Indian Journal of Ancient Medicine and Yoga

33
Review Article Volume 7 Number 1, January - March 2014

Overview of Academic Researches on Vranaropan (Tissue Healing)

Properties of Ayurvedic Drugs

Sathish H.S.*, Dudhamal T.S.**, Gupta S.K.***, Bhuyan C.****, Baghel M.S.*****
Abstract
Management of the wound probably would have been the first medico-surgical problem faced by
physicians. Around 235 research works have been carried out at the different institutions throughout
India till date on Vranaropan (wound healing) which is an integral part of the tissue healing. Major works
are carried out at Government Ayurvedic Medical College, Bangalore followed by Banaras Hindu
University, Varanasi and Institute for Post Graduate Teaching & Research in Ayurveda at Jamnagar.
Around 87 single drug and 139 compound preparations have been studied. 203 exclusive clinical works
were done, 24 experimental studies and only 07 clinico-experimental studies were reported. Compound
preparations with Ghrita (Ghee based preparations) and Taila (Oil based preparations) were preferred
among different formulations used. Maximum works were conducted on Dushtavrana (Infected/Chronic
wound) as it implies more problems to achieve the goal of healing. Apart from many works done in this
regard, still there is a lot of scope felt by the scholars to find out and establish a suitable wound healer from
the treasure of the ancient literatures. This review works have been carried out to give the glimpses of
works done at different institutions of India most of them are unpublished.
Keywords: Vranaropan; Dushtavrana; Shuddhavrana; Wound; Healing.

Introduction sciences to find out the solution which is better

The history of medical science is as old as
the skill of wound healing and it is difficult to
separate it. Wound management probably was
the first medico-surgical problem faced by
physicians. The more frequency of wound due
to injuries is more common than any other
diseases. Art of surgery actually revolves
around the Vrana[]1 (wound) and its
uneventful healing (Ropana[2]) process. The
term “Healing” does not only confine to Vrana
(wound) alone; it also denotes remedial
measure for any illness. Many works have been
carried out in each discipline of medical
Author’s Affiliation: *Asst. Professor, Dept of Shalya
Tantra, Parul Institute of Ayurveda, Vadodara, **Asst. Professor,
***Asso. Professor, ****Professor & Ex – HOD, *****Director,
IPGT & RA, Guj. Ayurved University, Jamnagar, Gujarat,
India.
Reprint’s request: Dr. Sathish H.S., Asst. Professor, Dept
of Shalya Tantra, Parul Institute of Ayurveda, Vadodara,
Gujarat, India.
E-mail: ayursathishhs@gmail.com
(Received on , accepted on )
than the contemporary ones. In Sushruta
Samhita, 1500 years old text book of Shalya
Tantra (Surgery), different chapters were
assigned to Vrana and its management. Priority
to the management of wounds in Shalya Tantra
is given always whether it is pathological one,
surgical or traumatic.
A vast scope of research still exists in the
area of wound management with Ayurveda
for the benefit of the science and humanity at
large. It is true that number of scientists and
medical experts are working alone or together
on various drugs and its different preparations
which may be helpful to achieve wound
healing comprehensively and in a better way.
A close study of Ayurveda reveals that a
number of plants were used both locally as
well as internally to achieve the goal of
Vranaropana and have shown the effectiveness
of Ayurvedic drugs.
Retrospective study of the research works
will be helpful to make a conclusive assessment
where these works were focussed and the
further direction where one should be headed

Volume
©Red 7 Number
Flower 1, January
Publication Pvt.Ltd- March 2014
34 Sathish H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs
for. This is an attempt to overview the entire
works carried out till date across the Ayurvedic
institutions of India.
Aims & Objectives
1. To know the trend and pattern of the
academic research works carried out at
different Ayurvedic institutions across
India on the tissue healing.
2. To showcase the unexplored avenues on
tissue healing in the field of Ayurveda.
Limitations of the Study
• The present article is an overview of the
titles and not a systematic review.
• Original theses were not accessed since
the present article is only – Title Survey
Materials & Methods
• Titles of the theses are procured from
‘Researches in Ayurveda’- A classified
directory of PG & PhD research works carried
out at various institutions throughout India,
compiled by Prof. M.S. Baghel.[3]
Method: Hand Search.
• By personal communication with certain
institution / faculty members.
Method: Personal communication.
Observations
As per Table 1, around 235 works are
carried out in vrana and few more works are
in progress. Major research works are carried
out on vrana by Govt. Ayurvedic Medical
College, Bangalore followed by Banaras Hindu
University and Institute for Post Graduate
Teaching & Research in Ayurveda, Gujarat
Ayurved University, Jamnagar. More research
works were reported on Dushta Vrana
(Infected ulcer) as per the data shown in Table
3, where 66 studies were on Shuddha vrana,
129 studies on Dushta vrana, 14 studies on
Dagdha vrana, 12 studies on Nadivrana while
on Vranashopha, 13 studies were noted.
As per Table 2, 188 research works have
been done by the Department of Shalya Tantra.
Apart from the M.D./M.S. thesis, 04 Ph.D.
research works are also recorded. Dravyaguna
department took next place in research works
on vrana with 22 works. As this branch deals
with identification and detail study of several
plants the works on vrana were carried out to
find out a suitable herb. Pharmaceutical aspect
of certain drugs has been also studied by
Rasashastra Department.
Exclusive clinical works amid the research
works were 203 in number while the
experimental studies were conducted on 24
and the clinico-experimental studies recorded
on 06 only. Majority of works were reported
on the clinical studies (Table 4).
87 Single drug preparations and 139
compound drug preparations were tested for
wound healing property. Few works on
indigenous drugs were carried out and
without having the details of formulations
used that works, it is iniquitous to comment
on this (Table 5).
Ghritas & taila dominate the formulation on
which majority of research works had been
carried. Probably the reason behind this could
be the drug delivery by these formulations is
more effective in result. Very few number of
research works are been carried out on other
formulation like kalka, rasakriya, kashaya etc.
Sushruta while advocating different
medicaments for vrana, he advises Ropana
Sapthaka/ Shodhana Saptaka (7 different
formulations for Ropana & Shodhana
respectively which include Kashaya, Varti,
Kalka, Sarpi, Taila, Rasakriya and Avachurnana.
There are specific indications for each
formulation and their roles are not much
evaluated (Table 6).
Indian Journal of Ancient Medicine and Yoga
 Sathis H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing) 35
Properties of Ayurvedic Drugs

