MILESTONE

H E L P I N G
C H E M I S T S

QUALITY ANALYSIS
STARTS WITH
BEST ELEMENTAL ANALYSIS
BEGINS WITH
GREAT SAMPLE PREP
GREAT SAMPLE PREPARATION

ETHOS UP
High Performance
Microwave Digestion System
 THE FIRST STEP
TO CONFIDENT
ULTIMATE EASE OF USE
AND CONTROL
R E S U LT S
It is a common misconception that all laboratory
microwave systems are alike; at Milestone we know
this is not true. Sample preparation is one of the
most impactful steps in trace metals determination.
The quality of analytical data obtained by ICP/ICP-
MS is directly reliant on digestion quality. Today,
microwave technology in sample preparation has been
UNRIVALED PERFORMANCE established in a variety of industries: Environmental,
Food, Pharmaceutical, Agriculture, Consumer Product
AND THROUGHPUT
Testing, Specialty Chemicals, Geological, Mining, and
many others. Milestone’s sample preparation solutions
maximize the AA/ ICP/ ICP-MS/ performance, and a
lab's overall analytical capability.

  FOCUS ON WHAT MATTERS: YOUR APPLICATION

EXPERTISE
AND KNOW-HOW Choosing the right system and configuration is a key
step in maximizing investment and expanding your
lab’s capabilities. Some of the most crucial parameters
that should be considered when choosing a microwave
digestion system include the following:

SAMPLE TYPE

SUPERIOR SAFETY LAB THROUGHPUT

AND RELIABILITY SIMPLICITY AND EASE OF USE
RELIABILITY
FLEXIBILITY

FLEXIBILITY
  SAFETY AND RELIABILITY IN SAMPLE PREPARATION
The ETHOS UP fully embodies Milestone’s philosophy towards, and knowledge of, microwave sample
preparation. Specifically designed for closed vessel acid digestion, it offers a perfect integration of
microwave hardware, user interface, reaction sensor technology and pressure resistant vessels. The
ETHOS UP is the most powerful system in the market, with two magnetrons and a total power of 1900
Watts. Microwave homogeneity is assured through a dedicated microwave diffuser. Safety and reliability
are Milestone’s priorities. Both factors are ever present in the foundation of the ETHOS UP’s design. The
cavity has a volume in excess of 70L, and is constructed entirely of stainless steel to ensure longevity
and structural integrity. Our unique pressure responsive door, also made of stainless steel, ensures
superior safety even with the most reactive samples. The safeVIEW high definition digital camera, allows
to safely look into the microwave cavity.
 In a digestion process the temperature controls the sample
decomposition and directly affects digestion quality.

EASE OF USE Milestone pioneered the use of infrared sensors combined

with an in-situ temperature sensor to more accurately
W I T H U N PA R A L L E L E D control the digestion cycle. Today, Milestone innovates

DIGESTION CONTROL again by combining all the benefits of in-situ and infrared
sensors into a single solution: the Milestone easyTEMP, a
direct contactless temperature sensor.

MILESTONE easyTEMP IN-SITU APPROACH INFRARED APPROACH

EASE
OF USE

DIRECT
CONTROL

PRECISION AND
ACCURACY

CONTROL IN
ALL VESSELS

HIGH
SAFETY

RUN ANY NUMBER

OF VESSELS
 H E L P I N G
C H E M I S T S

API (Active Pharmaceutical Ingredient) US EPA 3051

T1: T1:
Kw T2: 179 °C
°C T2: 199 °C °C
1.8 (set: 200 °C) (set: 180 °C)
P1: 200 P1:
1.6 P2: P2:
200
MW: 0 W MW: 0 W
US EPA 3051 1.4
13 12 11

150
5 4 14 34 33 10

T1:
6 35 32

1.2
3 15 36 31 9
7

150°C
16 37 30 8

T2: 179 °C
178
2
17
38
39
29

28
7

(set: 180 °C)

1

1.0
18 18 6
9 40 27
15 19 41 26 5

200 P1: 10
14
20 42
43
44 23
24
25 4

100
11 21 3

0.8 P2: 12 13 22 1 2

100 MW: 0 W
0.6 13 12 11

150
14 34 33 10
35 32
15 36 31 9

0.4
16 37 30 8
50
50 17

18
38
39
29

28
7

6
40 27

0.2
19 41 26 5
20 42 25 4
43 24
44 23

100
21 3
22 1 2

5 10 15 20 25 min 5 10 15 20 min

50 T1 T2 P1 P2 MW T1 T2 P1 P2 MW

5 10 15 20 min
MILESTONE www.milestonesrl.com MILESTONE www.milestonesrl.com
T1 H ET2 L P IP1N G P2 MW H E L P I N G
C H E M I S T S C H E M I S T S

