a Antimicrobial activity “the methanolic extract of B. hirta was active against Shigella spp. vsing the Vero coll Yine. The net was found to be non-cytotoxieand a9 Be ive antibacterial agent (Vijaya 995). Increased platelet count ‘The aqueous and methanolic extracts WO administered orally to albino Wistar ais. Platelet Count, bleeding time, and clotting time were Nietermined before and at different me intervals gfter administration of the extracts. "Admninistration of the aqueous extract 60 min significantly Teduced the bleeding time by 54% ompared to 49.5% for the methanolic extract. Similarly, Meetgg and 42.5% secuctions in clotting me WEE ‘achieved with the agueous and methanolic extracts, respectively, while platelet count me getions with the aqueous and methanone extracts lore 19-29% and 36.1% respectively. Thee: WA however, o significant correlation between, the ‘Jose and activities of the extracts. These findings validate the claim that E hirta arests bleeding sot modulates hemostasis COmeje 2007) ‘sedative and ansciolytic properties Tyopbilized aqueous extracts OFF, Hirka wee evaluated for behavioral effects nmice, The extract Ged not induce any toxic effect when it wat eTmninistered intraperitoneally and orally. Sedative properties could be confirmed ‘with high doses, by a decrease vorbehavioral parameters measured jn non-familiar environment tests. ‘aieonflct effects appeared at lower doses by an enhance- in nevf behavioral parameters measared s% the staiease test and in the Tight/dark choice situa tion test (Lanhers 1990). c. Recommendations ihe efficacy of B. hirta in the management of dengue ot dengue hemorrhagic fevers lacking (Natural ‘Medicines Comprehensive Database 2013). The wse of F. havea for the treatment of dengue has not yet been established. However the Philippine Depart- ment of Health is not against the use of &. hirta to treat dengue but stressed that this should be aecompanied by proper medical ‘consultation (PCHRD 2013). Safe use of E, hirta during pregnancy and lactation has not been established. It has been reported to cause ‘oth contraction and relaxation of the smooth muscles, In view of the lack of mney and lactationis pharmacological and toxicity date, he 1 Of. hirta especially during pregne phate not recommended (Natural Medicines ‘Comprehensive Database 2013, Hiermann and Bucar 1994). ‘Ovallyy E.hirea was reported t0 case nanere and vorniting. The sap contains latex that 8 toxic when ingested and which is highly «stating externally, casing photosensitive skin reac fons and severe inflamrpation, especially YPo ect with eyes or open cuts. "The tonicity £2 vovain high even in dried plant material, Prolonged and regulac contact with the sap js inadvis- wave because of its carcinogenic nature (ONIPO 2012, Micromedex 2012). “Written by R. ALVERO Reviewed by S14 Clinical evidence in support 0 @ 156 Euphorbia hirta 1. + Tawactawerst semua aun go stuera Tou wounuto9 jo wmpadopooual -oidonuieg‘souddygga om mOUNONEL NOLLNATILSIE -pogaue -aaaip pac Auey 389] 20 91001 uo] WES gnoge ‘plone Aypooug are saznsdteo 24 -sowiko papmord Jo spats paxyeas-w04s 30 S89PTe19 ‘AVIS tosuap wo 9ag0q pur Buoj wk | YROAP ‘Sysudand vo apruaox® ‘enoroumNt {19.948 SOIORIONTT OLE “aqppeas ax ut oand aise PauDzo1g ‘Ayjenst pue qqdreun oxy paseo? “Buo] WO SZT aqejosoure}-Buoyge 02 3uo}go-9NaH “snoypnstp ‘eusoddo dw savy Uf, “yst}dand 40 YsTPParuyo pure Boj wo oy or de Bapeards 20 ANDO “pure pattog yo ajduns Bur9q soysueAG OR ‘ageq aup mioxy poypeTesa YOU ‘ypense ‘qroy Aopen Spence we SE u NOLLATNOSAG TVDINVLOS (pwndsy 519-193 19559 (guy soso copvery) sonvtan’ “anseie8 Guy, ‘Sie 9103-50107 (ain zanpounnp ‘vavp-P4PP (Gey) uosquorng-o7n (ang) ynynqis-Bunyng (ey8st iqns) yrds Sung Cassia) amdoiing qm) s1#0109 Beg) s140109-0104 (uady) 9740309-0104 (oie) 19949 (8a) wooing vg (Gay) stuorging Gyn) Souoquuing Bouyoqrd (antsy) sibs ‘SaWWN'1YOOT sure prods viqaoudenr ony maofiynged viquoysns ‘SWANONAS seaoniquoude TV (in) youn (psn) eorassaerat (cosa) inden (og) #129 (uady) sous spwSout (ran) oyoquat By) opou eo Bate (sq, UA (uog) punapuay dcop ‘rasta 31g) vane aPs (guy) uma tf (aan) avant (yp) 771 Gay sao (ep) 7405507 (wep) uodunyndor a) woswsrys?l (sya) w9qvars eq) puepunioy ‘ets) o1osoz0s Gu) eo 104030) (usd wryosss (ans) svmBopy Buy) wrans (c0ya) zo0nm 0020-020% cans) yond caxdst SESH ‘emia sund-ssund (wags) wonanyy (ang) yoyod oqo Bey) puupuoyod (OM) ssn (ang) smanays -poom afeus aye sae pom nutpse myst SaWVN HSITON NOWHOD ee ANVLO@ ‘I PME}-EMEL ry aay rnquoydneCerny Deed Sr ee CONE ey Peat trey eed Rd Coens Cee aD ee cect) See ead Doe reas Pee Cue) Se ae Cre ater Mees) Orc ger enacted erg See) Se Re Re ented Pe Rcn Caal Geran amd Caras eet) Dro eee / er rr ad SO | SO A ELLUOLN PLL MSKO EycLh melon E qudeq Ww ueIgea SUC A tee Patt WLLL) teed IR LCLLLL LC®) jo vipodopAouy