Community for a Cure
We Stand Together in the Fight Against Breast Cancer!
Shannon loves her hair and being able to play with her daughter.
Beating and recovering
from breast cancer
LOCAL CHOICES: United Memorial Medical Center in Batavia is part of the efforts
Rochester Regional Health
Lipson Cancer Institute
S
hannon Brean credits the medical
team at the Lipson Cancer Insti-
tute of Rochester Regional Health
for saving her life and making it
possible to be the mother she wants to
be for her young son. Her gratitude goes
beyond the diagnosis and treatment of
the doctors.
Shannon was understandably anx-
ious after learning she had Stage 2
breast cancer in 2015, but Joel Yellin,
MD, a surgeon at Rochester General
Hospital, immediately put her at ease.
“He called me at 10 p.m. when he
was on vacation and says, ‘Shannon,
we’re going to take care of you.’ He
then got me in to see him in a couple of
days,” she says. “He had the best bed-
side manner and was always positive.
He was the most caring man I’ve ever
talked to in my life.”
Shannon was 45 and the mother of
6-month-old Berkley when she began
a treatment that included chemo-
therapy to shrink the tumor in her right
breast, a mastectomy, breast recon-
struction and radiation. Berkeley, now
3, was her inspiration through it all.
“I just kept thinking that when this
is over, he won’t remember that his
mommy couldn’t pick him up or play
with him or that she lost all her hair,”
Shannon remembers. “I thank my doc-
tors for that. They saved my life.”
Shannon credits her recovery to the
team at the Lipson Cancer Institute,
including Megan Carmel, MD, a Unity
Hospital OB/GYN at Clinton Crossings
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who diagnosed the cancer and referred
her to Dr. Yellin. Shannon had a full
team caring for her, including Saad
Jamshed, MD, an oncologist at the
Lipson Cancer Institute and Center for
Blood Disorders, Meri Atanas, MD, a
radiology oncologist, and Mark Daven-
port, MD, a plastic surgeon. The mul-
tidisciplinary team of physicians coor-
dinated all aspects of Shannon’s care.
Under Dr. Jamshed’s direction, Shan-
non underwent six rounds of chemo-
therapy to shrink the tumor and also
kill cancer cells that had spread to the
lymph nodes in her right armpit. Al-
though she was cancer-free following
chemotherapy treatment, she decided
to have a full mastectomy, performed
by Dr. Yellin, after testing positive for
the BRCA breast cancer gene. Breast
reconstruction was performed by Dr.
Davenport, with a final round of radia-
tion completing the treatment. Shan-
non’s recovery was truly a coordinated
effort.
“I am cancer-free today,” Shannon
says. “I feel good. I can play with Berke-
ley. And my hair is beautiful, if I do say
so myself!”
Consideer a donation to the Roches-
ter Regional Health Foundations.
With the 2014 merger of the Roch-
ester General and Unity Health Foun-
dations into one entity, Rochester Re-
gional Health Foundation, our central
Foundations Office in Irondequoit is
now comprised of four foundations,
with the other three being Clifton
Springs Hospital Foundation, Newark-
Wayne Community Hospital Founda-
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tion and United Memorial Medical
Center Foundation.
As a unified organization, our Foun-
dations Office helps make high-quality
healthcare available and accessible
to everyone in the communities we
serve by securing grants and philan-
thropic gifts to support system growth
and improvements. This is critical
funding that allows our health system
to provide a consistent model of care
that embraces and optimizes the lat-
est research and technology, employs
the top medical minds, introduces new
treatments and innovative programs
and offers care with kindness and re-
spect.
Caring about the sustained growth
of healthcare in each of our communi-
ties is a vital element to our collective
future and something that we must
accomplish together. As a nonprofit
health system, Rochester Regional re-
lies on each and every philanthropic
gift, no matter the size, to help ensure
the continuation of quality projects
and programs throughout our system.
The Foundations Office helps fund
initiatives across Rochester Regional’s
entire network of more than 150 loca-
tions, beginning with our five hospi-
tals:
* United Memorial Medical Center
in Batavia
* Rochester General Hospital
* Unity Hospital in Greece
* Newark-Wayne Community Hos-
pital in Newark
* Clifton Springs Hospital & Clinic in
Clifton Springs
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You’ve heard the
breast cancer myths?
Here are the facts
Dr. Lisa Paulis studies. False positives can
ELIZABETH WENDE BREAST CARE generate additional testing in
order to determine a true re-
T
he “Myths of Mam-
mography.” A screen- sult. In mammography, false
positive results can mean
ing mammogram is an
important step in a woman’s anything from additional
preventative healthcare rou- mammographic views, after
tine. Unfortunately, there is a which most patients will not
lot of misinformation regard- require further workup, to ul-
ing screening mammography trasound or minimally inva-
and breast cancer. Below are sive biopsy procedures. Out
the most frequent myths I en- of every 100 women who have
counter when dealing with my a mammogram; 95 will be
patients. told that their mammogram
results are normal, and 5 will
Myth be asked to return for addi-
