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Abstract
Chapter#1
Introduction
Epilepsy
Chapter#2
Methods
Subjects
Instrument
Material
Procedure
Chapter#3
Identifying Data
Case History
Behavioral observation
Interpretation
Chapter#4
Chapter#5
Chapter#6
Rehabilitation Plan
References
Abstract
The present comparative case study concerns the administration of the Mini mental status
examination (MMSE), clock drawing test (CDT) and Bender Visual Motor Gestalt Test
(BGT).The current study was carried out with two female subjects, a neurological patient of
eEpilepsy and a healthy subject. Both were 20 years old. After administration of the test
quantitative and qualitative interpretation were carried out. The neurological subject got a score
10 on MMSE which is below the cut off score of 23 which indicate the severe cognitive
impairment. He scored 7 on BGT which is above the cut off score i.e. 5 and made many errors on
Clock Drawing Test which indicates the presence of severe cognitive impairment. Normal
subject made accurate clock and showed correct time, the healthy subject scored 30 on MMSE
which is the highest possible score on MMSE and indicates no cognitive impairment and on
BGT he scored 1 which is also below the cutoff score and indicates him as being normal.
Chapter 1
Clock Drawing Test was published in1986. The first study association the CDT with the
screening of elderly prints with cognitive disorders, particularly the screening and follow up of
acute dementia and delirium. Since then, various studies have been carried out with the aim of
establishing criteria to apply and interpret CDT and evaluate its current role as screening
instrument for patients with cognitive impairment. Its contributions have also been investigated
in the assessment and follow up of delirium, focal cerebral lesions, Huntington’s diseases,
Step 1: Give patient a sheet of paper with a large (relative to the size of handwritten numbers)
pre-drawing circle on it, indicate the top of the page.
Step 2: instruct patient to draw numbers in the circle to make the circle look like the face of a
clock and then draw the hands of the clock to read “10 after 11”.
The procedure of the CDT beings with the instruction to the participant to draw a clock
reading a specific time after the task is completed, the test administrator draws a clock with the
hands set at the same specific time. Then the patient is asked to copy the image. Errors in clock
drawing are classified according to the following categories: omissions preservations, rotations,
misplacements, distortions, substitution and addition ,memory concentrations, initiations, energy
, mental clarity and indecision all are measure that are scored during this activity.
3 Inaccurate representation of 10
a) a).Minute hand point to 10
after 11 when visuo-spatial
b) b).Writes “10 after 11”
organization is perfect or shows
only minor deviations c) c).Unable to make any denotation of time
4 Moderate visuo-spatial
a) a).Moderately poor spacing
disorganization of times such that
b) b).Omits numbers
accurate denotation of 10 after 11
6 No reasonable representation of
a) a).No attempt at all
a clock
b) b).No semblance of a clock at all
c) c).Writes a word or name
Interpretation: higher scores reflect a greater number of errors and more impairment .A score of
(knowledge related ) ability , appearance , emotional mood, speech and thought patterns at the
time of evolution. It is one part of a full neurologic (nervous system ) examination and includes
the examiner’s observation about the patient ‘s attitude and cooperativeness as well as the
patients answers t o specific questions. The most commonly used test of cognitive functioning is
The MMSE consist of seven simple tasks for questions, grouped into seven domains:
1. Orientation to time.
2. Orientation to place.
6. Language.
7. Visual construction.
Scoring of MMSE
Administration by a trained interviewer takes approximately 10 minutes. The test yields a total
score of 30 and provides a picture of the subject’s present cognitive performance based on direct
points
commands
BGT is an individually administered paper and pencil test used to make a diagnosis of brain
damage. There are 9 geometric figures drawn in black. These figures are presented to the
examinee one at a time, then the examinee is asked to copy it on a blank sheet of paper.
Examinees are allowed to use eraser. The average time to complete the test is about 5-10
minutes. One method requires that the examinee view each card for five seconds after which the
card is removed. The examinee draws the figure from memory. This form of administration is
most commonly used.
Administration
Examinee is shown stimulus cards with designs and asked to copy each of the designs on a sheet
of paper. Cards are administered according to the original sequence. Then the examinee is asked
to redraw designs from the memory.
