Вы находитесь на странице: 1из 40
STATE OF MICHIGAN IN THE CIRCUIT COURT FOR THE COUNTY OF WASHTENAW BOBBY GLENN REYES, Plaintiff, vs UNIVERSITY OF MICHIGAN C.S. MOTT CHILDREN’S HOSPITAL Defendant. William C. Amadeo (P76194) MCMANUS AND AMADEO 2500 Packard Street Suite 106 Ann Arbor, MI 48104 609.816.9438 williamamadeo@grabellaw.com Agerney EON Baby Glenn Reyes oct 11 208 - nty © Washtenaw Cou! Clerk of the Court Civil Action No, 19-1053-CZ Hon, David S. Swartz / J. Michael Huget (P39150) James E. Stewart (P23254) Rian C, Dawson (P81187) HonioMaN LLP 315 East Eisenhower Parkway Suite 100 Ann Arbor, MI 48108-3330 734.418.2000 mhuget(@honigman.com jstewart@honigman.com rdawson@honigman.com Denise 52358) UNIVERSITY OF MICHIGAN OFFICE OF THE VICE PRESIDENT AND GENERAL COUNSEL 300 North Ingalls Building, 300 Ingalls Street Ann Arbor, Michigan 48109 diwin@med.umich.edu Attorneys for Defendant University of Michigan C. S. Mott Children's Hospital DEFENDANT UNIVERSITY OF MICHIGAN C.S. MOTT CHILDREN’S HOSPITAL'S RESPONSE TO EMERGENCY PETITION FOR STAY OF PROCEEDINGS AND REMOVAL/TRANSFER TO THE COURT OF CLAIMS 32480522.1 The family of Bobby Reyes is facing unfathomable heartbreak. But regardless of what sympathy this Court and the undersigned attomeys have for the family and the devastating reality they face, this Court simply cannot override the law that plainly states it has no authority to enter any relief here. And even ifit did, the circumstances do not permit the relief the Petition or Bobby’ s parents seek, The standards for keeping the TRO intact (or extending it for any length of time) have not been met, nor can they be. Since September 22, 2019, Bobby has been at University of Michigan's C.S. Mott Children’s Hospital (“Mott”) in the ongoing care of one of the nation’s top Pediatric Intensive Care Units (“PICU”), And, since then, his status has unfortunately not changed. Tests performed on Bobby tragically show that he has no detectable brain activity. The initial brain death examination performed by the head of Pediatric Neurology at Mott on September 24, 2019, found that Bobby had no detectable brain or brain stem function. An electrical encephalogram detected no electrical activity in Bobby's brain. And a cerebral blood flow study detected no blood flow to Bobby’s brain. All of these tests have concluded that Bobby is brain dead To confirm Bobby’s brain death diagnosis, accepted medical standards and Michigan law require that a second, confirmatory brain death examination occur. Bobby's parents understandably do not want their worst fears confirmed, and on September 30, 2019, obtained a temporary restraining order (the “Order”) from this Court preventing Mott from performing the second examination. Bobby’s parents and Mott then agreed to modify the order on October 9, 2019 (the “Modified Order”) after giving Bobby’s parents time to identify a transfer facility willing 32480522.1 to take over Bobby’s care, The Modified Order expired today at noon, Despite its legal right to do so, Mott has not proceeded with any testing or reassessment of Bobby’s care. But, also as of today, no facility will accept Bobby as a patient, and with each passing day, his condition worsens. Medically appropriate care for Bobby depends on an accurate diagnosis of his condition, and that accurate diagnosis hinges on the results of a second brain death examination. ‘This Court should therefore deny the Petition. I. FACTUAL BACKGROUND The relevant facts are set forth in two affidavits. First is that of Dr. Michael Quasney, who is the Medical Director of the PICU at Mott and is the attending physician who admitted Bobby to the PICU and has remained very involved in decisions around his care, Ex. 1, Affidavit of Dr. Michael Quasney (“Quasney Aff.”){]2. Next is the affidavit of Dr. Christian Vercler, who is the Chair of the Pediatric Ethics Committee and is familiar with Bobby's case and with the ethical and legal issues attended to his case, Ex. 2, Affidavit of Dr. Christian Vercler (“Vercler Aff”) 3. By law in Michigan, an individual who has sustained either “(a) irreversible cessation of circulatory and respiratory functions” or “(b) itreversible cessation of all functions of the entire brain, including the brain stem” is dead. MCL 333.1033; see also Ex. 2, Vercler Aff. 6. The law further requires that “[a] determination of death shall be made in accordance with accepted medical standards.” MCL 333.1033; Ex. 2, Vercler Aff. ] 6. Accepted medical standards include a second confirmatory examination after an initial brain death examination has determined that irreversible cessation of all functions of the entire brain has occurred. Ex. 1, Quasney Aff 8; Ex. 2, Vercler AfE. 7. On September 24, 2019, two days after Dr. Quasney admitted Bobby to Mott, Dr. Steven Leber, the head of the Division of Pediatric Neurology, performed an initial brain death examination on Bobby using a well-established and widely accepted method. Ex. 1, Quasney Aff. 3 32480522.1 16. The examination showed that Bobby had no detectable brain stem function. Zdl at 7. Along, with that examination, Bobby's primary care team performed two additional ancillary procedures, both for detecting brain death. Id. at $9. Clinicians often perform these two ancillary procedures, ‘when the second exam cannot be performed, usually because of clinical instability of the patient Id. at] 12. The first procedure, an electrical encephalogram (“EEG”), is used to detect electrical activity in the brain, Id. at $10, The EEG detected no electrical activity in Bobby's brain, Ia. The second, a cerebral blood flow study, detects blood flow to the brain, Jd. at Li. Bobby's cerebral blood flow study found that there was no blood flow to his brain. Jd. On top of the results of these studies, Bobby has exhibited several other signs of brain death, including organ failure and elevated creatinine kinase levels indicative of ongoing muscle decomposition. Id. at 15. Before Bobby could undergo a second, confirmatory brain death examination, however, his obtained an Order from this Court preventing that second examination from going forward. Ex. 2, Vercler Af. 19 Before the Court entered that Order on September 30, 2019, and since, Bobby's parents have sought to transfer Bobby to another facility. Id. at ]]16. As of October 11, 2019, however, every facility that Bobby’s parents and his primary care team have reached out to has declined to take on Bobby's care, See id. at J 17-18. Dr. Michael Quasney even personally reached out to numerous facilities in Michigan and across the country, but none were willing to accept Bobby. Id. at $17. As more time passes, it is less likely that Bobby will be stable enough to transfer if a transfer facility is identified and accepts Bobby as a patient. Id, at 19. ‘The University of Michigan’s Pediatric Ethies Committee has opined that blocking further examination of Bobby is ethically impermissible and prevents Bobby's primary care team from delivering medically appropriate care to Bobby. Ex. 2, Vercler Aff. 16. As the Ethics Committee 32480522.1 notes, appropriate care of a patient turns on an accurate diagnosis of the condition being treated Id. at] 10. 1. ARGUMENT A. This Court Lacks Jurisdiction To Enter Equitable Relief Binding Mott ‘The Emergency Petition for Stay of Proceedings and Removal/Transfer to the Court of Claims (the “Petition”) admits that the Court of Claims holds exclusive jurisdiction over claims against the State. MCL 500.6419"; Sprik v Regents of Univ of Mich, 43 Mich App 178, 184 (1972). ‘see MCL 390.1 (establishing the University of Michigan); MCL 390.8(3) (requiring the University of Michigan to have “a department of medicine”)? In limited circumstances, both the Circuit Court and Court of Claims may have jurisdiction over a claim against the State or one of its agencies, See MCL 600.6419(1); MCL 600.6421; MCL 600.6440. Claims against the State for equitable relief, such as the type of relief here, do not fall into this category. Rather, the Court of Claims retains “exclusive jurisdiction over the matter of declaratory or equitable relief” MCL 600.6421(2) (emphasis added) Only the Court of Claims has the jurisdiction, and therefore the authority, to issue the equitable relief sought here against Mott. While “[IJack of proper venue . .. can be corrected by transfer of a cause to the proper forum; lack of jurisdiction cannot.” Fox v Bd of Regents of Univ ' The Court of Claims has the power and jurisdiction to hear and determine “any claim or demand, statutory or constitutional, liquidated or unliquidated, ex contractu or ex delicto, or any demand for monetary, equitable, or declaratory relief or any demand for an extraordinary writ against the state or any of its departments or officers notwithstanding another law that confers jurisdiction of the case in the circuit court.” MCL 600.6419(1)(a). 