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GLIMEPIRIDE

Stephen Josh V. Lim BSN 3A


Generic Name GLIMEPIRIDE

Brand Name Amaryl

Classification HORMONES AND SYNTHETIC SUBSTITUTES; ANTIDIABETIC;


SULFONYLUREA
General Action Second-generation sulfonylurea hypoglycemic agent used for once-a-day
dosing.
Dose and Route Type 2 Diabetes Mellitus
Adult: PO Start with 1–2 mg once daily with breakfast or first main meal,
may increase to usual maintenance dose of 1–4 mg once daily (max: 8
mg/d)

Indications or Adjunct to diet and exercise in patients with type 2 diabetes, may also be
Purposes used in combination with insulin in type 2 diabetes.
Side effects CNS: Dizziness, asthenia, headache, blurred vision, changes in
accommodation.

GI: Nausea, vomiting, diarrhea, abdominal pain.

Hematologic: Leukopenia, agranulocytosis (rare), thrombocytopenia.

Metabolic: Hypoglycemia.

Skin: Rash, pruritus, erythema, urticaria, maculopapular eruptions.


Contraindications Hypersensitivity to glimepiride, diabetic ketoacidosis, pregnancy (category
C), lactation, nondiabetic patients with renal glycosuria.
Nursing Assessment & Drug Effects
Responsibilities
 Lab tests: monitor fasting and postprandial blood glucose and
urinary glucose frequently. Monitor glycosylated hemoglobin every
3–6 mo. Monitor periodically during long-term therapy: Liver
function tests, serum osmolarity, serum sodium, and CBC with
differential.
 Monitor for hypoglycemia especially with concurrent drugs which
enhance hypoglycemic effects.

Patient & Family Education

 Take a missed dose as soon as possible unless it is almost time for


next dose; NEVER take two doses at the same time.
 Avoid drinking alcohol or using OTC drugs without informing
physician.
 Use sunscreen and avoid sunlamps.
 Learn about adverse reactions and drug interactions.
 Do not breast feed while taking this drug.