How To Reverse Hearing Loss and Tinnitus

How to
reverse
Introduction EndAllDisease.com
• When I was in grade seven, I went to a dance with some of my buddies at a roller rink in Waterloo,
Ontario. It was called The Phoenix. I noticed the music was really loud but I didn’t really think too
much of it until the next morning. When I woke up, my ears were foggy and ringing; everything
and everyone sounded muffled. That was my first experience with hearing loss. Thankfully it was
only temporary and my hearing recovered completely.
• Oh and by the way that roller rink… the very next weekend after I was there it was shut down
because there was a fight and somebody ended up getting stabbed.
• Most of us who are blessed with good hearing take it for granted.
• Poor hearing is something that many people have to live with everyday and it comes at
tremendous cost to their quality of life and to society. If we could find a way to fix this problem it
would benefit us all.
• Medicine has some temporary fixes but has found no way to naturally restore hearing function
without the use of electronic devices. But maybe that’s because fixing people’s hearing naturally
and permanently isn’t profitable? We need to keep that possibility on the table.
• In this presentation, you’re going to learn how hearing works, the root cause of hearing loss and
how hearing loss can be prevented and maybe even reversed.
• Be sure to stick around until the end and I’ll tell you about some of the most important nutrients for
hearing as well as the specific foods most rich in these nutrients. That way you can eat them and
ensure your hearing is as good as it can be for your entire life.
How the Ear Works EndAllDisease.com
first phase
The unique shape of the outer ear directs sound into
the ear towards the ear drum. Behind the ear drum are
3 tiny bones. They are the smallest bones in the
human body, called the malleus, incus and stapes.
second phase
The ear drum and the bones behind it work in a piston-
like fashion to amplify the sound and transfer it to the
fluid inside a snail-looking organ called the cochlea. By
the time the sound reaches the cochlea, the sound
pressure is 22-times greater than when it first arrived.
third phase
The sound travels through the watery substance inside
of the cochlea until it reaches tiny hair cells called
stereocilia. The hair cells convert the mechanical
stimulation into electrical impulses, which are then sent
to the brain.[1]
Causes of Hearing Loss EndAllDisease.com
Hearing loss can be inherited; some people are born with it, but most times it’s cause by other
factors. Here are three of the most common types of hearing loss:
• Loud Noise – Noise-induced hearing loss is usually painless and occurs progressively over
time. Extreme loud noises like explosions can cause sudden hearing loss. An estimated 26
million people (15% of the population) in the US have high-frequency NIHL.[2]
• Ototoxic Medications – Certain medications can cause hearing loss. For example,
chemotherapy drugs, or certain antibiotics like streptomycin, neomycin or kanamycin.
• Age-Related Hearing Loss – A type of hearing loss that occurs with aging. To the person
with this type of hearing loss, speech may begin to sound muffled or unclear.
What are the mechanisms behind the three types of hearing loss?
Damaged auditory hair cells EndAllDisease.com
For all three types of hearing loss (poison-induced, loud noise

or age-related) the cause appears to be the same.
• “We have recorded from inner and outer hair cells (IHC,
OHC) in the guinea pig cochlea during and after exposure
to intense tones. Our results show functional changes in
the hair cells that may explain the origin of noise-
induced hearing loss.” [3]
• “Exposure to intense sound or ototoxic drugs may

damage the outer hair cells, thus drastically changing
both mechanical and electrophysiological responses of the
inner ear.” [4]
• Auditory outer hair cell degeneration is the most common

cause of hearing loss in humans. [5]
• “The classical pathology of [noise-induced hearing loss]