2 The Board of Regents for the University of Michigan is the operator of the University of Michigan Hospitals, of which C.S, Mott Children’s Hospital is a part. See Sections 11.36 and 11.42, The Bylaws of the University of Michigan Board of Regents, available at http://regents.umich.edu/bylaws/; see also Article I, Article IN| Amended and Restated Bylaws of the University of Michigan Health System Board, available at https: //wvww.med.umich.edu/exec/hhceb/bylaws.html. 5 32480522.1 of Mich, 375 Mich 238, 242 (1965). And so, “without jurisdiction of the subject matter, any action with respect to such a cause, other than to dismiss it, is absolutely void.” Id. The Petition’s attempt to distinguish For fails under the plain language of MCL 600.6421(2), as this case concerns a “matter of declaratory or equitable relief,” Moreover, the case the Petition references regarding circuit court jurisdiction over an action for monetary relief against a community college is also inapplicable, That case is presumably Doan v. Kellogg Community College, 80 Mich. App. 316 (1977). And there, the court determined that the community college was nota state agency because it was created by neither the constitution nor legislative act, Mott, on the other hand, is indisputably a state agency. Because this Court lacks jurisdiction, it cannot eure that defect by transferring the case to the Court of Claims. Furthermore, without jurisdiction, the Court lacked authority to enter any reliefiin this case, and the Order currently in place is void. As @ result, Michigan law demands that the TRO be dissolved and this case dismissed B. Even if this Court Had Jurisdiction, the Standards for Conti Have Not Been Met. ing the TRO Even if this Court were to somehow disregard the overwhelming body of Michigan ion to hear this case and to enter statutory and appellate authority to determine that it has jurisdi the order, the Plaintiff fails to meet the standards for continuing the TRO. ‘Michigan law places “the burden of justifying continuation of the order (] on the applicant for the restraining order whether or not the hearing has been consolidated with a hearing on a motion for a preliminary injunction or an order to show cause.” MCR 3.310(B)(5). Trial courts ‘may modify or dissolve an injunction in response to a motion if a change in circumstance warrants it. Michigan AFSCME Council 25 v Woodhaven-Brownstown School District, 293 Mich App 143, 146-147 n2 (2011). Bobby's parents have not shown any of the factors required to issue or to 32480522.1 continue equitable relief. See State Emps Ass'n v Dep't of Memal Health, 421 Mich 152, 157-58 (1984), Bobby’s parents have failed to show a likelihood of success on the merits. As detailed in the affidavit of Dr. Quasney, there is clear and convincing evidence that Bobby currently suffers from an “fi}rreversible cessation of all functions of the entire brain, including the brain stem,” and that that determination wes made “in accordance with accepted medical standards.” MCL 33,1033, Thus, according to the Michigan Determination of Death Act, Bobby is considered legally dead A continued injunction is also not in the public interest. It is in the public interest that medical care, even in such dire circumstances, be provided according to established norms. It is in the public interest, now, that Mott provide care to Bobby consistent with the accepted practices as detailed both in Dr. Quasney and Dr. Vercler’s affidavits. Otherwise, Mott would be in the ister the care impossible position of being required to retain a patient but not be permitted to admi it deems necessary, appropriate, and ethically required. It is in the public interest to avoid such a situation, ‘As to the requirement for showing irreparable harm were the injunction not to issue, the hard and inescapable fact is that the irreparable injury to Bobby has already occurred, as detailed in the affidavits of Drs. Quasney and Vercler. Tragically, nothing can change that fact. Finally, as to the comparative harm element of injunctive relief, continuing the injunction and preventing the Mott team from rendering the care the doctors deem appropriate simply does not benefit Bobby, At the same time, continuing the injunction prevents the highly-regarded professionals at Mott from providing the care it deems necessary. The fact that no other institution 32480522.1 (despite significant efforts by Mott and Bobby’s representatives) will take Bobby only underscores the propriety of Mott’s determination regarding how to proceed with Bobby’s medical care. Ill. CONCLUSION For the foregoing reasons, this Court should deny the Dated: October 11, 2019 32480522.1 the Petition seeks. Respectfully submitted, HONIGMAN LLP Attorneys for Defendant University of Michigan C.S. Mott Children’s Hospital ov) Nebel Hig — I. Michael Huget (P39150) 315 East Eisenhower Parkway Suite 100 ‘Ann Arbor, MI 48108-3330 734.418.2000 mbhuget@honigman.com CERTIFICATE OF SERVICE On October 11, 2019, I filed the foregoing documents with the Clerk of the Court, Ialso sent a copy of the foregoing papers via email to all counsel of record Dated: October 11, 2019 32480522.1 EXHIBIT 1 STATE OF MICHIGAN IN THE CIRCUIT COURT FOR THE COUNTY OF WASHTENAW BOBBY GLENN REYES, Plaintiff, vs. Civil Action No, 19-1053-CZ Hon. David S, Swartz UNIVERSITY OF MICHIGAN CS, MOTT CHILDREN’S HOSPITAL Defendant. / AFFIDAVIT OF DR. MICHAEL QUASNEY STATE OF MICHIGAN ) dss. COUNTY OF WASHTENAW) 1, MICHAEL QUASNEY, declare and state as follows: 1. Lhave knowledge of the facts stated herein based on my personal knowledge, am competent to testify to these facts, and will so testify if called and sworn as a witness. 2, Lam a tenured Professor in Pediatric Critical Care Medicine at the University of Michigan, licensed and board-certified in Pediatric Critical Care Medicine, and Division Director and Service Chief in the Division of Pediatric Critical Care Medicine. I am also the Medical Director of the Pediatric Intensive Care Unit (the “PICU) at C.S. Mott Children's Hospital (“Mott”), A curent copy of my Curriculum Vitae is attached as Exhibit A. 3. Thave practiced Pediatric Critical Care Medicine for over 25 years and performed scores of neurologic exams in attempts to elicit brain stem function for the purposes of the declaration of brain death, Thus, I am very familiar with these types of exams, including conducting them and analyzing their results. 32417469.1 4, In my academic capacity, I am involved in instructing and supervising medical students in the University of Michigan Medical School, pediatries intems and residents, and fellows in Pediatric Critical Care Medicine, I also instruct and supervise students, interns, residents, and fellows in other medical disciplines on how to care for critically ill and injured children, including children who have experienced severe anoxic brain injury after cardiac arrest. As such, [ attest thet I have sufficient familiarity with the relevant standards of care to opine on performing exams in detecting brain stem function and the declaration of brain death. 5. Iwas the attending physician who admitted Bobby Reyes to the PICU on the night of September 22, 2019, and have remained very involved in decisions around his care and in discussing his case with his parents, 6 On September 24, 2019, Bobby underwent en initial brain death examination, using ‘a widely and well-accepted methodology performed by the head of the Division of Pediatric Neurology, Dr. Steve Leber. Dr. Leber was involved in determining the standards for the declaration of brain death in children at the University of Michigan. 7. The results of that examination yielded that Bobby has no detectable brain stem function. 8. Typically, two separate physicians perform two separate brain death examinations to make the determination of death. In Bobby’s case, however, his parents, Sarah Jones and Jose Reyes, have refused to allow Bobby's primary care team to perform the second exam. 9. In addition to the first brain death examination, two ancillary studies were also performed on Bobby. 10, The first, an electrical encephalogram (“EEG”), is used to detect electrical activity in the brain. The EEG detected no electrical activity in Bobby's brain. 32417469.1 11, The second, a cerebral blood flow study, detects blood flow to the brain. The cerebral blood flow study did not detect any blood flow to Bobby’s brain. 12. Both of these ancillary studies are frequently performed in the determination of brain death when the second exam cannot be performed, usually because of clinical instability of the patient. 13. Each of these three tests—the brain death examination, the EEG, and the cerebral blood flow study—support the clinical diagnosis of brain death. 14, Bobby has not regained any evidence of brain function since his admission over two weeks ago on September 22, 2019. 15. During this time, he has increasingly demonstrated evidence of various other organ failures including failure of the liver and kidney. Failure of these organs is typical after the declaration of death. His creatinine kinase is also elevated, which is suggestive of ongoing muscle decomposition and in turn is contributing to his kidney dysfimetion. 16. Bobby’s parents wish to transfer him to another facility that will treat him and give him more time to recover. 17. I personally have reached out to several facilities and institutions out of state as ‘well os within the state of Michigan, No place has agreed to accept Bobby because of the severity ofhis anoxic injury. 18, The parents have given me names of other physicians that are helping them, but no cone has a facility willing to and capable of caring for him. 19, Bobby is also nearing the point of becoming too hemodynamically unstable to move. 20. Even if a long term care facility were to accept Bobby, he would have to have a 32417460.1 tracheostomy performed which I, as well as a Pediatric Otolaryngologist that the family contacted personally, would find morally and ethically wrong to do in his state, I declare under the penalty of perjury under the laws of the State of Michigan that the foregoing is true and correct. Further affiant sayeth not. \ MICHAEL QUASNE' Subscribed and sworn to before me this day of October, 2019 Notary Public Mish danbpypty, State of Michigan, My Commission Expires: “3, te [tore oese Ht AON Noe PUBL, STATE OF wr coat ocnisirew COMMISSION PRES er ACTIN COWMTY OF Te 30417468. EXHIBIT A Director, sorr2018 Michael W. Quasney, M.D., Ph.D. Professor Division of Pediatric Critical Care Medicine Department of Pediatrics and Communicable Diseases University of Michigan Medical School Education and Training 9/1973-8/1979 9/1979-12/1985 8/1984-6/1988 7/1988-6/1990 7/1990-6/1991 711991-6/1994 10/2012 ication and Licensure ‘Ann Arbor, Michigan 48109 (734) 764-5302 mquasney@med.umich.edu BS, Zoology, University of Michigan PhD, Cellular and Molecular Biology, University of Michigan MD, University of llinois Medical School, Chicago, IL Residency, Pediatrics, Northwestem University, IL Residency, Pediatrics, University of Tennessee, Memphis Fellowship, Pediatric Critical Care, University of Tennessee Leadership Development for Physicians in Academic Health Centers, Harvard School of Public Health Board Certifications Issue Date Expiration American Board of Pediatrics, Pediatric Critical Care Subspecialty 1998, 2006 2026 Licensure Issue Date Expiration Michigan #4301101921 