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Micrograph of the renal tubules of a 54
y/o female who had a sudden drop of BP
that lasted for about an hour
Identify the reversible pattern of cell
injury seen under the light microscope. Identify the type of necrosis seen.
MPTChua & LNCombate (Section B 2019)|3
PATHOLOGY SGD (First Shifting)
• Coagulative necrosis • The area with necrosis is replaced
by inflammatory cells, neutrophils
Describe the microscopic features. (violet), and necrotic debris
• Outline/architecture of cells still
seen but no more nucleus Give the possible causes and organs
• If the cell is striated, at first the where they occur.
striations are still visible but later • Stimulus: hypoxia for the brain,
on the striations will no longer be Pathologic stimulus for other
visible organs: pyogenic organism (Beta
helomytic Streptococcus sp.,
Give the possible causes and organs Staphylococcus sp.) for other
where they occur. organs
• Stimulus: hypoxia
• All organs except for the brain Explain the etiopathogenesis.
• Di ko gets ito
Explain the etiopathogenesis. • Occurs when autolysis or
• Not sure. Wala akong notes ditto. heterolysis predominates over
• Protein denaturation with the protein denaturation
preservation of the cell and tissue • Digestion of dead cells resulting in
framework transformation of the tissue into a
• The necrotic tissue undergoes liquid viscous mass
either heterolysis (degradation by
lysosomal enzymes of invading CASE 8
leukocytes) or autolysis (digestion
by its own lysosomal enzymes)
CASE 7
Identify the type of necrosis seen.
• Caseous necrosis
Liquefactive necrosis, brain tissue Describe the microscopic features.
• Amorphous eosinophilic material
Identify the type of necrosis seen. with cell debris
• Liquefactive necrosis • Necrotic area appears as a
structureless collection of
Describe the microscopic features. fragmented or lysed cells and
• Architecture of cells no longer amorphous granular debris
visible enclosed with a distinctive
Identify the type of necrosis seen.
• Enzymatic fat necrosis
Describe the microscopic features
• Vague cell outlines with calcium
depositions
Give the possible causes and organs
where they can occur
• Acute hemorrhagic pancreatitis
o Alcohol + Fatty food
o Pancreatic enzymes are
normally inactive in the
acini and become active
only in the duodenum
o Chronic pancreatitis –
alcohol → spasm of the
pancreatic duct (? O
pancreas ba ito) →
stimulate enzymes and
activate them while in the
parenchyma of the
pancreas → proteases can
degrade the blood vessel
wall causing hemorrhage,