NIHL is destruction of auditory hair cells.” [6]
• “The primary cause of hearing loss includes damage to

cochlear hair cells.” [7]
Converting sound waves to electrical signals happens to be done by the most fragile structures involved in
hearing. When they are damaged, hearing quality is reduced. According to mainstream theory,
auditory/cochlear hair cells cannot regenerate and hearing loss is irreversible.
Mitochondrial damage: The Root Cause EndAllDisease.com
In hearing loss, why do the cochlear hair cells die?
“Although details of the aging process differ in various organisms,

there is a common understanding that oxidative stress and
mitochondrial dysfunction play a major part in aging. The
auditory system is no exception…” [8,9]
“ROS [Reactive oxygen species] production increases with age and it

is known that oxidative stress and associated mitochondrial
dysfunction play an important role in aging and age-related
diseases.” [10,11]
“Underlying the classic set of cochlear pathologies that occur as a

result of noise exposure are increased levels of reactive oxygen
species (ROS) that play a significant role in noise-induced hair
cell death. Both necrotic and apoptotic cell death have been identified
in the cochlea.” [12]
“The important role of oxidative stress and mitochondrial dysfunction

in the development of ARHL has been established by reviewing
previous studies.“ [13]
Hearing loss is caused by oxidative stress and mitochondrial dysfunction.

Hearing Loss is A Metabolic condition EndAllDisease.com
• The cause of hearing loss has now been established.
• Although hearing loss can have a number of external causes, such

as excessive noise, poison or ageing, ultimately they all damage
hearing in the same way.
• The stressor causes hair cells to release nitric oxide, which binds to
cytochrome c oxidase, shutting down oxygen use and efficient
energy production, causing free electrons (free radicals) to escape
from the electron transport chain, causing damage to the
mitochondria.
• Hearing loss is caused by damage to the highly sensitive hair cells

contained within the cochlea. When the cells die hearing fails.
Insult Nitric oxide Mitochondrial Free radicals Damaged Hearing Fails

function Mitochondria
is inhibited via nitric Leak from electron Mitochondria in Cell death

> Is released
by cells > oxide binding to > transport chain > Hair cells damaged > (apoptosis)
cytochrome c oxidase
The Free Radical Theory of hearing loss
If increased free radical production is a cause of hearing loss, then can
antioxidants be used to prevent it from occurring?
Can Antioxidants Prevent hearing loss? EndAllDisease.com
When administered to animals prior to loud noise exposure, all of the following antioxidants have been
shown to prevent hearing loss:
• Glutathione [14,15]
• D-methionine [16]
• Ebselen [17]
• Resveratrol [18]
• Vitamin C [19,20]
• Coenzyme Q10 [21]
• Salicylate [22]
• N-acetylcysteine [23,24]
Furthermore, treatment up to 3 days after loud noise exposure was also able to reduce hearing loss to
some degree.
Antioxidants administered both before and after loud noise can

prevent and reverse hearing loss.
Red Light Therapy vs. hearing loss
Light in the red and near-infrared ends of the spectrum accelerate healing
in all cells and tissues. One of the ways they accomplish this is by acting
as potent antioxidants. They also inhibits nitric oxide production.
Can red and near-infrared light prevent or reverse

hearing loss?
Can Red Light prevent Hearing Loss? EndAllDisease.com
In a 2016 study, researchers applied near-infrared light to

auditory cells in vitro before placing them under oxidative stress
by exposing them to various poisons.
• After exposing the pre-conditioned cells to chemotherapy

poison and endotoxin, study researchers found that the light
altered the mitochondrial metabolism and oxidative stress
response for up to 24 hours post treatment.
• “We report a decrease of inflammatory cytokines and stress

levels resulting from NIR applied to HEI-OC1 auditory cells
before treatment with gentamicin or lipopolysaccharide,”
wrote study authors.
Results:
• Results of the study showed that pre-treatment with near-
infrared light reduced the pro-inflammatory markers
associated with increased reactive oxygen species and nitric
oxide.[25]
Near-infrared light administered before chemical poisoning can

prevent the release of factors that lead to hearing loss.
Study #1: Can Red Light reverse Hearing Loss? EndAllDisease.com
The effect of near-infrared light on hearing loss following chemotherapy poisoning was evaluated. Hearing
was assessed following gentamicin administration and again after 10 days of light therapy.
Wavelength
• 830nm near-infrared Power Density
• 900mW/cm2
Treatment Frequency and Duration
• Once a day for 10 days Dose
• 162-194 Joules
Results
• On scanning electron microscopic images, “LLLT significantly increased the number of hair cells
in middle and basal turns. Hearing was significantly improved by laser irradiation. After LLLT
treatment, both the hearing threshold and hair-cell count significantly improved.” [26]
•
Near-infraRed light administered after chemical poisoning can

regrow cochlear hair cells and restore hearing in mice.
In this study, rats were exposed to intense noise in both ears. Afterwards, their right ears were irradiated
with near-infrared light for 30 minute treatments everyday for 5 days.
Wavelength Frequency and Duration