02/1/2013 01/31/2020 Academic, Administrative, and Clinical Appointments Academic Appointments University of Tennessee He: 7/1994-6/1996 7/1998-6/2000 7/2000-6/2005 7/2005-9/2006 alth Science Center Instructor, Department of Pediatrics Assistant Professor, Department of Pediatrics Associate Professor, Department of Pediatrics Professor with tenure, Department of Pediatrics Michael Quasney, MD, PhO May 19, 2017 1 Medical College of Wisconsin 410/2006-11/2012 Professor with tenure, Department of Pediatrics University of Michigan 12/2012-present Professor with tenure Division Director, Pediatric Critical Care Medicine Department of Pediatrics Administrative Appointments University of Tennessee Health Science Center/Le Bonheur Children’s Medical Center 7/2001-6/2006 Medical Director, ECMO Program 07/2001-06/2004 Director, Pediatric Critical Care Fellowship Program 8/1995-6/2003 Medical Director, Special Care Unit 7/2001-6/2006 Medical Director, ECMO Program Medical College of WisconsiniChildren’s Hospital of Wisconsin 4/2011-11/2012 Chief of Medicine University of Michigan Health Systems/CS Mott Children’s Hospital 12/2012-present Chief of Pediatric Critical Care Services Clinical Appointments Le Bonheur Children’s Medical Center 7IM994-8/2006 Attending Staff Physician, Pediatric Intensive Care Unit Children’s Hospital of Wisconsin 10/2006-11/2012 Attending Staff Physician, Pediatric Intensive Care Unit CS Mott Children’s Hospital 42/2012-present Attending Staff Physician, Pediatric Intensive Care Unit Research Interests Genetics of acute lung injury and sepsis, molecular mechanisms of critical illness, long term outcomes of critical illness in children Michael Quasney, MO, PhO May 19, 2017 2 Grants A. Active (none currently) B. Previous Grants Title: Source: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title: ‘Source: Role: Dates: Direct Funds: Title ‘Source: Role: Dates: Direct Funds: Title: Souree: Role: Dates: Direct Funds: Genetic variation and biomarkers in children with acute lung injury NIH/NHLBI: 1RO1HLO95410-01A1 Principal investigator 4/1/2008-3/81/2014 $1,189,709 A prospective, open label study to assess the pharmacokinetics, safety and efficacy of anidulafungin when used to treat children with invasive candidiasis, including candidemia Pfizer Site Principal Investigator 10/41414-11/2012 $19,806/patient Genetic variation and biomarkers in children with acute lung injury (supplement) NIH/NHLBI: 3R01HLO95410-01A1S1 Principal Investigator July 2009-June 2011 $234,644. Calfactant therapy for direct acute respiratory distress syndrome and direct acute lung injury in adults and children Pneuma Partners Site Principal Investigator 5/7/2008-1/6/11 $23,000/patient Influence of genetic variation in pathogen recognition genes in pediatric lung injury ‘The Nathaniel Adamazyk Foundation Principal Investigator 2009-2010 $15,000 Genetic Polymorphisms in Pediatric Lung Injury NIH/NHLBI 1R21HLO72375-01A1 Principle Investigator July, 2004 - June, 2006 $401,500 Michael Quasney, MD, PhO May 19, 2017 3 B. Previous Grants (cont,) Title: Source: Role: Dates: Direct Funds: Direct Funds: Title: Source; Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title Soures: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Vascular Reactivity in Black Youth NIH/NHLBI Co-Investigator July , 2003 - June, 2008 $1,387,784 Gene polymorphisms prevention of disability National Institute of Health (NIA) Collaborating investigator July 2001 — June 2005 $1,627,613 Genetic polymorphisms in the TNF locus in children with Kawasaki disease American Heart Association-Southeastem Affliate Principal investigator July 1, 2000 ~ June 30, 2002 $118,800 Impact of TNF-a. and IL-10 gene polymorphisms on outcome in pneumonia ‘American Lung Association Principal investigator July 1, 2000 — June 30, 2002 $50,000 TNF and IL-10 polymorphisms in severe bacterial infections: association with outcomes Le Bonheur Children Medical Center Principal Investigator 1999 - 2000 $12,500 Functional domains of the human D1 dopamine receptor Crippled Children’s Research Foundation Principal investigator 1996 - 1999 $180,000 Long-term functional outcome of children after head trauma, Herbert and Mary Shainberg Neuroscience Research Program Co - Principal ti 1997-1998 $7,500 May 19, 2017" B. Previous Grants (cont) Title: Source: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title: Source: Role: Dates: Direct Funds: Title Source: Role: Dates: Direct Funds: B, Sub Incidence of retinal hemorrhages after cardiopulmonary resuscitation in pediatric patients Methodist Hospitals Foundation Research Grant Principal investigator 1996-1998 $56,000 Random mutagenesis of the Dai dopamine receptor University of Tennessee Medical Group Principal investigator 1995 $12,500 Random mutagenesis of the Da: dopamine receptor Le Bonheur Children's Medical Center Principal Investigator 1994 - 1995 $10,000 Random mutagenesis of the renal dopamine receptor West Tennessee Kidney Foundation Principle Investigator 1994 $5,000 fed/pending review Grants Honors and Awards University of Michigan Honors Council Research Grant, 1978 University of Michigan Cancer Research Institute Research Grant, 1979 NIH National Research Service Award, 1979 Rackham Graduate School Dissertation Grant, 1982 University of Michigan Cancer Research Institute Research Grant, 1983 Kass Fellowship, Infectious Diseases Sociely of America, 1998 Outstanding Clinical Research Award, Pediatric Critical Care Colloquium, 1999 Society of Critical Care Medicine Annual Scientific Award, 2008 ATS Respiratory Structure and Function Assembly Abstract Excellence Award, 2011 Selected Innovator speaker at Faster Cures Conference, New York, NY, 2011 Michael Quasney, MD, PhO May 19, 2017 5 Memberships in Professional Societies 06/1997-present 11/1992-present American Academy of Pediatrics Society of Critical Care Medicine Editorial Positions, Boards, and Peer-Review Service 06/2003-present 06/2003-present 06/1997-present 10/2009-present Ad hoc Reviewer, Critical Care Medicine Ad hoc Reviewer, Pediatric Critical Care Medicine Ad hoc Reviewer, Pediatrics ‘Ad hoc Reviewer, Intensive Care Medicine Committee, Organizational, and Volunteer Service 7/1995-6/1997 ‘711995-6/1997 7/1996-6/1998 7M1996-6/1998 7/1996-6/2000 1996-2006 ang97 40/1997-10/2000 6/1997-8/2006 4/1998 7/1998-10/2000 411999 9/2000 10/2000-9/2006 10/2001-6/2005 10/2009 41/2009 2009 2010 Utilization Review Committee Quality Improvement Committee Medical Records Committee Infection Control Committee Cardiovascular Morbidity and Mortality Subcommittee Hospital representative to National Association of Children’s Hospitals and Other Related Institutions (NACHRI) Intensive Care Physician with International Children’s Heart Foundation, Zagreb, Croatia Chairman, Critical Care Committee Morbidity and Mortality Committee Intensive Care Physician with International Children's Heart Foundation, Zagreb, Croatia Chairman, Cardiovascular Morbidity and Mortality Subcommittee Intensive Care Physician with international Children's Heart Foundation, Lima, Peru Intensive Care Physician with International Children's Heart Foundation, Shanghai and Nanjing, China Chairman, Harvey Team Review Committes Chairman, Morbidity and Mortality Committee NHLBI Program Project Special Review Committee NHLBI Program Project Special Review Committee Pediatric Academic Society Abstract Review Committee Pediatric Academic Society Abstract Review Committee el Quasney, MD, PhD May 18, 2017 6 Visiting Professorships, Seminars, and Extramural Invited Presentations Mutagenesis of dopamine receptor. Vanderbilt University, 7/1998. Do retinal hemorrhages accur after CPR in Children? A prospective, multi-institutional study. National Conference on Shaken Baby Syndrome, Salt Lake City, 9/1998 Genetic influences on outcome in the PICU. John Hopkins University, Baltimore, MD 2/2000 Genetic variation in critical iliness. 1* Annual Maureen Rich Lecture, Medical College of Wisconsin, 11/2008 Genetic polymorphisms in sepsis and lung injury. Medical College of Wisconsin, 11/2005 ‘Support of Genetic variations in Critical Care. University of Louisville, 4/2004 Influence of genetic variation on the severity of lung injury in children. University of Tennessee, Memphis, TN, 11/2008 Influence of genetic variation on the severity of lung injury in children with pneumonia. Children's Hospital Medical Center, Omaha, NE, 24 July 2009 Influence of genetic variation on the severity of lung injury in children with pneumonia, St Jude's Children’s Research Hospital, Memphis, TN, 11/2009 ECMO, Current Concepts in Pediatric Critical Care, Society of Critical Care Medicine, San Diego, CA, 1/2010. Underlying genetic risk factors for the development of community acquired pneumonia and progression to ARDS, Pediatric Academic Society, Denver, 5/2011 Underlying genetic risk factors for the development of sepsis, Mexico City, 5/2011 Molecular pathophysiology of sepsis, Mexico City, 5/2011 Genomics in Lung Disease, American Thoracic Society International Conference, Philadelphia, PA 5/18/2013 Initial steps for the stabilization of the child in shock, Partners in Pediatric Care |, Traverse City, MI 6/2/2014 Initial steps for the stabilization of the child in shock, Partners in Pediatric Care Il, Bay City, Ml 5/8/2014 Pediatric septic shock: si there a genetic susceptibility? Leon, Mexico; September 11-13, 2014. ‘Congreso Nacional De Terapia Intensiva Pediatrica 2014. Inflammatory response during cardiopulmonary reanimation. Leon, Mexico; September 11-13, 2014. Congreso Nacional De Terapia Intensiva Pediatrica 2014. Pediatric septic shock: what is the real clinical value of biomarkers. Leon, Mexi 11-13, 2014. Congreso Nacional De Terapia Intensiva Pediatrica 2014, Pediatric Critical Care Medicine and Collaborative Quality Improvement. Ann Arbor, Michigan, October 17, 2014. ; September Bibliography Peer-Reviewed Journals and Publications 4. Campbell, KL, P Bagavandoss, MD Byrne, JA Jonassen, TD Landefeld, MW Quasney, MM Sanders, and AR Midgley. Differential processing of the two subunits of human choriogonadatropin by granulosa cells. Il. In vivo studies. Endocrinology 109, 1858-1871, 1981 2. Dahmer, MK, MW Quasney, ST Bissen, and WB Pratt. Molybdate permits resolution of untransformed glucocorticoid receptors from the transformed state. J. Biol. Chem. 256, 9401- 9405, 1981. Michael Quasney, MD, PHO May 19, 2017 3. Quasney, MW. Association of SV40 T antigen with viral minichromosomes. Doctoral thesis, University of Michigan. 