Harrison 20th Ed Update

Chapter- Cutaneous Drug Reaction

Update your Harrison 19th Ed from Page No- 377 to 384

1. Warfarin necrosis of skin image (Fig: 74-2) : Changed

2. Pseudoporphyria (Fig: 74-1), Dysmorphic eyelashes in associated with

erlotinib (Fig: 74-3), Sorafenib-associated hand-foot syndrome (Fig: 74-5):
Deleted
3. In Toxic Erythema of Chemotherapy paragraph two new sentences added.
“Upto 50% of patients experience immune medicated skin eruption, including
granulomatous reactions, Dermatomyositis, Panniculitis and vasculitis”.
4. New image given for Toxic Erythema of Chemotherapy
5. New image given for allergic Contact dermatitis

6. Fixed Drug Eruptions: Image changed.

7. New Image given for: Drug-Induced Hypersensitivity Syndrome, Stevens -

Johnson syndrome, SJS- TEN Overlap, TEN, and Target like lesion in SJS.
8. Pustular Eruptions and Vasculitis: New image given
9. Table No-74-3 (Clinical Features of Severe Cutaneous Drug Reactions) changed
 Chapter: Principle of Clinical Pharmacology
Update your Harrison 19th Ed from Page No- 34 to 42

1. In Table 5-1 (Molecular Pathways mediating Drug Disposition) “Codeine

deleted from substrates column in 2nd row”
2. In Table 5-2 ( Genetic Variants and Drug Reactions): Many things changes
Variants in Other Genes
Variants in Other Genomes (Infectious Agents, Tumors)
Chapter: Molecular Mechanism of Microbial Pathogenesis

Update your Harrison 19th Ed; Volume-3 from Page No- 145e-1 to 10

1. In Table 145e-1: “Glycoprotein Complex gH/ gL/gQ1/gQ2 are added in

Human herpesvirus row”.

2. TLR and NLR pathway Algorithms image changed

 3. Autophagy, Apoptosis and Necrosis are newly added. Algorithmically
presentation of Autophagy and Apoptosis & Necrosis newly added.

Chapter: Approach to the Acutely Ill infected Febrile Patients

Update your Harrison 19th Ed from Page No- 779 to 784

1. In Table 147-1 “Few extra lines added in comments section of sepsis

without a clear focus”.
 2. In Table 147-1 “Few extra lines added in comments section of sepsis with
skin findings”.

Chapter: Immunization Principles and Vaccine Use

Update your 19th Ed Harrison, Page No-785; Table No 785 to 792

1. Update Table No 148-1

2. Update; Table No 148-2
3. Update; Table No 148-3
Commonly Used Vaccine in Adults
Chapter: Pneumonia
Update your 19th Ed Harrison, Page No- 803 to 812

1. Newly Added Table

2. Update Table 153-2; only Respiratory viruses added in ICU column.

3. Newly added Table
4. Update Table 153-5; Clindamycin (300 mg q6h) added in special corners.

5. Update, Table 153-6, Carbapenem-resiatant strains added in MDR

pathogens Column.
Chapter: Lung Abscess
Update your 19th Ed Harrison, Page No- 812- 815

1. Most common location of Primary Lung Abscess: Posterior upper lobe and
superior lower lobe
2. Most common location of Secondary Lung Abscess: It may vary with
underlying cases.
3. Differential Diagnosis of Lung Abscess:

