Genetic Anti-viral Long term

Virus Sketchy video Memory Hook Lecture Major Disease Transmission Diagnosis Basics of Pathogenesis Vaccines
information Therapy Consequences

Long-lived
Vireia, invasion of the Live-attenuated
1.2 - (Pico) Polio The Flamingo 01- Biology of Sequencing by RT- protective
Poliovirus +ss RNA Poliomyelitis Fecal-oral CNS, Lytic destruction of oral and killed- None
Virus Breeding Pool viruses PCR by the CDC immunity or
anterior horn cells virus injection
paralysis

Long-lived
1.3 - (Pico) Coxsackie Hand, foot, and Clinical diagnosis or Viremia, target skin, cell
Coxsackie Virus 02- Enterovirus +ss RNA Fecal-oral None None protective
Coxsackie A Cockatoos mouth disease RT-PCR death
immunity

Respiratory and
PCR and/or isolate Pleconaril Long-lived
1.1 - Picornaviridae The Peak-Orna Respiratory contact with Viremia leading to
D68 02- Enterovirus +ss RNA virus and culture for None (severe protective
Overview Animal Nursery Infection contaminated respiratory tract infection
cytopathic effect cases) immunity
surfaces
Vaccine
Long-lived
1.5 - (Pico) Hepatitis Hungry Hungry Hep IgM Serology by during
Hepatitis A Virus 02- Enterovirus +ss RNA Hepatitis Fecal-oral Viremia, target liver Killed-virus protective
A A Hippos antibody capture prodrone
immunity
period of

Rotateq: a live-
attenuated
pentavalent
vaccine
Rotarix: a live-
Short-term
2.7 - Reovirus attenated
DS segmented Viral antigen in stool Local replication, immunity, less
Rotavirus (Double Stranded A Race on the Rio 02- Enterovirus Diarrhea Fecal-oral vaccine None
RNA detected by EIA enterotoxin production severe
RNA) protective
reinfection
against one
genotype (more
commonly given
because fewer
doses required)