• 808nm near-infrared • 30 minute treatments everyday for 5 days
Results
• Measurement of the auditory brainstem response revealed an accelerated recovery of auditory
function in the groups treated with LLLT compared with the non-treatment group at days 2, 4, 7 and
14 after noise exposure. Morphological observations also revealed a significantly higher outer hair
cell survival rate in the LLLT groups.
Mechanism
• Looking for indicators of oxidative stress and apoptosis in untreated vs treated cells, researchers found
“Strong immunoreactivities were observed in the inner ear tissues of the non-treatment group, whereas
these signals were decreased in the LLLT group at 165mW/cm(2) power density.” [27]
“Our findings suggest that LLLT has cytoprotective effects against

NIHL via the inhibition of iNOS expression and apoptosis.”
In a 2012 study, nine rats were exposed to loud noise and the use of near-infrared light on hearing
recovery was tested. The day after loud noise exposure, the left ears of the rats were treated with
near-infrared light for 60 minutes for 12 days in a row. The right ears were untreated and considered
the control group.
Wavelength810nm near-infrared
Frequency and Duration

• 60 minute treatments everyday for 12 days
Results
• “After the 12th irradiation, hearing threshold was significantly lower for the left ears compared to
the right ears.” When observed using an electron microscope, the number of auditory hair cells in
the treated ears was significantly larger than that of the untreated ears. [28]
“Our findings suggest that low-level laser irradiation promotes

recovery of hearing thresholds after acute acoustic trauma.”
Red Light Therapy vs. tinnitus
• Tinnitus is a condition marked by constant ringing of the ears.
• Mainstream theory can’t really explain why tinnitus occurs. “Due to

large number of causes and limited knowledge of its pathophysiology,
tinnitus still remains an obscure symptom,” wrote one group of
researchers.
• The most likely theory for the cause of tinnitus states that when the
cochlear hair cells become damaged, they begin randomly sending
electrical signals to the brain.
• This would be a pretty horrendous thing to have to live with, so this

section is dedicated to anyone out there with tinnitus. If you know
anyone with it please send them this video/article or podcast episode.
Can red light alleviate ringing of the ears in people with tinnitus?
Can Red Light reverse tinnitus? EndAllDisease.com
In a 2014 study, researchers tested LLLT on 120 patients with untreatable tinnitus and
hearing loss. Patients were divided into two groups.
Group 1:
• Group one received laser therapy treatment for 20 sessions consisting of 20
minutes each
Group 2:
• Group two was the control group. They thought they received the laser treatment
but power to the devices was switched off.
Results
• “The mean difference of severity of tinnitus between the two groups was
statistically significant at the end of the study and 3 months after completion of
treatment.” [29]
“Low level laser radiation is effective for short-term treatment of Tinnitus

caused by sensorineural hearing loss and its impact may be reduced over the time.”
Dietary essentials for preventing hearing loss EndAllDisease.com
• The National Health and Nutrition Examination Survey[30] documented a significant relationship
between dietary quality and auditory sensitivity at high frequencies.
• Here are some dietary and lifestyle changes you can make to improve the quality of your hearing and
increase your resistance to hearing loss from various stressors as well as aging.
Nutrient or Lifestyle Factor Foods Highest in These Nutrients

