Академический Документы
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Purpose
A radiotherapy simulation system replicates the motions of a
radiotherapy treatment unit (see the Product Comparison titled Linear
Accelerators; Radiotherapy Units, Cobalt) to delineate (by radiographic,
fluoroscopic, or CT imaging) the tumor site and volume to be treated. The
two principal goals of radiation therapy simulation and planning are to
define the tumor volume (the region of the actual tumor and the
surrounding tissues that are considered to be at risk) and develop a
treatment technique that delivers a homogeneous dose of radiation to the
tumor while minimizing the dose to surrounding normal tissues. A
radiotherapy simulation system can localize the tumor and accurately
duplicate patient positioning for the specific radiotherapy treatment unit.
Combining technologies from both therapeutic and diagnostic radiology, a simulation system mimics the
movements of a linear accelerator. However, instead of emitting high-energy radiation, the system provides x-ray
imaging to determine, document, and externally mark the area to be treated. Once the potential field of
irradiation is established, areas or organs to be excluded from radiation treatment can be delineated. Some
simulators can also be used for planning brachytherapy treatment (see the Product Comparison titled
Brachytherapy Systems, Remote Afterloading).
Before the first treatment, the patient’s position is verified on the
radiotherapy unit itself with port films or electronic portal images.
Although they reveal only vague outlines of tissue densities, port UMDNS Information
films are adequate for comparison with the simulation films to
This Product Comparison covers the following
ensure exact replication of positioning, field size, and direction of device terms and product codes as listed in ECRI
the beam. Port films are taken at least weekly to document the Institute’s Universal Medical Device
Nomenclature System™ (UMDNS™):
accuracy of the prescribed radiation treatment.
Radiotherapy Simulation Systems [13-280]
CT-based simulation systems use a CT scanner with specialized Radiotherapy Simulation Systems, Computed
Tomography-Based [20-548]
hardware and software for radiotherapy simulation and treatment Radiotherapy Simulation Systems,
field delineation. Usually, the scanner is networked to a treatment Radiographic/Fluoroscopic-Based [20-547]
planning workstation. These systems are also called virtual
5200 Butler Pike, Plymouth Meeting, PA 19462-1298, USA Tel +1 (610) 825-6000 Fax +1 (610) 834-1275 Web www.ecri.org E-mail hpcs@ecri.org
Radiotherapy Simulation Systems
simulators because they allow patient marking without necessitating the generation of a treatment plan. In CT-
based simulation, the tumor is delineated on CT slices, the target volume is determined using a treatment
planning computer, and the treatment field is selected. The CT-based simulation system is then used to mark the
patient for radiation treatment; thus, imaging, treatment planning, treatment field delineation, and patient
marking can be accomplished in a single session. CT-based systems are also used for verification of tumor
margins and surrounding anatomy, posttreatment tracking of tumor regression, and 3-dimensional (3-D) image
analysis for multileaf collimators and conformal radiotherapy.
Principles of operation
Radiotherapy simulators
Radiotherapy simulators rotate 360° around a patient to define a tumor volume and navigate it to the
isocenter—the specified point of rotation that remains constant throughout treatment simulation. Isocenter
heights typically range from 120 to 127 cm. Most simulators use a Class II laser system to demarcate the isocenter.
Once the tumor volume has been delineated and positioned at the isocenter, it can be irradiated from any angle,
and irradiation of healthy organs can be avoided.
Localizing the tumor volume during simulation requires replicating certain mechanical and design features of
a typical radiotherapy unit and conventional radiographic and/or fluoroscopic equipment. The simulator must be
able to mimic basic motions and readouts of treatment units, avoid collisions while still allowing 360° rotation,
incorporate imaging systems, and maintain certain mechanical tolerances.
The simulator is composed of an x-ray system and a mechanical system and is capable of six major motions:
gantry rotation, focus-to-axis distance (FAD) adjustment, collimator rotation, image intensifier translation (lateral,
longitudinal, and radial), table translation (vertical, longitudinal, and lateral), and table rotation (around the
isocenter and pedestal).
distance between them, expresses the grid’s ability to remove scatter radiation. Average grid ratios are 8:1, 10:1,
and 12:1; grids with high ratios provide maximum contrast. A focused grid (which has angled lead strips) is most
often used.