Annual screening mam- tional mammogram and/or
mography is only important ultrasound testing. We feel
for patients with a family his- strongly that women should
tory of breast cancer. be aware of these statistics to
The Facts make an informed decision
Seventy-five percent of on how they weigh the risk of
women diagnosed with being one of the women who
breast cancer have NO fam- potentially needs additional
ily history of the disease. In workup versus the risk of not
the general population 12% screening. Of note, 12% of the
of women will develop breast cancers we diagnosed in our
cancer in their lifetime and community in 2018 were in
42,000 Americans will die their forties.
from breast cancer this year.
Women who are at a high- Myth
er than average risk due to Mammography is ineffec-
personal or family history, tive in screening for cancer
prior atypical biopsy results, in women with dense breast
certain genetic factors etc. tissue.
may benefit from additional The Facts
screening (ultrasound, MRI) Breast density is deter-
and/or genetic counseling. mined by the proportion of
However, the absence of fat and glandular tissue in the
risk factors should not pre- breast. The more glandular
vent a patient from pursuing tissue a patient has, the more
screening imaging. In our lo- “dense” the tissue is graded.
cal patient population only Each patient is assigned a
4% of the patients we diag- breast density classification
nosed last year had a known on their mammogram which
gene mutation. ranges from entirely fatty is-
sue to extremely dense glan-
Myth dular tissue. Small breast can-
Screening mammography cers can be harder to identify
should not be performed in on traditional mammograms
younger patients (ages 40-50) in patients with dense tissue,
due to false positive results. however a newer technol-
The Facts ogy called tomosynthesis (3D
A false positive is an area mammography) spreads out
that appears abnormal on the tissue to improve detec-
initial imaging but represents
normal tissue on subsequent See MYTHS AND FACTS A2
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2 • October 2019
Staying focused and beating breast cancer
By ROCHESTER REGIONAL HEALTH
Lipson Cancer Institute
When Kathleen Cook was
diagnosed with breast can-
cer, the first question her son
asked was, “Are you going to
die, Mom?” It’s a hard ques-
tion to answer for someone
who felt she was at one of the
healthiest points in her life.
“I had been working out on a
regular basis. I looked my best.
I felt my best. I was not the typ-
ical poster child for any sort of
a cancer. Especially with no
family history.”
Kathleen was scared. She
wondered if her kids would
grow up without a mother,
or if she would ever get to see
those special “firsts” in their
lives. She was looking for hope
and reached out through so-
cial media for help in picking
an oncologist and a surgeon.
The responses she received
from her post led her to Lipson
Cancer Institute.
“My oncologist gave me
such hope. I remember her
telling me it was survivable.”
Through the anxiety and fear,
Kathleen credits her Lipson
team with keeping her focused
on doing what she needed to
do to stay positive—and to
UMMC : Breast, cervical, colorectal screenings and more
By MALLORY DIEFENBACH
MDiefenbach@BataviaNews.com
BATAVIA — More than 84
million adults have predia-
betes and 90 percent of those
don’t know they have it.
Thankfully, the United
Memorial Medical Center
Healthy Living team’s Dia-
betes Prevention Program
recently earned preliminary
recognition from the Centers
for Disease Control and Pre-
vention.
“We’re one of the only pro-
grams in New York state and I
think we are the only program
in Western New York,” said
Amy Miller, registered dieti-
tian and certified diabetes
educator for Healthy Living.
The diabetes prevention
program offered by the CDC
is a year-long commitment
for individuals who sign up.
It’s meant to prevent or delay
the onset of Type 2 diabetes,
so it’s not meant for those
who already have the disease.
Jadriene Balduf, certi-
fied childbirth educator
for Healthy Living, said the
program’s goal is 5 percent
weight loss as a group.
Type 2 diabetes, unlike
Type 1 diabetes, can be pre-
vented. An epidemic of obesi-
ty, Miller said, is leading to an
epidemic of Type 2 diabetes,
with warning signs including
sedentary behavior, being
138 Court St., Geneseo, NY 14454
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live.
“The most important thing
to me right now is to be here to
see my kids grow old. I want to
be here for their prom. I want
to be here for their graduation.
I want to watch them grow up
and see what they become.
I want to see their children.
I want to be a grandparent. I
just want to live.”
About Lipson Cancer In-
stitute: When you’re facing
cancer, you quickly learn what
matters in life—family, friends
and the people providing your
care.
Be part of what matters.
Support Lipson Cancer In-
stitute — because great care
matters.
Lipson Cancer Institute was
founded on a commitment to
provide comprehensive can-
cer care from one integrated
program to treat the unique
needs of each patient.
Each day, our highly trained
and dedicated oncology teams
use leading-edge medical
technology to create and ad-
minister personalized cancer
treatment plans for our pa-
tients.
Consideer a donation to the
Rochester Regional Health
overweight, family history
and age.