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H E L P I N G
easyTEMP temperature control of an exothermic reaction
C H E M I S T S
Temperature profile of a soil digestion in accordance
during the digestion of an API with HNO3 and HCl with US EPA 3051 using the MAXI-44 rotor
in the SK-15 rotor
US EPA 3051
T1: Door locked
°C T2: 179 °C °C
(set: 180 °C) 200
S Add R1 R2
1
1
1
T2

200 P1:
1 1

1
1
1 150
P2: 100
MW: 0 W 50
12

Door locked
13 11
5 10 15 20
150
14 34 33 10
35 32
15 36 31 9

13 12 11 T1:
16 37 30 8
38 29
17

200
°C
39 28
7
14 34 33 10 T2: 179 °C
S Add R1 R2
T2
35
18

32
1 6
1 1
40 27

15 (set: 180 °C)

19 5

9
41 26

36
1 1

15020
31
42 25 4
1 1 43 24

P1:
44 23

100
1
21 3
22 1 2

INCREASED EASE OF USE AND PRODUCTIVITY

100
16 37 30 8 P2:
50
38 MW: 0 W
29
5 10 15 20 17 7
13 12 11
50 T1: 39 28
14 34 33 10 T2: 179 °C 18
35 32 6
40

ENHANCED CONTROL IN ALL VESSELS

15 9 (set: 180 °C) 27
36 31
P1: 19 41 5
37 26
16 30 8 P2:
5 10 15 20 min MW: 0 W 20 42 25 4
38 29 43 24
17 7 21 44 23 3
T1 39 T2 P1 P2 28MW

FAST, ACCURATE AND TRACEABLE

22 1 2
18 6
40 27
19 41 26 5
20 42 25 4
M I L21E S T 44
O N23E www.milestonesrl.com
SUPERIOR DIGESTION
M I L E S T O N E QUALITY
43 24
3
H E L P22 I N G 2
1 www.milestonesrl.com
C H E M I S T S
H E L P I N G
C H E M I S T S

LOWER RUNNING COSTS

MILESTONE www.milestonesrl.com
H E L P I N G
C H E M I S T S

This rotor diagram represents the digestion temperature

Door locked
in all vessels. The green color indicates if the vessel has 200
°C

S Add R1 R2
1
1
1
T2
1 1

1
1
1 150

achieved the set conditions 100

50

5 10 15 20
13 12 11 T1:
14 34 33 10 T2: 179 °C
35 32
15 36 9 (set: 180 °C)
31
P1:
16 37 30 8 P2:
MW: 0 W
The easyTEMP17
38
39
contactless29 7sensor directly controls
28

the temperature
18
40 of all samples 27
6
and solutions, providing
19 41 26 5
accurate temperature
20 42
43
feedback
24
25 4 to ensure complete
21 44 23 3
digestion in all vessels with superior safety. This
22 1 2

technology combines the fast and accurate reading

of an in-situ Mtemperature sensor with the flexibility
e a s y T E M P
ILESTONE
of an infrared sensor. The ETHOS UP software
www.milestonesrl.com
H E L P I N G
C H E M I S T S
DIRECT CONTACTLESS
provides digestion history traceability and temperature TEMPERATURE SENSOR
measurement for every sample. Temperature diagrams
and profiles are displayed in real-time, and can be IN ALL VESSELS
saved on the ETHOS UP terminal.
 F L E XIB ILT Y AND
PERFORMANCE
T H AT MAKE THE
DIFFERENCE
SK-15 ROTOR
Regardless of the samples you’re trying to digest, the
Milestone SK-15 rotor is always an effective option to
simplify your journey from sample to analysis, even
with hard-to-digest samples. The SK-15 is a high-
pressure and high-temperature rotor with a capacity
of up to 15 PTFE vessels of 100 mL suitable for
digestion of polymers, large food and feed samples,
pharmaceuticals, alloys and geological materials.
The table shows the recovery study with the SK-15
on pharmaceutical samples. The simplified design
of the rotor coupled with its large vessel capacity
ensures high productivity without compromising on
Sample As Cd Pb Hg performance. Safety is assured by our unique vent-
and-reseal technology, the foundation of Milestone’s
Spike value (mg/L) 15 2 5 3
position as the leader in closed vessel microwave
Capsules
91.1 92.3 102.3 97.6 digestion. Milestone has recently evolved this already
Recovery % (n=3)
advanced technology (US Patent 5,270,010), providing
Capsules
1.4 1.4 1.4 0.3 the operator with unsurpassed safety and performance
RSD (%)
capabilities by further increasing the temperature and
Dietary Supplement
100.2 95.4 95.2 97.5 pressure capacities of the vessels.
Recovery % (n=3)
Dietary Supplement
0.6 1.6 1.3 1.5
RSD (%)

A safety spring built into the cover allows for

precise venting of the vessel, if that should
occur. Once the pressure has been reduced
to a containable level, the cover closes again.
Only the excess pressure, mainly generated
by CO2, NOX fumes, is therefore released,
allowing for a complete recovery of even
volatile elements.

