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Author
Anthony W Chow, MD, FRCPC, FACP
Section Editor
Stephen B Calderwood, MD
Deputy Editor
Allyson Bloom, MD
Contributor disclosures
All topics are updated as new evidence becomes available and our peer review process is complete.
Literature review current through: Apr 2016. | This topic last updated: Jul 16, 2015.
INTRODUCTION — Deep neck space infections most commonly arise from a septic focus
of the mandibular teeth, tonsils, parotid gland, deep cervical lymph nodes, middle ear, or
sinuses. These deep cervical space infections have become relatively uncommon in the
postantibiotic era. Consequently, many clinicians are unfamiliar with these conditions. In
addition, with widespread use of antibiotics and/or profound immunosuppression, the classic
manifestations of these infections, such as high fever, systemic toxicity, and local signs of
erythema, edema, and fluctuance, may be absent.
Deep neck space infections often have a rapid onset and can progress to life-threatening
complications [1]. Thus, clinicians must be aware of such infections and should not
underestimate their potential extent or severity.
The relevant anatomy, microbial etiology, clinical manifestations, diagnosis, and treatment of
deep neck space infections will be reviewed here. Peritonsillar abscesses and submandibular
space infections (Ludwig's angina), suppurative parotitis, and odontogenic, middle ear, and
sinus infections are discussed in detail separately. (See "Peritonsillar cellulitis and abscess"
and "Submandibular space infections (Ludwig's angina)" and "Suppurative parotitis in adults"
and "Epidemiology, pathogenesis, and clinical manifestations of odontogenic infections" and
"Acute otitis media in children: Epidemiology, microbiology, clinical manifestations, and
complications" and "Acute otitis media in adults (suppurative and serous)" and "Acute
sinusitis and rhinosinusitis in adults: Clinical manifestations and diagnosis" and
"Uncomplicated acute sinusitis and rhinosinusitis in adults: Treatment".)
Cervical fascia — The muscles, vessels, and visceral structures of the neck are enveloped by
the cervical fascia, which has a superficial and deep component (figure 1 and figure 2). The
superficial cervical fascia consists of the subcutaneous tissues of the neck, which completely
enclose the head and neck and is continuous with the platysma anteriorly.
The deep cervical fascia has three layers: superficial, middle, and deep, which can be thought
of as defining a series of cylindrical compartments that extend longitudinally from the base of
the skull to the mediastinum (figure 1):
●The superficial or investing layer of the deep cervical fascia encloses all of the deeper parts
of the neck, beginning at the nuchal line and extending anteriorly, dividing to enclose the
trapezius, sternocleidomastoid, and strap muscles as well as the submaxillary and parotid
glands.
●The middle or pretracheal fascia encloses the cervical viscera including the pharynx,
esophagus, larynx, trachea, thyroid, and parathyroid glands.
●The deep or prevertebral fascia arises from the nuchal ligament and encloses the vertebral
column and muscles of the spine. The prevertebral fascia originates posteriorly on the spinous
processes and encircles the splenius, erector spinae, and semispinalis muscles (figure 1 and
figure 2). Prior to completing its circle anterior to the vertebral bodies, it fuses to the
transverse processes. At this point, it is split into two layers: the alar fascia anteriorly and the
prevertebral fascia posteriorly.
All three layers of the deep cervical fascia contribute to the carotid sheath, which forms a
neurovascular compartment that encloses the carotid artery, the internal jugular vein, and the
vagus nerve.
Fascial spaces — There are three spaces between the planes of the deep cervical fascia that
are of major clinical importance [2]:
Other spaces arising from the cervical fascia with potential for deep neck infections include:
the “danger” space, the prevertebral space, the pre-tracheal space, the peritonsillar space, and
the parotid space. The masticator space, which lies lateral and anterior to the parapharyngeal
space and consists of the masseteric, pterygoid, and temporal spaces, is described in detail
elsewhere; infection of the masticator space arises most frequently from molar teeth,
particularly the third molars (wisdom teeth). (See "Complications, diagnosis, and treatment of
odontogenic infections".)
