Vitamins
Product Name : NUTRI 10 OB
Form : CAPSULE
Packaging : Blister Pack by 10’s
(Box of 30’s)
Positioning (USP) : Nutrified Mommies
Nutrified Babies
Price : P7.00 per capsule
P210 per box of 30’s
Composition : Folic Acid, Iron, Zinc, Vitamins
Target Consumer : Pregnant and lactating Woman (Women of Reproductive age)
Dosage : Pregnant women
(1st – 3rd trimester) Lactating women
114
(1st – 2nd semester) One capsule daily or as prescribed by a physician.
Indications : Reduces pregnancy stress,
Increases supply of energy,
Improves immune system,
Prevents Iron deficiency anemia and
Birth defects.
FDA Registration No. :FR – 70891
Category : Food Supplement
Manufacturer : Novagen Pharmaceutical Co., Inc.
Distributor : Wert Philippines,Inc.
Product Code : NUR4
Bar Code No. : 4806511170517
Composition :
Getting enough Folic Acid
The Centers for Disease Control and Prevention (CDC) recommends that all women of
childbearing age — and especially those who are planning a pregnancy — consume about 400
micrograms (0.4 milligrams) of folic acid every day. Adequate folic acid intake is very important
115
before conception and at least 3 months afterward to potentially reduce the risk of having a fetus
with a neural tube defect.
Folic Acid
That's why it's so important for all women of childbearing age to get enough folic acid — not
just those who are planning to become pregnant. Only 50% of pregnancies are planned, so any
woman who could become pregnant should make sure she's getting enough folic acid.
For a woman to have a healthy baby means making sure she’s healthy, too. One of the most
important things a woman can do to help prevent serious birth defects in their baby is to get
enough Folic acid every day + Iron + Zinc + Vitamins— even before, during conception and
after pregnancy.
Iron Elemental (as Ferrous Fumarate)
116
Iron (II) fumarate, also known as ferrous fumarate, is the iron (II) salt of fumaric acid, occuring as a
reddish-orange powder, used to supplement iron intake, occurring as a reddish-orange powder,
used to supplement iron intake. Pure ferrous fumarate has an iron content of 32.87%, therefore
one tablet of 300 mg iron fumarate will contain 98.6 mg of iron (548% Daily Value based on 18 mg
RDI).
Ferrous fumarate is a type of iron. You normally get iron from the foods you eat. In your body, iron
becomes part of your hemoglobin and myoglobin. Hemoglobin carries oxygen through your blood
to tissues and organs. Myoglobin helps your muscle cells store oxygen.
Ferrous fumarate is used to treat iron deficiency anemia (a lack of red blood cells caused by having
too little iron in the body).
Iron deficiency is the world’s leading nutritional disorder and cause of anaemia.
As many as 4-5 billion people, or 66-80% of the world’s population, may be iron deficient, while 2
billion- over 30% of the world’s population- are anaemic, mainly due to iron deficiency.
-Quantifying selected major risks to health. World Health Report 2002.Reducing

Risks.Promoting Healthy Life. Geneva: World Health Organization, 2002-52-54.
Zinc Elemental (Zinc Sulfate)
Zinc is a naturally occurring essential mineral that is present in some foods and is also widely
available as a nutritional supplement, either by itself or combined with other vitamins and minerals.
Zinc serves many important roles in both men and women, including immune function, protein
synthesis, wound healing, DNA synthesis, and cell division.
117
According to the Linus Pauling Institute at Oregon State University, an estimated 82 percent of
pregnant women worldwide are likely to suffer from a zinc deficiency. This may be because more
zinc is required during pregnancy to ensure the natural health and development of the fetus.
Zinc deficiencies in pregnant women may play a role in a number of adverse outcomes of
pregnancy, including low birth weight, premature birth, delivery complications, and congenital
abnormalities.
Adequate zinc intake in women during pregnancy may reduce the risk of these complications.
ADVANTAGES
 900 mcg folic acid
 Combination Essential Nutrients specifically needed by women
AVAILABILITY & PRICE
 Php 210.00 / box of 30’s
 Php 7.00 / capsule
DOSAGE
Pregnant women (1st – 3rd trimester)
lactating women (1st – 2nd) semester
One capsule daily or as prescribed by a physician.
118
SUMMARY
 COMPOSITION
Folic Acid 900mcg, Iron (Ferrous Fumarate) 38mg, Zinc 9.6mg , Vitamins
 ACTION
Folic Acid – to prevent birth defects
Iron – To prevent Iron Deficiency Anemia
Zinc – to boost immune system
Vitamins – to strengthen and boost immune system
 INDICATION
Reduces pregnancy stress,
increases supply of energy,
improves immune system,
prevents Iron deficiency anemia
Prevent birth defects
 DOSAGE
Pregnant women (1st – 3rd trimester)
Lactating women (1st – 2nd semester):
One capsule daily or as prescribed by a physician.
119
 AVAILABILITY – Box of 30’s
PRICE – 7.00 per capsule (221 per box)
120
COMPOSITION:
Vitamin A (as Palmitate) 1,000 IU
Vitamin D3 (Cholaciferol) 200 IU
Calcium Phosphate 150 mg
121
Taurine 100 mg
Vitamin C (Ascorbic Acid) 75 mg
Lysine 30 mg
Vitamin B3 (Niacinamide) 16 mg
Iron (elemental) 12 mg
Vitamin E (as Acetate) 12 IU
Zinc (elemental) 6.4 mg
Vitamin B5 (as Calcium Pantothenate) 4 mg
Vitamin B2 (Riboflavin) 1.3 mg
Vitamin B6 (Pyridoxine) 1.3 mg
Vitamin B1 (Thiamine) 1.2 mg
Vitamin B9 (Folic Acid) 400 mcg
Vitamin B12 (Cyanocobalamin) 2.4 mcg
INDICATION:
Helps optimize brain function, prevent iron deficiency anemia, boost immune system, maintain good
appetite and enhance normal body function.
DOSAGE:
1 capsule a day or as prescribed by the physician
AVAILABILITY & PRICE:
Box of 30s
210.00/box
7.00/cap
122
123
There is nothing that training cannot do.
Nothing is above its reach or below it. It
can turn bad morals to good, good
morals to bad; it can destroy principles,
it can recreate them; it can debase angels
to men and lift men to angels.
- Mark Twain
TRAINING MANUAL by WJM 2019 for WERT Academy
124