A tray assembly with shielding trays (also called shadow or block trays) is available for most simulators and is
located below the collimator. Custom-shaped lead blocks are placed in the trays to prevent the x-ray beam from
irradiating excluded parts of the treatment field. These trays should be adjustable to match the focus-to-tray
distances for all simulated therapy units.
Simulator tables that require a deep pit in the floor can usually be lowered to facilitate patient access; however,
the presence of the image intensifier under the table can limit the minimum table height. If the table is supported
on wheels, special railing and flooring may be necessary to ensure stability.
The patient couch should be identical to that of the radiotherapy treatment unit to guarantee proper
positioning of the patient for treatment. Couch accessories, such as armrests or headrests, should also be similar
to those of the treatment unit. In addition, the table must be radiolucent so that it does not degrade the images
produced.
An isocentric chair that is compatible with existing simulators has been developed for radiotherapy simulation
and treatment in the upright position. The chair is positioned under the gantry arm, between the image intensifier
and the x-ray head; after the gantry is rotated to the lateral position, the base of the chair is locked into place to
produce a stable platform. A laser located on the ceiling can be used to verify the chair’s isocenter. Mediastinal
tumors and head and neck tumors and lesions can be more effectively imaged and treated in the upright position;
both treatment and simulation in the anteroposterior-posteroanterior, opposed lateral, and multiple oblique field
orientations are possible with this chair design. One manufacturer currently offers an isocentric chair as an
option.
Controls for table movement, gantry rotation, SAD adjustment, collimator rotation and diaphragm adjustment,
field-defining wire adjustment, and image intensifier translation should be located in the simulator room. A
ceiling-mounted pendant that allows easy tableside access to these local controls is generally provided in the
simulator room. Controls for the x-ray generator should be located in a separate remote control room (adjacent to
the simulator room), along with a control console duplicating the local controls and including controls for SAD,
gantry angle, and field size. Both the local and remote control devices usually provide digital readouts.
Anticollision devices are used to safeguard equipment and protect the patient from injury. Without these
devices, collisions are likely between the collimator assembly and the patient or tabletop; between the image
intensifier and the patient, tabletop, or floor; and between the x-ray tube housing and the floor. A mechanical
touchbar/microswitch or an electronic position sensor combined with a microprocessor is commonly used as an
anticollision device; both prevent resumption of simulator motion following a possible collision and require the
operator in the simulator room to override the anticollision mechanism. Some units rely on warning lights
activated by an impending collision. Regardless of the system, emergency stop switches should be strategically
placed in both the simulator room and the remote control room.
Because radiation therapy is administered with the patient on a flat treatment couch, CT scanning is performed
with the patient lying in the treatment position on a flat couch top or removable flat pad insert. (The curved
tabletop used for diagnostic imaging alters the position of internal anatomy in relation to external anatomic
landmarks.) Acquired CT data is transferred via a network to the treatment planning system. Other image data,
such as from positron emission tomography (PET), can be combined with the CT data. The planning workstation
is used to localize the tumor, delineate the target volume, and calculate coordinates to mark the patient’s skin for
radiotherapy. The simulator controls the laser marking system, which indicates where to mark the skin
intersection of the target volume center. Beam’s-eye-view images can be displayed and printed to visualize the
planned treatment beam in relation to anatomy. Digitally reconstructed radiographs (DRRs)—maps representing
beam attenuation along rays drawn from the radiation source—are comparable to simulator films and are
generated at various beam orientations to verify or modify patient positioning, collimator angles, beam width,
SAD, and gantry positioning during treatment.
For electronic transfer of simulation data, the CT-based simulation system can be networked to the treatment
planning system, record-and-verify and digital portal imaging systems, and the linear accelerator using Ethernet
connections and compliance with the Digital Imaging and Communications in Medicine for Radiotherapy
(DICOM RT) Standard. DICOM RT standardizes the way radiotherapy data is transferred from one piece of
equipment to another and among multivendor devices.