“And then when it’s not
prevented and you develop it,
there are so many problems
it has on your body besides
your insulin network,” Miller
said.
Those who want to check
on whether they have pre-
diabetes may visit DoIHave-
Prediabetes.org to take the
screen to see if they qualify.
Those who do have diabe-
tes can also attend Healthy
Living’s living healthy with
diabetes class.
For more information, call
(585) 344-5331.
In addition to the diabetes
support, Healthy Living also
provides:
• CPR classes where people
can learn more about basic
life support, early CPR and
defibrillation;
• Nutrition, in which a reg-
istered dietitian evaluates
Alan S. Cole
Lic. R.E. Salesperson
585-750-3320
Breast Cancer Awareness 2019
Foundations.
With the 2014 merger of the
Rochester General and Unity
Health Foundations into one
entity, Rochester Regional
Health Foundation, our cen-
tral Foundations Office in
Irondequoit is now comprised
of four foundations, with
the other three being Clifton
Springs Hospital Founda-
tion, Newark-Wayne Com-
munity Hospital Foundation
and United Memorial Medical
Center Foundation.
As a unified organization,
our Foundations Office helps
make high-quality healthcare
available and accessible to ev-
eryone in the communities we
serve by securing grants and
philanthropic gifts to support
system growth and improve-
ments. This is critical funding
that allows our health system
to provide a consistent model
of care that embraces and op-
timizes the latest research and
technology, employs the top
medical minds, introduces
new treatments and innova-
tive programs and offers care
with kindness and respect.
Caring about the sustained
growth of healthcare in each
of our communities is a vital
your specific needs and daily
routine, and offers practical
suggestions on meal plan-
ning, dining out;
• Health Rx, a safe, encour-
aging introduction to exercise
for those ready for the physi-
cal, mental and social ben-
efits of a healthier lifestyle;
• MOMS (Medicaid Obstet-
rical and Maternal Services)
program where early prenatal
care is essential to your health
and that of your baby;
• Childbirth classes for
expectant mothers, during
INSURANCE AGENCY
Support
research for
a Cure!
Services at the Batavia and Geneseo offices include the latest 3D mammography
with C-View, screening breast ultrasound and same day mammogram results.
Kathleen Cook, who stayed positive and beat breast cancer.
element to our collective fu-
ture and something that we
must accomplish together.
As a nonprofit health system,
Rochester Regional relies on
each and every philanthropic
gift, no matter the size, to help
ensure the continuation of
quality projects and programs
throughout our system.
The Foundations Office
helps fund initiatives across
Rochester Regional’s entire
which coaches prepare them
for pregnancy, childbirth,
postpartum, newborn care
and parenting;
• Infant feeding class, in
which parents can learn
about the benefits of breast-
feeding, the importance of
support, infant feeding cues
and breastfeeding logistics;
• Baby cafe, a weekly sup-
port group for breastfeeding
mothers and pregnant wom-
en who plan to breastfeed;
• Family and friends CPR
and safety where parents,
grandparents and caregivers
will discover safety issues to
address, such as poison con-
trol and first aid;
• Cancer services program
where they provide breast,
cervical and colorectal can-
cer screenings at no cost to
women over 40 and men over
50 who do not have health in-
surance;
• Cancer support group,
41 Liberty Street
Batavia, NY 14020
Phone: (585) 219-4214
Fax: (585) 219-4877
network of more than 150 lo-
cations, beginning with our
five hospitals:
* United Memorial Medical
Center in Batavia
* Rochester General Hospi-
tal
* Unity Hospital in Greece
* Newark-Wayne Commu-
nity Hospital in Newark
* Clifton Springs Hospital &
Clinic in Clifton Springs
which is open to all people
with any type of cancer;
• Cancer screening pro-
gram, an education and out-
reach service which connects
you to your physician to dis-
cuss options for breast and/
or prostate cancer screenings,
while proving additional sup-
port to ensure your needs are
met;
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Myths and facts
From A1
tion. Additionally, screening
breast ultrasound provides
another way to “see through”
the density and find small
masses. Mammograms re-
main the most
accurate tool available to
diagnose ductal carcinoma in
situ or DCIS which can be the
earliest form of breast cancer
we can identify. In patients
with dense tissue, consid-
eration should be given to
screening mammography ac-
companied by ultrasound to
offer the most comprehensive
benefits of imaging.
Major health organizations,
such as the American Cancer
Society, as well as our local
imaging community continue
to recommend that women
should be screened annually
beginning at age 40. For more
information go to mammog-
raphysaveslives.org and talk
to your healthcare provider.
(As the first dedicated
breast clinic in the US, Eliza-
beth Wende Breast Care has
been serving the greater Roch-
ester, NY area since 1975, with
the latest technology and
experienced breast imaging
professionals)
• Peer education program
reaches out into Genesee,
Wyoming, Monroe and Or-
leans counties to provide peer
focused education and assis-
tance regarding breast and
prostate cancer screenings.
 Breast Cancer Awareness 2019 October 2019 • 3

