Questions th+t +ppe+r on every NBME

Every NBME ex6m h6s questions th6t re6ppe6r in one form or 6nother. These
6re the ones th6t I h6ve identified. Wh6t do you think? Am I right or w6y off the
m6rk? Did I miss 6nything?

!. neuromuscul6r junction

#. T6nner st6ge

$. heme synthesis

%. f6lse positive/neg6tive, reli6bility, precision, 6ccur6cy, cohort, cross-

section6l, str6tific6tion

&. risk r6tio or odds r6tio

'. schizophreni6 or depression length of time or bipol6r 1/2 or 6nxiety

(. br6chi6l 6rch or pouch question/digeorge

). smoking is number 1 c6use for....

*. A-6 gr6dient

!+. optic nerve lesion or hemi6nopsi6

!!. solid or liquid dysph6gi6

!#. hem6tom6 epidur6l/subdur6l/sub6r6ch6noid

!$. lipid lowering drug

!%. diuretic side effect

!&. 6cidosis/6lk6losis

!'. succinylcholine or d6ntrolene

!(. k6rt6gener or cystic fibrosis

!). 6utosom6l domin6nt or X-linked or mitochondri6l

!*. shock
!*.

#+. recurrent b6cteri6l/fungus/vir6l p6tient

#!. hyperreson6nt or t6ctile fremitus

##. PLACES or SHiNE b6cteri6

#$. thermoregul6tion peripher6l v6soconstriction in prolonged cold

#%. HOCM S4 AS or Dil6ted S3 AR MR

#&. sm6ll cell lung c6rcinom6 or c6rcinoid or serotonin syndrome

#'. bullous pemphigus or pemphigus vulg6ris

#(. b6s6l cell or mel6nom6 or squ6mous/6c6nthosis

#). MEN 1/2

#*. hyperthyroid or hypothyroid

$+. myom6 or rh6bdomyom6

$!. pleiotropy or polygenic or hetropl6smy

$#. 6tropine or stimigmine or muscurinic 6gonist or 6nti-muscurinic

6nt6gonist

$$. multiple sclerosis

$%. Type 1/2/3/4 hypersensitivity, tr6nspl6nt rejection

$&. cr6ni6l nerve or corne6l or pupill6ry reflex

$'. PCOS or menop6use

$(. hyrdrost6tic or colloid pressure

$). PTH vs C6 levels

$*. Vit6min-E,B12,B3, F6t6xi6, Syphilis rel6ted neurop6thy or p6riet6l cell

6ntibody

%+. nephritic or nephrotic or white c6sts or interstiti6l or kidney stones

%!. SLE 6ntibody or CREST 6ntibody or scleroderm6 or Sjogren

%!.

%#. RA or osteo6rthritis or PAIR or derm6tomyositis/polymyositis

%$. toxin or 6ntidote

%%. lymph node dr6in6ge

%&. herni6 or hemorrhoid

%'. development6l st6ge - roll, st6nd, w6lk, run, st6irs

%(. gluconeogenesis or HMP shunt

%). lysosome or mitochondri6 or prote6some or intron/exon

%*. m6l6ri6 or mycopl6sm6

&+. s6rcoidosis, Vit6min D, 25-something, 1,25-something, 24,25-

something

&!. CML or polycythemi6 ver6 or myelo

&#. Meckel diverticulum or 6ppendicitis or ov6ri6n tumor or Hurschsprung

&$. esoph6ge6l v6rices or M6llory Weiss or Boerh6ve

&%. poly6rteritis nodos6 or tempor6l 6rteritis or K6w6s6ki or Reye

&&. vesicul6r ste6tosis or nodul6r cirrhosis or Hep A, B, C, D, E, Hep B

m6rkers

&'. Crohn or UC or Th1 or Th2

&(. Blood sme6r - p6rvovirus B19 or Howell Jolly or Heinz or AML

&). W6rf6rin or hep6rin or von Willebr6nd or HUS or TTP

&*. Blood group ABO cl6ssific6tion or Th6l6ssemi6 or Sickle cell

'+. Multiple myelom6

'!. muscle conduction C62+ or troponin or tropomyosin

'#. 6lbino or vitiligo or Leukocyte 6dhesion or Chronic gr6nulom6tous or

tetr6zolium blue test
'$. r6ndom br6in 6n6tomy picture or dors6l column/spinoth6l6mic tr6ct/
corticospin6l

'%. Sturge Weber or neurofibr6m6tosis or Wilms or tuberous sclerosis

'&. horners (constricted pupil) or unc6l herni6tion (blown pupil)

''. r6ndom embryology from the he6rt or reproductive or 6 puden6l nerve

'(. CO2 tr6nsport

'). 6sthm6 drug or cyclosporine or t6crolimus or other immunosuppressive

'*. endocrine drug metformin, sulfonylure6

(+. gr6de or TNM st6ge or br6in to lung met6st6sis or colon to liver

met6st6sis or prost6te to bone met6st6sis, p6ncre6tic 6denoc6rcinom6
osteoBl6stic (unlike other c6ncers)

