10/09/2018

Integrated Metabolism Pathway

Wawasan Biokimia

Rahmat Eko Sanjaya

KBK Biokimia

Organization
of Life
Entire organism
System
Tissue
Cells
Organelle
Molecules
Atoms

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What is Biochemistry?
Biochemistry is the study of the chemical
interactions of living things.
Biochemists study the structures and
physical properties of biological
molecules.
– Often are involved in the manufacture of
new drugs and medical treatments
Ciri Zat Hidup
1. Susunan molekul zat hidup: rumit, kompleks dan
terorganisasi dengan rapi.
2. Setiap komponen zat hidup mempunyai fungsi
berlainan dan khusus.
3. Zat hidup berkemampuan untuk mengambil energi
dari sekelilingnya.
4. Zat hidup memiliki kemampuan untuk
mereplikasi/mereproduksi diri.
(Wirahadikusumah, 1989)

Biochemistry:
Elements in Living Organisms Where Chemistry & Biology Meet
The most common elements found in living
(SuperChemistry)
organisms include: Living things require millions of chemical
–Carbon (C) reactions just to survive.
–Oxygen (O) Metabolism = all the chemical reactions
–Nitrogen (N) occurring in the body.
–Hydrogen (H) Organic molecules:
–
–Phosphorus (P) usually associated with living things.
– always contain CARBON.
–Sulfur (S) – are “large” molecules, with many atoms
– always have covalent bonds (share electrons)

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Apa yang dipelajari Biokimia?

1. Struktur kimia komponen makhluk hidup dan hubungannya
dengan fungsi biologis Macro = large
(Struktur dan Fungsi Biomolekul)
2. Metabolisme dan bioenergetika, keseluruahn reaksi kimia yang
4 types of macromolecules
terjadi dalam makhluk hidup 1. Carbohydrates
(Metabolisme & Bioenergetika)
3. Biologi molekul, proses-proses dan senyawa-senyawa kimia yang 2. Lipids
menyimpan dan meneruskan informasi biologis
(Aliran Informasi Genetik) 3. Proteins
(Catatan Kuliah ITB, Biokimia I: Struktur & Katalis) 4. Nucleic Acids
Biokimia merupakan disiplin ilmu penelitian. Hasil penelitian
digunakan sebagai konsep pembelajaran
(kedokteran, pertanian, nutrisi dan bidang lainnya).

Organisms can be classified according to their source of energy

Phylogeny of the three domains of life by Carl Woese (sunlight or oxidizable chemical compounds) and their source
Berdasarkan gen 16S rRNA of carbon for the synthesis of cellular material.

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Landmarks in the Biochemistry Now;

evolution of life on Biotechnology
Earth (Genetic Engineering
& BioInformatic)

Kary received a Nobel Prize in

chemistry in 1993, for his
invention of the polymerase chain
reaction (PCR). The process,
which Kary Mullis conceptualized
in 1983, is hailed as one of the
monumental scientific techniques
of the twentieth century.
(karymullis.com)

“Highly original and significant, virtually dividing biology

into two epochs of before PCR and after PCR” Thermo-
The New York Times cycler

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