Scheme of the Vent-And-Reseal technology

  MAXI-44 ROTOR
Many laboratories need to increase productivity and
reduce the turn-around-time in metals analyses. The
MAXI-44 perfectly matches these needs, providing
high productivity, reliability and superior ease of use.
The MAXI-44 is a high-throughput rotor featuring up to
44 PTFE vessels of 100 ml suitable for a wide range of
samples, such as environmental, agriculture, food, and
feed. The MAXI-44 is perfect for routine applications,
combining an unmatched ease of use with the highest
sample throughput available on the market today. The
table shows the recovery study with MAXI-44 on Lake
sediment BCR280R.

Certified value Recovery %

Sample RSD (%)
THE IDEAL TOOL FOR As
(mg/Kg)
33.4 ± 2.9
(n=3)
98.4 2.1
HIGH PRODUCTIVITY Co 16.8 ± 0.9 91.3 2.4

L A B O R AT O R I E S
Cr 126 ± 7 95.2 2.0
Cu 53 ± 6 90.3 1.7
Zn 224 ± 25 93.4 2.1

  SK-15 APPLICATIONS   MAXI-44 APPLICATIONS

Agriculture Beverage Ceramics Chemicals Clinical Agriculture Beverage Environmental

Cosmetics Environmental Food & Feed Geochemistry Metals Food & Feed Officials Pharmaceutical

Petrochemical Officials Pharmaceutical Pigments Polymers

SMART SOFTWARE
TO SAVE
YOUR TIME
The ETHOS UP comes with a dedicated touch
screen terminal with easyCONTROL software which
incorporates our expertise and knowledge in microwave
sample preparation. The ETHOS UP user-interface
provides full control of all digestion parameters,
complete documentation and improves the overall
procedure. The terminal is equipped with multiple
USB and Ethernet ports for interfacing the instrument
to external devices and to the laboratory network.The
ETHOS UP controller is user-friendly, icon-driven, multi-
language and 21 CFR Part 11 compliant. To find the
method which best suits your application, simply select
one of the hundreds of preloaded methods or create a
new one yourself using our intuitive software. Once you
press ‘START’ the system will automatically follow the
user defined temperature profile using a sophisticated
PID algorithm. The preloaded applications, including
all US EPA methods, virtually eliminate any need
for method development. Each preloaded method
includes a temperature profile, sample size and choice
of reagents. To further simplify the workflow in the
lab the ETHOS UP is equipped with a backlit logo
that indicates the digestion progress, showing to the
operator the actual status of the process, such as
heating, cooling, sample ready and error messages.
 Food & Feed Terminal Settings Service
Baby Food MAXI-44 Panel Users Update LAN Trail
Barley MAXI-44 All System Access Errors Application
Beech Leaves MAXI-44
Time Changes
Bovine Liver MAXI-44
28.02.17 14:21:01 Seg6=00:02:00/1000W7210°C/0°C/30.0bar/0/0/3
Bovine Milk MAXI-44
28.02.17 14:21:11 Start: P Test
Butter MAXI-44
28.02.17 15:10:34 P test_20170228_14211.dpr: saved to: A/Data/P Test_
Calcium Alginate MAXI-44
28.02.17 15:26:19 Start: Milk powder_tests elastomer
Casein MAXI-44
28.02.17 16:26:24 Program finished
Chcolate MAXI-44
28.02.17 16:44:04 Milk powder_test elastomer_20170228_152619.dpr:
Cocoa Powder MAXI-44
01.03.17 08:52:22 Login Admin (Administrator)
Cofee MAXI-44
01.03.17 08:52:29 test for thermo_mat.fat: File read error.
Corn Starch MAXI-44
01.03.17 08:53:32 Start: Milk powder_test elastomer
Dried Fish MAXI-44
01.03.17 09:43:47 Milk powder_test elastomer_20170301_085332.dpr:
Dried Meat MAXI-44
01.03.17 09:58:24 Login Admin(Administrator)
Dry Infant Formula MAXI-44
01.03.17 09:59:34 New Method from database: P Test Digestion Agricol
Deed for Fish MAXI-44
01.03.17 10:01:21 Login (Service)
Fish in Oil MAXI-44
Filter Usage
Fresh Meat MAXI-44

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H E L P I N G H E L P I N G
C H E M I S T S C H E M I S T S

