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BIT1004 Cell biology and Biochemistry L T P J C

3 2 2 0 4
Pre-requisite NIL Syllabus version
1.1
Course Objectives:
1. Analyze cell structure and its functions
2. Illustrate the structure and functions of biomolecules
3. Distinguish the concept of central dogma, cell cycle and cell signalling

Expected Course Outcome:


1. Define and recall the cell structure and functions
2. Classify the cell constituents and biomolecules
3. Demonstrate the characteristic features, properties and types of macromolecules
4. Formulate the basic concepts of enzymes and its regulations
5. Elaborate the principles and regulations of replication, transcription and translation mechanism
6. Appraise the skills of cell cycle events and signal transduction process in cell, tissue and organ
level

Student Learning Outcomes (SLO): 2,7


2. Having a clear understanding of the subject related concepts and of contemporary issues
7. Having computational thinking (Ability to translate vast data in to abstract concepts and to
understand database reasoning)
Module:1 Cell structure and Functions 6 hours
Prokaryotic and eukaryotic cell structure; biomembrane, Transport across cell membranes –
passive diffusion, facilitated diffusion, co-transport and active transport. Cell organelles,
cytoskeleton structure and functions.

Module:2 Biomolecules 6 hours


Types of macro molecules, metabolites and products. Properties of water. Cellular carbohydrates,
lipids and their classification.

Module:3 Proteins 6 hours


Classification and properties of amino acids. Peptides and structure of proteins.

Module:4 Enzymes 7 hours


Classification, catalysis, properties, cofactors, coenzymes and inhibitors. Thermodynamics and
kinetics - Michaelis-Menten equation. Regulatory enzymes.

Module:5 Nucleic acids 4 hours


DNA and RNAs. Nucleoside and nucleotides. Structure, function and properties of nucleic acids.

Module:6 Central dogma 7 hours


Transcription, translation and protein synthesis in organisms. Replication of DNA. Gene and
chromosomal mutations.
Module:7 Cell cycle and signal transduction 7 hours
Mitosis and meiosis. Cell cycle control system, regulation of check points by mitogens, cyclins
and cdks. Cell signaling and transport: Autocrine, paracrine and endocrine signaling molecules,
secondary signaling molecules and signal transduction.

Module:8 Contemporary issues: 2 hours


Industrial expert lecture

Total Lecture hours: 45 hours

Text Book(s)
1. Harvey Lodish , Arnold Berk , Chris A. Kaiser , Monty Krieger, Anthony Bretscher ,
Hidde Ploegh, Angelika Amon ,Matthew P. Scott. 2012. Molecular Cell Biology 7th
edition. W.H. Freeman. USA.
Reference Books
1. Victor Rodwell, David Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil.
2015.
2. Harpers Illustrated Biochemistry 30th Edition. McGraw-Hill education, USA.
3. Geoffrey M. Cooper and Robert E. Hausman. 2013. The Cell: A Molecular Approach. 6th
edition. Sinauer Associates, Inc. USA.
4. Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts
and Peter Walter. 2014. Molecular Biology of the Cell. 6th edition. Garland Science, USA.

Mode of Evaluation: CAT / Assignment / Quiz / FAT / Project / Seminar


List of Challenging Experiments (Indicative)
1. Preparation of reagents, buffers and basic calculations. 2 hours
2. Quantitative estimation of reducing sugars in samples. 2 hours
3. Quantitative estimation of non-reducing sugars. 2 hours
4. Quantitative estimation of proteins. 2 hours
5. Functioning of microscopes; studying the diversity of cells using permanent 2 hours
slides.
6. Subjecting cells to different pH, concentrations and analyzing the structural 2 hours
changes occurring due to osmosis.
7. Growing root tips of different plants and comparing the chromosome 2 hours
number by fixing at metaphase stage.
8. Comparison of various stages of Meiosis I and Meiosis II during 2 hours
microsporogenesis of Rheo discolor.
9. Extraction of genomic DNA from a microbe/plant/animal cell. 2 hours

10 Quantification of DNA/RNA 2 hours


Total Laboratory Hours 20 hours
Mode of evaluation: Written examinations, assignments and quizzes
Recommended by Board of Studies 03-08-2017
Approved by Academic Council No. 46 Date 23-08-2017