1985. 4, Hadlock, KG, MW Quasney, and LC Lutter. Immunoprecipitation of the Simian Virus 40 late transcription complex with antibody against T-antigen. J. Biol. Chem. 262, 15527-18537, 1987. 5. Cohn, SL, H Salwen, MW Quasney, N Ikegawa, JM Gowan, CV Herst, RH Kennet, ST Rosen, JA DiGiuseppe, and'GM Brodeur. Prolonged N-myc protein half-lfe in @ neuroblastoma cell line lacking N-myc amplification. Oncogene, 5, 1821-1828, 1990. 6. Cohn, SL, H Salwen, MW Quasney, N Ikegaki, JM Cowan, CV Herst, B Sharon, RH Kennett, and ST Rosen. High levels of N-my¢ protein in'a neuroblastoma cell line lacking N-myc. amplification, Progress in Clinical and Biological Research, 366:21-27, 1991 7. Zuckerman, 8, MW Quasney, P Bozman, and G Stidham. ‘Care of critically il children with cancer. Current Opinions in Pediatrics, 4:462-468, 1992. 8. MW Quasney and RJ Legglacro. Pleural effusion associated with histoplasmosis. Pediatric Infectious Disease Journal, 12:415-418, 1993. 9. Senogles, SE and MW Quasney. The use of iransfection techniques in the study of the Dz dopamine receptor. Endocrine Methods, pg. 355-369, 1996. 10.Odom, A, E Christ, K Byrd, N Kerr, R Walling, M Bugnitz, F Barr, J Ring, S Storgion, J Cochran, G Stidham, and M Quasney. Incidence of retinal hemorrhages in pediatric patients after cardiopulmonary resuscitation: a prospective study. Pediatrics, 99:63, 1997. 11.Quasney, MW, K Orman, J Thompson, J Ring, § Mubadda, R Schoumacker, D Watson, W Novick, $ Dietcher, and R Joyner. Plastic Bronchitis Occurring Late Following Fontan's Procedure: Treatment with Nebulized Urokinase and a Cardiac Pacemaker. Critical Care Medicine, 28:2107-2111, 2000. 12.Quasney, MW, D Goodman, M Billow, L Easterling, L Frankel, D Habib, M Heitschmidt, S Kurachek, F Moler, V Montgomery, M Moss, S Murman, T Rice, B Richman, and S Tilden. Efficacy cf routine chest radiographs in pediatric intensive care units. Pediatrics, 107:241-248, 2001. 13, Buckingham, SC, MW Quasney, and JP DeVincenzo. Respiratory syncytial virus infections in the pediatric'intensive care unit: clinical characteristics and risk factors for adverse outcomes. Pediatric Critical Care Medicine, 2:318-323, 2001 14. Quasney MW, DE Bronstein, R’ Cantor, Q Zhang, C Stroupe, H Shike, JF Bastian, T Matsubara, M Fujiwara, K Akimoto, JW'Newburger, and JC Burns. Increased frequency of alleles associated with elevated TNF-a levels in children with Kawasaki disease. Pediatric Research, 49:686-690, 2001 1.Livingston, JC, V Perk, JR Barton, S Eifering, B Haddad, WC Mabie, MW Quasney, BM Sabai. Lack of association of severe preeclampsia with maternal and fetal mutant alleles for tumor necrosis factor a. and lymphotoxin a genes and plasma tumor necrosis a. levels. American Joumal of Obstetrics and Gynecology, 184:1273-1277, 2001, 16.Waterer, GW, MW Quasney, RM Cantor, and RG Wunderink. Septic shock and respiratory fallure in community-acquired pneumonia have different TNF polymorphism associations. ‘American Journal of Respiratory and Critical Care Medicine, 163:1599-1604, 2001 17.Quasney, MW , Q Zhang, S Sargent, M Mynatt, J Glass, J McArthur. Increased frequency of the TNF-a-308 A allele in adults with HIV dementia. Annals of Neurology, 50:157-162, 2001 18.Kurachek SC, CJ New, MW Quasney, T Rice, RC Sachdeya, NR Patel, J Takano, Easterling, M’Scanlon, N Musa, Ru Brill, D Wells, GS Park, S Penfil, KG Bysani, MA Nares, L Lowrie, £ Chiochetti, B Lindgren. Extubation in Pediatric Inlensive Care Units: A’Multicenter Study of Risk Factors and Outcomes. Critical Care Medicine, 32:1632-1643, 2003. 19. Delos Santos NM, BH Ault, AG Gharavi, SB Kritchevsky, MW Quasney, EC Jackson, KA Fisher, SY Woodford, BL Mitchell, LW Gaber, KL Arheert, and RJ Wyatt. Angiotensin: converting enzyme genotype and outcome in pediatric IgA nephropathy. Pediatric Nephrology, 17:496-502, 2002. 20.McArthur JA, Q Zhang, and MW Quasney. Association between the A/A genotype at the lymphotoxin-alpha+250 site and increased mortality in children with positive blood cultures. Pediatric Critical Care Medicine, 3:341-344, 2002. Michael Quasney, MD, PhO May 19, 2017 8 21.Waterer GW, L ElBahlawan, MW Quasney, Q Zhang, LA Kessler, and RG Wunderink. Heat shock protein-2+1287 AA homozygotes have an increased risk of septic shock in adults with community acquired pneumonia. Critical Care Medicine, 31:1367-1372, 2003. 22.Yende S, MW Quasney, EA Tolley, and RG Wunderink. Association of tumor necrosis factor gene polymorphisms and prolonged mechanical ventilation after coronary artery bypass, surgery. Critical Care Medicine, 31:133-140, 2003. 23.Waterer GW, SC Buckingham, LA Kessler, MW Quasney, and RG Wunderink. Decreasing beta-lactam resistance in pneumococci from the Memphis region: Analysis of 2152 isolates from 1996-2001. Chest, 124:519-525. 2003. 24. Senogles SE, TL Heimert, ER Odife, and MW Quasney. A region of the third intracellular loop of the D2s dopamine receptor dictates Gi coupling specificity. Journal of Biological Chemistry, 279:1601-1606, 2004. 25. Yende S, MW Quasney, EA Tolley, and RG Wunderink. ical relevance of angiotensin- converting enzyme gene polymorphisms to predict risk of mechanical ventilation after coronary artery bypass surgery. Critical Care Medicine, 32:922-927. 2004. 26. Kazzi SN, SM Jacques, F Quershi, MW Quasney, UO Kim, [A Buhimschi. Tumor necrosis factor-alpha allele Iymphotoxin-alpha+250 is associated with the presence and severity of placental inflammation among preterm births. Pediatric Research, 56:94-98, 2004. 27.Quasney MW, GW Waterer, MK Dahmer, GK Kron, Q Zhang, LA Kessler, and RG Wunderink. Association between surfactant protein B polymorphism and the risk of respiratory failure in adults with community acquired pneumonia. Critical Care Medicine, 32:1115-1119 2004. 28.Kazzi SNJ, UO Kim, MW Quasney, and | Buhimschi. Polymorphism in tumor necrosis factor-0 and risk and severity of bronchopulmonary dysplasia among very low birth weight infants. Pediatrics, 114:2243-248, 2004. 29.Bledsoe B, K Groshart, Q Zhang, MW Quasney, A Disanjh. The microextraction of RNA from archival cardiac allografts embedded in paraffin. Clin Transplant, 18: 591-595, 2004. 30.Elbahlawan, LM, GS Stidnam, MC Bugnitz, SA Storgion, and MW Quasney. Severe systemic reaction to Loxosceles Recluse spider bites in a pediatric population. Pediatric Emergency Gare, 21: 177-180, 2005. 31.Dahmer MK, A Randolph, S Vitali, MW Quasney. Genetic polymorphisms in sepsis. Ped Crit Care Med, 6: S61-S73, 2005. 32, Kazzi SNJ and MW Quasney. Deletion alfele of angiotensin-converting enzyme is associated with increased risk and severity of bronchopulmonary dysplasia. Journal of Pediatrics, 147:818-822, 2005. 33.Elbahlawan L, $ Binaei, M Christensen, Q Zhang, MW Quasney, MK Dahmer. 82-adrenergic receptor polymorphisms in African American children with asthma, Pediatric Critical Care Medicine, 7:15-18, 2006. 34.Kazzi SNJ, G Tromp, MW Quasney, IA Buhimschi, and J Janisse. Haplotypes of Tumor Necrosis Factor Gene and Levels of Tumor Necrosis Factor-alpha in Preterm Infants. Pediatric Research, 64:165-170, 2008. 35.Patwari, P, O'Cain, P, Goodman, DM, Smith, M, Krushkal, J, Liu, C, Somes, G., Quasney, MW, and Dahmer, MK. Interleukin-1 receptor antagonist intron 2 VNTR Polymorphism and Respiratory Failure in Children with Community Acquired Pneumonia, Ped Crit Care Med, 9:553-559, 2008. 36. Levy, H, A Murphy, F Zou, C Gerad, B Klanderman, B Schuemann, R Lazarus, C Garcia, JC Celedon, M Drumm, M Dahmer, M Quasney, G Cuiting, MR Knowles, GB Pier, C Lange, and ST Weiss. IL-18 polymorphisms modulate cystic fibrosis lung disease. Pediatric Pulmonary, 44:580-593, 2009. Michael Quasney, MD, PhO May 19, 2017 ° 37.61 Saleeby, C.M., Li, R., Somes, G.W., Dahmer, M.K., Quasney, M.W., DeVincenzo, J.P. Surfactant Protein A2 Polymorphisms and Disease Severity in a Respiratory Syncytial Virus Infected Population. J Pediatr., 156:409-14, 2010. PMID: 19914637 38.Park, S.K., Amos, L., Rao, A., Quasney, M.W., Matsumura, Y., Inagaki, N., Dahmer, M.K. Identification and Characterization of a Novel ABCA3 Mutation, Physio! Genomics, Jan 8;40(2):94-9, 2010, PMID: 19861431, 39. Russell, R.A., Quasney, M.W., Halligan, N., Li, $.4., Simpson, P., Waterer, G., Wunderink, R. G., Dahmer, M.K. Genetic Variation in MYLK and Lung Injury in Children and Aduits with Community-Acquired Peumonia, Pediatr, Crit. Care Med., 2010. PMID: 20081554 40.Kelsey, R., Alpert, B., Dahmer, MK, Krushkal, J. Quasney, MW. Beta-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in black adolescents and young adults. Psychophysiology, 47:863-873, 2010. PMID: 20374546 41.Sapru, A, and M.W. Quasney. Host genetics and pediatric sepsis. Open inflammation, 4:82- 100, 2011. 42.McArthur, J, and M.W. Quasney. The role of selenium in sepsis. Open inflammation, 4:115- 419, 2011. 