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ATORVASTATIN CALCIUM

Generic Name ATORVASTATIN


CALCIUM
Brand Name Lipitor

Classification CARDIOVASCULAR AGENT; ANTILIPEMIC AGENT; HMG-COA;


REDUCTASE INHIBITOR (STATIN)
General Action Atorvastatin is an inhibitor of reductase 3-hydroxy-3-methyl-glutaryl
coenzyme A (HMG-CoA), which is essential to hepatic production of
cholesterol. Lipitor increases the number of hepatic low-density-lipid
(LDL) receptors, thus increasing LDL uptake and catabolism of LDL.
Dose and Route Hypercholesterolemia
Adult: PO Start with 10–40 mg q.d., may increase up to 80 mg/d
Child/Adolescent: PO 10–17 y: Start with 10 mg q.d., may increase up to 20
mg/d
Indications or Adjunct to diet for the reduction of LDL cholesterol and triglycerides in
Purposes patients with primary hypercholesterolemia and mixed dyslipidemia.
Side effects Body as a Whole: Back pain, asthenia, hypersensitivity reaction, myalgia,
rhabdomyolysis. CNS: Headache. GI: Abdominal pain, constipation,
diarrhea, dyspepsia, flatulence, increased liver function tests. Respiratory:
Sinusitis, pharyngitis. Skin: Rash.
Contraindications Hypersensitivity to atorvastatin, myopathy, active liver disease,
unexplained persistent transaminase elevations, pregnancy (category X),
lactation.
Nursing Assessment & Drug Effects
Responsibilities
 Monitor for therapeutic effectiveness which is indicated by
reduction in the level of LDL-C.
 Lab tests: Monitor lipid levels within 2–4 wk after initiation of
therapy or upon change in dosage; monitor liver functions at 6 and
12 wk after initiation or elevation of dose, and periodically
thereafter.
 Assess for muscle pain, tenderness, or weakness; and, if present,
monitor CPK level (discontinue drug with marked elevations of
CPK or if myopathy is suspected).
 Monitor carefully for digoxin toxicity with concurrent digoxin use.

Patient & Family Education

 Report promptly any of the following: Unexplained muscle pain,


tenderness, or weakness, especially with fever or malaise; yellowing
of skin or eyes; stomach pain with nausea, vomiting, or loss of
appetite; skin rash or hives.
 Do not take drug during pregnancy because it may cause birth
defects. Immediately inform physician of a suspected or known
pregnancy.
 Inform physician regarding concurrent use of any of the following
drugs: erythromycin, niacin, antifungals, or birth control pills.
 Minimize alcohol intake while taking this drug.
 Do not breast feed while taking this drug.