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Difference between Humoral immunity and Cell mediated immunity.

Adaptive or acquired immunity are of two types- HMI and CMI.

HUMO L IMMUNITY CELL MEDIATED IMMUNITY


1. Immunity which can be transferred 1. Immunity that is mediated by speci ed
through serum. WBC called T-lymphocytes and all
phagocytes.
2. Here plasma cell produce antibody 2. Some of the intracellular microbes (virus
molecules in response to an antigen. ese & few bacteria) survive & proliferate within
ab molecules circulate in blood, enter the phagocytes & other host cells.
tissue via in ammation and a ach to a ...Ab in blood can’t destroy them. ese are
speci c antigen, which are then killed by the targets of CMI. Via CMI these
phagocytosis. microbes are destroyed or the entire
infected cell is lysed & the very source of
infection is destroyed.
3. Immunoglobulins are the principal 3. CD + cytolytic T lymphocytes (CTLs)
mediators. are the principal mediators of CMI.
4. Cells involved- B cell, TH cell. 4. TC cell, TH cell.
5. Ab provided by B-cells & plasma cells 5. Here T lymphocytes recognize the
have distant effects. B cells/TH cells are microbial ag & produce cytokines locally
produced in bone marrow & lymphoid t h at i n c rea s e m i c ro b i a l ac t i o n o f
organs, but then they enter the circulation phagocytes and stimulate in ammation.
or mucosal secretion and excert their Mainly 3 types of cells are involved-
effecter functions at the location of ag. CD4+ & CD8+ : macrophage activation by
secreting cytokines (INF-g).
CD8+ (CTL)- Cell lysis.
Natural killer (NK) cells- Cell lysis.
6. Active againts bacterial toxins & viruses 6. Bacteria & viruses located within
that are circulating freely in body uid. phagocytic or infected host cells & against
fungi, protozoa, helminth & even cancer
cells.
7. Not much signi cant in transplantation 7. very much signi cant in transplantation
reaction. reaction.
8. e effector response in HMI can be 8. No such distinction is present.
primary or secondary.
On primary exposure to an ag the
native B cells are activated & differentiated
into ab- producing cells and memory cells.
On secondary exposure to ag, the B
cells of the prev iously immunized
individual provide a ready supply of
circulating ab. At the same time, ag activates
the long lived memory B cells to produce
large quantity of speci c ab.

IgD

Igm Immature Mature


Heavy B B
chain Cell Cell

IgM IgM
Pre B Cell
(Can’t recognize ag)

Activation, Proliferation,
Light chains of IgM Differentiation.
not synthesized

IgD
Memory IgM
Plasma
B IgA
Cell IgG
Cell
IgE

IgG / IgE / IgA


{
Circulation and peripheral lymphoid
organ (i.e.-Outside bone marrow).

Differentiation of B lymphocytes.

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