Scoring of BGT
The time of examinee took, examinee’s approach to draw each design is carefully noted and
analysis is made according to the lack’s scoring system based on the scores obtained by the
examinee.
Introduction
Epilepsy is a common medical and social disorder or group of disorders with unique
characteristics. Epilepsy is usually defined as a tendency to recurrent seizures. The word
“epilepsy” is derived from Latin and Greek words for “seizure” or “to upon”. This implies that
epilepsy is an ancient disorder; indeed, in all civilizations it can be traced as far back as medical
records exist. In fact, epilepsy is a disorder that can occur in all mammalian species, probably
more frequently as brains have become more complex. Epilepsy is also remarkably uniformly
distributed around the world. There are no racial, geographical or social class boundaries. It
occurs in both sexes, at all ages, especially in childhood, adolescence and increasingly in ageing
populations.
The periodic clinical features of seizures are often dramatic and alarming, and frequently
elicit fear and misunderstanding. This in turn has led to profound social consequences for
sufferers, which has greatly added to the burden of this disease. In ancient times, epileptic attacks
were thought to be the result of invasion and possession of the body by supernatural forces,
usually malign or evil influences, requiring exorcism, incantations or other religious or social
approaches. Today, seizures are viewed as electromagnetic discharges in the brain in predisposed
individuals, attributable in part to putative genetic factors, underlying neurological disorders, and
largely unknown neurochemical mechanisms. A wide range of different seizure types and
epilepsy syndromes have been identified. Patients are now treated with pharmacotherapy,
occasionally with neurosurgical techniques, as well as with psychological and social support.
Symptoms
Because epilepsy is caused by abnormal activity in brain cells, seizures can affect any
process your brain coordinates. Seizure signs and symptoms may include,
Temporary confusion
A staring spell
Uncontrollable jerking movements of the arms and legs
Loss of consciousness or awareness
Psychic symptoms
Symptoms vary depending on the type of seizure. In most cases, a person with epilepsy will
tend to have the same type of seizure each time, so the symptoms will be similar from episode to
episode.
Doctors generally classify seizures as either focal or generalized, based on how the
abnormal brain activity begins.
Focal seizures
When seizures appear to result from abnormal activity in just one area of your brain, they're
called focal (partial) seizures. These seizures fall into two categories.
These seizures don't cause a loss of consciousness. They may alter emotions or change
the way things look, smell, feel, taste or sound. They may also result in involuntary jerking of a
body part, such as an arm or leg, and spontaneous sensory symptoms such as tingling, dizziness
and flashing lights.
Generalized seizures
Seizures that appear to involve all areas of the brain are called generalized seizures. Six
types of generalized seizures exist.
Absence seizures. Absence seizures, previously known as petit mal seizures, often occur in
children and are characterized by staring into space or subtle body movements such as eye
blinking or lip smacking. These seizures may occur in clusters and cause a brief loss of
awareness.
Tonic seizures. Tonic seizures cause stiffening of your muscles. These seizures usually
affect muscles in your back, arms and legs and may cause you to fall to the ground.
Atonic seizures. Atonic seizures, also known as drop seizures, cause a loss of muscle
control, which may cause you to suddenly collapse or fall down.
Clonic seizures. Clonic seizures are associated with repeated or rhythmic, jerking muscle
movements. These seizures usually affect the neck, face and arms.
Myoclonic seizures. Myoclonic seizures usually appear as sudden brief jerks or twitches of
your arms and legs.
Tonic-clonic seizures. Tonic-clonic seizures, previously known as grand mal seizures, are
the most dramatic type of epileptic seizure and can cause an abrupt loss of consciousness,
body stiffening and shaking, and sometimes loss of bladder control or biting your tongue.
Causes
Epilepsy has no identifiable cause in about half of those with the condition. In the other,
the condition may be traced to various factors.
Genetic influence. Some types of epilepsy, which are categorized by the type of seizure
you
experience or the part of the brain that is affected, run in families. In these cases, it's likely
that there's a genetic influence.