43.Dahmer, M.K., O'Cain, P., Patwari, P.P., Simpson, P., Li, S.H., Halligan, N., Quasney, M.W. The influence of genetic variation in surfactant protein B on severe lung injury in African American children, Crit, Care Med, 39:1138-1144, 2011. PMID: 21283003 (high impact paper selected for editorial comment. Crit Care Med) 44.De Jesus, L.C., S.N.J. Kazi, M.K. Dahmer, X. Chen, and MW Quasney. Role of angiotensin converting enzyme gene polymorphisms in persistent pulmonary hypertension of the newborn. Acta Paediatrica, Mar 19, 2011. PMID: 21418104 45.Turmer, D., Simpson P., Li S.H., Scanlon M., Quasney, M.W. Racial disparities in pediatric intensive care unit admissions. Southem Medical Journal, 104:640-646, 2011. PMID: 21886083 46.Kelsey, R., Alpert, B., Dahmer, MK, Krushkal, J. Quasney, M.W. Alpha-adrenergic receptor gene polymorphisms and cardiovascular reactivity to stress in black adolescents and young adults, Psychophysiology, 49:401-412, 2012. PMID: 22091949 47.Elbahlawan, L.., J. McArthur, MW. Quasney, D. Pei, K Srivastava, M.K. Dahmer, R. Barfield. Association of IL-1b-511 polymorphism with severe veno-occlusive disease in pediatric matched myeloabiative allogeneic hematopoietic stem cell transplantation. Journal of Pediatric Hematology and Oncology, 34:175-179, 2012. PMID: 22305218 48.Baughn, J.M., MW. Quasney, P. Simpson, D. Merchant, S.H. Li, H. Levy, M.K. Dahmer. Association of CFTR gene variants with acute lung injury in African American children with pneumonia. Critical Care Medicine, 40:3042-3049, 2012. PMID: 22890249 49.Park, S.K., M.K. Dahmer, and M.W. Quasney. MAPK and JAK-STAT signaling pathways are involved in the oxidative stress-induced decrease in expression of surfactant protein genes. In press, Cellular Physiology and Biochemistry, 30:334-346, 2012. PMID: 22739240 50. Levy, H., X. Wang, M. Kaldunski, S. Jia, J. Kramer, S. Pavletich, M. Reske, M.W. Quasney, M.K. Dahmer, J Gorski, and M.J. Hessner. Transcriptional signatures as a disease-specific and predictive inflammatory biomarker for type 1 diabetes. Genes and Immunity, 13:593-604 2012.PMID: 22972474 51. Wong, H.R., S. Salisbury, Q. Xiao, N.Z. Cvijanovich, M. Hall, G.L. Allen, N.J. Thomas, RJ. Freishtat, N. Anas, K. Meyer, P.A. Checchia, R. Lin, T.P. Shanley, M.T. Bigham, A. Sen, J Nowak, M.W. Quasney, J.W. Henricksen, A. Chopra, S. Banschbach, E. Beckman, K. Harmon, P. Lahni, and C.J. Lindsell, The pediatric sepsis biomarker risk model. Critical Care, 16:R174-R182, 2012.PMID: 23025259 Michael Quasney, MD, PhO May 19, 2017 10 52.Wong HR, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Cheeshia PA, Lin R, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Shanley TP. Interleukin-27 is @ novel candidate diagnostic biomarker for bacterial infection in critically ill children. Critical Care, 6:R213, 2012 PMID:23107287 53.Willson, DF, NJ Thomas, R Tamborro, & Truemper, J Truwit, M Conaway, C Traul, EE Egan, and the Pediatric Acute Lung Injury and Sepsis Investigators Network*. Pediatric Calfactant in acute respiratory distress syndrome trial. Pediatric Critical Care Medicine, 14:657-665, 2013. PMID: 23846250 54,Willson, DF, NJ Thomas, R Tamborro, E Truemper, J Truwit, M Conaway, C Traul, EE Egan, and the Pediatric Acute Lung Injury and Sepsis Investigators Network*, The relationship of fluid administration to outcome in the pediatric Calfactant in acuter respiratory distress syndrome trial. Pediatric Critical Care Medicine, 14:666-672, 2013, PMID: 23925143 55.Abdulebda K, NZ Cvijanovich, NJ Thomas, GL Allen, N Anas, MT Bigham, M Hall, RJ Freishtat, A Sen, K Meyer, PA Checchia, TP Shanley, J Nowak, M Quasney, SL Weiss, A Chopra, § Banschbach, E Beckman, CJ Lindsell, and HR Wong. Post-ICU admission fluid balance an pediatric septic shock outcomes: a risk-stratified analysis. Critical Care Medicine, 42:397-403, 2014, PMID: 24145842 56.Wong, HR, SL Weiss, JS Jr Giuliano, MS Wainwright, NZ Gvijanovich, NJ Thomas, GL Allen, NN Anas, MT Bigham, M Hall, RU Freishtat, A Sen, K Meyer, PA Checchia, TP Shanley, J Nowak, M Quasney, A Chopra, JC Fitzgerald, R Gedeit, S Banschbach, E Beckman, P Lahni, K Hart, and CJ Lindsell. Testing the prognostic accuracy of the updated pediatric sepsis biomarker risk model. PLoS One, 9:e86242, 2014. PMID 24489704 57.Chen J, ES Wilson, MK Dahmer, MW Quasney, GW Waterer, C Feldman, RG Wunderink. Lack of Association of the Caspase-12 Long Allele with Community-acquired Pneumonia in People of African Descent and a Mouse Model of Streptococcus pneumoniae-mediated Pneumonia. PLoS One, 9:689194, 2014, PMID: 24586588 58.Wong, HR, SL Weiss, JS Jr Giuliano, MS Wainwright, NZ Cvijanovich, NJ Thomas, GL Allen, N Anas, MT Bigham, M Hall, RJ Freishtat, A Sen, K Meyer, PA Checchia, TP Shanley, J Nowak, M Quasney, A Chopra, JC Fitzgerald, R Gedeit, $ Banschbach, E Beckman, K Harmon, P Lahni, and CJ Lindsell. The temporal version of the pediatric sepsis biomarker risk model. PLoS One, 9:092121, 2014. PMID 24626215, 59. Atkinson SJ, Cvijanovich NZ, Thomas NJ, Allen GL, Anas N, Bigham MT, Hall M, Freishtat RJ, Sen A, Meyer K, Checchia PA, Shanley TP, Nowak J, Quasney M, Weiss SL, Banschbach S, Beckman E, Howard K, Frank E, Harmon K, Lahni P, Lindsell CJ, Wong HR. Corticosteroids and pediatric septic shock outcomes: a risk stratified analysis. PLoS One, 9:e112702, 2014. PMID 25386653 60.Wong, HR, NZ Cvijanovich, N Anas, GL Allen, NJ Thomas, MT Bigham, SL Weiss, JC Fitzgerald, PA Checchia, K Meyer, TP Shanley, M Quasney, M Hall, R Gedeit, J Nowak, RS Shekhar, 8 Gertz, E Dawson, K Howard, K Harmon, © Beckman, E Frank, and CJ Lindsell. Developing a clinically feasible personalized medicine approach to pediatric septic shock American Journal of Respiratory and Critical Care Medicine, 191:309, 2015. PMID 25489881 61. The Pediatric Acute Lung Injury Consensus Conference Group. Pediatric Acute Respiratory Distress Syndrome: Consensus Recommendations from the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, Feb, 2015. PMID 25647235 62,Sapru, A, H Flori, MW Quasney, MK Dahmer, for the Pediatric Acute Lung Injury Consensus Group. Pathophysiology of pediatric acute respiratory distress syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. Michael Quasney, MD, PhD May 19, 2017 " 63.Khemani, RG, LS Smith, JJ Zimmerman, $ Erikson for the Pediatric Acute Lung Injury Consensus Group. Pediatric Acute Respiratory Distress Syndrome: Definition, Incidence, and Epidemiology: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2016. 64.Flori, H, MK Dahmer, A Sapru, MW Quasney for the Pediatric Acute Lung Injury Consensus Group. Co-morbidities_and severity of pediatric acute respiratory distress syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2018. 65.Rimensberger, PC, IM Cheifetz, for the Pediatric Acute Lung Injury Consensus Group. Ventilatory Support in Children With Pediatric Acute Respiratory Distress Syndrome: Proosedings From the Pediairic Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. 66.Tamburro, RF, MCJ Kneyber, for the Pediatric Acute Lung Injury Consensus Group. Pulmonary-Specific Ancillary Treatment for Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference, Pediatric Critical Care Medicine, April 2015. 67.Valentine, SL, VM Nadkami, MAQ Curley, for the Pediatric Acute Lung Injury Consensus Group. Nonpulmonary Treatments for Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. 68.Emeriaud, G, CJL Newth, for the Pediatric Acute Lung Injury Consensus Group. Monitoring of Children With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference, Pediatric Critical Care Medicine, April 2015. 69.Essouri, S, C Carroll, for the Pediatric Acute Lung Injury Consensus Group. Noninvasive Support and Ventilation for Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. 70.Dalton, HJ, DC Macrae, for the Pediatric Acute Lung Injury Consensus Group. Extracorporeal ‘Support in Children With Pediatric Acute Respiratory Distress Syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. 71.MW Quasney, Lopez, Y, M Santschi, S Watson for the Pediatric Acute Lung Injury Consensus Group. Morbidity and long-term outcomes of pediatric acute respiratory distress syndrome: Proceedings From the Pediatric Acute Lung Injury Consensus Conference. Pediatric Critical Care Medicine, April 2015. 72.Wong, HR, NZ Cvijanovich, N Anas, GL Allen, NJ Thomas, MT Bigham, SL Weiss, JC Fitzgerald, PA Checchia, K Meyer, TP Shanley, M Quasney, M Hall, R Gedeit, J Nowak, RS Shekhar, § Gertz, E Dawson, K Howard, K Harmon, E Beckman, & Frank, and CJ Lindsell. A multibiomarker-based model for estimating the risk of septic acute kidney injury. Critical Care Medicine, May, 2015. PMID 25962083 73. Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, and Lindsell CJ. Prospective Testing and Redesign of a Temporal Biomarker Based Risk Model for Patients With Septic Shock Implications for Septic Shack Biology. EBioMedicine, 2:2087-2093, 2015. PMID 26844289 74,MK Dahmer, T Cornell, and MW Quasney. Genetic and epigenetic factors in the regulation of the immune response. Current Opinions in Pediatric, Jun, 28:281-286, 2016. PMID 27043086 75. Wong HR, Atkinson SJ, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitegerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak Michael Quasney, MD, PHO May 19, 2017 2 J, Raj $8, Gertz 8, Lindsell CJ. Combining prognostic and predictive enrichment strategies to identify children with septic shock responsive to corticosteroids. Critical Care Medicine, 44:e1000-1003, 2016. PMID: 27270179 76. Perez-Marques, F, P Simpson, K Yan, MW Quasney, N Halligan, D Merchant, and MK Dahmer. Association of Polymorphisms in Genes of Factors Involved in Regulation of Splicing of Cystic Fibrosis Transmembrane Conductance Regulator mRNA with Acute Lung Injury in Children with pneumonia. Critical Care, 20:281, 2016. PMID: 27596159 77.Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Howard K, Harmon K, Lahni P, Frank E, Hart KW, TC Nguyen, and Lindsell CJ. Pediatric Sepsis Biomarker Risk Model-Il: Redefining the Pediatric Sepsis Biomarker Risk Model With Septic Shock Phenotype. Critical Care Medicine, 44:2010-2017, 2016, PMID: 27513637 78.Kawai, Y, AG DeMonbrun, RS Chamber, NA Nolan, BA Dolcourt, NM Malas, and MW Quasney. A Previously Healthy Adolescent with Acute Encephalopathy and Decorticate Posturing. Pediatrics, 139:e20153779, 2017, PMID: 27940505 79, Sampath V, Bhandari V, Berger J, Merchant D, Zhang L, Ladd M, Menden H, Garland J, Ambalavanan N, Mulrooney N, Quasney M, Dagle J, Lavoie PM, Simpson P, Dahmer M. A functional ATG16L1 (T300A) variant is associated with necrotizing enterocolitis in premature infants. Pediatric Research, Jan 18, 2017. PMID: 27893720 80.Agus MS, Wypij D, Hirshberg EL, Srinivasan V, Faustino EV, Luckett PM, Alexander JL, Asaro LA, Curley MA, Steil GM, Nadkami VM; HALF-PINT Study Investigators and the PALISI Network. Tight glycemic control in critically ill children. New England Journal of Medicine, 376:729-741, 2017. PMID: 28118549 81.Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz §, Grunwell JR, Opoka A, Wong HR. Glucocorticoid receptor polymorphisms and outcomes in pediatric septic, shook. Pediatric Critical Care Medicine, 18:299-303, 2017. PMID: 28178077 82, Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald J, Checchia PA, Meyer K, Quasney M, Hall, M, Gedeit R, Freishtat RU, Nowak J, Raj, SS, Gertz S, Grunwell JR, Lindsell, CJ. Improved Risk Stratification in Pediatric Septic Shock Using Both Protein and mRNA Biomarkers. PERSEVERE-XP. Amer J Respir Crit Care Medicine, 169:494- 501, 2017. PMID: 28324661 83.Wong HR, Cvijanovich NZ, Anas N, Allen GL, Thomas Nu, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutti R, Gertz S, Grunwell JR, Lindsell CJ. Endotype transitions during the acute phase of pediatric septic shock reflect changing risk and treatment response. Critical Care Medicine, 46:6242, 2018, PMID 29252929 84, Stenson EK, Cvijanovich NZ, Anas N, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Checchia PA, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Raj SS, Gertz S, Grunwell JR, Wong HR. Hyperchloremia is associated with complicated course and mortality in pediatric patients with septic shock. Pediatric Critical Care Medicine, 19:155, 2018. PMID:29394222 85. Napolitano LM, Rajajee V, Gunnerson KJ, Maile MD, Quasney M, Hyzy RC. Physician training in critical care in the United States: Update 2018. Journal of Trauma and Acute Care Surgery, Feb, 2018. PMID: 29462084. 86,Dahmer MK, Quasney MW, Sapru A, Gildengorin G, Curley MAQ, Matthay MA, Flori H; BALI and RESTORE Study Investigators and Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Interleukin-1 Receptor Antagonist Is Associated With Pediatric Acute Michael Quesney, MD, PhO May 19, 2017 8 Respiratory Distress Syndrome and Worse Outcomes in Children With Acute Respiratory Failure. Pediatric Critical Care Medicine, 19:930, 2018. PMID-30095747, 87. Stenson EK, Cvijanovich NZ, Allen GL, Thomas NJ, Bigham MT, Weiss SL, Fitzgerald JC, Jain PN, Meyer K, Quasney M, Hall M, Gedeit R, Freishtat RJ, Nowak J, Lutfi R, Gertz S, Grunwell JR, Wong HR, Anas N. Hyperchloremia is associated with acute kidney injury in pediatric patients with septic shock. intensive Care Medicine, 44:2004, 2018. PMID;30324289 88. Yagiela LM, Barbaro RP, Quasney MW, Pfarr MA, Ursu DC, Prosser LA, Odetola FO. Outcomes and Patterns of Healthcare Utilization After Hospitalization for Pediatric Critical Illness Due to Respiratory Failure. Pediatric Critical Care Medicine, 20:120, 2019. PMID:30418338 89. Levy H, Jia S, Pan A, Zhang X, Kaldunski M, Nugent ML, Reske M, Feliciano RA, Quintero D, Renda MM, Woods KJ, Murkowski K, Johnson K, Verbsky J, Dasu T, Ideozu JE, McColley S, Quasney MW, Dahmer MK, Avner &, Farrell PM, Cannon CL, Jacob H, Simpson PM, Hessner WJ. Identification of molecular signatures of cystic fibrosis disease status with plasma-based functional genomics. Physiol Genomics, 51:27, 2019. PMID:30540547 90. Faustino EVS, Hirshberg EL, Asaro LA, Biagas KV, Pinto N, Srinivasan V, Bagdure DN, Steil GM, Coughlin-Wells K, Wypij D, Nadkarni VM, Agus MSD, Mourani PM, Chima R, Thomas NJ, LiS, Pinto A, Newth C, Hassinger A, Bysani K, Rehder KJ, Kandil S, Wintergerst K, Schwarz A, Marsillio L, Cvijanovich N, Pham N, Quasney M, Flori H, Federman M, Nett S, Viteri S, Schneider J, Medar S, Sapru A, McQuillen P, Babbitt C, Lin JC, Jouvet P, Yanay O, Allen C; Heart And Lung Feilure-Pediatric INsulin Titration (HALF-PINT) Study Investigators. Short- Term Adverse Outcomes Associated With Hypoglycemia in Critically ll Children, Critical Care Medicine, 47:706, 2019. PMID:30789401 91.Fiori H, Sapru A, Quasney MW, Gildengorin G, Curley MAQ, Matthay MA, Dahmer MK; BALI and RESTORE Study Investigators, Pediatric Acute Lung Injury and Sepsis Investigators, (PALISI) Network. A prospective investigation of interleukin-8 levels in pediatric acute respiratory distress failure and acute respiratory distress syndrome. Critical Care, 23:128, 2019. PMID:30995942 Non Peer-Reviewed Publications Quasney, MW. ACE genetic variation end lung injury: Are we predisposed to develop ARDS? Critical Care Medicine, 34:1261-1262, 2006. . Quasney, MW. Genetic influences on severe lung injury: how many more genes? Critical Care Medicine, 35:976-977, 2007. . Quasney, MW. Genetic variation, acute lung injury, and Kipling's six honest serving men. Critical Care Medicine, 36:2678-2680, 2008. Dahmer, MK and MW Quasney. Profiling pediatric sepsis. Critical Care Medicine, 37:1795- 1796. 2608, Ren Book Chapters 1. Dahmer, MK and Quasney, MW. Genomic Medicine. In Textbook of Pediatric Intensive Care. 4th ed. Eds. Rogers 2006. 2. Dahmer, MK and Quasney, MW. Genetic Polymorphisms in Critical Care and lliness. in Pediatric Critical Care Medicine: Basic Science and Ciinical Evidence. Eds. Wheeler, Wong, and Shanley. Springer-Varlag (London). 2008. 3. Jardine, D, MK Dahmer, and M Quasney. Individuality, Gene Array Analysis and Critical Care. In Pediatric Critical Care, 4" ed. Elsevier, 2010. Michel Quasney, MD, PhO May 19, 2017 4 4. Meyer, M, R Niebler, and MW Quasney. Extracorporeal Membrane Oxygenation. In Current Concepts in Pediatric Critical Care, Eds. Spinella and Nakagawa. Society of Critical Care Medicine, 2011, 5. Dahmer, MK and MW Quasney. Genomics and sepsis, In Current Concepts in Pediatric Critical Care, Eds. Spinella and Nakagawa, Society of Critical Care Medicine, 2012. 8. Dahmer, MK and Quasney, M. OMICS and Critical Care. In Textbook of Pediatric intensive Care. 4th ed. Eds. Rogers 2014, Michael Quesney, MD, PhD May 19, 2017 6 Abstracts 1. Biagas, KV, JM Leventhal, and MW Quasney. Functional outcomes of children with traumatic brain injury. Proceedings of The International Trauma Anesthesia and Critical Care Society, Baltimore, MD, 1997. 2. Eades, SK, MW Quasney, JC Ring, MB Wilson, RK Mottem, and ML Christensen. Pharmacokinetics (PK) of continuous infusion furosemide (Fi) in critically ill children, Southern Society for Pediatric Research, 1998. 3. Buckingham, SC, Quasney, MW, and JP DeVincenzo. Effects of community-wide respiratory syncytial virus immune globulin prophylaxis on pediatric intensive care unit admissions. Society for Pediatric Research, May, 1998. 14. Quasney, M and S Senogles. Random mutagenesis of the third intracellular loop of the D2s. dopamine receptor. American Society of Biochemistry and Molecular Biology, 1998. 15. Quasney, Mand N Kerr forthe Pediatric Crital Care Study Group, Do retiel hemorthages occur after CPR in children? A prospective, multi-institutional study. National Conference on Shaken Baby Syndrome, Salt Lake City, Sept 1998. 16. Quasney, M and D Goodman and the National Association of Children’s Hospitals and Related institutions. Efficacy of routine chest radiographs in pediatric intensive care units: a ‘multi-institutional study. Pediatric Critical Care Colloquium, Chicago, Sept, 1998. 17. Quasney, M and N Kerr for the Pediatric Critical Care Study Group. Do retinal hemorthages occur after CPR in children? A prospective, multinsttutional study. Pediatric Critical Care Colloquium, Chicago, Sept, 1998. 18. Bronstein, DE, Q Zhang, C Stroupe, JC Burns, H Shike, JF Bastian, JW Newburger, and MW Quasney. Polymorphisms within the locus for tumor necrosis factor (TNF) in children with Kawasaki disease. Infectious Diseases Society of America, Nov, 1998, 19, Bronstein, DE, JC Bums, AN Dill, J Shike, JF Bastian, JW Newburger, T Matsubara, Q Zhang, C Stroupe, and MW Quasney. Tumor necrosis factor a. (TNF-a) and lymphotoxino0 (LT-a) gene polymorphisms in children with Kawasaki disease (KD). Sixth International Kawasaki Disease Symposium, Waikoloa, Hawaii, Feb, 1999. 20. Shoukih, T, M Wilson, DT Crouse, BK English, Q Zhang, and MW Quasney. Serum TNF-a, IL-6, and ICAM-1 levels in bacteremic and non-bacteremic febrile children. SPR, San Fransisco, May, 1999. 24, Quasney, MW, Q Zhang, C Stroupe, DE Bronstein, H Shike, JF Bastian, JW Newberger, and JC Burns. ‘Genetic polymorphisms in'the regulatory region of the TNF-o gane in children with Kawasaki disease. SPR, San Fransisco, May, 1999, 22, Bugnitz, M, D Newton, P Hess, and M Quasney, Impact of not following pre-transport recommendations on outcome in pediatric transports. American Academy of Pediatrics, 1999. 23. Quasney, MW and Q Zhang. Bacteremic children with the AJA genotype at the lymphotoxin +250 site have a higher mortality. Pediatric Critical Care Colloquium, Portland, Sept, 1999. 24. Biagas, KV, JM Leventhal, and MW Quasney. Functional outcomes in children and their families with traumatic brain injury. Pediatric Critical Care Colloquium, Portland, Sept, 1999, 25. Waterer, GW, MW Quasney, Q Zhang, CB Jones, and RG Wunderink. The impact of the ‘TNF +250 gene polymorphism on the severity of community acquired pneumonia. American College of Chest Physicians Annual Scientific Meeting, Chicago, IL, Nov 1999. Chest 1999: 116:265S_ 26. Waterer, GW, MW Quasney, Q Zhang, CB Jones, and RG Wunderink. The TNF-0-308 gene polymorphism does not appear to influence the severity of community acgired pneumonia, Lovelace Respiratory Research Institute Symposium, Sante Fe, Oct 1999. www.lovelace- symposium.ora/199: 27. Livingston, JC, V Park, JR Barton, B Haddad, D Crouse, S Elfering, M Quasney, B Mabie, and BM Sibai. Tumor necrosis facior alpha polymorphisms, plasma levels, and severe preeclampsia, Society for Maternal-Fetal Medicine, Miami Beach, FL, Feb, 2000. 28. Livingston, JC, B Haddad, D Crouse, V Park, M Cassie, K Brown, M Quasney, and BM Sibal Neither neonatal polymorphisms in the tumor necrosis factor alpha gene nor plasma tumor Michael Quesney, MD, PHD May 18, 2017 6 necrosis factor alpha levels are associated with complications of prematurity. Society for Maternal-Fetal Medicine, Miami Beach, FL, Feb, 2000 29, Waterer, GW, MW Quasney, Q Zhang, CB Jones, and RG Wunderink. Impact of the ‘TNFB+250 and TNFa-308 gene polymorphisms on the development of septic shock in community acquired pneumonia. American Thoracic Society 2000 Intemational Conference, Toronto, Canada, May, 2000. Am J Respir Crit Care Med 2000; 161:A129. 