Knowing something just isn’t right

It started with a feeling that
something just wasn’t right.
That’s when Bajro Rizvanovic
decided to drive himself to the
emergency room.
“They told me it was a tumor
the size of a baseball in my co-
lon. I had Stage 4 cancer.” Ba-
jro was just 30 years old.
“He’s very young and
healthy and vibrant… and we
wanted to treat things in an
aggressive way with the goal
of curing the cancer,” explains
Dr. Greg Connolly. “After sev-
eral months of chemotherapy,
we did scans that showed
things had gotten significantly
smaller. I think he was very
happy when he saw those re-
PHOTO SUBMITTED
sults.” Bajro took advantage of local cancer treatment programs.
The Byron-Bergen varsity girls soccer team was amoung the teams raising money as part of this Bajro was on the road to re-
year’s Day of Soccer. covery. But he was not alone.
“Shortly after I was diag- cancer.” ers.
nosed, Dr. Connolly suggested Together, brother and sister “Me and my sister were
that the immediate family get found the care they needed awarded our lives back … and
checked out. And, what do you through Rochester Regional there’s no better feeling than
know, my sister was Stage 3 Health and the Lipson Cancer that. You just want to give back
cancer,” reveals Bajro. “It was Institute. Now, both cancer in some way.”
colon cancer, the same kind of free, Bajro and his sister are at
the forefront of Lipson believ-