Chapter: Osteomyelitis
Update your 19th Ed Harrison, Page No- 840- 845

1. Global Consideration of Osteomyelitis

2. Update; Osteomyelitis in Long Bone

 Pathogenesis: “Chronic Osteomyelitis can recur after a symptom-free
interval > 70 years”.
Note: 19th Ed mentioned: > 50 years
 Epidemiology: “In contrast, after open fracture the risk of osteomyelitis
ranges from 2% up to 30%.”
Note: 19th Ed mentioned: 2% up to 15%.”
 Clinical Manifestations: “After internal fixation, Osteomyelitis can be
classified as acute (≤ 3 weeks), delayed (3-10 weeks) or late (chronic)
infection”.
 Global Consideration: Newly Added
3. Update; Periprosthetic Joint Infection (PJI)
 Epidemiology: “The rate of risk for secondary PJI during S. aureus
bacteremia is 30-40%.
 Microbiology:
 About 50-70% of cases of PJI are caused by staphylococci (S.
aureus and Coagulase-negative staphylococci).
 Streptococci: 6-10%
 Gram negative bacilli: 4-10%
4. Update; Sternal Osteomyelitis
 Epidemiology: “The incidence of poststernotomy wound infection varies
from: 0. 5- 2%.
Note: - Harrison’s 19th Ed mentioned: 0.5- 5%.
 Microbiology:
 Most common caused by Coagulase-negative staphylococci: 40-60%
followed by gram negative bacilli (15-25%), S.aureus (10-20%) and
P. acnes (2-10%).
 Global Consideration: Newly Added

5. Update; Foot Osteomyelitis

 Epidemiology: About 20-60% of patients with diabetic foot infection
have confirmed Osteomyelitis.
Note: Harrison’s 19th Ed mentioned: 60- 80%.
 Microbiology: “When only bone biopsy samples are considered, the
leading pathogens are S. aureus (25-40%), anaerobes (5-20%), and
various gram-negative bacilli (18-40%).
Note: Harrison’s 19th Ed mentioned: S. aureus (30-40%), anaerobes (10-
20%), and various gram-negative bacilli (30-40%).
Chapter: Approach to the Patient with Disease of the Respiratory
System
Update your 19th Ed Harrison, Page No- 1661

1. Update, Table 305-1

 Myasthenia gravis newly added in examples of Restrictive
pathophysiology-neuromuscular weakness category.
 Pulmonary venoocclusive disease & vasculitis newly added in examples
of pulmonary vascular Disease category.
Chapter: Disturbance of Respiratory Function
Update your 19th Ed Harrison, Vol-3 Page No- 306e 1-7

1. Two new image added in Fig 306e-4

Chapter: Acute Viral Hepatitis
Update your 19th Ed Harrison, Page No- 2004-2022

1. Update, Table No 360-1: “C 100-3, C33c, C22-3, NS5:- Deleted; only HCV
core antigen mentioned”

2. Update, Table No 360-2

Chapter: Chronic Hepatitis
Update your 19th Ed Harrison, Page No- 2031

1. Update; Table No- 362-1

2. Update; Table 362-7

3. Therapeutic Regimens
Chapter: Urticaria, Angioedema and Allergic Rhinitis
Update your 19th Ed Harrison, Page No 2118

1. Newly Added Table

Chapter: Mastocytosis
Update your 19th Ed Harrison, Page No 2120

1. Update; Table 376-2

2. Newly added Table: “B & C findings for Diagnosis for SSM and ASM”

3. Update; Table 376-3 “Diagnostic Criteria for Systemic Mastocytosis”

Chapter: Systemic Sclerosis (Scleroderma) and Relative Disorders
Update your 19th Ed Harrison, Page No 2154-2165

1. Newly added Image: “Multi-Organ involvement in Systemic Sclerosis”

2. Newly added table: Classification criteria for Diagnostic of Systemic Sclerosis”

ACA= Anterior Cerebral Artery, MCP= Metacarpophalangeal Joint, PAH=

Pulmonary Arterial Hypertension

3. In Pathogenesis Paragraph: New Figure added” The characteristic

Constellation of Vasculature”
4. Update: Table382-1

5. Update Table 382-4

6. Newly added Figure: “SSC Associated with nail-fold capillary alteration”

7. Newly added Table: “Prominent Gastrointestinal Manifestations of SSc and

their Management”
8. Newly added figure: “Renal Changes in Sclerodema Renal crisis “

9. Newly added figure “SSc associated with autoantibodies:

Immunofluorescence pattern”
Chapter: Osteoarthritis
Update your 19th Ed Harrison, Page No 2232

1. Update; Table No-394-1

Chapter: Osteoarthritis
Update your 19th Ed Harrison, Page No 2255 and 400 e 1 -6

1. Newly added TABLE: “Genetic causes of G protein receptor Disorders”