30. Waterer, GW, MW Quasney, Q Zhang, AD Hall, and RG Wunderink. The impact of the ‘TNFB+250 gene polymorphism on type | respiratory failure in community acquired pneumonia. American Thoracic Society 2000 International Conference, Toronto, Canada, May, 2000. Am J Respir Crit Care Med 2000; 161:A124, 31. Waterer, GW, MW Quasney, Q Zhang, CB Jones, and RG Wunderink. The TNFB+250 and TNFa-308 gene polymorphisms are important in community acquired pneumonia (CAP). The Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Melbourne, Australia, April, 2000. Respirology 2000; 5(Supp)):A13. 32. Waterer, GW, MW Quasney, J McArthur, Q Zhang, CB Jones, and RG Wunderink. Impact of the IL 10-1082 gene polymorphism on community acquired pneumonia, The European Respiratory Society Annual Scientific Meeting, Florence, Italy, September 2000. Eur Resp J 200; 16 (Suppi):4328 $8. Quasney MW), S Dakin, J Ring, M Bugnitz, A Hardin, § Storgion, J Newsom, and G Stidham..Impact of race and pre-term birth on admissions to a pediatric intensive care unit PICU). 3" World Congress on Pediatric Intensive Care, June, 2000. 34. MoArthur J, Q Zhang, U Meduri, F Stentz, MW Quasney. Increased frequency of the A allele at the TNF-a-308 site in ARDS, 3 World Congress on Pediatric Intensive Care, June, 2000. 35. Quasney MW and Q Zhang. Polymorphic analysis of the TNF locus in bacteremic children. 3% World Congress on Pediatric Intensive Care, June, 2000. 96, Yende, & MW Quasney, and RG Wunderik, Impact of tumor necrosis factor (TNF) gene polymorphisms on outcomes of coronary artery bypass graft surgery (CABG). Chest 2000 Annual Meeting, 2000. 37. Waterer GW, Buckingham 8, Quasney MW, and Wunderink RG. Pneumococcal antibiotic resistance in'Memphis, 1999: American College of Chest Physicians Annual Scientific Meeting, San Francisco, CA, Oct, 2000, Chest 2000; 118.4117. 38. Shaikh, KM, Yende, S, Waterer GW, Quasney MW, and Wunderink RG. Effect of tumor necrosis factor (TNF) gene polymorphisms on restoration of bady temperature after coronary artery bypass. American College of Chest Physicians Annual Scientific Meeting, San Francisco, CA, Oct. 2000. Chest 2000; 118:A113. 39. Waterer, GW, MW Quasney, R Cantor, Q Zhang, and RG Wunderink. The impact of TNF polymorphisms on the presentation and outcome of community-acquired pneumonia. Australian and South East Asian Tissue Typing Association Conference, December, 2000. 40. Waterer, GW, MW Quasney, R Cantor, Q Zhang, CB Jones, and RG Wunderink. Increased risk of death from community-acquired pneumonia (CAP) associated with the A ailele of the TNF-c-238 polymorphism. American Thoracic Society Annual Scientific Meeting, San Francisco, CA, May 2001 41. Waterer GW, MW Quasney, R Cantor, LA Kessler, Q Zhang, and RG Wunderink. Association between FegRila (CD32) polymorphism and susceptibility to bacteremia inpatients with community-acquired pneumonia (CAP). American Thoracic Society Annual Scientific Meeting, San Francisco, CA, May 2001. 42. Wunderink RG, Waterer GW, RM Cantor, and MW Quasney. TNF gene polymorphisms and the variable presentation and’ outcome of community-acquired pneumonia. Thomas L Petty Aspen Lung Conference, June, 2001; Chest 2002; 121:87S. 43. Quasney MW, Waterer, GW, MK Dahmer, D Turner, Q Zhang, RM Cantor, and RG Wunderink. ICAM-1 Gly241Arg polymorphism has no impact on ARDS of septic shock in community-acquired pneumonia, Thomas L Petty Aspen Lung Conference, June, 2001. 44. Von Essen SG, MW Quasney, J Frysek, AL Spiker, M Carlson, J Bush, DJ Romberger, SI Rennard, J Spencer. Toll-like receptor 4 and TNF polymorphisms in farmers with airway disease. American Thoracic Society Annual Scientific Meeting, May 2002. 1 Quasney, MD, PhD May 19, 2017 W 45, Waterer GW, MW Quasney, LA Kessler, L Bahlawan, Q Zhang, and RG Wunderink. ACE (Dil) genotype and community-acquired pneumonia (CAP). American Thoracic Society Annual ‘Scientific Meeting, May 2002. 46. Kazi SNJ, SM Jacques, F Qureshi, | Rubowitz, and MW Quasney. Does genetic polymorphism in the tumor necrosis factor locus affect the severity of placental inflammation among preterm births? Society of Pediairic Research Meetings, May, 2002. 47. Kazzi SNJ, MW Quasney, and K Hayes-Hart. Frequency distribution of alleles of turnor necrosis factor (TNF) promoter region which are associated with elevated levels of TNF-a. in very low birthweight infants (VLBWI). Society of Pediatric Research Meetings, May, 2002. 48. Bahlawan L, M Christensen, S Binzei, C Murphy, Q Zhang, and M Quasney. Lack’ of association between the TNF-o. regulatory region genetic polymorphisms associated with elevated TNF-a levels and children with asthma. Aspen Lung Conference, June, 2002. 49. Binaei S, M Christensen, C Murphy, Q Zhang, and M Quasney. f2-adrenergic receptor polymorphisms in children with statis asthmeticus, Aspen Lung Conference, sJune, 2002, 50. Tuladhar JT. Bugnitz MC, Newton D, Hess P, and MW Quasney, Impact of Pre-transport recommendations on oulcome in pediatric transports. 14" Annuai Pediatric Critical Care Colloquium and 1® San Diego Pediatric Trauma Conference, October 2-5, 2002. 51. Bahlawan L and MW Quasney. Severe systemic reaction to Loxoscele recluse spider bites in pediatric population. 14" Annual Pediatric Critical Care Colloquium and 1* San Diego Pediatric rauma Conference, October 2-5, 2002. 52. de os Santos NM, BH Ault, AG Gharavi, SB Kritchevsky, MW Quasney, EC Jackson, KA Fisher, SY Woodford, BL Mitchell, LW Gaber, and RJ Wyatt. Angiotensis-converting enzyme (ACE) genotype and prognosis in pediatric IgA nephropathy (IgAN). Journal of Investigative Medicine, 133A, 2002. 53. Kazzi SNJ, UO Kim, MW Quasney, K Hayes-Hart, IA Buhimschi. Alleles Frequency and Genotype Distribution of TNF-a2Promoter Locus in Low Birth Weight Infants (LBWI), Society for Pediatric Research Annual Meeting, Seaitle, WA, 2003. 84, Kazzi SNJ, UO Kim, MW Quasney, IA Buhimschi. The Effect of Genetic Polymorphism in TNF-c0Gene on Levels of TNF-ailin Bronchoalveolar Lavage Fluid (BAL) of Preterm Infants at Risk of Bronchopulmonary Dysplasia (BPD). Sociely for Pediatric Research Annual Meeting, Seattle, WA, 2003. 55. Kazzi SNJ, UO Kim, MW Quasney, IA Buhimschi. Does Polymorphism in Tumor Necrosis Factor-alpha (TNF-c) Promoter Locus Affect the Susceptibility and/or Severity of Bronchopulmonary Dysplasia (BPD) Among Very Low Birthweight Infants (VLBW). Society for Pediatric Research Annual Meeting, Seattle, WA, 2003. 86. Kazzi SNJ, SM Jacques, F Qureshi, MW Quasney, UO Kim, K Hayes-Hart, IA Buhimschi TNF-a. Allele Lymphotoxin-«. +250 (LT-Cia, +250) Increases the Risk and Severity of Placental Inflammation Among Preterm Births. Society for Pediatric Reseerch Annual Meeting, Seatle, 57. Yende, S, MW Quasney, and RG Wunderink. Pro12Ala polymorphism in PPARy is associated with lower risk of mechanical ventilation after coronary artery bypass graft surgery (CABG). Chest 2000 Annual Meeting, Orlando, FL, 2003. 58, Colpaert K, S Percy, M Quasney, R Brill, B McGarr, L Easterling, TB Rice, R Berens, and NACHRI PICU Focus Group. Evaluation of pediatric code cart medications. Pediatric Critical Care Colloquium, New York, New York, 2004, 59. § Percy, Colpaert K, M Quasney, R Brill, R Gibson, L Easterling, TB Rice, R Berens, and NACHRI PICU Focus Group. Code team composition in NACHRI hospitals. Pediatric Critical Care Colloquium, New York, New York, 2004. 60. R Berens, Colpaert K, S Percy, M Quasney, R Brill, B McGarr, TB Rice, and NACHRI PICU Focus Group. Pediatric code blue review comparisons between free-standing hospitals and hosplta-within-hospita settings. Pediatrie Creal Care Colloquium, New York, New York, 4. 61. S Percy, Colpaert K, M Quasney, R Brill, L Easterling, TB Rice, R Berens, and NACHRI PICU Focus Group. Frequency of tiered response teams in NACHRI institutions. Pediatric Critical Care Colloquium, New York, New York, 2004. Michael Quasney, MD, PhO May 19, 2057 16 62. R Berens, Colpaert K, S Percy, M Quasney, R Brill, B McGarr, TB Rice, and NACHRI PICU Focus Group. Assessment of the extent of code blue review in pediatric hospitals. Pediatric Critical Care Colloquium, New York, New York, 2004. 63, CM El Saleeby, MK Dahmer, MW Quasney, JP DeVincenzo. The association of surfactant protein A 1 (SPAM) genotypes and disease severity within an RSV infected population. Society of Pediatric Research, 2005. 64. M Auth, T Spentzas, M Quasney, J Lutterman, S Pace-Wassil. Nesiritide infusion-in pediatric ICU patients. Society of Critical Care Medicine, 'San Francisco, CA, Jan 2008. 65. PP Patwari, DM Goodman, M Quasney, M Dahmer. Interleukin-1 genetic polymorphisms in children with community acquired pneumonia. Society of Critical Care Medicine, San Francisco, CA, Jan 2008. 66. P.O'Cain, M Dahmer, P Prasad, Q Zhang, M Smith, J Krushkal, and MW Quasney. The angiotensin converting enzyme D/D genotype is associated with mechanical ventilation in Caucasian children with community acquired pneumonia. Pediatric Critical Care Colloquium. Feb 2006, 67. J Krushkal, KD Lamar, M Puljic, P O'Cain, Q Zhang, M Smith, M Dahmer, and M Quasney. Candidate gene association analysis of severe lung injury in pediatric community acquired’ pneumonia. 11* International Congress on Human Genetics, Brisbane, Australia, 2006. 68, De Jesus, LC, SNJ Kazzi, MW Quasney, M Dahmer, X Chen. Angiotensin Converting Enzyme Gene Polymorphism in Persistent Pulmonary Hypertension of the Newborn. Pediatric ‘Academic Societies’ Annual Meeting, Toronto, Canada, May 2007. 69. M Dahmer, P Patwari, P O’Cain, D Goodman, J Krushkal, G Somes, C. Liu, M Smith, M Quasney. interleukin receptor antagonist intron 2 polymorphisms anc. ung injury in cleren with community-acquired pneumonia. Aspen Lung Conference, Aspen, CO, June 2007. 70. P O’Cain, P Patwari, M Smith, M Dahmer, M Quasney, The surfactant protein B+1580 polymorphism and lung injury in children with community-acquired pneumonia. Aspen Lung Conference, Aspen, CO, June 2007. 71. HLevy, A Murphy, F Zou, C Gerard, B Klanderman, J Celedén, M Drumm, M Knowles, M Dahmer, M Quasney, G Pier, C Lange, and S Weiss. Polymorphisms in the IL-1 gene family and lung sisease severity n patents with cyst fbrosis. Aspen Lung Conference, Aspen, CO, June 2007. 72. RM Kelsey, BS Alpert, SR Gabel, JA Thompson, R Li, MK Dahmer M, and MW Quasney. Cardiovascular reactivity and beta-1-adrenergic receptor gene variation in black youth. 