Table 1: Institution Wise Theses carried Out on Vrana across India

S hu ddh a Du sht a Dagd ha
S r. v ran a vra na vr ana Nad i V rana sh oph a N o. of
Inst itut io n Name C oncep tual v ran a
No . (Healin g (In fec ted (Bu rns (In flammation ) Th eses
(S inus )
wo und ) Woun d) / Sc alds )
Gov t. A yurvedic Med ic al C oll eg e
1 Bang alore 04 18 01 - 01 04 28
Fac u lty o f Ay urv ed a, I.M.S. , B HU ,
2 05 15 02 - - 02 24
V aranas i
I.P. G. T. & R .A.,
3 05 13 - - - - 18
Gujarat Ay urv ed Uni versi ty , Jam n agar
Gov t. A yurvedic Col lege
4 01 09 - - 05 - 15
Hy d erabad
Ayurv ed M ahav id yal aya
5 04 09 - - 01 01 15
Nas ik, Pun e U niv ersi ty
6 S D M Co llege Of Ayu rv eda, U dup i 04 10 - - - - 14
S N K Jabs hetty Ayu rved ic
7 03 07 02 - 02 - 14
Med ic al C oll eg e, Bi dar
Sh ri Ay urv eda Mah av id yal aya
8 02 07 01 01 - 02 13
Nag p ur U niv ersi ty
Gov ernm en t Ay ur ved ic Col lege,
9 05 07 - - - 01 13
Thi ru van anthpu ram
A L N Rao Mem ori al Ay urv ed ic
10 13 - - - - - 13
Med ic al C oll eg e, Ko ppa
Gov t. Ayurv eda Mah avi dy alaya,
11 Nan d ed 03 06 01 - - 01 11
Gov t. Ay ur ved ic Col lege,: Nag pur
12 04 06 01 - - - 11
Un ivers ity, N agpur
Tilak Ay urv ed Mah avi dy alaya,
13 03 05 02 - 01 - 11
Un ivers ity, P une
S D M Co llege Of Ayu rv eda
14 01 04 01 - 01 01 08
Has san
R K Tos han iw al Ayurv eda
15 Mah avi dy alaya 03 03 02 - - - 08
Am aravati Un iv ersity, Ak ola
T M A E So ciet y`S Ay urv edi c M edi cal
16 - 02 01 - 01 - 04
C olleg e, H os pet
17 Ayurv eda M ahav id yal aya, Hu b li 01 01 - - - 01 03
Alv a`S Ayurvedic Med ic al C oll eg e
18 01 02 03
Mo odabi di ri
19 NIA, Jaip ur 01 01 - - - - 02
Sh ri Jagadguru Gur us id des h war C o -
Operati ve Ho spital And Research
20 - 02 - - - - 02
Ins ti tu te (Sh ri J G C H Society ),
Gh atap rabh a
Dr B N M Ru ral A yurved M edi cal
21 01 - - - - - 01
C olleg e, Bi japur
Dr. NR S G o vt. A yu rved ic M edi cal
22 01 - - - - - 01
C olleg e
B V C ol lege Of Ayu rv ed
23 Bharti V idya Peth Deem ed Un iv ersity, 01 - - - - - 01
Pun e
S G R A yurved Mah avi dy alaya,
24 Sh olapu r - 01 -- - - - 01
Ins tutute For P os t Grad uate T eac hin g
& Res earc h State Ayurvedic Co llege
25 - 01 - - - - 01
B R Ambedkar Bih ar Un iv ersity,
Muzaffarpu r
Ash w in i Ayurv edic Medical C olleg e,
26 Davan agere - - - - 01 - 01
Total 66 129 14 01 12 13 235