For more information, see the following Product Comparisons:
Radiotherapy Treatment Planning Systems
Radiotherapy Record and Verify Systems; Portal Digital Imaging Systems
Linear Accelerators; Radiotherapy Units, Cobalt
Reported problems
Common problems previously included the misalignment of the collimator caused by the weight of the beam
block assembly wearing on the bearings of the x-ray tube housing.
Additionally, inadequate support could cause tabletop deflection when weight greatly exceeding that of the
average patient was applied to the table. Because tabletop deflection can result in inaccurate radiographic
imaging and, hence, inaccurate patient positioning, purchasers should ensure that all tables are installed with
proper support and stabilizing devices.
While computers are used more extensively in radiotherapy, human error remains a possibility. Therefore,
quality assurance procedures remain extremely important.
Purchase considerations
ECRI Institute recommendations
Included in the accompanying comparison charts are ECRI Institute’s recommendations for minimum
performance requirements for R/F and CT radiotherapy simulation systems.
The most important consideration for R/F simulation systems is the ability to position the patient with respect
to the beam in such a way that radiotherapy is simulated as close as possible to the patient. Therefore, the system
should have a SAD ranging from 80 to 150 cm and a source-to-image distance (SID) ranging from 80 to 200 cm
and the gantry should be able to rotate ±150° above and ±180° below a 100 cm SAD. The patient table should be
capable of a wide range of translations (at least 70 cm vertically, ±20 cm laterally, and 100 cm longitudinally) and
rotations (360° pedestal rotation and ±95° isocenter rotation) to allow for proper patient positioning. Also, the
simulator should be capable of ±90° collimator rotations and image intensifier translations of ±20 cm laterally, ±20
cm longitudinally, and 60 cm radially.
A three-phase x-ray generator is preferred because it allows higher tube currents at very short exposure times,
nearly constant potential, and higher effective kVp. The generator should be capable of radiographic output of 40
to 150 kV, 10 to 800 mA, and up to 1,000 mAs and fluoroscopic output of 40 to 125 kV and up to 20 mA. To
enhance details and minimize the image width of the treatment area, smaller focal spot sizes of 0.6 mm or 1 mm
are preferred. A simulator with an image x-ray field of 45 cm2 at a 100 cm SAD, a 12° anode angle, and a 23 cm
image intensifier with a coverage area of 70 cm2 meets minimum recommendations.
The standard system components for a CT-based radiotherapy simulation system should include the CT
gantry, laser alignment, control console, and workstation. If the CT scanner is not included, then the system
should be capable of interfacing with any DICOM-compatible CT scanner.
There are a number of important CT specifications that purchasers should consider. The scanner should have a
large bore diameter of 70 to 80 cm, a 60 cm maximum field of view, and multislice capability with 0.5, 1, 2, 4, 5,
and 10 mm slice widths. Also, the scanner should have an axial spatial resolution of 10 lp/mm at a 50%
modulation transfer factor and a low-contrast resolution of 4 mm at 0.3% at 2 rads, as well as noise levels of 0.3%
at 3 rads. The system should be able to reconstruct 20 images per second, digitally reconstruct radiographs in less
than 1 second, and instantaneously reconstruct with beam’s-eye-view.
The laser marking system should be configured with three moving diode lasers capable of 635 nm wavelengths
and should have a positioning accuracy within ±0.5 mm and a less than 1.5 mm projected beam pattern; the
system should also produce less than 1 mW power output.
Other important considerations are networking and system interfacing, specifically Transmission Control
Protocol/Internet Protocol Ethernet connections and the ability to interface with any DICOM RT-compatible
radiotherapy treatment planning system.
Other considerations
The radiotherapy simulation suite should include a shielded room for the simulator and x-ray generator, as
well as separate control and treatment planning rooms. The control room, which houses the generator control
panel and the simulator remote controls, should be separated from the simulator room by a large lead- or plate-
glass window. The treatment planning room houses the computer and its peripherals, which should be
compatible with the simulator system.
The installation of some radiotherapy simulation systems may require the use of a pit. The pit—a recessed
portion of the floor—provides both an anchor for the base of the simulator and a conduit for cables and wiring.