Submandibular space — The submandibular space lies within the submental and
submandibular triangles between the mucosa of the floor of the mouth and the superficial
layer of the deep cervical fascia. It is subdivided by the mylohyoid muscle into the sublingual
space (which contains the sublingual gland, hypoglossal nerve, part of the submandibular
gland, and loose connective tissue), and the submylohyoid space (also known as the
submaxillary space, which contains the submandibular salivary gland and lymph nodes)
(figure 3). The two divisions communicate posteriorly around the mylohyoid muscle. It is this
space that is primarily involved in Ludwig’s angina. Infection within the sublingual space
results in gross swelling of the tongue that can result in acute airway obstruction. Infection of
the submylohyoid space may spread posteriorly along the styloglossus muscle into the
parapharyngeal space and continue to spread into the loose areolar tissue of the
retropharyngeal space, and then further inferiorly into the superior mediastinum.
The anterior compartment contains no vital structures but rather only fat, lymph nodes,
connective tissue, and muscle. It is the compartment most closely related to the tonsillar fossa
and the internal pterygoid muscle. The posterior compartment contains the ninth to twelfth
cranial nerves superiorly and the tenth cranial nerve more inferiorly, the carotid sheath and its
contents, and the cervical sympathetic trunk. The carotid sheath, which runs in the posterior
aspect of the parapharyngeal space, pierces the cone at its apex to enter the mediastinum
(figure 4).
Infection of the lateral pharyngeal space may result from pharyngitis, tonsillitis, parotitis,
otitis, or mastoiditis, as well as odontogenic infections, especially if the masticator space is
involved. (See "Complications, diagnosis, and treatment of odontogenic infections".)
Danger space — Posterior to the retropharyngeal space is the danger space, which is bound
by the alar fascia anteriorly and the prevertebral fascia posteriorly (figure 1 and figure 2). It
extends from the base of the skull and descends freely through the entire posterior
mediastinum to the level of the diaphragm (T1 to T2) where the two fascial layers fuse. Thus,
the danger space provides the most important anatomic route for contiguous spread between
the neck and the chest.
Prevertebral space — The prevertebral space is bound by the prevertebral fascia, which
originates posteriorly on the spinous processes and encircles the splenius, erector spinae, and
semispinalis muscles (figure 1 and figure 2). Prior to completing its circle anterior to the
vertebral bodies, it fuses to the transverse processes. At this point, it is split into two layers:
the alar fascia anteriorly and the prevertebral fascia posteriorly. The prevertebral space
extends from the base of the skull to the coccyx, thus allowing organisms to spread as far
down as the psoas muscle sheath.
Pretracheal space — The pretracheal space comprises the anterior portion of the visceral
compartment and completely surrounds the trachea and esophagus (figure 1). It is contiguous
with the carotid sheath laterally and with the superior mediastinum inferiorly.
Peritonsillar space — The peritonsillar space lies between the capsule of the palatine (faucial)
tonsil medially, the superior constrictor muscle laterally, and the tonsillar pillars anteriorly
and posteriorly (figure 5). A dreaded complication of a peritonsillar abscess (Quinsy) is to
rupture through the superior constrictor muscle and extend directly into the parapharyngeal
space, which lies posterior to the tonsillar bed.
Parotid space — The parotid space is formed by the splitting of the investing fascia at the
level of the stylomandibular ligament to enclose the parotid gland within a superficial capsule
and a deep capsule (figure 6). The superficial capsule is thick and strong, tightly adherent to
the superficial pole of the parotid gland. The deep capsule adjacent to the dorsal lobe of the
parotid gland, however, is thin and infection in the gland can easily penetrate through this
capsule and extend through the stylomandibular tunnel into the parapharyngeal space. The
stylomandibular ligament effectively separates the parotid space from the submylohyoid
space.
Lymph nodes — The lymph nodes of the head and neck can be divided into 10 principal
groups (figure 7). Six of these (occipital, mastoid, parotid, facial, submandibular, and
submental nodes) form a collar at the junction of the head and neck. Within this collar, the
sublingual and retropharyngeal nodes lie near the base of the tongue. The anterior and lateral
cervical nodes form a chain along the front and side of the neck, respectively. The lateral
cervical chain serves as a common root for drainage. The final conduit from all lymphatics in
the head and neck is the large deep chain situated along the carotid sheath. When inflamed,
these nodes become adherent to the fascial sheath of the vessels; thus, a suppurative infection
of the cervical lymph nodes may frequently invade the bloodstream.