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…to provide innovative quality products

for the betterment of people from all walks

-WERT Mission Statement excerpts

Vitamins C I DAYZINC FAMILY

 What are nutrients and their functions

Consequences of malnutrition in children and adolescents

⇒ Growth failure and stunting

⇒ Poor growth in children

⇒ Reduced muscle mass and strength

⇒ Impaired intellectual development

⇒ Delayed sexual development

⇒ Increased lifetime risk of osteoporosis

⇒ Tiredness, loss of energy

⇒ Altered mood – malnutrition can be associated with depression

⇒ Consequences of specific micronutrient deficiencies

The commonest are given below:

 Iron deficiency can cause anaemia

 Vitamin D deficiency causes rickets in children and osteomalacia in adults

 Vitamin C deficiency causes scurvy

 Vitamin A deficiency causes night blindness

• Fruit and vegetables

What does RENI stand for?

RENI stands for Recommended Energy and Nutrient Intake (nutrition)

Toddlers and preschoolers (1-6 years )

 Best time for Visual development.

School going children (6-12 years )

 Apparently healthy looking children have sub-clinical or biochemical deficiencies of vitamin A,

Energy is the ability to do work and is measured in terms of calories.

Vitamin D helps to maintain calcium homeostasis.

 Water also assists in removing waste products from the body.

and a deficiency results in oxidative stress.

Vitamin E deficiency may cause disorientation and vision problems.

Low levels of vitamin E can lead to muscle weakness.

Zinc Deficiency cause severe infections.

HEALTH AND WELLNESS

To achieve high-level wellness, a person needs to move progressively on a

EFFECTS OF POOR NUTRITION IN CHILDREN

B. Intellectual Development and Education

C. Emotional and Psychological Development

Early Childhood Development

Inadequate intake of nutrients can impair growth and development in children.

 Plenty of fresh fruits and leafy, green vegetables

 Protein like chicken, fish, meat, and eggs

 Whole grains like steel-cut oats and brown rice

 Kids on a vegetarian diet, a dairy-free diet, or other restricted diet

 Particularly active kids who play physically demanding sports

Multivitamins I NUTRI10 SYRUP & PLUS

 Nutri10Plus is a multivitamin composed of CGF, Taurine, Lysine and Zinc.

⇒ With added benefits of Ascorbic Acid for better nutrients absorption .

⇒ Plus Vitamins A,D and E and Vitamin B complex

2018 KEY MESSAGE - SYRUP

2018 KEY MESSAGE - DROPS

CGF (Chorella Growth Factor) 5 mg *

* No Established RENI (Recommended Energy and Nutrients Intakes per day)

⇒ 6 months - 2 yeas old: 1 mL

⇒ Less than 6 months : 0.5mL or as directed by a pediatrician.

CGF (Chorella Growth Factor) 100 mg *

Complete and high in composition of multivitamins with added Ascorbic Acid of

 Effective, Safe and Assured Quality

Nutri10Plus is manufactured by an FDA accredited and cGMP certified healthcare

 More Value for Money

Major Drugstores Nationwide

Easy Patient Compliance

Nutri10Plus Oral Drops 30mL – P135.00