Table 2: Department wise Theses Table 3: Distribution of the Theses as Per

Distribution carried out on Vrana the Type of Study
Sr . N o. of T hesis
Department Sr. N o. o f study
N o. M.D./M .S. Ph.D.
Type of Study
1. Shaly a T antra ( Surge ry) 188 04 No. reco rded
2. D ravyagun a (A yurv edic
22 - 1. Clinical Study 203
p harm a col ogy)
3. P rasuti & stri ro ga 2. Clinico-Experimental Study 07
10 -
(O bstret ics & G yn ae colo gy) 3. Exper ime ntal Study 24
4. Rasash a stra & B haish ajya
08 -
Kalpana (Ph ar m acy )
5. Kaya Chik itsa &
Table 4: Type of Drug preparations Used
04 -
P an ch akarm a (M edicin e) for Vranaropan
6. Rach an a Sh arir a
02 - S ing le d r ug Pr ep a ra t io n s 87
(A nato my )
7. A gada T antra (Toxi cology ) 01 - C o mp o u n d d ru g P re pa r at io n s 1 39

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36 Sathis H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs

Table 5: Different Formulations used for

Continued............
Vranaropan
38 Nimba (Azadirachta indica A Juss)
Sr. No. Formulation No. of Thesis
1. Taila (Oil based preparations) 48 39 Bhallataka (Semecarpus anacardium Linn)
2. Ghrita ( Ghee based preparations) 34 40 Murivena
3. Lepa (Ointments) 13 41 Yava ( Hordeum vulgare Linn)
4. Kalka (Paste) 12 42 Manjishtha ( Rubia cordifolia Linn)
5. Choorna (Powder) 08
45 Notonia grandiflora D. C
6. Varti (Medicated sticks) 08
7. Malahara ( Ointments) 06
46 Raktapadi (Adiantum lunulatum Burm)
8. Kshara ( Alkalies) 03 47 Parnabeeja (Kalanchoe pinnatapus
9. Kwatha ( Decoctions) 04 48 Daruharidra ( Berberis aristata DC)
10. Yamaka ( Ghee + Oil based preparations) 01 49 Tila ( Sesamum indicum Linn)
11. Bhasma ( Incinerated preparations) 01
50 Yastimadhu ( Glycyrrhiza glabra Linn)
12. Rasakriya ( Aqueous extract) 01
51 Arjuna (Terminalia Arjuna
52 Hamsapadi (Adiantum Lunulatum Burm
Table 6: List of Single Drug Preparations 53 Ishwarimoola (Aristolochia Indica Linn)
1 Mams arohini(Soymid a febr ifuga Roxb) 54 Tila ( Sesamum indicum Linn)
2 Udu mb ara ( Ficu s racem osa L inn) 55 Yastimadhu ( Glycyrrhiza glabra Linn)
3 Yashada Bhasma 56 Ksudra Seventika (Tridax pocumbens)
4 Karanja ( Pongamia p inn ata Linn) 57 Yastimadhu ( Glycyrrhiza glabra Linn)
5 Daruharidra ( Ber ber is aristata DC ) 58 Udumbara ( Ficus racemosa Linn)
6 Lajjalu (M imosa p udica) 59 Manjishtha ( Rubia cordifolia Linn)
7 Daruharidra ( Ber ber is aristata DC ) 60 Vacha ( Acorus calamus)
8 Erandakarkati(Caria papaya Lin n) 61 Nirgundi ( Vitex negundo Linn)
9 Haritaki( Termina lia cheb ula Retz) 62 Patola (Trichosanthes dioica Roxb)
10 Ksudra Sev entika(Tridax pocum bens) 63 Sariva ( Hemidesmus indicus R Br)
11 Patola (Trichosan thes dio ica Roxb) 64 Saptaparna ( Alstonia scholaris Linn)
12 Patala ( Stereos pe rmum suave olens DC ) 65 Kanchanara (Bauhinia variegate Linn)
13 Jati ( Jasminu m off icin ale Lin n) 66 Nimba (Azadirachta indica A Juss)
14 Arag wadha (C assi a fi stula) Arjuna(Terminalia arjuna (Roxb) W &A)
67
15 Jati ( Jasminu m off icin ale Lin n)
68 Karanja (Pongamia Pinnata Pierre)
16 Pilu ( Salvadora pe rsi ca Li nn)
69 Shigru (Moringa Oleifera Lam)
17 Asthi Shrinkhala (Ci ssus qua ndrangular is)
70 Hamsapadi (Adiantum Lunuiatum Burm )
18 Karpoora(Cinn amomu m campohora)
71 Mayurashikha (Actiniopteris Dichotkuhn )
19 Jhin jhireeta (Triu mfetta rotundifoli a L am)
72 Karpoora(Cinnamomum camphora)
20 Svarna-K sheeri (Argemone maxicana)
21 Svarna-M akshika (Copper pyr ite) 73 Haritaki( Terminalia chebula Retz)
22 Karanja ( Pongamia p inn ata Linn) 74 Bala (Sida cordifolia)
23 Daruharidra ( Ber ber is aristata DC ) 75 Kadali ( Musa paradisiacal Linn)
24 Doorva ( C yn odon dactylon Linn) 76 Yastimadhu ( Glycyrrhiza glabra Linn)
25 Lodhra(Symplocos racemosa) 77 Dhataki ( Woodfordia fruticosa Linn)
26 Dhataki ( Woodfordia fr uticosa Linn ) 78 Madhu (Honey)
27 Nirgundi ( Vitex neg undo Linn) 79 Haridra ( Curcuma longa)
28 Nimba (A zadirach ta indica A Juss) 80 Guggul(Commnifera mukul)
29 Udu mb ara ( Ficu s racem osa L inn) 81 Yastimadhu ( Glycyrrhiza glabra Linn)
30 Man jishtha ( R ubia cordifolia Lin n) 82 Karanja (Pongamia Pinnata Pierre)
31 Kiratati kta (Swertia chir ata) 83 Manjishtha ( Rubia cordifolia Linn)
32 Tuttha ( Copper s ulphate) 84 Jati (Jasminum Grandiflorum Linn)
33 Arka ( Calotr opis proce ra ) 85 Yastimadhu ( Glycyrrhiza glabra Linn)
34 Nirgundi ( Vitex neg undo Linn) 86 Sandhya Raga (Mirabilis Jalapa. Linn)
35 Udu mb ara ( Ficu s racem osa L inn) 87 Kshudra Sevantika (Tridax Procumbens Lin )
36 Madhu (Honey)
37 Vata-Praroha (Ficus be ngalen sis Li nn)