How to lower breast cancer risk

JANE E. BRODY about what women can do on cigarettes a day for 20 or more
The New York Times News Service their own to lower their risk years had a third higher risk

F
ear of breast cancer is
widespread, yet many
women don’t realize
that adopting protec-
tive living habits may help keep
it at bay. The habits described
below may also help to ward off
other life-threatening ills, like
heart disease and diabetes.
Certainly, women have
ample reason to worry about
The Byron-Bergen girls junior varsity team also did its part to raise money. Byron-Bergen was breast cancer. The disease is
joined in the local effort by teams from Attica Central School. very common. One woman
in eight in the United States
will develop it in the course
of a lifetime. The American
Cancer Society estimates that
Byron-Bergen students find ways to this year 252,710 new cases of
invasive breast cancer will be
of getting breast cancer in the of developing invasive breast
first place. cancer, and girls who started
One of the most important smoking before age 15 were
actions is an inaction: not nearly 50 percent more likely
smoking. The incidence of to get breast cancer.
smoking has fallen significant- An editorial in The Journal
ly in the last half century, yet of Clinical Oncology last year
every day on the streets of New stated that as many as 20,000
York I still see young women women in the United States
and teenage girls smoking. A continue to smoke even after
decadeslong study conducted a diagnosis of breast cancer.
among 102,098 women in Nor- The authors, Dr. Barbara A.
way and Sweden found that,
compared with nonsmokers, See RISK A6
those who smoked 10 or more
Lois Gerace, GRI
Licensed Associate Real Estate Broker