1.6 - (Norwalk) Lysis and shedding of Type specific

Noroviruses Cali Sea Cruise 02- Enterovirus +ss RNA Diarrhea Fecal-oral RT-PCR by film array None None
Calicivirus epithelial cells immunity
Amantidine Annual
-RNA, Local replication in
A Night Shift at the 03- Respiratory Film array RT-PCR Live-attenuated or reinfection due
Influenza virus 2.1 - Orthomyxovirus segmented, "The Flu" Respiratory respiratory tract, necrosis
Orthodontist's virus ii assay and killed-virus Neuraminida to antigenic shift
enveloped of epithelial cells
se inhibitors and drift
1.4 - (Pico) 04- Respiratory Film array RT-PCR Lytic replication in the Type-specific
Rhinoviruses Paranormal Mixer + RNA Common cold Respiratory None None
Rhinovirus virus ii assay respiratory epithelium immunity
Preventative Short-term
Severe lower Local replication in
Respiratory 04- Respiratory -ss RNA, Film array RT-PCR monoclonal immunity, less
2.2 - Paramyxovirus Paranormal Mixer respiratory tract Respiratory respiratory tract, necrosis None
Syncytial Virus virus ii enveloped assay antibody, severe
infection in children of epithelial cells
Palivizumab reinfection
 Glucocorticoi
Local replication in
04- Respiratory -ss RNA, Clinical diagnosis or ds for severe Short-term
Parainfluenza Virus 2.2 - Paramyxovirus Paranormal Mixer Croup Respiratory respiratory tract, necrosis None
virus ii enveloped RT-PCR cases of immunity
of epithelial cells
Clinical , confirmed by Croup
Respiratory Replication in respiratory
05 - Systemic -ss RNA, serology or Live-attenuated Long-term
Mumps Virus 2.2 - Paramyxovirus Paranormal Mixer Mumps (before the tract, viremia, targeting None
virus enveloped sequencing performed vaccine, MMR immunity
Parotitis) parotid gland
by public, confirmed
Clinical health by
serology or Live-attenuated Long-term
05 - Systemic -ss RNA, Replication in respiratory
Measles Virus 2.2 - Paramyxovirus Paranormal Mixer Measles Respiratory sequencing performed vaccine, MMR, None immunity, rare
virus enveloped tract, viremia, rash
by public health with boosters SSPE
department Long-term
1.9 - Togavirus Toga-toga- 05 - Systemic +ss RNA, Respiratory, Replication in respiratory
Live-attenuated immunity,
Rubella Virus "German Measles" Serology None
Group togavirus virus enveloped Mother to Fetus tract, viremia, rash vaccine, MMR Congenital
Intravenous Rubella
Clinical diagnosis/
Erythema Ig for aplastic
05 - Systemic Serology or PCR of Replicates in Erythroid Long-term
Parvovirus b19 3.9 - Parvovirus Bombs Away ssDNA Infectiosums (Fifth Respiratory None crisis in
virus serum from aplastic precursor nuclei immunity
Disease) immunocomp
crisis
Serology and romised
Mother-to-child, HAART: Suseptability to
confirmation by
transfusion, IV multiple RT- oppertunistic
1.11 Retrovirus One Cane to Rule +RNA western blot; RT-PCR
HIV 06 HIV Progress to AIDS drug abuse, Depletion of CD4+ T cells None inhibitors and infections,
(HIV/AIDS) them all Lentivirus for viral load in
sexual protease progression to
response to HAART;
inhibitors AIDS, death
sequencing to look for
Clinical presentation, Replicates in epithelia,
Herpes Simplex 07- Latent Herpes DNA, Cold Acyclovir and Latent infection
3.1 HSV 1 & HSV 2 Herpes Hermes Contact can PCR from infected latent in trigeminal None
Virus I Viruses I enveloped sores/Encephalitis Priteliver with recurrence
tissue ganglia, reactivation
Latent infection
Clinical presentation,
Replicates in epithelia, with recurrence,
Herpes Simplex 07- Latent Herpes DNA, Genital lesions, PCR of infected Acyclovir and
3.1 HSV 1 & HSV 2 Herpes Hermes Contact latent in sacral ganglia, None Neonatal death
Virus II Viruses I enveloped Neonatal Herpes tissue, culture virus Priteliver
reactivation or neurological
from lesion
impairment or
Replicates in respiratory
epithelium, viremia, rash, Latent infection
Varicella-Zostar 3.4 Varicella Zoster Varicella Zeus-ter 07- Latent Herpes DNA, Chicken pox/
Respiratory Clinical presentation latent in dorsal root Live-attenuated Acyclovir with reacurrence
Virus Virus Virus Viruses I enveloped Shingles
ganglia, reaccurence as as shingles
shingles can occur
Latent infection
with sporadic
Monospot (heterophile
3.2 Epstein-Barr 07- Latent Herpes DNA, Infectious Respiratory, Replicates and latent in B shedding,
Epstein-Barr Virus Ye Old Epstein Bar Ab) and/or serology None None
Virus Viruses II enveloped mononucleosis Salivia cells Burkitts
for IgM to VCA
lymphoma,
Nasopharyngeal
Infects epithelium, cell Latent infection
Contact: salivia,
Post-transplant proliferation, latency in Tc with life-long
Cyto "Mega-Lo" 07- Latent Herpes DNA, secretions, PCR, Serology, Ganciclovir
Cytomegalovirus 3.3 Cytomegalovirus pneumonia, ells, macrophages, and None shedding of
virus Viruses II enveloped mother to Histology or Letermovir
Neonatal CMV other cells, sporadic virus, Sequelae
newborn
shedding in neonates
Sudden onset of fever,
Human Herpes The Roses of 07- Latent Herpes DNA, Roseola/ exanthem fever resolves, THEN red
3.5 HHV-6 Roseola Respiratory Clincical presentation None None Latent infection
Virus 6 & 7 Roseola Viruses II enveloped subitum rash appears, latency in T
cells
 sarcoma lesions
T cells control infection,
Human Herpes 3.6 - HHV-8 Kaposi's Ring around a 07- Latent Herpes DNA, Clinical presentation in AIDS patients
Kaposi's Sarcoma Sexual contact activation occurs during None None
Virus 8 Sarcoma Kaposi Viruses II enveloped and PCR unless treated
immunosupression
with HAART
Clincical presentation, Virus production Type 16, 18, 31
11 Oncogenic Warts, Cervical Virus-like
Papilloma Virus 3.8 - Papillomavirus Pilloma Bugs DNA Contact Hybridization (Pap associated with cell None Cervical
Viruses carcinoma particle vaccine
smear) differentiation Carcinoma