47" Annual Meeting of the Society for Psychophysiological Research, Savannah, GA, Oct 2007. Published in Psychophysiology, 44:S98, 2007. 73. M Quasney, N Halligan, M Smith, C Wang, and MK Dahmer. Influence of genetic variation in the surfactant protein B gene on severity of community acquired pneumonia in children. Sociely of Critical Care Medicine, Honolulu, HA, Feb, 2008. 74, RA Russell, MW Quasney, and MK Dahmer. Genetic variability within the myosin light chain kinase gene and severity of community-acquired pneumonia in children. Pediatric Critical Care Colloquium, Whistler, Canada, March 2008. 75. MK Dahmer, M Baldwin, N Halligan, C Wang, MW Quasney. Haplotypes in the surfactant protein-B and interieukin-1B genes are associated with need for mechanical ventilation in children with community acquired pneumonia. 58 Annual Meeting of the American Society of Human Genetics, Philadelphia, PA Nov, 2008 76. RM Kelsey, BS Alpert, SR Gabel, J Krushkal Adkins, MK Dahmer M, and MW Quasney. Cardiovascular reactivity and alpha-adrenergic receptor gene polymorphisms in black youth, 67" Annual Scientific Meeting of the American Psychosomatic Society, Chicago, IL, March, 2009. 77. SK Park, L Amos, A Rao, Y Matsumura, N Inagaki, MW Quasney, and MK Dahmer. Analyses of anovel ATP binding cassette (ABC) A3 mutant. American Thoracic Society International Conference, San Diego, CA, May, 2009. Michael Quasney, MD, PhO May 19, 2017 18 78, J Baughn, M Quasney, and M Dahmer. The CFTR gene and alveolar fluid balance in children with community acquired pneumonia, American Thoracic Sociely International Conference, San Diego, CA, May, 2010. 79. M Quasney, A Sapru, and M Dahmer. Mannose binding lectin variants in children with community aequired pneumonia, Aspen Lung Conference, Aspen, CO, June, 2010. 80. J Baughn, P Simpson, $ Li, M Quasney, H Levy, M Dahmer. Genetic variation in the cystic fibrosis transmembrane conductance regulator gene (CFTR) is associated with the need for mechanical ventilation in pediairic patients with community-acquired pneumonia. American Thoracic Society, Denver, CO, May, 2011 81. H Levy, J Shuang, M Reske, K Schneck, H Lai, A Laxova, M Dahmer, M Quasney, P Farrell, M Hessner. Use of serum induced transcriptional signatures as @ predictive disease specific marker for cystic fibrosis, Seventh Annual NIH Directors Pioneer Award Symposium, Washington, DC, Sept 11, 2011. 82, J Shadiey, M Dahmer, and M Quasney. Transcriptome analysis demonstrates differential mRNA splicing pattems in response to LPS. Society of Critical Care Medicine, Phoenix, AZ, Jan 17, 2015, 83, MJ Ashbrook, K Pohl, A Pawluszkal, MW Quasney, KL Mert. Clinical Characteristics and Course of Human Metapneumovirus in Critically Ill Infants and Children: A Multisite Study in Michigan. Medical Student Research Symposium, Detroit, MI, January, 2016. 84. Sapru, A, Dahmer, MK, Flori, H, Sim, MS, Curley, MAQ, Gildengorin, G, Matthay, M, Quasney, MW, for the BALI Study Investigators and the Pediatric Acute Lung injury and Sepsis (PALISI) Network, Elevated Plasminogen Activator Inhibitior-1 (PAI-1) plasma levels are associated with deveiooment of pediatric acute respiratory distress syndrome (PARDS) and clinical outcomes in intubated children with Acute Respiratory Failure. Annual Meeting of the Pediatric Academic Societies, San Francisco, Califomia, May 2017. 85. Flori, H, Dahmer, MK, Quasney, MW, Gildengorin, G, Curley, MAQ, Matthay, M, Sapru, A, for the BALI Study Investigators and the Pediatric Acute Lung Injury and Sepsis (PALISI) Network. Plasma interleukin-8 (IL-8) is associated with severity of oxygenation defect and mortality in children with acute respiratory failure. Annual Meeting of the Pediatric Academic Societies, San Francisco, California, May 2017. 86. Dahmer, MK, Fiori, H, Quasney, MW, Gildengorin, G, Curley, MAQ, Maithay, M, Sapru, A, for the BALI Study Investigators and Pediatric Acute Lung Injury and Sepsis (PALIS!) Network Elevated plasma interleukin-1 receptor antagonist levels are associated with the development of pediatric acute respiratory distress syndrome (PARDS). Annual Meeting of the Pediatric Academic Societies, San Francisco, California, May 2017. Michael Quasney, MD, PhO May 19, 2017 20 EXHIBIT 2 STATE OF MICHIGAN IN THE CIRCUIT COURT FOR THE COUNTY OF WASHTENAW BOBBY GLENN REYES, Plaintiff, vs. Civil Action No. 19-1053-CZ Hon. David 8, Swartz ‘UNIVERSITY OF MICHIGAN C.S, MOTT CHILDREN’S HOSPITAL Defendant, i AFFIDAVIT OF DR. CHRISTIAN VERCLER STATE OF MICHIGAN ) COUNTY OF WASHTENAW ; a 1, CHRISTIAN VERCLER, declare and state as follows 1 I have knowledge of the facts stated herein based on my personal knowledge, am competent to testify to these facts, and will so testify if called and swom as a witness, 2. joined the faculty at the University of Michigan in 2013 and since 2014 have been the Chair of the Pediatric Ethics Committee at the University of Michigan. In addition to my medical training, { have a Master's Degree in Bioethics and completed a one-year Clinical Ethies Fellowship at the Center for Ethics at Emory University. I am also a member of the Bioethics Group of the American Academy of Pediatrics. 3. Tam also a member of the Clinical Ethics Consultation Team, Clinicians often call in the Clinical Ethics Consultation Team to render an opinion on ethical issues a primary care team may be facing regarding a patient’s care. S24iner 4, Iwas a member of the Clinical Ethics Consultation Team thet performed a consultation on October 3, 2019, regarding Bobby’s case and the ethics regarding performing a second confirmatory brain death examination. As a result, 1 am familiar with Bobby’s case and the ethical issues facing his primary care team. 5. In my view, there are two main ethical issues present in the case of Bobby Reyes. The first is the obstruction of appropriate care of the patient by the parents blocking further neurological examination. The second is the request of futile, non-beneficial, or medically inappropriate interventions. 6. Since 1981, the Uniform Determination of Death Act, which has been adopted by the state of Michigan, states: “An individual who has sustained either (1) irreversible cessation of circulatory and respiratory functions, or (2) irreversible cessation of all functions of the entire brain, including the brain stem, is dead. A determination of death must be made in accordance with accepted medical standards.” 7, Accepted medical standards include a second confirmatory examination after an initial brain death examination has determined that imeversible cessation of all functions of the entire brain has occurred. 8 In Bobby’s case, his primary care team has performed one brain death examination and two ancillary procedures that show Bobby's entire brain, including his brain stem, have ceased! to function. 9. However, Bobby's family is preventing Bobby's primary care team from performing the second, confirmatory brain death examination. The family has even obtained a court order to prevent the second examination from occurring. 247478. 40. This presents a dilemma for Bobby’s primary care team, as appropriate care of a patient depends upon an accurate diagnosis of the condition being treated, 11, Blocking further examination of Bobby in this regard is ethically impermissible as it prevents the primary care team from delivering medically appropriate care to Bobby. 12, If Bobby has suffered brain death, all current medical interventions are inappropriate, as they ate of no benefit to Bobby. 13. The concern ethically is that the prevention of neurological examination and the continuation of invasive medical interventions is serving to merely delay the parent's acceptance of the reality of the tragic death of their son. Subjecting a person to interventions and procedures that do not benefit the person and are only of benefit to a third party is ethically impermissible. 14, There's broad consensus within the field of bioethics is that physicians have a duty to act beneficently and nonmaleficently, respect patient autonomy, and consider issues of justice in every situation. However, the autonomy of the patient or the decision-maker does not extend to measures that are determined to be medically futile, medically inappropriate, non-beneficial, or harmful. (¢.f. the UMHS Non-Beneficial Treatment Policy.) 15. Bobby's primary care team has determined that escalation of interventions, including the addition of more technology or medications, and attempts at resuscitation are non- beneficial for Bobby, as they cannot change the underlying physiology and cannot prevent further loss of integrated function of various organ systems. 16. _ Itisacceptable for Bobby’s primary care team to not escalate from the current level of medical intervention and to change Bobby's code status to Do Not Attempt Resuscitation (DNAR) without the permission of the patient's parents. serra. 17, Clinicians have no duty to engage in actions that they have determined to be of no medical benefit, even if patients and/or families request it. Thus, in this case, the duty to respect, autonomy is oveitidden by the providers! duties to act beneficently and non-maleficently. 18, The Pediatrie Ethics Commitee recommends performing a confirmatory neurological examination to confirm the irreversible cessetion of all functions of the entire brain, including the brain stem. If Bobby is dead, all medical interventions would cease, If Bobby is not dead, then further interventions aimed at rehabilitation could be instituted. The present situation of continuing medical interventions in @ patient with an unknown diagnosis regarding brain death is ethically impermissible, as it violates the professional integrity of the clinicians and does not respect the bodily integrity of the patient. J declare under the penalty of perjury under the laws of the State of Michigan that the foregoing is true and costect Further affiant sayeth not, CHRISTIAN VERC Em Subscribed and sworn to before me this day of October, 2019 re £0 (ULAR PT 0 - tary Public, yshpaas County, State of Michigan, - My Commission Expires: Jan 0%, 2023 ae S2ar Tat

Вам также может понравиться