Indian Journal of Ancient Medicine and Yoga

 37

Table 7: List of Compound Preparations Continued...........

48. Karanja Malahar
1. Amritadi Guggulu Karanjadi Ghrita
49.
2. Analadi Thaila Pichu 50. Karanjadi Ghrita
3. Apamarga Kshara Taila 51. Karanjadi Taila
4. Apamarga Kshara-Sootra 52. Karanjadi Tailam
5. Aragvadadi Varti 53. Karanjaditaila
6. Aragvadhadi Varti 54. Karkaradi Ghritam
7. Aragwadadi Sutra Varti 55. Karpoora Ghrita
8. Bhallatakadyam Taila 56. Karpoora Ghrita
9. Bhudhatryadi Taila 57. Karpooradi Dhoopana
Chandanadi Tailam 58. Kasisadi Taila
10.
59. Ksara Taila
11. Chandanadi Yamakam
60. Kshara
12. Chandraprabha Gutika
61. Kshara Lepa
13. Darana Lepa
62. Lodhra – Haridra Avachoorna
14. Darvyadi Ghrita 63. Madhu Ghruta Yukta Nimba Kalka
15. Dashanga Lepa 64. Madhu Sarpi
16. Dooravadi Tela 65. Madhuchhistadi Ghrita
17. Doorvadi Ghrita 66. Madhuchistadi Grutha
18. Durvadi Ghritam 67. Madhusarpi
19. Durvadi Taila 68. Madhusarpi
20. Durvadi Taila 69. Madhu-Sarpi
21. Durvadi Thailam 70. Madhuyashti Siddha Ghrita
22. Dwiharidra Rasakriya 71. Madhuyukta Jatyadighruta
72. Magadhyadi Taila
23. Gairikadya Malahara
73. Manjishtadi Ghrita
24. Ghontaphaladi Varti
74. Manjishthadi Ghrita
25. Gouradya Ghritam
75. Manjishthadi Ghrita
26. Gugguladi Dhoopanakarma
76. Manjishtha-Siddha Ghrita
27. Guggulu-Panchapala 77. Nimba (Patra) Taila
Choorna 78. Nimba Patola Patra Kwatha
28. Guggulu-Tiktaka Ghrita 79. Nimba Patradi Lepa
29. Haridradi Malahara 80. Nimbadi Kalka
30. Haridradi Taila 81. Nimbadi Kwatha
31. Jatyadi Ghrita 82. Nimbadi Taila
32. Jatyadi Ghrita 83. Nimbapatradi
33. Jatyadi Ghruta 84. Nimbapatradi Lepa
34. Jatyadi Taila 85. Nimbapatradi Lepa
86. Nirgundi Taila
35. Jatyadi Taila
87. Nyagrodhadi Ghrita
36. Jatyadi Taila
88. Pancha Tikta Guggulu Ghritam
37. Jatyadi Taila
89. Pancha-Valkala Kashaya
38. Jatyadi Taila 90. Panchavalkala Kwatha
39. Jatyadi Taila 91. Patola Taila
40. Jatyadi Tela 92. Pratisarana Kshara
41. Jatyadi Thaila 93. Pratisaraneeya Kshara
42. Jatyadi Varti 94. Punarnavadi Lepa
43. Jatyadigritha 95. Rasa Mezhugu
44. Kalanusaryadi Taila 96. Rasa-Sindoora
45. Kamkshi Malahara 97. Rasnadi Tab
46. Kanadi Taila 98. Ropana Ghrita
99. Saindhav Varti
47. Karanja Ghrita