Mother-to-child, Nucleoside
transfusion, IV reverse
Partial dsDNA, Serology by antibody Viremia, targeting of the Hepatocellular
Hepatitis B Virus 3.12 - Hepatitis B Hep B Love 12 Viral Hepatitis Hepatitis drug abuse, Subunit vaccine transcriptase
enveloped capture liver, persists in cells Carcinoma
sexual inhibitors
(NRTIs)

Transfusion, IV
Direct acting
1.8 - (Flavi) Hepatitis +ssRNA, drug abuse, RT-PCR, sequencing Viremia, targeting of the Hepatocellular
Hepatitis C virus The Hep Sea 12 Viral Hepatitis Hepatitis None anti-virals
C enveloped contact with for genotype, serology liver, persistant infection Carcinoma
(DAAs)
blood

Mother-to-child, Nucleoside
transfusion, IV Co-infection with HBV, reverse
ss RNA viroid, Serology by antibody HBV subunit Chronic Hepatitis
Hepatitis Delta virus 3.12 - Hepatitis B Hep B Love 12 Viral Hepatitis Fulminant Hepatitis drug abuse, viremia, targeting of the transcriptase
enveloped capture vaccine or Death
sexual liver, fulminant disease inhibitors
(NRTIs)
Long-lived
Serology or RT-PCR
Hepatitis Viremia, targeting of the immunity; high
Hepatitis E virus - - 12 Viral Hepatitis +RNA Fecal-oral by the public health None (in trials) None
(developing world) liver mortality during
department
Clinical diagnosis, pregnancy
Viremia, extensive Long-term
1.7 - Flavivirus 14 Emerging +ss RNA, Mosquito bite (w/ confirmation by
Yellow Fever Virus Flavor Packed Flavi Yellow Fever replication and cell death Live-attenuated None immunity or
Group Viruses enveloped urban cycle) serology by public
in the liver death
health department Antibody
dependant
1.7 - Flavivirus 14 Emerging Hemorrhagic fever/ ELISA for NS1, Immunopthogenesis
Dengue Virus Flavor Packed Flavi +ss RNA Mosquito bite None None enhancement of
Group Viruses Break bone fever serology or RT-PCR causing fever and rash
disease if
infected
Immunitywith
or
1.7 - Flavivirus 14 Emerging +ssRNA, Encephalitis, death (more
West Nile Virus Flavor Packed Flavi Mosquito bite RT-PCR and serology Viremia, CNS infection None None
Group Viruses enveloped meningitis neurologic
disease in the
Long-term
St Louis 1.7 - Flavivirus 14 Emerging +ssRNA,
Flavor Packed Flavi Encephalitis Mosquito bite RT-PCR and serology Viremia, CNS infection None None immunity or
Encephalitis virus Group Viruses enveloped
death (rare)
Polyarthralgia
Chikugunya fever, Serology or RT-PCR
1.9 - Togavirus Toga-toga- 14 Emerging +ssRNA, Viremia, polyarthralgia, can last weeks
Chikugunya Virus myalgias, Insect vector by the public health None None
Group togavirus Viruses enveloped rash or months;
arthralgias department
Serology or RT-PCR recovery
Long-term
EEE, WEE, and 1.9 - Togavirus Toga-toga- 14 Emerging +ssRNA,
Encephalitis Mosquito bite by the public health Viremia, CNS infection For horses only None immunity or
VEE Group togavirus Viruses enveloped
-/+ segmented department death
California 14 Emerging Long-term
2.5 - Bunyavirus Paul Bunyavirus RNA, Encephalitis Mosquito bite Serology Viremia, CNS infection None None
