Академический Документы
Профессиональный Документы
Культура Документы
Role of endoscopic
therapy -
controversial
Clot removal usually
attempted after inj.
Underlying lesion
can then be
assessed, treated if
necessary
Endoscopic th.
High risk stigmata of recent hemorrh.
Inj+thermal coag. endoclip
Post-endoscopy management
low risk ulcers – prompt feeding, oral PPI th.
ulcers requiring endoscopic th.-PPI iv (72 h.)
Determine H. pylori status
Discharge patients on PPI
duration dictated by
etiology and
need for NSAIDs/aspirin
CV disease on low dose aspirin:
restart as soon as
bleeding has resolved
Peptic ulcer hemorrhage
Surgical intervention- 10% of patients
– Indications
–Failure of endoscopy
–Significant rebleeding after 1st endoscopy
–Ongoing transfusion requirement
–Need for >6 units over 24 hours
–Earlier for elderly, multiple co-morbidities
E.g. Under-running of ulcer (bleeding DU),
wedge excision of bleeding lesion (e.g. GU),
partial/total gastrectomy (malignancy)
Mallory Weiss tears -5% UGIB
Mucosal /submuc.
lacerations at the GEJ
History of recent
nonbloody vomiting +
excessive retching,
followed by haematemesis after alcohol intake
Endos: – tear at the GEJ
80-90% stops spontaneusly
Rebleeding – endos. electro-coagulation,
Angiographic embol. or surgical oversewing
Endos. hemostasis
Rebleeding-tatoo
Surgery – wedge resection
Watermelon stomach -GAVE
Rows or stripes of ectatic mucosal blood
vessels
from the pylorus towards the antrum
Cause?
Older women,
end-stage renal disease
liver cirrhosis, scleroderma
Linear / diffuse angiomas
Endos. th.- APC
Surgery-antrectomy
Upper GI malignancy
1% of severe, 3% of any UGIB
Bening (leiomyoma, stromal tu)
Malignant – primary or sec.
Large, ulcerated masses
Endos. hemostasis –temporal controll
Angiogr.+embilozation – severe UGIB
External beam radiation- palliative
hemostasis in cases of advanced disease
surgery
Variceal Bleeding
Vasoconstrictor th.
Antibiotics
Resuscitation
ICU level care
Endoscopy
ALternative / rescue th.
Beta blockade
asoconstrictor therapy
Goal: Reduce splanchnic blood flow
Terlipressin – only agent that improves
control of bleeding and survival
Vasopressin
Somatostatin
Octreotide (somatostatin analogue)
Efficacy is controversial;
Standard dose: 50 mcg bolus, then 50 mcg/hr
drip for 3-5 days
Angiectasias
Hemorrhoids
Colitis (IBD, Infectious, Ischemic)
Neoplasm
Post-polypectomy bleed (up to 2 weeks)
Dieulafoy’s lesion
LGIB - etiology
Diverticulosis – 40-55%
– Right sided lesions > left
– 10% rebleed in 1st year and 25% at 4 years
– 90% stop spontaneously
Angiodysplasia – 3-20%
– Most common cause of SB bleeding in >50 y/o
– >50% are in right colon
Neoplasia
– Typically bleed slowly
Inflammatory conditions
– 15% of UC patients, 1% of chron’s patients
– Radiation, infectious, AIDS rarely
Vascular
Hemorrhoids
– >50% have hemorrhoids, but only 2% of bleeding attributed to them
Others meckel’s, polyps, solitary rectal ulcer, Dieulafoy’s lesion of the colon,
portal colopathy, NSAIDs, intussusception, or bleeding following colonoscopic
biopsy or polypectomy.
LGIB - etiology
Colon Rectum Anus
Colitis
Angiodysplasia
LGIB - diagnostics
Evaluation
Same for UGIB bleed; If unstable – first EGD
After stable – Rectal exam., anoscopy for
hemorrhoids
Colonoscopy
Within 12 hours- in stable patients without massive
bleeding
Selective visceral angiography
Need >0.5 ml/min bleeding
40-75% sensitive if bleeding at time of exam
Tagged RBC scan
Can detect bleeding at 0.1 ml/min
85% sensitive if bleeding at time of exam
Not accurate in defining left vs right colon
LGIB – Risk Stratification
Predictors of severe* LGIB:
HR>100
SBP<115 0 factors: ~6% risk
Syncope
nontender abdominal 1-3 factors: ~40%
examination
bleeding during first 4 hours >3 factors: ~80%
of evaluation
aspirin use
>2 active comorbid conditions
Readily available
Can detect bl. rate of 0.5 ml/min
Can localize site of bleeding
(must be active) and provide info
on etiology
Useful in the actively bleeding
but hemodynamically stable
patient
Role of Surgery
Reserved for patients with life-threatening
bleed who failed other options
General indications: hypotension/shock
despite resuscitation, >6 U PRBCs
transfused
Preoperative localization of bleeding source
important
LGIB - treatment
Emergency resuscitation - as described
Pharmacological
– Stop NSAIDS/anti-platelets/anti-coagulants if safe
Endoscopic
– OGD (15% have upper GI source!)
– Colonoscopy – dg. + th. (injection, diathermy, clipping)
Angiographic
– Selective embolization for poor surgical candidates
– Can lead to ischemic sites requiring later resection
Surgery
– Ongoing hemorrhage, >6 units or ongoing transfusion
requirement
LGIB - treatment
Radiological
CT angiogram – diagnostic only (non-invasive)
Determines site and cause of bleeding
Assess activity
of bleed
active inactive
Prep for
NG lavage
Colonoscopy
Positive Negative
No risk for UGIB
Risk for UGIB
EGD
negative Hemodynamically
Treat lesion stable?
positive
Algorithm: Evaluation of Patient with
Hematochezia
Hemodynamically
stable?
No Yes
Angiography
Consider “urgent
(+/- Tagged RBC
colonoscopy” vs.
scan) /
traditional
Surgery if life-
approach
threatening
Small intestinal bleeding-sources
Angioectasia 20–55%
Tumor 10–20%
Crohn’s disease 2–10%
NSAID enteropathy 5%
Coeliak dis. 2–5%
Meckel diverticulum 2–5%
Dieulafoy lesion 1–2%
Ectopic varices 1–2%
Portal hypert. enteropathy 1–2%
Irradiation enteritis <1%
Aliment Pharmacol Ther 2011; 34:416–423K. Liu* & A. J. Kaffes, Mussetto A et al. Dig Liv Dis. 45 (2013) 124– 128.
Small bowel endoscopy