In addition to the regional lymph nodes of the head and neck, both the nasopharynx and the
oropharynx are richly endowed with mucosa-associated lymphoid tissues similar to the
bronchus-associated lymphoid tissues and the gut-associated lymphoid tissues. In particular,
the aggregation of lymphoid tissues surrounding the nasopharynx is known as Waldeyer's
ring and comprises the palatine, lingual, adenoidal, and tonsillar lymphoid tissues. Acute
inflammation involving these tissues, such as during acute tonsillopharyngitis, croup, otitis
media, retropharyngeal abscess or Epstein-Barr virus (EBV) mononucleosis, may result in
acute airway compromise and constitutes a medical emergency [3,4].
Potential routes of spread — The deep cervical fascial spaces are normally bound together by
loose connective tissue and intercommunicate to varied degrees. The potential pathways of
extension from one space to another are illustrated in the accompanying figure (figure 8). A
thorough understanding of the potential anatomic routes of infection not only provides
valuable information on the nature and extent of infection but also suggests the optimal
surgical approach for effective drainage.
MICROBIOLOGY — Deep neck space infections are typically polymicrobial and represent
the normal resident flora of the contiguous mucosal surfaces from which the infection
originated. Due to the close anatomic relationships, the resident flora of the oral cavity, upper
respiratory tract, and certain parts of the ears and eyes share many common organisms (figure
9) [5]. Although as many as 50 to 100 bacterial species may be present on the oral or
nasopharyngeal mucosal surface, the typical deep neck space infection includes, on average,
five or six bacterial types [6,7]. Anaerobes generally outnumber aerobes on all mucosal
surfaces of the oral cavity by a factor of 10:1 [8].
The most common organism isolated from deep neck space infections is Streptococcus
viridans, reflecting its abundance in the mouth [9-11]. Most abscesses originating from the
teeth also harbor oral anaerobes, including Peptostreptococcus species, Fusobacterium
nucleatum, pigmented Prevotella species such as Prevotella melaninogenica (formerly
Bacteroides melaninogenicus), and Actinomyces species [12].
Klebsiella pneumoniae has been frequently isolated from deep neck space infections in
Taiwan, particularly from diabetic patients. This species is a more common pathogen in
various infections in Southeast Asia than in most other regions [10,14,15]. (See "Clinical
features, diagnosis, and treatment of Klebsiella pneumoniae infection".)
Infections arising from the pharynx frequently contain oral anaerobes and facultative
streptococci, particularly Streptococcus pyogenes. In a study of 847 patients with peritonsillar
abscess, Fusobacterium necrophorum was the most commonly detected species (23 percent),
followed by S. pyogenes (17 percent), and group C or G streptococci (5 percent) [16]. (See
"Complications of streptococcal tonsillopharyngitis".)
Infections of the prevertebral space usually originate from contiguous spread of a cervical
spine infection (such as discitis or vertebral osteomyelitis), by local instrumentation of the
trachea or esophagus, or by hematogenous seeding. There is a predominance of gram-positive
organisms, the most common being Staphylococcus aureus. Less common organisms include
various facultative gram-negative bacilli, mycobacteria, and fungi. Intravenous drug use,
immunosuppression, alcoholism, and diabetes mellitus are known risk factors [17,18]. Thus,
the microbiology of prevertebral space infections is quite different from that of
retropharyngeal or odontogenic deep neck infections.
Because of the dense superficial layer of the deep cervical fascia and its musculofascial
planes, a fluctuant mass is not readily appreciated in deep neck space infections. Palpation of
the oral cavity, when possible, may help in identifying such a mass or focal tenderness. The
characteristic signs of deep pus are pitting or a doughy feeling on firm deep palpation.
Specific sites of infection are often associated with characteristic clinical manifestations and
physical findings:
●Dysphonia and hoarseness are late findings in neck infections and may indicate involvement
of the tenth cranial nerve
●Stridor and dyspnea signify airway obstruction and may be manifestations of local pressure
or spread of infection to the mediastinum.