support those going through cancer
BERGEN — During last
Saturday’s Byron-Bergen Day
of Soccer, the Byron-Bergen
and Attica soccer teams joined
forces to raise money for good
causes. Modified, junior var-
sity and varsity girls and boys
faced off for a full day of com-
petition at the Byron-Bergen
Soccer Stadium. All the teams
played hard, but, Byron-Ber-
gen said, the ultimate winners
were the Wilmot Cancer Insti-
tute and Crossroads House.
The two organizations will
split the more than $2,300 in
proceeds.
“We all love being part of
the charity event, the whole
team does,” said Byron-Ber-
gen senior and varsity co-cap-
tain Miriam Tardy. “Honestly,
the hardest part is choosing
which type of cancer to sup-
port. That’s why this year we
chose to support all cancer
research.”
The student-led event be-
gan at 9:30 a.m. and contin-
ued until the close of the last
game, which began nine hours
later. The annual fundraiser
to support cancer research
was launched almost a decade
ago by the varsity girls soccer
team in support of a team-
mate’s loved one. The event,
free and open to the public,
has grown into a community
tradition, raising thousands
of dollars annually and more
than $12,000 since its incep-
tion. Money is raised through
donations, T-shirt and food
sales, and vendors.
“I love this fundraiser,” said
senior and co-captain Kelsey
Fuller. “It’s a great opportu-
nity to show who we are as
people and really give back to
the community.”
Senior co-captain Melissa
MacCowan said, “This is my
sixth year participating. It’s
Cell: 585.356.2113
diagnosed, and 40,610 women
will die from the disease.
Regular screening is touted
Office: 585.343.8434
Fax: 585.343.0915
Email: LGerace@GeraceRealty.com
as the most effective way to re-
about raising money, but also support different parts of the duce breast cancer deaths, al-
about raising awareness.” community,” said Fuller. though experts continue to de-
This year, the teams decid- Athletic Director Richard bate who should be screened,
ed to expand its philanthropic Hannan said, “Our athletes how often and at what ages. ®
efforts to include Crossroads take great pride in giving back But not nearly enough is said 6 Ellicott Avenue, Batavia, NY 14020
House in Batavia. Crossroads to the community,” said Ath-
provides hospice services to letic Director Richard Han-
residents of Genesee and Wy- nan. These are both wonderful
oming County free of charge.
“We have been supporting
cancer research for years and
organizations and I’m always
impressed by the teams’ dedi-
cation.”
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4 • October 2019
Saying yes to physical activities for breast cancer survivors
By Susan Berger
F
or more than 25 years,
many breast cancer sur-
vivors were given a life-
long, life-changing warn-
ing: Do not lift anything over five
pounds, avoid getting mani-
cures, taking saunas or even
gardening since it might lead to
a painful complication called
lymphedema, which can cause
irreversible swelling in the arm
and often hardening of skin.
The condition is usu-
ally caused by the removal of
lymph nodes, which is done
during breast cancer surgery
to determine if the cancer has
spread. The nodes are part of
the body’s lymphatic system,
which protects against invaders.
Lymphedema happens when
a blockage, often because of
scarring from surgery or radia-
tion, causes fluid to accumulate,
painfully and often irreversibly.
Doctors treating breast can-
cer patients long thought that
infection or injury would cause
inflammation, which in turn
would overload the lymphatic
system causing the swelling and
pain of lymphedema.
But based on studies over the
past decade, the old warnings of
lymphedema do’s and don’ts
have been dramatically relaxed.
Many of these warnings, said
Simona Shaitelman, associate
professor of radiation oncol-
ogy at the University of Texas
MD Anderson Cancer Center,
were little more than “old wives’
tales,” which in recent years
have been debunked based on
results of a group of well-run
studies.
Kathryn Schmitz, a profes-
sor of public health sciences
at Penn State Cancer Institute
and president of the American
College of Sports Medicine,
conducted those studies, which
showed that a careful return to
working out with weights did
not increase the risk of lymph-
edema.
Estimates of how many
people post-cancer treatment
get lymphedema vary widely. A
2018 study in the New England
Journal of Medicine estimated
between 14 to 40 percent of
women post-breast cancer
surgery got lymphedema, with
newer surgical methods and
treatments helping to reduce
the numbers. (Treatment for
other kinds of cancers, includ-
ing prostate, ovarian and mela-
noma, can also cause lymph-
edema.)
For years, breast cancer doc-
tors used axillary lymph node
dissection (removal of lymph
nodes in the underarm) to see
if cancer has spread beyond the
tumor, often removing between
10 and 40 of the nodes, which
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From gardening to fitness, because of studies, being active is now beneficial after breast cancer surgery.
made the changes for lymph-
edema fairly high.
In the late 1990s, sentinel
node biopsy (removing only
the node closest to the tumor,
to start with to see if the cancer
had spread, and then looking at
others only if necessary) came
into use to allow fewer lymph
nodes to be surgically removed.
Although this decreases the
chance of developing lymph-
edema, it can still occur — the
New England Journal of Medi-
cine calculated the risk for
women using the sentinel node
Dontiá
Since 1951
Breast Cancer Awareness 2019
technique at about 6 to 10 per-
cent.
“It depends on how many
138 Court St., Geneseo, NY 14454
Cell: 585-315-6617
Office: 585-243-2643 ext 101
Fax: 585-243-1838
pat@abcolerealestate.com
www.abcolerealestate.com
Breast Cancer Awareness Month
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for air travel, Shaitelman said.
“There is no data to say that
even with mild lymphedema
you should wear that.”
Precautions about manicures
and avoiding heat are now also
viewed with more nuance.
A small 2017 study by Florida
State University researchers
not only found that resistance
exercise training in women
who have breast cancer-related
lymphedema, or are at risk for it,
wasn’t harmful but reported it
may in fact be “beneficial to de-
crease the signs/symptoms and
development of lymphedema.”
Schmitz said that in addition
to her research that showed
slow progressive weight training
would not cause lymphedema,
there are other important ben-
efits of exercise for women who
have had breast cancer surgery.
Many women lose fitness and
cardiovascular function after
breast cancer treatment having
had chemotherapy and radia-
tion. She often hears breast can-
cer survivors say they feel liked
en [with sentinel node biopsy]
they “aged a decade in that year
with 12 nodes removed.”
of treatment.”
In addition to warnings about
“Exercise improves fatigue,
working out and not lifting any-
anxiety, depression, sleep,
thing heavy, women were told
bone health, physical func-
to wear a compression sleeve
tion, cardiovascular health and
when traveling by air, to prevent
improves body composition,”
air pressure causing lymph flow
Schmitz said.
problems, and not to have blood
She and her research team
pressure readings or blood
developed the Strength After
draws on the affected arm.
Breast Cancer program, where
Shaitelman, who oversees a
specially trained physical thera-
lymph screening initiative that
pists provide rehabilitation ser-
helps patients treat lymph-
vices to breast cancer survivors
edema early and is involved in
to improve their fitness. The
ongoing research, cites a 2016
program, funded by National
study by researchers at Harvard
Cancer Institute, has partnered
Medical School and Massa-
with Klose Training, which
chusetts General Hospital that
provides online training for
investigated these warnings
physical therapists and is being
and found they were based on
utilized by over 600 physical and
anecdotal evidence. “Despite
occupational therapists world-
the prevalence and persistence
wide, Schmitz said.
of recommendations to pursue
Katherine Kopkash, director
precautionary behavior after
of oncoplastic breast surgery at
breast cancer treatment, few
NorthShore University Health-
data exist to support these prac-
System outside Chicago, agrees
tices,” the study said.
with the modern approaches,
“Five years ago, we stopped
keeping safety in mind.
giving a prophylactic sleeve”
nodes were removed,” Schmitz
said. “Patients need to know
how many — I have seen wom-
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 Breast Cancer Awareness 2019 October 2019 • 5

Researchers looking for the correct There are many

cancer target for treatment services in
By Carl Zimmer
Livingston and
Wyoming counties
The New York Times News Service

