CIPROXIN

This medication is used to treat a variety of bacterial infections. It

works by stopping the growth of bacteria.treats only bacterial
infections. It will not work for virus infections (such as common
cold, flu). Unnecessary use or overuse of any antibiotic can lead to
its decreased effectiveness.

CLASS: quinolone antibiotics

INFECTIONS, DOSE, FREQUENCY, USUAL DURATIONS

Skin and skin structure 500-750mg Q12hours 7 to 14 days

Bone and joint 500-750mg Q12hours 4 to 8 weeks
Complicated intra- 500mg Q12hours 7 to 14 days
abdominal
Infectious diarrhea 500mg Q12hours 5 to 7 days
Typhoid fever 500mg Q12hours 10 days
Uncomplicated urethral 250mg Single Single dose
and cervical gonococcal dose
infection
Inhalational anthrax(post- 500mg Q12hours 60 days
exposure
Plague 500-750mg Q12hours 14 days
Chronic bacterial 500mg Q12hours 28 days
prostatitis
Lower RTI 500-750mg Q12hours 7 to 14 days
UTI 250-500mg Q12hours 7 to 14 days
Acute sinusitis 500mg Q12hours 10 days
Acute uncomplicated 250mg Q12hours 3 days
cystitis
Pharmacology
Mechanism of Action
Inhibits relaxation of DNA; inhibits DNA gyrase in susceptible
organisms; promotes breakage of double-stranded DNA
Absorption
Bioavailability (PO): ~50-85%
Peak plasma time (PO): Immediate-release, 0.5-2 hr; extended-
release, 1-2.5 hr
Distribution
Distributed widely throughout body; tissue concentrations often
exceed serum concentrations, especially in kidneys, gallbladder,
liver, lungs, gynecologic tissue, and prostatic tissue; cerebrospinal
fluid (CSF) concentration is 10% in noninflamed meninges and
14-37% in inflamed meninges; crosses placenta; enters breast
milk
Protein bound: 20-40%
Vd: 2.1-2.7 L/kg
Metabolism
Metabolized in liver
Enzyme inhibitor: CYP1A2
Elimination
Half-life: 2-5 hr (children); 3-5 hr (adults)
Excretion: Urine (30-50%), feces (15-43%)

CONTRAINDICATIIONS
Hypersensitivity; concurrent tizanidine administration
ADVERSE EFFECTS
Tendonitis and tendon rupture, peripheral neuropathy, cns effects,
exacerbation of myasthenia gravis, Hypersensitivity reactions,
hepatotoxicity, severe adr with concomitant theophylline,
clostridium difficile-associated diarrhea, prologation qt interval,
development of drug resistant bacteria, phototoxicity,