Researchers have linked some types of epilepsy to specific genes, though it's estimated that
up to 500 genes could be tied to the condition. For most people, genes are only part of the
cause of epilepsy. Certain genes may make a person more sensitive to environmental
conditions that trigger seizures.
Head trauma. Head trauma as a result of a car accident or other traumatic injury can cause
epilepsy.
Brain conditions. Brain conditions that cause damage to the brain, such as brain tumors or
strokes, can cause epilepsy. Stroke is a leading cause of epilepsy in adults older than age
35.
Infectious diseases. Infectious diseases, such as meningitis, AIDS and viral encephalitis,
can cause epilepsy.
Prenatal injury. Before birth, babies are sensitive to brain damage that could be caused by
several factors, such as an infection in the mother, poor nutrition or oxygen deficiencies.
This brain damage can result in epilepsy or cerebral palsy.
Risk factors
Age. The onset of epilepsy is most common during early childhood and after age 60, but
the condition can occur at any age.
Family history. If you have a family history of epilepsy, you may be at an increased risk of
developing a seizure disorder.
Head injuries. Head injuries are responsible for some cases of epilepsy. You can reduce
your risk by wearing a seat belt while riding in a car and by wearing a helmet while
bicycling, skiing, riding a motorcycle or engaging in other activities with a high risk of
head injury.
Stroke and other vascular diseases. Stroke and other blood vessel (vascular) diseases can
lead to brain damage that may trigger epilepsy. You can take a number of steps to reduce
your risk of these diseases, including limiting your intake of alcohol and avoiding
cigarettes, eating a healthy diet, and exercising regularly.
Brain infections. Infections such as meningitis, which causes inflammation in your brain
or spinal cord, can increase your risk.
Prognosis
Prognosis One in three people with a single unprovoked seizure will have a second
seizure over the next five years (39). Treatment should be considered only to prevent
recurrence, not to prevent epilepsy. Untreated, after a second seizure, 75% will have another
seizure within the next one or two years (40). Whether “seizures beget seizures” is unclear.
Numerous predictors for recurrence, control, remission and intractability have been developed
at the onset and during treatment. Most important are diagnosis by syndrome and response to
the first appropriately prescribed and taken AED. Persistence of seizures after two AEDs
requires pre-surgical evaluation, as chances of remission are less than 5% with a third AED
and 50–80% following successful surgies
Chapter 2
METHODOLOGY
Subject of a patient of epilepsy and normal functioning subject. Both subjects were females of
age 16. Th e present comparative case study was conducted to analyze the differences in the
neurological functioning
Material
The materials provided during the assessment session of the present comparative case
study included pencil, eraser, ruler, sharpener, and papers.
Procedure
The present study was conducted to analyze the difference in the neurological functioning
of the two subjects. Among whom one was the patient epilepsy while the other was a normal
functioning subject. After taking the permission, rapport was built with both the subjects as their
history was recorded. Then tests including MMSE, CDT, and BGT were applied on them. After
administration of the tests the interpretation was done both qualitative and quantitative for
comparative study of both the subjects.
Chapter#3
Administration of test
Duration of sessions
Two sessions were conducted with client from 20th March 2018 to
21th March 2018
Referral
Client’s mother was the referral.
Identifying Data
Subject Client
Name A.B.C A.B.C
Age 20 years 20 years
Gender female female
Religion Islam Islam
Qualification class 8 matric
Socio-economic status lower class lower class
Father alive/dead Died Alive
Father’s education un-educated B.A
Father’s occupation jobless clerk
Mother alive/dead Alive Alive
Mother’s education un-educated un-educated
Mother’s occupation house wife house wife
No. of siblings 3 siblings 4 siblings
Birth order third born child second born child
Marital status un married un married
Neurological illness epilepsy Nil
Neurological test MMSE, CDT, BGT MMSE, CDT, BGT
Temporary confusion
A staring spell
Uncontrollable jerking movements of the arms and legs
Loss of consciousness or awareness
Bleeding from nose
Family history
The patient belongs to a family of lower socioeconomic status, living in Islamabad .Her father
was died and her brothers were living separate. She was living with her mother alone. She was
the third born in last child of the family. And also was educated at primary level. Her mother
was working in others houses their no other sources so that’s why had a low socioeconomic
status. There was no evidence of any neurological history to be mention in her past .