Volume 7 Number 1, January - March 2014

38 Sathis H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs

Table 8: List of Taila Preparations

Continued.........
101. Saindhavadi Varti 1. N im badi T ail a
102. Sakshaudra Nimbadi Ghrita 2. Kas isad i T aila
3. Ks ara T aila
103. Samagandhi Taila
4. Mag ad h yad i T aila
104. Saptanga Guggulu
5. Jati P u sh pa T aila
105. Savarnikarana Yoga 6. B hu dh atry ad i T aila
106. Shamana Lepa 7. Jati taila
107. Shodhana Kesari Lepa 8. P ilu taila
108. Surasadi Taila 9. Asth i Sh rinkh ala taila
Swatha Malhar 10. Yas htim ad hu vad i oil
109.
11. D urv ad i T aila
110. Taleesadya Taila
12. Vajraka T ail a
111. Tiktadi Ghrita 13. Kar anjad i T ailam
112. Tiktadi Ghrita 14. Vajra-K and a Tai la
113. Tiktadya Ghrita 15. Arka T aila
114. Tila Kalka And Madhu 16. N im ba (P atra) T aila
115. Tilakalka And Madhu. 17. B hal latak taila
Tilakalkadi Lepa 18. Jaty ad i taila
116.
19. Kar anjad iT aila
117. Triphala Guggulu
20. Jaty ad i T hail a
118. Triphala Guggulu 21. Jaty ad i T aila
119. Triphala Guggulu 22. Kar anjad i T aila
120. Triphala Guggulu 23. D urv ad i T aila
121. Triphala Guggulu 24. Jaty ad i T aila
122. Triphala Kvatha 25 . Kan adi T aila
26 . Ap am arg a K sh ara taila
123. Triphala Kwatha
27 . N irg und i taila
124. Triphala Yog 28 . P atola tai la
125. Tuga-Ksheeriryadi Lepa 29 . H arid rad i taila
126. Tuthakadyo Malahara 30 . T alee sad ya T aila
127. Udumabaradi Ghana-Vati 31 . D urv ad i T hailam
128. Udumbara Ksara 32 . Sam ag and hi T aila
33 . Kalan usar yad i T aila
129. Vajraka Taila
34 . B hal latakady am Tai la
130. Vajra-Kanda Taila
35 . Ch and anad i T ailam
131. Vanshalochanadi Lepa 36 . Vran araksh asa & Lajj alu M oo la T ail
132. Viparithamalla Taila 37 . bala taila
133. Vranaghna Malahar 38 . Sur asad i T aila
134. VranapahariRasa 39 . D oorav adi T ail a
135. Vranarakshasa & Lajjalu Moola Tail 40 . Jaty ad i T aila
41 . Yas htim ad hu sid d ha taila
136. Vranaropana Taila
42 . Kar anjs idd h a tai l
137. Vruna Raksha Taila
43 . Jaty ad i taila
138. Yashtimadhuvadi Cap 44 . Vip arith am alla T aila
139. Yashtimadhuvadi Oil 45 . Vran arop ana T aila
140. Yestiyadi Ghana Vati 46 . Jaty ad i T aila
47 . Jaty ad i T aila
48 . Analad i T h aila
Discussion
Due to the diversity of the types of Vrana, it
always imposed the challenge to the researcher
Vrana is the favourite area of Shalya Tantra
for better management. In search of better
for research works. It is a vast subject afflicting
drugs, prescribed in the classical texts, many
the human being since ages and attracting the
trials have been conducted for evaluating the
physicians for its comprehensive management.

Indian Journal of Ancient Medicine and Yoga

 Sathis H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing) 39
Properties of Ayurvedic Drugs

Table 9: List of Ghrita Preparations Table 11: List of Choorna & Varti
1 Tiktadi G hrita Preparations
2 Jatyadi Ghrita Sr. Choorna Sr. Varti
3 Jatyadigritha No. Preparations No Preparations
4 Jatyadi Ghrita Lodhra – Haridra Aragwadadi
1 1
Avachoo rna Sutra Varti
5 Madhuyukta Jatyadighruta
Guggulu-Panchapala Aragvadhadi
6 Karanjadi Ghrita 2 2
Cho orna Varti
7 Karpoora Ghrita 3 Lodhra Choorna 3 Saindhava Varti
8 Nyagrodhadi Ghrita 4 Dhataki Choorna 4 Jatyadi varti
9 Manjishthadi Ghrita 5 Nirgundi Choo rna 5 aragvadadi v arti
10 Karanja Ghrita Gho ntaphal adi
6 Dhataki Choorna 6
Varti
11 Daruharidra Ghrita
7 Dhataki Choorna 7 Saindhav Varti
12 Doorva Ghrita 8 Haridra churna 8 Saindhavadi Varti
13 Udumbara-Siddha Ghrita
14 Manjishta-Siddha Ghrita Table 12: List of Malahara Preparations
15 Tiktadya Ghrita 1 V r a na gh na M a la ha r
16 Madhuchhistadi Ghrita 2 K a r an ja M al ah ar
17 Karkaradi Ghritam 3 K a m ks h i M a la h ar a
18 Guggulu-Tiktaka Ghrita 4 H ar id ra d i M a la ha ra
19 Udumbara siddha ghrita 5 G a irik ad y a M a lah a ra
6 T u t ha ka d y o M al ah ar a
20 Manjishtha-Siddha Ghrita
21 Manjishtadi Ghrita
effectiveness. An effort has been made to
22 Sadyo nirmita Goghrita
summarise the all trials by assessing their titles.
23 Durvadi ghritam
Approximately 235 works were reported
24 Darvyadi Ghrita
Karpoora Ghrita
which showed clear dominance of trials on
25
26 Tiktadi G hrita
vranaropana in the research studies of Shalya
27 Gouradya Ghritam
Tantra by 26 Ayurvedic institutions, offer
28 Doorvadi G hrita Postgraduate course in this speciality. Some
29 Ropana Ghrita research works on vrana were also carried out
30 Karanjadi Ghrita in other departments as well which again
31 Manjishthadi Ghrita shows dominating nature of the disease. On
32 Manjishtha siddha ghruta Dushtavrana more projects were reported
33 Madhuyashti Siddha Ghrita which shows the real challenging area for the
34 Madhuchistadi Grutha rsearch workers.
203 exclusive clinical works were done out
Table 10: List of Lepa & Kalka Preparations
Sr . N o. Le pa Pre parations Sr. No . K alka Pr eparations
1 Ha r itaki Lepa 1 Tilakalka an d m adh u .
2 Sh am ana Lep a 2 Tilakalkadi le pa
3 D ar a na Lepa 3 Nim badi kalk a
4 Ni m ba pa tradi Lep a 4 Tila Kalka an d Ma dhu
5 Ni m ba P a tradi Lep a 5 Madh u gh ru ta y ukta ni m ba kalka
6 Ksh ar a Le pa 6 Nir gu ndi k al ka
7 Tilakalk adi Le pa 7 Nim ba kalka
8 Ni m ba pa tradi Lep a 8 Vata -pr aroh a k alk a
9 D ash an ga Lep a 9 Tila kalka
10 Vanshal ochan adi Le pa 10 Ya shtim a dhu ka lka
11 Sh odha na ke sa ri lep a 11 Tila kalka
12 Tu ga-Kshee ri ryadi Lep a 12 Ya sti m adhu k alk a
13 Pu narna va di Lep a