Army personnel with NIHL or NIHL and
tinnitus had lower vitamin B12 levels than
normal hearing subjects.[31]
Smokers have a higher risk of developing

high-frequency hearing loss than non-
smokers with a similar occupational noise
exposue.[32,33]
In military settings where exposure to loud
noises are inevitable, a significant
correlation was found between noise-
induced hearing loss and serum
magnesium concentrations in air force
pilots.[34]
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Check out the Show Notes
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References 1 May 10th, 2019 | EndAllDisease.com
1. Fuchs PA, Glowatzki E, Moser T. The afferent synapse of cochlear hair cells. Curr Opin Neurobiol. 2003;13(4):452-8.
https://www.ncbi.nlm.nih.gov/pubmed/12965293
2. Sha SH, Schacht J. Emerging therapeutic interventions against noise-induced hearing loss. Expert Opin Investig
Drugs. 2017;26(1):85-96.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5527323
3. Cody AR, Russell IJ. Outer hair cells in the mammalian cochlea and noise-induced hearing loss. Nature.
1985;315(6021):662-5.
4. Ulfendahl M. ["The cochlear amplifier". A crucial component of the hearing mechanism]. Lakartidningen.
1997;94(45):4077-80.
5. Wiwatpanit T, Remis NN, Ahmad A, et al. Codeficiency of Lysosomal Mucolipins 3 and 1 in Cochlear Hair Cells
Diminishes Outer Hair Cell Longevity and Accelerates Age-Related Hearing Loss. J Neurosci. 2018;38(13):3177-3189.
6. Sha SH, Schacht J. Emerging therapeutic interventions against noise-induced hearing loss. Expert Opin Investig
Drugs. 2017;26(1):85-96.
7. Rhee CK, He P, Jung JY, et al. Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing
loss. J Biomed Opt. 2013;18(12):128003.
8. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998;78(2):547-81.
9. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol. 1956;11(3):298-300.
10. Balaban RS, Nemoto S, Finkel T. Mitochondria, oxidants, and aging. Cell. 2005;120(4):483-95.
11. Lin MT, Beal MF. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature.
2006;443(7113):787-95.
12. Henderson D, Bielefeld EC, Harris KC, Hu BH. The role of oxidative stress in noise-induced hearing loss. Ear Hear.
2006;27(1):1-19.
13. Fujimoto C, Yamasoba T. Oxidative stresses and mitochondrial dysfunction in age-related hearing loss. Oxid Med Cell
Longev. 2014;2014:582849.
14. Ohinata Y, Yamasoba T, Schacht J, Miller JM. Glutathione limits noise-induced hearing loss. Hear Res. 2000;146(1-2):28-
34.
15. Yamasoba T, Nuttall AL, Harris C, Raphael Y, Miller JM. Role of glutathione in protection against noise-induced hearing
loss. Brain Res. 1998;784(1-2):82-90.
16. Campbell KC, Meech RP, Klemens JJ, et al. Prevention of noise- and drug-induced hearing loss with D-methionine. Hear
Res. 2007;226(1-2):92-103.
17. Pourbakht A, Yamasoba T. Ebselen attenuates cochlear damage caused by acoustic trauma. Hear Res. 2003;181(1-
2):100-8.
18. Seidman M, Babu S, Tang W, Naem E, Quirk WS. Effects of resveratrol on acoustic trauma. Otolaryngol Head Neck Surg.
2003;129(5):463-70.
19. Mcfadden SL, Woo JM, Michalak N, Ding D. Dietary vitamin C supplementation reduces noise-induced hearing loss in
guinea pigs. Hear Res. 2005;202(1-2):200-8.
20. Heinrich UR, Fischer I, Brieger J, et al. Ascorbic acid reduces noise-induced nitric oxide production in the guinea pig ear.
Laryngoscope. 2008;118(5):837-42.
21. Fetoni AR, Piacentini R, Fiorita A, Paludetti G, Troiani D. Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer
hair cell survival in a guinea pig model of noise induced hearing loss (NIHL). Brain Res. 2009;1257:108-16.
22. Yamashita D, Jiang HY, Le prell CG, Schacht J, Miller JM. Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience. 2005;134(2):633-42.
23. Hoffer ME, Balaban C, Slade MD, Tsao JW, Hoffer B. Amelioration of acute sequelae of blast induced mild traumatic brain injury by N-acetyl cysteine: a double-
blind, placebo controlled study. PLoS ONE. 2013;8(1):e54163.
24. Bielefeld EC, Kopke RD, Jackson RL, Coleman JK, Liu J, Henderson D. Noise protection with N-acetyl-l-cysteine (NAC) using a variety of noise exposures, NAC
doses, and routes of administration. Acta Otolaryngol. 2007;127(9):914-9.
25. Bartos A, Grondin Y, Bortoni ME, et al. Pre-conditioning with near infrared photobiomodulation reduces inflammatory cytokines and markers of oxidative stress in
cochlear hair cells. J Biophotonics. 2016;9(11-12):1125-1135.
26. Rhee CK, He P, Jung JY, et al. Effect of low-level laser treatment on cochlea hair-cell recovery after ototoxic hearing loss. J Biomed Opt. 2013;18(12):128003.
27. Tamura A, Matsunobu T, Mizutari K, et al. Low-level laser therapy for prevention of noise-induced hearing loss in rats. Neurosci Lett. 2015;595:81-6.
28. Rhee CK, Bahk CW, Kim SH, et al. Effect of low-level laser treatment on cochlea hair-cell recovery after acute acoustic trauma. J Biomed Opt.
2012;17(6):068002.
29. Mirvakili A, Mehrparvar A, Mostaghaci M, et al. Low level laser effect in treatment of patients with intractable tinnitus due to sensorineural hearing loss. J Lasers
Med Sci. 2014;5(2):71-4.
30. Spankovich C, Le prell CG. Associations between dietary quality, noise, and hearing: data from the National Health and Nutrition Examination Survey, 1999-
2002. Int J Audiol. 2014;53(11):796-809.
31. Shemesh Z, Attias J, Ornan M, Shapira N, Shahar A. Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. Am J Otolaryngol.
1993;14(2):94-9.
32. Tao L, Davis R, Heyer N, et al. Effect of cigarette smoking on noise-induced hearing loss in workers exposed to occupational noise in China. Noise Health.
2013;15(62):67-72.
33. Mehrparvar AH, Mollasadeghi A, Hashemi SH, Sakhvidi MJ, Mostaghaci M, Davari MH. Simultaneous effects of noise exposure and smoking on OAEs. Noise
Health. 2015;17(77):233-6.
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Am. 1983;74(1):104-8.