IMAGING — Computed tomography (CT) is the imaging modality of choice for the
diagnosis of deep neck space infections [19]. CT allows the critical evaluation of soft tissues
and especially bone from a single exposure (image 1). In addition, the axial imaging format
of CT is particularly well suited to the head and neck. Because CT can localize a process and
define its extent, particularly extension into the mediastinum or the cranial vault, it is also an
invaluable tool for planning and guiding aspiration for culture or open drainage.
Magnetic resonance imaging (MRI) is useful for assessing the extent of soft tissue
involvement and for delineating vascular complications. However, MRI takes significantly
longer than CT to obtain good quality images, which may cause discomfort or claustrophobia
[19]. In addition, individuals with certain implanted devices cannot undergo MRI. (See
"Principles of magnetic resonance imaging".)
Plain radiography is of limited utility for the evaluation of deep neck space infections; it is
sometimes helpful for detecting retropharyngeal swelling or epiglottitis [19]. (See 'Clinical
features and diagnosis' below.)
Parotid space infections — Acute suppurative parotitis is characterized by the sudden onset
of unilateral induration and erythema that extends from the cheek to the angle of the jaw. The
parotid gland becomes swollen and extremely tender. Purulent discharge may be expressed
from the orifice of the parotid duct with gentle pressure. Although a stone obstructing the
salivary duct may predispose to bacterial infection, inspissated secretions and/or stasis are
more common predisposing features. Three factors that predispose to suppurative parotitis
are: acutely diminished salivary flow, poor oral hygiene, and increased susceptibility to
infection [20]. Thus, acute suppurative parotitis is typically seen in elderly, debilitated, and/or
dehydrated patients who may be diabetic or taking anticholinergic medications that decrease
salivary flow.
The microbiology of acute suppurative parotitis is quite variable and is often polymicrobial.
Staphylococcus aureus is by far the most frequently isolated pathogen, but anaerobes are also
common. Acute suppurative parotitis is discussed in more detail elsewhere. (See
"Suppurative parotitis in adults".)
Prevertebral space infections — Infections of the prevertebral space usually originate from
contiguous spread of a cervical spine infection (such as discitis or vertebral osteomyelitis), by
local instrumentation of the trachea or esophagus, or by hematogenous seeding. There is a
predominance of gram-positive organisms, the most common being Staphylococcus aureus.
Less common organisms include various facultative gram-negative bacilli, mycobacteria, and
fungi. Intravenous drug use, immunosuppression, alcoholism, and diabetes mellitus are
known risk factors [17,18]. Thus, the microbiology of prevertebral space infections is quite
different from that of retropharyngeal or odontogenic deep neck infections.
The diagnosis of a prevertebral space infection may be difficult to make clinically because
only 75 percent of patients complain of back or neck pain, 50 percent present with fever, and
one-third have neurologic deficits ranging from nerve root pain to paralysis [18]. Computed
tomography or magnetic resonance imaging is immensely helpful for differentiating a
prevertebral space infection from a retropharyngeal abscess. Complications of prevertebral
space infections arise from spinal epidural collections that cause cord compression.
Irreversible paralysis occurs in 4 to 22 percent of patients [18]. Spread of infection to or from
the disc or vertebrae may cause local destruction with mechanical instability of the spine.
Since the prevertebral space extends from the base of the skull down to the coccyx and is
contiguous with the psoas muscle sheath, seemingly distant abscesses can form within the
psoas muscle in a patient who has a prevertebral space infection [23].
Infection of the parapharyngeal space may arise from different sources throughout the neck.
Dental infections are the most common underlying cause, followed by peritonsillar abscess,
and rarely parotitis, otitis, or mastoiditis (Bezold's abscess). Infection of the anterior
compartment of the parapharyngeal space is more common than the posterior compartment.
(See "Epidemiology, pathogenesis, and clinical manifestations of odontogenic infections" and
"Complications, diagnosis, and treatment of odontogenic infections" and "Suppurative
parotitis in adults".)