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40 Sathis H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs
of total 235, while experimental studies were
24 and only 07 clinico-experimental studies
were reported. It shows the clinical importance
of the studies with well supported
experimental studies, particularly for new
combinations of the drugs. Few numbers of
works on DagdhaVrana (burn wound) were
noted and there is a need to work more on
this area; because healing of burn wound itself
is a burning problem and need to be worked
hard to find out a suitable drug or drug
formulation which will lift the glory of this
branch as well.
‘Vaikrutapaham’- the cosmetic valued
remodelling of scar and good appearance of
wound site after healing has been the
uniqueness of the Shalya Tantra. Only 02
works were conducted related to this field and
require more work to be done on the topics of
Avasadana Karma (Normalizing hyper trophied
tissue), Krushnikarma (Hyper pigmentation),
Pandukarama (Hypo pigmentation),
Romasanjanana (Growing of hair) which may
offer good cosmetic value in the beauty
conscious society. So call for researches in these
areas is arising.
Conclusion
Vrana is such a condition which can come
across at any point of life for any one. Healing
of the wound without any complications
within short span of time is reflecting the art
of healing. The theses conducted across India
on vranaropan were shown many aspects for
selecting the problems and related drug as well
as drug formulation. Researchers were always
in search of a best tool which can overcome
the obstacles in healing. So that, majority of
works was targeted on Dushtavrana because
it is still a challenging issue for the physicians
and surgeons. The works seems to be only on
local application of ghee and oil based
preparations where the other therapeutic
modalities were less tested, which is actually
needed as Sushruta had explained 60 special
ideas for treating vrana. On Dagdha vrana very
less number of works were reported; many
more types of Vrana need to be tried. There is
call for more scientific and applied research
on other therapeutical preparations described
by our ancient literatures. As this study is a
bird’s eye view on the works on Vrana.
Majority of the titles were unclear about the
mode of treatment. Hence, with detailed
information on each thesis, more data will be
collected, which will be helpful in knowing the
protocol and outcome of each work. The
present study has shown only the trend of
research conducted on Vrana at different
Ayurvedic institutions of India.
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Pramehaja Vrana i.e. diabetic wounds. 2005.
103.Bhat Manjunath. The study of Triphala Kvatha
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112.Sreejith KP. Comparative study of Jatyadi taila
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113.Nadakuduru Tejo Lakshman. A comparative
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129.Sanjay Trivedi. Management of Dagdha vrana
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131.Lakhpati AM. Dushta-Vranon mein Kamkshi
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148.Chandra Kumari S. Pramehaghana and
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150.Vijay R. Anti-inflammatory and wound-healing
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151.Vimala N. Study on Rasa Mezhugu and its
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152.Jagatap VK. Study on Raktapadi on
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153.Rathod SP. A study on Parnabeeja (Kalanchoe
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155.Bindu, B. Management of Dusta Vrana with
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157.Jayakrishnan G. An experimental and clinical
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158.Pankaj P Surve. A study on Saptaparna w.s.r. to
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159.Pradeep. Wound Healing Property of
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160.Binu Alappat A. Comparitive Study On Wound
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161.Harihara Prasad Rao H. Standardisation of
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162.Vinod V Joshi. An Experimental evaluation of