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For all three types of hearing loss (poison-induced, loud noise

• “Exposure to intense sound or ototoxic drugs may

• Auditory outer hair cell degeneration is the most common

• “The classical pathology of [noise-induced hearing loss]

• “The primary cause of hearing loss includes damage to

In hearing loss, why do the cochlear hair cells die?

“Although details of the aging process differ in various organisms,

“ROS [Reactive oxygen species] production increases with age and it

“Underlying the classic set of cochlear pathologies that occur as a

“The important role of oxidative stress and mitochondrial dysfunction

Hearing loss is caused by oxidative stress and mitochondrial dysfunction.

• The cause of hearing loss has now been established.

• Although hearing loss can have a number of external causes, such

• Hearing loss is caused by damage to the highly sensitive hair cells

Insult Nitric oxide Mitochondrial Free radicals Damaged Hearing Fails

is inhibited via nitric Leak from electron Mitochondria in Cell death

Antioxidants administered both before and after loud noise can

Can red and near-infrared light prevent or reverse

In a 2016 study, researchers applied near-infrared light to

• After exposing the pre-conditioned cells to chemotherapy

• “We report a decrease of inflammatory cytokines and stress

Near-infrared light administered before chemical poisoning can

Near-infraRed light administered after chemical poisoning can

Wavelength Frequency and Duration

“Our findings suggest that LLLT has cytoprotective effects against

Frequency and Duration

“Our findings suggest that low-level laser irradiation promotes

• Mainstream theory can’t really explain why tinnitus occurs. “Due to

• This would be a pretty horrendous thing to have to live with, so this

“Low level laser radiation is effective for short-term treatment of Tinnitus

Nutrient or Lifestyle Factor Foods Highest in These Nutrients

Smokers have a higher risk of developing

Red Light Therapy: Miracle Medicine

Cancer: The Metabolic Disease Unravelled

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