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(SEPPIC Patent )
C/3276/GB/01/march2006 / 1
SEPIWHITE MSH
MAIN CAUSES OF PIGMENTATION DESORDERS ?
Solar
Ageing process
exposure
PIGMENTATION DESORDERS
Unesthetic aging spots
Uneven complexion
Hormonal disturbance :
-Contraceptive/ Estrogenic
treatment (due to menopausis) Irritation
/ Pregnancy Inflammation
C/3276/GB/01/march2006 / 2
SEPIWHITE MSH
STRATEGY – SEPIWHITE MSH BIRTH
BIOLOGICAL DATAS
+ -
MC1R AGRP : Agouti Related Protein
MSH : Melanotropin
melanocytes
Melanin
Undecylenoyl phenylalanine
CH2=CH-(CH2)8-CO-NH-CH-COOH
I
CH2-C6H5
+ -
MC1R Affinity for α-MSH receptor
ProtGαS
MELANOGENESIS
C/3276/GB/01/march2006 / 6
SEPIWHITE MSH
FLASH LIGHTENING IN VIVO EFFICACY : ASIAN PANEL
- Lightening chromametric D •
•
Water / Aqua
Chlorphenesin
10.00
0.10
%
%
measurement at D0 and D7 • Lactic acid 3.00 %
E • Fragrance 0.07 %
: Luminosity (L* Parameter)
and ITA (Individual Typologic
Angle) on normal skin and Test performed in Thaïland (Bangkok)
on pigmented spots
+ tolerance of the formula
(a* Parameter describing
erythema)
C/3276/GB/01/march2006 / 7
SEPIWHITE MSH
LIGHTENING IN VIVO EFFICACY : ASIAN PANEL
* **
1,2
1,4
73% of volunteers
L* parameter
evolution in
**
in comp ar ison
1
to DO
0,6
0,4
* 0,4
0,2
0
-0,1
D7 normal skin D7 pigmented spots
D7 normal skin D7 pigmented spots
-0,1 * **
-0,6
D7 normal D7 pigmented
-1,1 skin spots
C/3276/GB/01/march2006 / 9
Summary of SEPIWHITE MSH
efficacy
C/3276/GB/01/march2006 / 10
SEPIWHITE MSH
LIGHTENING EFFICACY - SUMMARY
Lightening effect at 2% on volunteers :
SEPIWHITE MSH
- « tan removal » test (28 days)
New concept for - Asian panel : visible effect after 2 months
an effective (formulated alone – pH 6,8) or very quick
lightener effect after 7 days (NEW study : Sepiwhite
MSH combined with AHA&BHA – pH 4)
1. Undecylenoyl phenylalanine
Excellent cutaneous bio-affinity (lipoaminated structure)
Pure and unique patented molecule (ELINCS underway)
C/3276/GB/01/march2006 / 12
Formulation guidelines
C/3276/GB/01/march2006 / 13
SEPIWHITE MSH
FORMULATION GUIDELINES
REMINDER :
2. Clear lotions :
Soluble in water if pH > 7
In all cases (for acid or basic formula) we advice to use a « weak base »
(such as Triethanolamine) for neutralizing SEPIWHITE MSH. The base
must be entirely incorporated at the beginning of the formulation.
C/3276/GB/01/march2006 / 14
SEPIWHITE MSH
FORMULATION GUIDELINES
C/3276/GB/01/march2006 / 15
SEPIWHITE with AHA - BHA
Weak base
RECOMMENDATIONS
SEPIWHITE MSH
C/3276/GB/01/march2006 / 16
SEPIWHITE with AHA - BHA
LAST RECOMMENDATIONS
C/3276/GB/01/march2006 / 17
Nota
The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product.
Except as set forth above, SEPPIC* makes no warranties, whether express, implied or statutory, as to the product which is the subject of this document . Without limiting the
generality of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose. Buyer assumes all risk and
liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth herein is furnished free of charge and is
based on technical data that SEPPIC* believes to be reliable. It is intended for use by persons having technical skill and at their own discretion and risk. Since conditions of use
are outside SEPPIC*'s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in connection with any use of this information. Nothing herein is to be
taken as a license to operate under or a recommendation to infringe any patents.
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