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c

Figure 22.8

cc

Targeted inhibition of gene expression Ê Ê

6  c c cc   cccc   


 c  cÊ Êc c

 c   cc  c   c c  ccc cc


 c c  cc


 c 

 c  c ccc  c
c


c c  c   ccc
 c   cc c  cc c

  cc cccc    c  


c   c


 cc c
 c c
 ccc c
c  cccc 

  c  c   ccc


 c c c c  cc  c

  cc
c c  c c   cc
 c  cccc


c
  c  c c  c  c cc   c c ccc
 c
cc c  c  cc
c   cc  cc

 c    c


 c c
c   cc   cc c

 c  cc c


c   c cc  c c cc  c

cc c   c  c


 cc c c   c cc

 c c  c  c   c  c cc   c


c  c  ccc c  cccc   c

Π

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 c cc c c


c ccc   cc c  ccc

   
 c  cÊ Êc c  cc  c cc c  cc c

 cc  c   cc


c

 c  c c  c   c ccc

 c ccc c c c  ccc  c  cc c  c cc  c

 c  c c


c c   cc 
 c c  c c  cc

   cc c  ccc cc  ccc ccc

   ccc c  c   c

ccc c c  ccc  c  c


c c ccc

 c c
c  c  c cc
c  c cc c  cc

c    c
 c 
c
c c c c  c  c 
c
 c cc   c ccc
c  c c c c   c   c

 c   c  cc c c  c  c c   cc c  c cc c

   c   c


c  c c  c c   ccc    c

c
cc c
 cc
 ccc
c   c   cc
c c c

c
c   ccc  c c  cc c
c  c  c
c

 cc c


c  c c    ccc  c  c  c c

  cc c  c


c  ccc c   c   c  c c

   c

 c  ccc   c  c


c c ccc cc  c   c c

 c cc c c  cÊ Êc


  ccc  c cccc
c

ccc c   c6  c cc


 c 
c c ccc

   c
  cc  cc  c
 c   c   cc  ccc

 c c 
c  c c
cc
 c cccc c    c

  c
cc c c  ccc  c  c
cc c c    c

c  cc c c 


 cc  c  cc cc  c
c c

  cc cc  c


c c  c  c
ccc


cc c
c c c
 ccc c c  c
c c

c  c c cc c cc c  cc c  cc c

  c

Figure 22.8c
  ccc  c  cÊ 

 cc

Figure 22.8

Targeted inhibition of gene expression Ê Ê

6  c c cc   cccc   


 c  cÊ Êc c

 c   cc  c   c c  ccc cc


 c c  cc


 c 

 c  c ccc  c
c


c c  c   ccc
 c   cc c  cc c

  cc cccc    c  


c   c


 cc c
 c c
 ccc c
c  cccc 

  c  c   ccc


 c c c c  cc  c

  cc
c c  c c   cc
 c  cccc


c
  c  c c  c  c cc   c c ccc
 c
cc c  c  cc
c   cc  cc

 c    c


 c c
c   cc   cc c

 c  cc c


c   c cc  c c cc  c

cc c   c  c


 cc c c   c cc

 c c  c  c   c  c cc   c


c  c  ccc c  cccc   c

 c  cc   cc  ccc  c  c c c   cc

   c 
 c   c  cc ccc c
c  c
 c  c 

cc

Mc „ Ê ÊÊÊ Ê  


  c c c

 cc c


c  c    cc c cc

 c  ccccc c
 c 
c
 c c c

 cc c c   ccc cc    c


   cc c ccc  cc c cc  c

   cc   ccc  c c  cc ccc

 ccc  c
 cc! c  c"cc c

  c   ccc c  c c cc

 c ccc c c c    c c


c

 cc cc c


ccc6ccc c6ccc6c cc

ccccc ccccc c c

Mc „ Ê ÊÊÊ Ê  


  c  c   c

 ccc    c   cc   cc c

cc
c   c cc c
c cc  c   c


cc  cc
  cc c   c cc c


 c   c

Mc „ Ê ÊÊÊ Ê  Ê   c   c


cc  c c c c  cc  cc

cc  cc   c   c


 c   c