Clinical features — The cardinal clinical features of parapharyngeal space infections are:
●Trismus
Dyspnea may be prominent as edema and swelling involve the epiglottis and larynx. Swelling
of the pharyngeal wall, if present, will be behind the palatopharyngeal arch and is easily
missed. Suppuration may advance quickly to other spaces, particularly to the retropharyngeal
and "danger" spaces, possibly reaching the mediastinum inferiorly or the base of the skull
superiorly.
Swelling and displacement of the parotid gland usually occur with infection in either the
anterior or posterior compartment.
Diagnosis — The source and extent of infection is best evaluated by computed tomography
(CT) or magnetic resonance imaging (MRI). (See 'Imaging' above.)
Complications
There are no characteristic symptoms or signs of a carotid sheath infection. A history of sore
throat is usually but not always present, and may be mild or unilateral; there may be a latent
period of up to three weeks before obvious manifestations of a deep neck space infection
develop. The patient presents either in a toxic condition or insidiously with a fever of
undetermined origin. Trismus is absent, and signs of local suppuration may be subtle initially
because of the tight connective tissue around and within the carotid sheath. In some patients,
there is diffuse swelling along the sternocleidomastoid muscle with marked tenderness and
torticollis to the opposite side.
Carotid artery mycotic aneurysms have a mortality rate of approximately 20 percent [26].
Erosion of the carotid artery is a potentially devastating complication. This complication
arises from an arteritis due to contiguous inflammation, resulting eventually in the formation
of a false aneurysm, which may rupture. Erosion and rupture of the carotid artery may be
heralded by recurrent small hemorrhages from the nose, mouth, or ear ("herald bleeds"). This
is followed by hematoma formation in the surrounding tissues, a protracted clinical course,
and eventually the onset of shock due to exsanguination. Ligation of the carotid artery may be
necessary in cases of major hemorrhage, but the mortality rate remains high, and the risk of
stroke is significant [1].
Retropharyngeal and danger space infections — Retropharyngeal abscesses are among the
most serious of deep space infections, since infection can extend directly into the anterior or
posterior regions of the superior mediastinum, or into the entire length of the posterior
mediastinum via the danger space (figure 1 and figure 2). Retropharyngeal infections can
occur in both children and adults. Retropharyngeal infections in children are discussed
separately. (See "Retropharyngeal infections in children".)
Clinical features and diagnosis — Infection may reach the retropharyngeal space from either
local or distant sites. Penetrating trauma (eg, from chicken bones or following
instrumentation) is the usual source of local spread; in such cases, a sore throat or difficulty
in swallowing or breathing may be the first indication of infection. More distant sources of
infection include odontogenic sepsis and peritonsillar abscess (now a rare cause). Infection
from these sources may often obscure the diagnosis of a retropharyngeal abscess because of
associated trismus, which makes direct examination of the posterior pharyngeal wall difficult.
The differential diagnosis includes cervical osteomyelitis, Pott's disease, meningitis, and
calcific tendonitis of the long muscle of the neck (figure 10) [27]. In this setting, CT scans
and/or x-rays of the lateral neck are especially helpful and may demonstrate cervical lordosis
with swelling and gas collections in the retropharyngeal space, causing anterior displacement
of the larynx and trachea (image 2 and image 1). The radiograph should be evaluated for
increased thickness of the prevertebral soft tissues, air or air-fluid levels, and the presence of
foreign bodies. The soft tissues of the posterior wall of the hypopharynx are normally about 5
mm deep, less than one third the diameter of the fourth cervical vertebra (C4). In the presence
of a retropharyngeal space infection, the pharynx or upper airway is displaced anteriorly by
more than one half the width of the C4 vertebral body. Radiographs may also help to
differentiate retropharyngeal from prevertebral space infection arising from cervical vertebral
osteomyelitis [28,29]. (See 'Imaging' above.)
Clinically, the onset of acute necrotizing mediastinitis is rapid and is characterized by the
following:
●Rupture of mediastinal abscess into the pleural cavity with empyema or development of
loculations
The mortality of acute necrotizing mediastinitis in adults is high (25 percent), even when
appropriate antibiotics are administered. (See "Aspiration pneumonia in adults".)
Empiric regimens are based upon the expected microbiology and immune status of the host,
and coverage should be narrowed if microbiologic data become available. The antibiotic
doses recommended below are intended for patients with normal renal function; dosing of
many of these agents must be reduced in patients with renal dysfunction.