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163.Sunil Kumar. An Experimental Evaluation On
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164.Nisha Babu. An Experimental Evaluation Of
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165.Pronab Haldar. Pharmaceutical &
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166.Rama Kumar R. A Pharmaceutical And
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167.Anuradha. Pharmaceutical and Experimental
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168.Jagadish Mayya A. A Comparative
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169.Shukla Das. A Pharmaceutical & Experimental
Study Of Vranarakshasa & Lajjalu Moola Tail
W.S.R.To Vrana Ropana Property. 2010.
170. Kadri MJ. Dushta vranavar Haridra churna
avachurnan. 1994.
171.Sheikh Arefa. Dushta vranawar Guggul
dhupanacha parinam abhyasane. 1995.
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45
172.Kale Lakshmi. Agantuj vranawar
Yashtimadhusiddha tailacha parinam
abhyasan. 1995.
173.Gujjarwar Shrinivas. Vranashothawar
Raktamokshan Parinam Abhyasane. 1996.
174.Birhade. To study effect of madhu pratisaran
on garbhashay greeva vrana. 1998.
175.Dnyaneshwar Chavan. Effect of Karanjsiddha
tail on Dushta vrana. 2004.
176.Mali Sandip. Dagdha vranavar Manjishtha
siddha ghrutacha parinam abhyasane. 2004.
177.Yogita B. Watpade, To study the efficacy of
Triphala guggulu in treatment of Post operative
wound. 2004.
178.Diwakar Patel. To study the efficacy of
Sakshaudra Nimbadi ghrita in the
management of Dushta Vrana ( Infected
wound). 2005.
179.Kakade Pravin. Agnidagdha vranat triphala
yog vranakarmacha parinam abhyasane. 2006.
180.Lohana NT. Roll of local application of
Dwiharidra Rasakriya in the management of
dushtavrana at lower limb. 2006.
181. Sunil G. Dhawale, Role of Triphala guggulu in
different doses in the management of post
operative wound w.r.t. T.V.H. 2006.
182. Qureshi. Role of “Udumbara Ksara” in
treatment of Dusta Vrana. 1993.
183.Deshmukh RD. Vrana Chikitsa mein Lodhra –
Haridra Avachoorna ki Upayogita – Ek
Adhyayana. 1994.
189.Sharma K. Role of Tridax pocumbens in the
management of wounds & bleeding piles.
1994.
190.Dixit Shilpa. Gairika Shodhana evam
Gairikadya Malahara ka Sidhma-Vrana
Vyadhi par Aturalayein Adhyayana. 2000.
191.Dhore S Rajesh. Therapeutic evaluation of
Madhusarpi (on healing effect) in Sadyo-Vrana
(skin deep – Chhinna-Vrana and Ghrista-
Vrana – incised and lacerated wound). 2001.
192.Kathane Vandana. Role of Kanadi Taila in the
Vrana of Madhumehi person. 2001.
193.Bhattad Manisha. Clinical studies of Haridradi
Malahara (ointment) in the management of
Nija-Vrana. 2003.
194.Kasture Rupali V. Clinical study of
Vanshalochanadi Lepa in the management of
Dagdha-Vrana. 2005.
46 Sathish H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs
195.Sakharkar Bhagyashri, Clinical evaluation of
Tila Kalka and Madhu w.s.r. to Sandhana
Karma. 2006.
196.Sangrame Mahendra. Management of ulcers in
diabetic patients on principles mentioned in
Sushruta Samhita. 2007.
197.Jain Shraddha. Experimental valuation of
antiulcer property of Yashtimadhu. 2008.
198.Chavan JG. To study the ropana effect of
Udumbara siddha ghrita on Shuddha Vrana.
1997.
199.Patil DR. Comparative study of efficacy of
different taila snehas in Acchapana Kalpana
w.s.r. to Haridradi taila (Vrana ropana taila).
1998.
200.Bhavasar Shubhada. To study the effect of
Apamarga Kshara taila in Nadi Vrana as
Pratyaneeka Chikitsa. 1998.
201.Rout Aparna. Manjishtha-Siddha Ghrita cha
Vrana-Ropanartha Upayoga. 1998.
202.Kulkarni Vinayak. To study the efficacy of
Vacha ( Acorus calamus) in the treatment of
Dushtavrana. 2000.
203.Gaikawad DB. Study of Vrana – Shodhana &
Ropana property of Nimbadi Lepa. 2002.
204.Tilu Girish. Study of Vrana-Shodhaka Karma of
Sariva ( Hemidesmus indicus R Br). 2002.
205.Vaidya Amol. The Comparative study of
Manjishtadi Ghrita & Sadyo nirmita Goghrita
for local application on Dagdha Vrana(Burns).
2003.
206.Borate Sanchin. To study the efficacy of Nimba
Patola patra kwatha for Vrana Kshalana
(Shodhana) in treatment of Dushtavrana. 2004.
207.Chikaram M K. Efficacy of Nirgundi taila for
Vrana ropana – Shodhana in the treatment of
Dushtavrana. 2005.
208.Pagar Vishal V. To Study The Efficacy OF
Patola taila for local application in Dagdha
Vrana (Burn). 2005.
