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INTRAVENOUS AGENTS FUNCTION SIDE EFFECT ADVANTAGE METABOLISM

1.PRPPOFOL -respiratory 
depression 
Produces -hypotension Recovery Glucuronidatin
unconsciousness occurs in the liver
within one-arm within 5
brain circulation minutes Elimination
time following T1/2 is 3 – 4.8
 bolus hours
 induction
Total dose 0.3% of drug
Intravenous excreted
Anaesthesia unchanged
(TIVA)
Little protein
Continuous binding
infusion to
maintain
anaesthesia

2.THIOPENTONE
(BARBITURATE) Hypotension
Produces Respiratory Recovery
unconsciousness depression occurs
within one-arm Delayed recovery if within 5 – 7
brain circulation large doses minutes
time not suitable for although
infusion (up to 30% there is a
of drug unchanged significant
24 hours post “hangover”
injection) effect
Zero-Order kinetics compared
Context Sensitive to propofo
Half Life
Can cause
extensive skin
necrosis if injected
into tissues, (due to
pH10.8)

CONTRAINDICATION

Airway obstruction
Haemodynamic
compromise

Porphyria: Rare
disorder of Heme
molecule
metabolism
Autonomic,
psychiatric, GIT
symptoms
Barbiturates can
precipitate an attack

3.KETAMINE(PHENCYCLIDINE)
4.ETOMIDATE(IMIDAZOLE)

1.ISOFLURANE
2.SEVOFLURANE

MUSCLE 
RELAXANTS 
-Tracheal 
intubation RISK
-Awareness
-Abdominal /
thoracic surgery -Residual muscle
weakness post-
-To permit ‘light’ op
anaesthesia
during surgery

NON-COMPETIVE NEUROMUSCULAR BLOCKERS


1. Block
COMPETATIVE
NEUROMUSCULAR
BLOCKER
1.SUCYLNYCHOLINE

VALPORIC ACID

ACETAMINOPHEN (PARACETAMOL)

HALOTIN

Lignocaine can be used with adreanaline @ without adrenaline

---can be used as anti arithyymics

Adrenaline -----causes the blood vessel to vasoconstriction----causes prevent blood flow of blood clot
Ester linked with local anathetics---more common with allergy

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