Patients with risk factors for MRSA infection should be treated empirically with vancomycin
(15 to 20 mg/kg IV every 12 hours) or linezolid (600 mg orally or IV every 12 hours). Risk
factors for MRSA include a history of intravenous drug use, comorbid disease (eg, diabetes
mellitus), and residing in a community or hospital where there is a substantial incidence of
MRSA.
•Cefepime (2 g IV every 12 hours) plus metronidazole (500 mg IV every six to eight hours)
or
In patients who are recovering, it is important to restrict all oral intake until the swallowing
impairment, which may have a prolonged course, has resolved completely.
In addition, patients with risk factors for MRSA infection should be treated empirically with
vancomycin (15 to 20 mg/kg IV every 12 hours) or linezolid (600 mg orally or IV every 12
hours). Risk factors for MRSA include a history of intravenous drug use, comorbid disease
(eg, diabetes mellitus), and residing in a community or hospital where there is a substantial
incidence of MRSA.
●Ceftriaxone 1 g IV every 24 hours plus metronidazole 500 mg IV every six to eight hours
or
●Ciprofloxacin (400 mg IV every 12 hours) plus clindamycin (600 mg IV every six to eight
hours)
In addition, patients with risk factors for MRSA infection should be treated empirically with
vancomycin (15 to 20 mg/kg IV every 12 hours) or linezolid (600 mg orally or IV every 12
hours). Risk factors for MRSA include a history of intravenous drug use, comorbid disease
(eg, diabetes mellitus), and residing in a community or hospital where there is a substantial
incidence of MRSA.
●Cefepime (2 g IV every 12 hours) plus metronidazole (500 mg IV every six to eight hours)
or
In addition, patients with risk factors for MRSA infection should be treated empirically with
vancomycin (15 to 20 mg/kg IV every 12 hours) or linezolid (600 mg orally or IV every 12
hours). Risk factors for MRSA include a history of intravenous drug use, comorbid disease
(eg, diabetes mellitus), and residing in a community or hospital where there is a substantial
incidence of MRSA.
Duration — Therapy should generally be continued for two to three weeks for
parapharyngeal or retropharyngeal space infections until fever and leukocytosis have resolved
and local tenderness and swelling have subsided. Longer courses are required when
complications are present. We favor intravenous antibiotics for the entire duration of
treatment.
●Deep neck space infections are typically polymicrobial and represent the normal resident
flora of the contiguous mucosal surfaces from which the infection originated. Due to the
close anatomic relationships, the resident flora of the oral cavity, upper respiratory tract, and
certain parts of the ears and eyes share many common organisms (figure 9). (See
'Microbiology' above.)
●The most common organism isolated from deep neck space infections is Streptococcus
viridans, reflecting its abundance in the mouth. Most abscesses originating from the teeth also
harbor oral anaerobes, including Peptostreptococcus species, Fusobacterium nucleatum,
pigmented Prevotella species such as Prevotella melaninogenica (formerly Bacteroides
melaninogenicus), and Actinomyces species. (See 'Microbiology' above.)
●Computed tomography is the imaging modality of choice for the diagnosis of deep neck
space infections. Magnetic resonance imaging is useful for assessing the extent of soft tissue
involvement and for delineating vascular complications. (See 'Imaging' above.)
●For deep neck space infections that involve a drainable collection, aspiration or surgical
drainage should be performed. (See 'Treatment' above.)
●Appropriate antibiotics based upon the likely microbiology of the infection are essential for
a successful outcome of deep neck space infections. Empiric regimens for each type of deep
neck space infection are discussed above (table 2). The final selection of antimicrobial
therapy should be guided by culture results and susceptibility data, whenever possible. (See
'Treatment' above.)
●For both immunocompetent and immunocompromised patients who are at risk for
methicillin-resistant Staphylococcus aureus (MRSA) carriage or infection, such as those with
a history of intravenous drug use or comorbid disease (eg, diabetes mellitus), or those in
communities or hospitals where there is a substantial incidence of MRSA, we suggest that
MRSA coverage be included in the treatment regimen (Grade 2C). (See 'Treatment' above.)