Systems that require a pit for operation should have an appropriately planned simulation suite.
Modifying a conventional radiotherapy simulator to perform CT simulation can cost from $250,000 to $300,000,
and adding hardware and software to an existing CT scanner can cost from $160,000 to more than $200,000.
Purchasing a new CT-based simulation system can cost from $400,000 to more than $1,600,000. Buyers should
consider the number of CT simulations that will be performed to determine whether the purchase of a CT scanner
dedicated to simulation is justifiable. If a CT-based simulation package is considered for an existing CT scanner,
buyers should evaluate the potential for conflicts with room use for diagnostic imaging procedures.
With the advances in radiotherapy treatment planning, any hospital currently looking to advance their
radiotherapy services will need a radiotherapy simulation dedicated CT scanner. CT simulation is necessary for
intensity-modulated radiotherapy (IMRT), which allows a high dose of radiation to be delivered to a tumor while
minimizing irradiation of surrounding healthy tissue.
Environmental considerations
As a result of increasing concerns over the environment and the conservation of resources, many
manufacturers have adopted green shipping and production methods, as well as features that improve the energy
efficiency of their products or make them more recyclable. In addition, healthcare facilities and device
manufacturers have begun to adopt green initiatives that promote building designs and work practices that
reduce waste and encourage the use of recycled materials.
Some companies are moving to reduce lead and other toxic substances in radiology suites. Tungsten and
plastics can replace select lead parts during manufacturing. In addition, components made from recyclable
materials and systems manufactured in green plants are desirable. A number of manufacturers are redesigning
key system components such as x-ray tubes to reduce energy consumption.
End-of-life costs need to be considered as well. Facilities should look for manufacturers who offer take-back
programs on entire imaging systems or their components. If a supplier does not offer such an arrangement, the
hospital must absorb the costs of disposing of the system according to local environmental protection laws when
it is replaced.
Stage of development
Radiotherapy units have been available since the early 1960s; however, the simulator was not established as an
essential therapeutic tool until the early 1970s, when the linear accelerator—the chief mode of external-beam
radiation therapy—was introduced. CT simulation was introduced in the early 1990s and was frequently used to
complement conventional radiotherapy simulation. However, ongoing developments in radiotherapy, such as
IMRT, multileaf collimators, and conformal therapy, along with the increasing emphasis on digital imaging and
networking different imaging modalities, have stimulated growth in the use of CT simulation. CT is now the
primary modality used for simulation.
Bibliography
Aird EG, Conway J. CT simulation for radiotherapy treatment planning. Br J Radiol 2002 Dec;75(900):937-49.
Barrett A, Dobbs J, Morris S, et al. Practical radiotherapy planning. 4th ed. New York: Oxford University Press; 2009.
Cho PS, Lindsley KL, Douglas JG, et al. Digital radiotherapy simulator. Comput Med Imaging Graph 1998 Jan-
Feb;22(1):1-7.
Hendee WR, Ibbott GS, Hendee EG. Radiation therapy physics. 3rd ed. Hoboken, (NJ): Wiley-Liss; 2004.
Jani SK, ed. CT simulation for radiotherapy. Madison (WI): Medical Physics Publishing; 1993.
Miller RW, Raubitschek AA, Harrington FS, et al. An isocentric chair for the simulation and treatment of radiation
therapy patients. Int J Radiat Oncol Biol Phys 1991 Jul;21(2):469-73.
Nagata Y, Nishidai T, Abe M, et al. CT simulator: a new 3-D planning and simulating system for radiotherapy:
part 2. Clinical application. Int J Radiat Oncol Biol Phys 1990 Mar;18(3):505-13.
Nishidai T, Nagata Y, Takahashi M, et al. CT simulator: a new 3-D planning and simulating system for
radiotherapy: part 1. Description of the system. Int J Radiat Oncol Biol Phys 1990 Mar;18(3):499-504.
Ragan DP, Tongming H, Mesina CF, et al. CT-based simulation with laser patient marking. In: 3-D radiation
treatment planning and conformal therapy: proceedings of an international symposium. Madison (WI):
Medical Physics Publishing; 1993.
Taylor J. Imaging in radiotherapy. London: Croom Helm; 1988.