T
wenty years ago, the fight
against cancer seemed
as if it were about to take
a dramatic turn.
Traditionally, cancer doctors
for cancer screening
fought the disease with crude Special to The LCN tion, there are other factors
weapons, often simply poison-
Cervical cancer is high- that increase a woman’s risk
ing fast-growing cells whether
ly preventable because of developing cervical can-
they were cancerous or healthy.
screening tests and a vac- cer, including:
But then a team of research-
cine to prevent HPV infec- * Not having regular Pap
ers hit on a new strategy: drugs
tions are available. When tests
targeting proteins produced by
cervical cancer is found * Not following up with
cancer cells that seemed neces-
early, it is highly treatable your health care provider if
sary to their survival.
and associated with long you had a Pap test result that
Once such drug, Gleevec,
survival and good quality of is not normal
worked spectacularly in pa-
life. * Having HIV, the virus
tients with chronic myeloid leu-
There usually aren’t any that causes AIDS, or another
kemia. But the clinical trials that
symptoms of cervical cancer condition that makes it hard
followed mostly have produced
in its earliest, most treatable for your body to fight off
disappointments. According
stage. So it is important for health problems
to a study published earlier this
year, only 3% of cancer drugs women to get a Pap test (or
Pap smear) regularly. The Smoking
tested in clinical trials between
Pap test can prevent cervical There are many ways
2000 and 2015 have been ap-
cancer or find it early. In the women can live a healthy
proved to treat patients.
United States, the Pap test lifestyle and help improve
A study published earlier this
has reduced cervical cancer outcomes related to cancer.
month in the journal Science
rates by more than 70%. These include not smok-
Translational Medicine offers
Cervical cancer is almost ing and avoiding second-
one reason for the failure: Sci-
always caused by persis- hand smoke, making
entists are going after the wrong
tent infection with the hu- healthy food choices, get-
targets.
man papillomavirus (HPV), ting regular physical activ-
“I hope people will really
which is a common virus ity, maintaining a healthy
wake up to the need to be much
that can be spread from one weight, and getting recom-
more rigorous,” said Dr. William
person to another during mended cancer screenings.
Kaelin, a professor of medicine
sex. Women who are sexu- New York State and the
at Harvard University who was
ally active can reduce their Centers for Disease Control
not involved in the new study.
risk for HPV infection by and Prevention fund Cancer
Jason Sheltzer, a cancer bi-
using latex condoms dur- Services Program Partner-
ologist at Cold Spring Harbor
exposed the cells to the MELK- unreliable tools. But some critics questioned ing sex and by reducing the ships in each county to pro-
Laboratory in New York state,
targeting drug. It stopped the “A lot of the drug targets that whether RNAi was all that pre- number of sexual partners. vide access to cervical can-
and his colleagues made the
cancer cells anyway — even are in clinical trials today were cise. The technique may block Females between the ages cer screening to uninsured
discovery as they were trying
though they lacked the gene discovered with the best tech- not just a target protein, but of 9 and 26 or their parents women, ages 40 and older.
to come up with a new test for
that the drug targeted. nology from five or 10 years certain others as well. Sheltzer can also talk to their doc- If you are 40 or over, call the
breast cancer.
Seltzer wondered if he simply ago,” he said. tested this possibility with one tor about the HPV vaccine, Livingston and Wyoming
In certain forms of the dis-
had stumbled across a pecu- That technology, known as of the drugs in his experiment, which protects against the Counties Cancer Services
ease, cancer cells make high
liar case. So he widened his re- RNAi, seemed at the time like it OTS964. types of HPV that most of- Partnership for more
levels of a protein called MELK.
search, running the same exper- could zero in on cancer targets The researchers gave the ten cause cervical cancer. information or to see if
Extremely high levels can mean
iment with 10 other drugs. All with high precision. “Everyone drug to colonies of cancer cells Routine Pap tests are still you qualify for a free cancer
poor odds of survival for the pa-
were protein-targeting medica- thought finally we had the genie with the target protein removed. important even if someone screening at 1-800-588-
tient.
tions currently in clinical trials. in the lamp,” Kaelin said. Most still died — but a few did has received the vaccine. 8670.
Earlier studies had indicated
that MELK was essential to the With each drug, the scien- RNAi allows scientists to craft not. In addition to HPV infec-
spread of the cancer; indeed, tists got the same results. Every a molecule to block cells from The researchers sequenced
researchers were already testing supposedly essential protein making a particular protein. If the DNA of the surviving cells.
a drug for breast cancer that tar- turned out to be expendable blocking a protein’s production It turned out they all had muta-
gets the MELK protein. in the cancer cells, yet all these stopped cancer cells from grow- tions in the same gene, which Free Estimates Cut Down on
Two undergraduates in Shel- cells stopped growing when the ing, scientists looked for a drug encodes a protein called CD- Your Monthly
tzer’s lab, Ann Lin and Christo- scientists applied the drug. that also targeted that protein. K11B. Bills with Better
This sort of mistake may lead Insulation:
pher J. Giuliano, used CRISPR, Wet spray
the revolutionary DNA-editing to failures in clinical trials, Shel- cellulose
tool, to snip out the gene for tzer said. “When you design a Debbie Kaiser insulation in
MELK in cancer cells. The cells clinical trial, you want to pick Licensed Real Estate Salesperson new builds
should have stopped growing, out the patients who are most OR dry blown
likely to respond,” he said. “That Cell: 585.356.5217 in side walls
but to the surprise of the scien- and attics
trial may fail because you’re Office: 585.343.8434
tists, they did not.
picking the wrong people to give Fax: 585.343.0915
“The cancer cells did not care
whatsoever,” Sheltzer said. that drug to.” Email: DKaiser@GeraceRealty.com ADDITIONS & RENOVATIONS!
It was odd that the cells didn’t The mistakes Sheltzer has un- • Insulation (wet spray or dry blown)
need a supposedly essential covered may have come about • Pole Barns • Garages • Kitchens
gene. Odder still was what because the scientists who were • Bathrooms • Siding and Windows
®
hunting for drug targets used
happened when the scientists 6 Ellicott Avenue, NY 14020 Bill Sr. (585) 356-4992