209.Siddaiah Aradyamath. Effect of Doorvadi
Ghrita on Madhumehaja Vrana. 2001.
210.Biradar Vijaya Kumar. Management of Dusta-
Vrana w.s.r. to Virechana. 2001.
211.Pathak Avinash. Effect of Pratisaraneeya
Kshara in Nadi-Vrana w.s.r. to pilonidal sinus.
2002.
212.Balareddy Shivaputra. Effect of
Jalaukavacharana in the management of Pittaja
Dushta-Vrana. 2003.
213.Shindhe Pradeep Shahajirao. Effect Of Ropana
Ghrita In The Management Of Dagdha Vrana.
2008.
214.Betagiri Santosh Shreekant. Effect Of
Jalaukavacharana In The Management Of
Pittaja Vranashopha. 2008.
215.Anitha HR. Role Of Savarnikarana Yoga In The
Management Of Rudha Vrana. 2010.
216.Varun Behi. Role Of Surasadi Taila In Kaphaja
Dushta Vrana As Shodhana Effect. 2011.
217.Shegokar Madhuri M. Dushta-
Vranamadhyache Yashtimadhu Siddha
Ghritacha Vrana-Ropanartha Upayoga va
Tulanatmaka Adhyayana. 1994.
218.Sakarkar Ujjvala. Vrana-Ropanartha
Dooravadi Telacha Upayog Ek Tulanatmaka
Adhyayana. 1996.
219.Bhandari PS, Vrana-Ropanartha Jatyadi
Telacha Upayoga va Ek Prayogatmaka
Adhyayana. 1998.
220.Gangasagar BY. Vrana-Ropanartha Karanjadi
Ghritacha Upayoga – Ek Prayogatmaka
Adhyayana. 1998.
221.Soni Laxmi R. Role of Dhoopana on Dushta-
Vrana. 1999.
222.Abdul Nabi AS. Role of Manjishthadi Ghrita in
the management of burn (Dagdha- Vrana – A
comparative study. 2003.
223.Dane PR. A comparative study of Dhataki
Choorna Avachoornana in the management of
Dushta-Vrana. 2004.
224.Deshapande Priti. Role of Tuga-Ksheeriryadi
Lepa in the management of Dagdha- Vrana – A
comparative study. 2005.
225.Rajashekhar H, Management Of Dusta Vrana
With Tuthakadyo Malahara. 2005.
226.Deeepak Naryal. A Comparative Study Of
Effect Of Madhuchistadi Grutha With Silver
Sulfadiazine In Dagdha Vrana. 2007.
227.Pavani M. A Clinical Study In The
Management Of Nadi Vrana With Saindhavadi
Varti. 2007.
228.Saji Desayus. Management Of Bahya Guda
Gata Vrana (Peri-Anal Wound) With Lekhana
Karma And Application Of Analadi Thaila
Pichu - A Clinical Study. 2008.
229.Paliwar Amit Ashok. Management Of Vrana
Shopha By Punarnavadi Lepa And
Indian Journal of Ancient Medicine and Yoga
 Sathish H.S. et al / Overview of Academic Researches on Vranaropan (Tissue Healing)
Properties of Ayurvedic Drugs
Jaloukavacharana-A Comparative Clinical
Study. 2006.
230.Ravindra G Varma. A Critical Study Of
Indigenous Suture Materials W.S.R To
Management Of Kshataja Vrana. 2008.
231.Markandeya G Jedar. A Critical Analysis Of
Vrana Chikitsa [Wound Management] With
Special Reference To Madhumehajanya Vruna
[Diabetic Wound]. 2009.
232. Shehna SR, Analytical Study Of The Plant
Sandhya Raga (Mirabilis Jalapa. Linn) With
Special Reference To Its Vranaropana Property
In Comparison With Madhusnuhi (Smilax
China Linn). 2005.
233.Jayalakshmi R. A Clinical Study On The
Efficacy Of Shata Dhautha Ghruta In The
Management Of Dushta Vrana. 2008.
234.Deepthi S. A Comparative Clinical Study On
The Efficacy Of Viparithamalla Taila And
Jatyadi Taila In Dushta Vrana. 2009.
235.Sharma GL. Vrana Ropana mein Jatyadi taila ki
karmukata ka adhyayan. 1997.
236.Rajesh Kumar Gupta. Vrana me Madhusarpi
evam sarpi haridra ki karmukata ka
chikitsatmak adhyayan. 2005.
237.Naik Paragouda Basagouda. Comparative
Efficacy Of Vranaropana Taila And Jatyadi
Taila In The Management Of Vrana ( Wounds
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47
And Ulcers). 2006.
238.Sugate Shridhar Keshav. Evaluation Of
Kshudra Sevantika (Tridax Procumbens Lin )
Taila In Comparison With Jatyadi Taila In The
Management Of Vrana. (Wounds & Ulcers).
2007.
239.Dhulappa D Mehatre. Pharmacognostical And
Phytochemical Study Of Jati (Jasminum
Grandiflorum Linn) With Special Reference To
Its Vranaropana (Wound Healing Activity)
Property. 2008.
240.Badarinarayana. Pharmaceutical and clinical
study of vranapahari rasa w.s.r. to its
vranaropana property. 2008.
241.Nawale Vijay T. A clinical trial of Madhuyashti
Siddha Ghrita Parishek as Vrana Ropaka in
Yonigat (Prathamavarta & Bahya Yoni) Sadyo
Vrana formed during Prasava. 2005.
242.Gabale HS. Role of Vrana-Ropana and Vrana-
Shodhana oil on wound. 1990.
243.Surendra Kumar. Katipaya Pramukha Vrana-
Shodhaka Dravyon ka Tulanatmaka
Adhyayana. 2000.
244.Vikram S. A Clinical Compararive Study On
The Efficacy of Ghontaphaladi Varti And
Saindhav Varti In The Management Of Nadi
Vrana. 2007.