Supplier information
Chart A: R/F Radiotherapy Simulation Systems
HUESTIS MEDICAL
Huestis Medical [162412]
PO Box 718
Bristol, RI 02809-0718
Phone: (401) 253-5500, (800) 972-9222 Fax: (401) 253-7350
Internet: http://www.huestismedical.com
E-mail: sales@huestis.com
INVAP
INVAP SE [237889]
Avenida Cmte Luis Piedrabuena 4950
San Carlos de Bariloche R8403CPV
Argentina
Phone: 54 (2944) 409300 Fax: 54 (2944) 409339
Internet: http://www.invap.com.ar
E-mail: marketing@invap.com.ar
NUCLETRON
Nucletron Corp [106839]
8671 Robert Fulton Dr
Columbia, MD 21046
Phone: (410) 312-4100, (800) 336-2249 Fax: (410) 872-4199
Internet: http://www.nucletron.com
E-mail: info@us.nucletron.com
Nucletron SA [361441]
Avenida de Castilla 2 Parque Empresarial San Fernando Edificio Francia Planta 2a Esc A
San Fernando de Henares E-28830
Spain
Phone: 34 (918) 250068 Fax: 34 (918) 250069
Internet: http://www.nucletron.com
E-mail: info@es.nucletron.com
SHINVA
Shinva Medical Instruments Co [452207]
Shinva Medical Scientific Zone Zibo New & High Tech Zone
Zibo City 255086
People's Republic of China
Phone: 86 (533) 3587719 Fax: 86 (533) 3587722
Internet: http://www.shinva.com
E-mail: sales@shinva.com
VARIAN ONCOLOGY
Varian Medical Systems Deutschland GmbH [161079]
Alsfelder Strasse 6
Darmstadt D-64289
Germany
Phone: 49 (6151) 73130 Fax: 49 (6151) 703273
Internet: http://www.varianinc.com
E-mail: de.info@varianinc.com
Waukesha, WI 53188
Phone: (262) 544-3011, (800) 643-6439 Fax: (262) 544-3384
Internet: http://www.gehealthcare.com
PHILIPS
Philips Argentina SA Dept Sistemas Medicos [415453]
Vedia 3892 Cassila 3479
Capital Federal 1429
Argentina
Phone: 54 (11) 45467699 Fax: 55 (11) 45467697
Internet: http://www.medical.philips.com
E-mail: lorenzo.vallerga@philips.com
SIEMENS ONCOLOGY
Siemens AG Siemens Health Services [401832]
Hartmannstrasse 16
Erlangen D-91052
Germany
Phone: 49 (9131) 840 Fax: 49 (9131) 842379
Internet: http://www.siemensmedical.com
Siemens Medical Solutions USA Inc Oncology Care Systems Group [399203]
4040 Nelson Ave
Concord, CA 94520-1200
Phone: (925) 246-8200, (888) 826-9702 Fax: (925) 246-8284
Internet: http://www.siemensmedical.com/oncology
E-mail: info@smsocs.com
TOSHIBA
Toshiba America Medical Systems Inc [101894]
2441 Michelle Dr
Tustin, CA 92780
Phone: (714) 730-5000, (800) 421-1968 Fax: (714) 734-0362
Internet: http://www.medical.toshiba.com
E-mail: info@tams.com
Internet: http://www.medical.toshiba.com.au
E-mail: intouch@toshiba-tap.com
Note: The data in the charts derive from suppliers’ specifications and have not been verified through
independent testing by ECRI Institute or any other agency. Because test methods vary, different products’
specifications are not always comparable. Moreover, products and specifications are subject to frequent changes.
ECRI Institute is not responsible for the quality or validity of the information presented or for any adverse
consequences of acting on such information.
When reading the charts, keep in mind that, unless otherwise noted, the list price does not reflect supplier
discounts. And although we try to indicate which features and characteristics are standard and which are not,
some may be optional, at additional cost.
For those models whose prices were supplied to us in currencies other than U.S. dollars, we have also listed the
conversion to U.S. dollars to facilitate comparison among models. However, keep in mind that exchange rates change
often.
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