138 Court St., Geneseo, NY 14454

127 North St., Batavia, NY
Cell: 585-746-6330 (585) 345-0417
Office: 585-243-2643
Fax: 585-243-1838 SAVE THE DATE
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6 • October 2019 Breast Cancer Awareness 2019

Risk menopausal women. Among

women already treated for
breast cancer, consuming the
against taking supplements of
isoflavones, a source of high
concentrations of plant-based
A good diet is linked to better results
From A3 alcohol equivalent of three or estrogen.
By LAURIE McGINLEY calories while consuming daily in the first place, not whether it
four drinks a week increases It’s also best to avoid satu- Post wire services servings of vegetables, fruit and provided a mortality benefit.
the risk of a recurrence, es- rated fats. Although there is

Parker and John P. Pierce of
the University of California,
San Diego, said breast cancer
patients who quit smoking can
add significantly to the benefits
of postoperative chemothera-
py and radiation.
Another important fac-
tor under personal control is
weight. As body mass index, or
BMI, rises, so does a woman’s
risk of developing breast can-
cer, especially if she carries
much of her excess weight
around her waist. That’s be-
cause abdominal fat is par-
ticularly metabolically active,
producing growth factors and
hormones, including estrogen,
that can stimulate the growth
of breast cancer cells.
Dr. Walter Willett, professor
of epidemiology and nutrition
at Harvard T.H. Chan School of
Public Health, told Nutrition
Action Healthletter in 2010:
“Probably the single most im-
portant thing women can do
to reduce their risk of breast
cancer is to avoid weight gain
in adult life.”
Being overweight also di-
minishes a woman’s chances
of surviving breast cancer, al-
though it is not known whether
losing weight after a breast
cancer diagnosis enhances
a lasting remission. My vote:
Don’t wait for definitive evi-
dence, since shedding excess
weight can reduce the risk of
heart disease, diabetes and
several other cancers.
A third factor clearly related
to breast cancer risk is alcohol.
Women who consume two to
five drinks a day are 40 percent
more likely to get breast can-
cer than nondrinkers. In fact,
just one drink a day can raise a
W
omen who followed a grains. Previously released data has
pecially for postmenopausal no overall link between dairy
lower-fat diet rich in The dietary-intervention shown that a lower-fat diet did
women and women who are products and breast cancer
fruits, vegetables and group fell short of the goal; not result in a reduced risk for
overweight or obese. risk, high-fat dairy foods like
grains had a lower risk of dying they managed to reduce their developing breast cancer.
However, a drink now and cheese, ice cream and whole
of breast cancer than those on a fat consumption to about 24.5 The breast cancer experts
then is not likely to be a prob- milk, which naturally contain
higher-fat diet, according to the percent, and then “drifted up also noted that the mortality
lem. As a breast cancer survivor estrogen, may shorten the lives
results of major study released to about 29 percent,” accord- benefit took almost 20 years to
for 18 years, I remain an occa- of breast cancer survivors.
Wednesday. ing to lead study author Rowan emerge, and some said that
sional drinker who has at most Based on a number of
The conclusions, from the Chlebowski of the Los Angeles it was not clear which dietary
two drinks a week and often studies, including a 20-year
latest analysis of the federally Biomedical Research Institute component was responsible for
none. follow-up of young American
funded Women’s Health Initia- at Harbor-UCLA Medical Cen- the benefit — the reduced fat or
As for what to eat, I’ll give nurses, the American Cancer
tive, provide the first random- ter. Members of the group lost 3 the additional fruits, vegetables
you one guess. The diet widely Society suggests that women
ized clinical-trial evidence that percent of their body weight on and grains.
promoted as protective against limit their consumption of red
diet can reduce postmeno- average. Still, the women in that The study authors said the di-
heart disease also is most effec- meat (beef, pork and lamb) to
pausal women’s risk of dying of group who developed breast etary-modification group used
tive against breast cancer. That two meals a week and greatly
breast cancer, the researchers cancer had a lower risk of death a diet similar to one called DASH
diet emphasizes fiber-rich limit or avoid processed meats
said. Past observational stud- than the women developed the — for Dietary Approaches to
vegetables, fruits and whole like bacon, sausage, luncheon
ies, which do not measure cause disease and followed their regu- Stop Hypertension — which is
grains, minimizes protein meats and hot dogs.
and effect, have had inconsis- lar diets. designed to prevent or treat high
foods like red meat that are rich Now to a personal favorite:
tent findings. Chlebowski said the study blood pressure.
in saturated fats, and includes physical activity. Not only can
The results “are exciting and showed that women could im- The new study “adds more
few if any sugar-sweetened regular exercise help to prevent
empowering for the patient,” prove their health by making evidence on the impact of diet,
foods and drinks. breast cancer and promote
said Elisa Port, chief of breast modest changes in what and but I wouldn’t rely on it to rec-
A recent analysis of 15 pro- recovery from the disease, but
surgery at Mount Sinai Health how much they eat. “This is di- ommend a specific diet to a
spective studies found the low- it also protects against many
System in New York, who was etary moderation. It’s not like patient,” given that people re-
est risk of breast cancer among other chronic ills and can help
not involved in the study. “This eating twigs and branches,” he act differently to different diets
women with the highest intake women achieve and maintain a
is a wake-up call for women — said. “It’s what people were eat- depending on their biology,
of fruit and vegetables. How- normal body weight.
there’s something they can do, ing, say, 20 years ago, before you said Neil Iyengar, an oncologist
ever, the strongest association More than 50 observational
rather than just waiting for the could pick up 900 calories in one at Memorial Sloan Kettering
was found, not for women who studies conducted here and
shoe to drop.” candy bar.” Cancer Center. “I tell patients if
changed their diets after breast in many other countries have
The trial involved more than The dietary intervention they eat more plant-based food,
cancer, but for those who ate found that active women have
48,000 women who did not lasted for 8.5 years and included less red meat, decrease alcohol
lots of fruit and vegetables ear- a lower risk of developing
have breast cancer when they several sessions with nutrition- and maintain a healthy weight,
ly in life and continued to do so breast cancer and lower mor-
enrolled in the study and was ists. The latest analysis repre- they might have a reduced risk
as adults. tality if they get it.
conducted at 40 centers across sents a follow-up of almost 20 of breast cancer recurrence or
Especially protective are You don’t have to become a
the United States. From 1993 years. Experts on breast cancer death.” The study did not look
vegetables and fruits rich in jock or run marathons to glean
to 1998, the women were ran- generally praised the study but at the effect of diet on the risk
substances called carotenoids, protection. Activities like brisk
domly assigned either to follow expressed some reservations. of breast cancer recurrence.
the orange-colored plant pig- walking are effective, especial-
their usual diet, in which fat ac- For one thing, the study was A separate study is looking at
ments that are precursors of ly if done for an hour a day. But
counted for 32 percent of daily designed to determine whether whether weight loss, achieved
vitamin A. These include not even 30 active minutes a day
calories on average, or to try to a low-fat diet could reduce the through cutting back calories
just sweet potatoes, carrots are better than none.
reduce fat intake to 20 percent of risk of developing breast cancer and increasing physical activity.
and winter squash but also
dark-green leafy vegetables
like spinach and kale, as well
as fruits like cantaloupe and
tomatoes.
With regard to soy foods, the
jury is still out. Although Asian Real Estate Services
women who consume lots of Ask me about the 100% Money Back Guarantee!
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Alcohol consumption af-
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that increase cancer risk in
both premenopausal and post-
tive substance in soy — isofla- Cell: 585.721.2155
vones — showed no benefit Office: 585.343.6750
among women who eat a West- davidadams@howardhanna.com
HowardHanna.com
ern diet. And experts caution

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The event is hosted by Genesee County ABATE and Stan’s Harley

Davidson and supported and co-hosted with Genesee County Ladies
of Harley Combat Vets (CVMA 19-6), CMA (Barnabas Riders #724)

52&+(67(55(*,21$/+($/7+35(6(1760$0026$1'0$.(29(56

$UH\RXRUROGHU"*UDE\RXUJLUOIULHQGVVFKHGXOHDVFUHHQLQJPDPPRJUDPDQGHQMR\D)5((
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Stan’s Harley Davidson
4425 W. Saile Dr., Batavia 7KXUVGD\2FWREHU_âSP
Registration 10am-11:45am and KSU at 12:00pm 7KH-HURPH&HQWHU &DOOWRUHVHUYH\RXUVSRW
$20/Rider • $10/Passenger %DQN6W
Join us for this fun event and ride, and let’s raise money for a %DWDYLD1< 
great cause! There will be 50/50 raffles, basket raffles, door
prizes, special item raffles, food trucks, breakfast in the 6DORQVHUYLFHVJUDFLRXVO\GRQDWHGE\7KH6SDDW$UWHPLV
morning, vendors and more. Don’t forget to wear your PINK
to show support! Get to Stan’s early and enjoy the vendors. 5RXWLQHPDPPRJUDPVFUHHQLQJVDUHFRYHUHGE\PRVWLQVXUDQFHSURYLGHUV)LQDQFLDODVVLVWDQFH
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