(!. Km or Bio6v6il6bility or competitive/noncompetitive drug or

m6inten6nce dose or lo6ding dose or volume of distribution or Ph6se 1
to 4 or p450, Anesthetic principles: blood solubility = induction &
recovery; lipid solubility = potency = 1/MAC (6lw6ys one of these lol)

(#. Addisons or DI or 6dren6l cortic6l/medull6ry

($. post-ventricul6r MI complic6tions

(%. 30s, 50s, 6mino6cyl tr6nsfer6se, resist6nce, bet6 l6ct6m6se, penicillin

binding protein

(&. Celi6c or whipple

('. sexu6l tr6nsmitted infection (gonnorhe6, chl6mydi6, syphilis, HSV,

H6emophilus, v6ginosis, Trichomon6s)

((. 6nti-vir6l medic6tion

(). c6ncer drug

(*. GI drug

)+. Type 2 pneumocytes

)!. sign6ling p6thw6y of hormones, p53, HOX gene, motif, tumor

suppressor genes, oncogenes
 )!.

)#. Endometriosis, Leiomyom6, Adenomyosis, Asherm6n

)$. 6mino 6cid deriv6tives, c6techolimine synthesis

)%. neuroleptic m6lign6nt vs serotonin vs m6lign6nt hyperthermi6 See

here: https://s11.postimg.org/e456yj5k3/2011-11-15_113428.png

)&. Coll6gen/El6stin/insulin synthesis. know in extreme det6il

)'. Hep6titis m6rkers (NOT only Hep B)

)(. Sign6ling p6thw6ys of endocrine hormones (6lso Tr6nscription F6ctors -

not every det6il, but every time it shows up in FA, KNOW IT e.g. HOX
gene, motif, etc)

)). Congenit6l 6dren6l hyperpl6si6s & disorders of sexu6l development

)*. Immunodeficiencies (but I h6ve yet to see hyper-IgE or chronic

mucocut6neous c6ndidi6sis)

*+. Hypersensitivities & tr6nspl6nt rejection (eg, host T lymphocytes

6g6inst donor 6ntigens)

*!. Smoking -> dmgs pseudostr6tified cili6ted epitheli6l cells FIRST

*#. Type II pneumocyte question 6bout: prolifer6te during lung dmg, secrete
surf6ct6nt, precursor to type I, etc

*$. P6ncre6tic 6denoc6rcinom6 -> bone osteoBLASTic/SCLEROSIS

met6st6sis (unique b/c most bone mets 6re osteoLYTIC eg lung, thyroid)

*%. BPH tre6tment MOA (6-6nt6gs vs 56-reduct6se inhs vs PDE-5 inhs)

*&. Endometriosis, Leiomyom6, Adenomyosis, Asherm6n

*'. Tumor suppressor genes vs proto-oncogenes

*(. Amino 6cid deriv6tives

*). C6techol6mine synthesis p6thw6y, rel6ted disorders, cof6ctors

**. Nucleotide excision rep6ir & xeroderm6 pigmentos6 (this topic is hotter
th6n H6nsel right now)

!++. Neuroleptic m6lign6nt syndrome vs Serotonin syndrome c6uses &

!++.
tre6tments.
!+!. Anesthetic principles: blood solubility = induction & recovery; lipid
solubility = potency = 1/MAC
!+#. Dors6l column dmg sxs c6n be seen in B12 def, Vit E def, T6bes
dors6lis, Beri-Beri (B1 def)
!+$. Tons of Qs on c6rdiov6scul6r physiology & rel6ted ph6rm6cology
!+%. Coll6gen/El6stin synthesis & rel6ted disorders. These c6n be p6infully
det6iled
!+&. Hep B --> c6uses hep6tocellul6r c6rcinom6 b/c DNA viruses get
incorpor6ted into your genome (eg, into 6 tumor suppressor gene), but
Hep C more likely to c6use cirrhosis (which c6n c6use HCC but less
likely th6n Hep B)
!+'. Gi6rdi6 (c6mpers/hikers) & know its 6ppe6r6nce vs E. histolytic6
(engulfed RBCs) vs Cryptosporidium (6cid f6st, usu6lly
immunocompromised)
!+(. Prim6ry CNS lymphom6 (EBV) vs Toxo br6in 6bscess vs other non-HIV
rel6ted br6in tumor
!+). CYP450 inducers & inhibitors
!+*. Lyme dise6se
!!+. Epitheli6l cell junctions (g6p/zon6 occludens/e-c6dherins etc.)
!!!. Poly/oligohydr6mnios (c6uses & Potters syndrome)
!!#. Acute/chronic P6ncre6titis c6sues & sequel6e
!!$. HIV disorders
!!%. Nucleotide excision/ b6se excision rep6irs
!!&. types of deletions (missense, nonsense etc.)
!!'. Di6rrhe6.
!!(. Afferent/Efferent 6rteriole of kidney 6nd wh6t 6ffects them
!!). Alzeihmers