The healthy subject belonged to a family of upper middle socio economic class. The subject lives
in Islamabad . Subject’s father was a government employee. She was the second born child of
family. She enjoyed healthy relationship with her family. There was no history of any
Personal History
Client was 20 years old female. Client’s education was only up to class 8th . Client’s birth
was normal, and she was a healthy child. Client had 3 siblings and she was a last-born child of
her family. Client’s relationship with her family was good. Client’s family was not well educated
her father was jobless and now he was not alive and her two brother were married and lived
separate. When she was 16 years old she suffered from an attack of complex partial seizure and
fits. In early two years of her illness she had few seizures attacks but after two years of her
illness she suffered from seizure attack twice and thrice in a day. Her MRI and CT-Scan reports
suggest that she suffered from epilepsy. She gets hospitalized for about two to three times.
Doctors diagnosed that she suffered from Tonic Clonic Epilepsy. She also had anxiety and fear
to come in the front of any unknown persons. She had only one friend. She also had inferiorty
feelings that nobody likes her.
Behavioral Observation
Client was lying on a bed and frighten . Her hands and legs were trembling and not had
eye contact with doctor she was too much shy and spoke in a very low tone. The client was so
depressed and confused and she was worried about her problem. She had a fear that every person
wants to kill her to give harm to her that’s why she had a fear from every unknown person. She
did answered properly and had difficulty to understand.
During the assessment sessions the patient was thoroughly observed for 150 minutes. The patient
was not interesting in test. She had difficulty in reading and understanding question. She did not
maintain the eye contact properly. She used to stare the wall of the room whenever she had
difficulty in giving the answer. She had problems of attention. She used compensatory
mechanisms on many subtests such as counting on fingers, repetition and the frequent use of
paper pencil. She was easily distracted due to the environmental stimuli. She completed the test
in 55 minutes.
Family History of patient
The patient was belong to a middle socio-economic status, living in Islamabad. he was
doing government job and financial condition of the family was satisfactory. He was second
born child in family. His father was retired government employee and had middle socio
economic background. There was no evidence of any neurological his past. Selection of Normal
Client
For the comparison with a neurological patient, a normal client was taken with the
same demonstration variables for the comparative study. Otherwise we cannot properly
the context both clients were belonging to the same class and had same age. Their family
background and age was similar . Social and economic life was somewhat identical too.
Economic status etc was selected so to draw a comparison between the different
stages of their lives to understand what resulted in impairment of tumor client . Also the
difference in their tests indicate how a tumor client is different in his response as compared to the
normal one.
Behavioral observation
During the interview, the client was sitting on a chair in a relaxed and calm manner. He
was very co-operative. He answers of all the questions honestly. He didn’t show any resistance.
He maintained stable eye contact. There was a connection between his words and sentences. His
tone was normal with normal speech. It was easy to built rapport with him. The client expressed
that he does not like to communicate with strangers but he tries his best that they don’t' built any
The healthy subject was also belonged to the family of middle socio-economic class. The
subject lives in Islamabad. she was a student . she was the 3rd born child of the family. she
enjoyed a healthy relationship with his family. There was no history of any neurological
The history alone can be very suggestive as to the cause of the patient’s symptoms and
There is no medical and psychiatric history of a normal client. she doesn’t have any
Informal Assessment
During the session the client was thoroughly observed. she was co-operative and
Throughout the interview the client was observed keenly and no sign of any pathology was
observed by informal behavioral observation. she was sincere and seemed to be hardworking.
Her relationship with his family is stable which indicate his balance personality and healthy
nature.
Interpretation of the MMSE
Quantitative Interpretation
Neurological patient Healthy subject
The total score of the patient was calculated The total scores of the subject are found to be
total 10 out of 30. This score is below in the 29. As this score are above the cut-off scores
cut-off scores of 23, which indicates severe 23, it may be said that the patient is well
cognitive impairment in the subject. oriented and unimpaired.
Qualitative Interpretation
Interpretation of CDT
The subjects were presented a blank sheet of paper and were asked to draw a clock with hands
showing time of half past ten. The drawn clocks were interpreted according to 10-point scoring
system proposed by.
