ASSIGNMENT

Submitted by:
Mishal Gulzarin

Submitted to:
Sir Izhar Ullah

Topic:
Types of Receptors and their location

Roll No:
15

Sources:
www.slideshare.net
Pharmacology written by Lippincott
Pharmacology written by Katezung and Trevor’s
 ASSIGNMENT
Submitted by:
Sehrish Ali Khan

Submitted to:
Sir Izhar Ullah

Topic:
Types of Receptors and their location

Roll No:
47

Sources:
www.slideshare.net
Pharmacology written by Lippincott
Pharmacology written by Katezung and Trevor’s
 Types of Receptors:

There are two types of receptors.Those are:

 1)Internal receptors
 2)Cell surface receptors

1)Internal/Intracellular/Cytoplasmic receptors:

 Found in cytoplasm of cell

 Respond to hydrophobic ligand molecules

Example:

Steroid receptors

Cell surface receptors/Trasnmembrane receptors/Cell specific proteins:

 Performs signal transduction,converting an extracellular signal into an intracellular

signal.

Classification:

There are general categories of cell surface receptors:

 Ion channel linked receptors

 G-protein linked receptors
 Enzyme linked receptors

1)Ligand gated ion channels:

 Receptors bind with ligand.

 Open a channel through the membrane that allows ions to pass through.
 Conformational change in the protein’s structure that allows ions such as Na,Ca,Mg,
and H2 to pass through.

Example: Cholinergic nicotinic receptors

Receptor Location Mechanism Major functions

M1 Nerve endings Gq coupled Increase IP3,DAG
cascade
M2 Heart,some nerve endings Gi coupled Decrease cAMP,
activates K+
channels
M3 Effector cells,Smooth Gq coupled Increase IP3,DAG
muscle,Glands,Endothelium cascade
Nn ANS ganglia Na+-K+ ion channel Depolarizeses,
evokes action
potential
Nm Neuromuscular end Plate Na+-K+ ion channel Depolarizes, evokes
action potential

2)G-protein coupled receptors:

 Binds with a ligand and activate a membrane protein called a G-

protein
 The activated G-protein then interacts with either an ion channel or
an enzyme in the membrane.
 Each receptor has its own specific extracellular domain and G-
protein binding site.

Example: Alpha and Beta adrenoceptors

Receptor Location G-protein Second messanger Major function

Alpha 1 Effector Gq Increase IP3,DAG Increase
tissue:smooth Ca+,causes
muscle,glands contraction,secr
etion
Alpha 2 Nerve Gi Decrease cAMP Decrease
endings,some transmitter
smooth muscles release,causes
contraction
Beta 1 Cardiac Gs Increase cAMP Increase heart
muscle,juxtaglo rate,force and
merular renin release
apparatus
Beta 2 Smooth Gs Increase cAMP Relax smooth
muscle,liver, muscles:increase
heart glycogenolysis,h
eart rate and
force
Beta 3 Adipose cells Gs Increase cAMP Increases
lipolysis
Dopamine Smooth muscle Gs Increase cAMP Relax renal
vascular smooth
muscle
3)Enzyme linked receptors:

 Cell surface receptors with intracellular domains that are associated with an enzyme.
 Normally have large extracellular and intracellular domain.
 When a ligand binds to the extracellular domain,a signal is transferred through the
membrane and activates the enzyme,which eventually leads to a response.

Example:Tyrosine Kinase receptor