Encephalitis Virus Viruses immunity
enveloped
2.7 - Reovirus
Colorado Tick Fever A Race on the Rio 14 Emerging DS segmented Serology by the public Verimia, inflamation and Long-term
(Double Stranded Fever and rash Tick bite None None
Virus (Grande Prix) Viruses RNA health department rash, recovery immunity
RNA)
 -/+ segmented Inhalation of Viral replication in Long-term
14 Emerging Pulmonary Serology by the public
Hantavirus 2.5 - Bunyavirus Paul Bunyavirus RNA, secretions from respiratory tract, None None immunity and
Viruses syndrome health department
enveloped infected animal inflamation, pneumonia latency
Supportive
care, Non-
Long-term
FDA
Direct contact Viremia, replication in all immunity,
14 Emerging -ss RNA, approved
Ebolavirus 2.4 - Filovirus Soccer Field'o virus Hemorrhagic fever with blood or RT-PCR from sera cells, cell death, organ None persistant
Viruses enveloped specific
body fluids failure infection, or
antibodies,
death
vaccines in
Common cold development
Pandemic
(229e, OC43),
potential of
croup (NL63),
14 Emerging Respiratory, fecal- Local replication and cell emerging viruses
Coronavirus 1.10 - Coronavirus Kingdom of Sars +ssRNA pneumonia in Film array PCR None None
Viruses oral death like SARS and
elderly (HKU1);
MERS, type
pandemic potential
specific immunity
SARS & MERS
04- Respiratory
Multiple UR
virus ii; 02 Replication in epithelial Live-attenuated Long-term
Adenoviruses 3.10 - Adenovirus A Den-O Lions DNA syndromes, Respiratory Film array PCR None
Enteroviruses; 10 cless, viremia (military only) immunity
conjunctivitis
Virology Seminar
CDC would sequence Eradicated!
DNA
Smallpox virus 3.11 - Poxvirus Pox in a box 15 Viral Vaccines Smallpox Respiratory the virus and follow up Viremia and rash Live-attenuated None Candidate
enveloped
on contacts Anti-rabies Ig vaccine vector
post
Bite or contact
Detection of viral Replication in muscle, exposure, no
Rabid Wrecking 15 Viral Vaccines -ss RNA, with secretions Immunity or
Rabies Virus 2.3 - Rhabdovirus Rabies antigens in the brain; spread from nerves to Killed-virus effective
Yard & 13 CNS Viruses enveloped from racoon, Death
RT-PCR for genotype brain therapy after
skunk, or bat
onset of CNS
symptoms Long-term
Molluscum DNA Molluscum Clinical diagnosis from Painless lesions that take immunity,
3.11 - Poxvirus Pox in a box 15 Viral Vaccines Contact None None
Contagiosum enveloped contagiosum pearl-like lesions months to resolve persistant in
AIDS cdc
From patients
Fever, rash in 20%
website: "once a
of people infected; Sexual contact
RT-PCR and serology Fever rash and viremia in None (17D- person has been
1.7 - Flavivirus 14 Emerging +ssRNA, Microcephaly (in (semen);
Zika Virus Flavor Packed Flavi done by CDC or mom; microcephaly in based vaccines None infected, he or
Group Viruses enveloped babies of pregnant mosquito (aedes
Public Health Dept fetus in development) she is likely to be
mothers infected aegypti) bite
protected from
with the virus)
future infections"