Quantitative Interpretation.
Qualitative Interpretation.
Interpretation of BGT.
Quantitively Interpretation.
Qualitative Interpretation.
.
Discussion and Conclusion
Discussion
After the scoring of the test, one of the normal and one of the patient of seizure disorder a
marked difference was found in between performance of both client and a normal person.
In epilepsy Patient, stress is the most common self reported trigger for seizures. Recently
some studies have been done, to try to uncover why this is. Scientist have long thought that stress
play a role in epileptic seizures and new evidence suggest that epilepsy patient who believe this
is the case experience a different brain response when faced with a nerve wracking situation.
Researches from the university of Cincinnati performed functional MRI during a stressful
math exercise on sixteen epilepsy patients who pegged stress as a factor in their seizure control
and seven patients who did not, those who perceived stress to have an impact on their epilepsy
showed greater brain activation then the other during intimidating part of the test. (James Selph,
2016) In the present case the MRI report suggest the over activity of different brain areas during
the stressful activities as client was suffering from financial crises.
A study conducted by Andree Delahaye-Duriez et al (2016), showed that an abnormal
clock drawing may suggest executive cognitive dysfunctioning and should prompt further testing
or referral. In the present case the subject also had drawn the clock with great difficulty and
problems it might suggest disturbance in the executive functioning of the subject.
It was evident that an epilepsy results in hippocampus damage. The function of
hippocampus is in memory. (James Selph, 2016) In the present case the client was also unable to
recall her previous events and she also remained in state of temporary confusion.
Conclusion
Several laboratory tests were included in neurological examination of the patient. The
evidence of damage in frontal lobe was found. The results of MRI and CT-Scan showed that
there was severe damage in the frontal lobe of the patient. Various other tests were done for the
further neurological evaluation.
Chapter#5
Limitations and Suggestions
Limitations
The case was conducted in few sessions which were not enough to gather sufficient
information related to disorder.
As the client was hospitalized so she takes tranquilizers and other drugs. This effect the
performance and mental status of the client on the test.
Only one test was administered on the client. This test measures only. This also measures
psychological disturbance due to neurological disorders. More tests would have provided
better information of a client’s mental state.
The sample was limited. Only one subject is taken from the normal population and her
cognitive ability is compared with that of the neurological patient. It is not necessary that
all the subjects who belong to a normal and healthy population show good performance
on test. Even a normal person could show poor performance because of many reasons.
Suggestions
The sample size should be larger. At least five subjects should be taken from normal
population and performance of each individual must be compared with another person
and neurological patient.
Besides the administration of performance test some psychological test such as MMPI,
anxiety scale, Beck’s depression inventory etc should be applied in order to determine
psychological impact of illness and disease.
There should be well developed rapport with the client so that she would provide
extensive and intensive information without any hesitancy.
The purpose of the study should be beneficial rather just to focus on the performance of
the client.
Chapter no 5
REHABILITATION
Epilepsy patients may need to adjust certain elements of their lifestyle, such as recreational
Anticonvulsant drugs are the most commonly prescribed treatment for epilepsy. The fundamental
treatment that essentially every patient receives is medication. There are more than 20 epileptic
drugs available in the market, including. Most side effects of anticonvulsants is relatively minor,
Clobazam (onfi)
Clobazam helps prevent absence, secondary, and partial seizures. It belongs of drugs called
benzodiazepines. These drugs are often used for sedation, sleep, and anxiety.
According to the Epilepsy Foundation, this medication may be used in children as young as 2
years old in rare cases, this drug may cause a serious skin reaction.
Diazepam is used for treat cluster and prolonged seizures. This drug is also a benzodiazepine.
References
Kate Wighton New epilepsy gene network identified by scientists retrieved from
http://www3.imperial.ac.uk/newsandeventspggrp/imperialcollege/newssumma
ry/news_12-12-2016-17-14-54
James Selph. Juvenile Myoclonic Epilepsy. Medscape Reference. June 24, 2016;
http://emedicine.medscape.com/article/1185061-overview.
https://ghr.nlm.nih.gov/condition/juvenile-myoclonic-epilepsy.