Name: _____________________________________ Date:_______________ Pd: _______

Allied Health Potts

1. Adaptive immune cells will interact mainly at the _______________________ in the body.
a. What about this organ makes it a good place for the cells to interact? ____________________________
_____________________________________________________________________________________

2. The adaptive immune system is divided into two responses: The _______________________ response, which uses B
cells, and the _____________________________ response, which uses T cells.

3. What is one difference between antigen that B cells respond to vs. antigen that T cells respond to? ___________
____________________________________________________________________________________________
____________________________________________________________________________________________

4. Fill in the following information about the different types of T cells. You may choose which two to expand on, but you
must list all three.
a. First type: _______________________________
i. Abbreviated: _______
ii. Surface marker: ________
iii. Function: ______________________________________________________________________
______________________________________________________________________________
b. Second type: _______________________________
i. Abbreviated: _______
ii. Surface marker: ________
iii. Function: ______________________________________________________________________
______________________________________________________________________________
c. Third type: _______________________________

5. What is the purpose of the MHC? ________________________________________________________________

____________________________________________________________________________________________
____________________________________________________________________________________________

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 6. Fill in information for one of the classes of MHC below. Circle your choice: MHC I or MHC II
a. What type of cell is it found on? ________________________________________
b. What does it show antigen to? ________________________________________
c. What is the purpose of this MHC (what does it allow to happen)? ________________________________
_____________________________________________________________________________________

7. T and B cells originate from a cell called a _______________________________________. As they are formed, they
will generate unique TCR and BCR surface receptors through ____________________________________.

8. The first part of the formation of B and T cells is called ________________________________________. The purpose
is to kill cells that ____________________________________. They are killed through a process called
______________________.
a. It’s more complex in T cells due to the ____________, and only the only cells that survive are those that
________________________________.
b. The resulting cells are _____________________ (because they have specific a specific BCR or TCR) but also
__________________ (because they haven’t seen their matching antigen yet).

9. Once antigen binds to the B or T cell, the second phase of B and T cell formation will occur. This is called
_________________________________________.
a. When antigens bind, it is called _____________________________. This leads to cells dividing, called
_________________________________. When they divide they will become functionally more specific,
which is called ____________________________________.

EXTRA CREDIT:
10. Why will NK cells be able to “pick up the slack” for some T cells? What is it that they are able to do that is similar
to T cell functioning, and when/why will it occur? ___________________________________________________
____________________________________________________________________________________________
____________________________________________________________________________________________
____________________________________________________________________________________________

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