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Nur Azizah

145070500111002
ABSTRACT
Hydrochlorothiazide (HCT), thiazide diuretics, has comparatively short elimination half life,
about 5.6 to 14.8 hours with bioavailability of 65-72%. the short half-life leads to increased
frequency of drug use and decreased medication adherence. So as to enhance the bioavailability
and to reduce the difficulties associated with HCT, it is decided to design a transdermal drug
delivery system for this drug. Transdermal patches are used to deliver certain doses of drugs
through the skin and into the bloodstream. Three formulations of Transdermal patches were
fabricated by solvent evaporation technique using Hydroxy Propyl Methyl Cellulose polymer
(HPMC), and Polyvinyl Pyrrolidone (PVP) to make the controlled release formulation. The
prepared patches were wvaluated for their physicochemical characteristics and in-vitro drug
release study. Physicochemical parameters like organoleptic, weight variation, thickness
uniformity, and folding endurance were evaluated. In vitro permeation studies through snake
skin were carried out using modified Franz diffusion cell. All the formulations exhibited
satisfactory physicochemical characteristics. Among the formulations prepared, On the basis of
in vitro drug release studies (24 hours) formulation code PII was found to be better than other
formulation and it was selected as the optimized formulation. The results from in vitro drug
release shows that the release of drug from patches increase with increase in concentration of
HPMC. Drug release from optimized patch followed Korsmeyer-Peppas model zero and first
order kinetic model, and higuchi model. The present study can be concluded that formulation
code PII found to be the ideal patch, shown the maximum drug permeation of 90.04% at the end
of 24 h followed Higuchi diffusion kinetics.

Keywords : Transdermal patch, HCT, HPMC, PVP, Optimized, Franz diffusion cell
ABSTRAK
Hydrochlorothiazide (HCT), diuretik Thiazide, memiliki waktu paruh pendek, sekitar 5,6-14,8
jam dengan bioavailabilitas 65-72%. waktu paruh yang pendek tersebut menyebabkan frekuensi
peggunaan obat meningkat dan menyebabkan kepatuhan minum obat menurun. Jadi, untuk
meningkatkan biovailabilitas dan mengurangi frekuensi penggunaan HCT, yaitu dengan
menggunakan transdermal patch. Transdermal patch digunakan untuk menghantarkan obat
dengan dosis tertentu melalui kulit dan masuk ke aliran darah. 3 formulasi Patch transdermal
dibuat dengan teknik “solvent evaporation” menggunakan kombinasi polimer HydroxyPropil
Metil Selulosa (HPMC) dan Polyvinyl Pyrrolidone (PVP) untuk membuat formulasi pelepasan
terkontrol. Hasil patch dievaluasi untuk karakteristik fisikokimia dan studi pelepasan obat in-
vitro. Parameter fisiko - kimia seperti organoleptis, keseragaman bobot, ketebalan, dan daya
lipat. Penelitian difusi in vitro dilakukan melalui kulit ular dengan menggunakan Franz diffusion
cell. Semua formulasi tersebut menunjukkan karakteristik fisikokimia yang memuaskan.
Diantara formulasi yang dihasillkan, berdasarkan studi pelepasan obat in vitro (24 jam), kode
formulasi PII ternyata lebih baik dari formulasi lainnya dan dipilih sebagai formulasi yang
optimal. Laju difusi semua formulasi menunjukkan bahwa laju difusi mengalami penurunan
ketika konsentrasi HPMC diturunkan. Laju pelepasan obat patch dioptimasi mengikuti
Korsmeyer-Peppas model, zero dan first order kinetic model, dan higuchi model. Penelitian ini
dapat disimpulkan bahwa patch transdermal dengan code PII adalah sebagai patch yang ideal
dan optimum, ditunjukkan dengan permeasi obat maksimum 90,04% pada akhir 24 jam
mengikuti Higuchi diffusion kinetic.

Kata kunci : Transdermal patch, HCT, HPMC, PVP, optimum, Franz diffusion cell

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