List of food & feed methods, part of the expansive Audit trail tacking in full compliance
library containing over 300 built-in methods with 21 CFR part 11

°C bar
100
200 T1
175 80
150

nnect
Included with the ETHOS UP is a unique web-based
125 60

milestone
100
75 40

application: Milestone Connect. This app allows you to

50
25 20

2 4 6 7 10 12 14 16 18 20 22 24 26 28 30 32 34 36 38 40 42 44 46 48

Nr t MW T1 VAC Stirrer
become a part of the Milestone community and gain
[W ] [ °C ]
1 00:15:00 1800 200
exclusive access to a robust library of information:
2 00:15:00 1800 200

3 00:00:00 lists of parts, technical notes, user manuals, video

tutorials, continuously updated application notes and
all relevant scientific articles. Milestone Connect also
MILESTONE www.milestonesrl.com
H E L P I N G
C H E M I S T S
extends instrument control to your smartphone, tablet
or PC, allowing remote monitoring of the system. With
Milestone Connect you have instant support 24/7.

Door locked
°C

T1: 21 °C
200 T1

150

100

(set: 21 °C)
50

10 20 30 40

5 4

T2:
6

21 °C
3
7
2
178
1
18
9
15
10

P1: 1.0 bar

14
11
12 13

P2: 0%
MW: 0W
t: 00:50:00
MILESTONE www.milestonesrl.com

MILESTONE
H E L P I N G
C H E M I S T S

C30 O N N E C T
YEARS OF EXPERIENCE
AT YOUR FINGERTIPS
Door locked
°C
200
S Add R1 R2
1
1
1 T1
1 1

1
1
1 150

100
50

10 20 30 40

T1: 21 °C
5 4 (set: 21 °C)
6 T2: 21 °C
3 P1: 1.0 bar
P2: 0%
 The ETHOS UP embraces Milestone’s philosophy of
a “microwave labstation”. The ETHOS UP platform
MILESTONE ETHOS UP is capable of several applications beyond microwave

MUCH MORE
THAN A DIGESTION SYSTEM
digestion. Extraction of pollutants from environmental
samples can be done in just few minutes, consuming
less solvent than other technologies, thereby
improving productivity while decreasing costs, all
in full accordance with the US EPA 3546. Additional

fastEX-24 SK-10/12
Extraction rotor for environmental applications High-pressure digestion rotor

Soxhlet fastEX-24
SR-12
100% Extraction rotor for total fat determination
in food samples

PCBs PAHs TPH Dioxins Organic BNAs

semivolatiles

Milestone fastEX-24 recovery study and comparison

vs Soxhlet for various organic compounds.
accessories are available to further expand the ETHOS
UP capabilities: additional digestion rotors, inserts MEETING R E G U L AT I O N S :
and micro-inserts to reduce blanks in the digestion MILESTONE'S
VA L I D AT I O N
processes, a dedicated configuration for total fat
determination in food samples which greatly improves

PACKAGE
turn-around-time, and an ashing accessory which
converts the digestion system into a microwave muffle.

Compliance with regulations and data

traceability requirements are paramount
in the modern analytical lab, such as
MMR-15 pharmaceutical, nutraceutical or other
Evaporation/Concentration rotor regulated industries. Milestone’s operating
software, easyCONTROL, is fully compliant
with FDA regulation 21 CFR part 11.
The Milestone Validation Package gives
access to our factory trained engineers and
specialists during the qualification process,
enabling a fast implementation of the
ETHOS UP in full accordance with Good
Manufacturing Practice (GMP) guidelines. The
comprehensive Milestone Validation Package
(MVP) assures the complete qualification
of the instrumentation. Different validation
packages are available based on your
specific needs: DQ (Design Qualification), IQ
(Installation Qualification), OQ (Operational
Qualification), PQ (Performance Qualification)
and re-qualification.
ultraFAST
High-temperature muffle furnace
(up to 1200°C)
MILESTONE Established in 1988, Milestone is headquartered in Italy and

HELPING CHEMISTS has offices in Germany, Switzerland, the Unites States, China,
Japan and Korea. We operate worldwide through a network
of over 100 exclusive distributors, all providing our customers premium application and service support.
Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample
preparation and direct mercury analysis in the world. Our industry-leading technology, in combination
with fast, responsive service and applications support, allows Milestone to support our goal of providing
you the highest return on investment possible.

ADDITIONAL MILESTONE SOLUTIONS FOR ELEMENTAL ANALYSIS

ultraWAVE duoPUR/subCLEAN traceCLEAN DMA-80

The Game Changer in Acid Purification Acid Steam Direct Mercury Analyzer
Microwave Digestion System Cleaning System

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