WOZHOU OASIS CHEMICALS CO., LTD.

MATERIAL SAFETY DATA SHEET

PRODUCT: TRICLOSAN USP

Dated Printed :18/04/2015 PAGE: 01 /07

SECTION 1: CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

1. PRODUCT DETAILS

Product Name : TRICLOSAN

Chemical Name : 2,4,4’-Trichloro 2’-hydroxy diphenyl ether.
Chemical Formula : C12 H7 Cl3 O2
Molar Mass : 289.5
Chemically Family : CHLORO PHENOL
Use : ANTI MICROBIAL AGENT

SECTION 2: Composition / information on ingredient

Chemical name CAS No. Proportion

2,4,4’-Trichloro 2’-hydroxy diphenyl ether. 3380-34-5 100%

Exposure Limit Toxicity Data

ACGIH/PPM OSHA/PPM
TWA STEL PEL % By Wt Dermal (Rabbil) LD50> 6,000mg/kg
None None None 100 Inhalation (Rat) LD50> 140mg/m3
Ingestion (Rat) LD50>5,000 mg/kg

SECTION 3: PHYSICAL AND CHEMICAL PROPERTIES

Appearance : White crystalline powder

Odour : Light aromatic
Solubility : Soluble in alcohol, chloroform, acetone etc.
Boiling point : Not applicable
 PAGE: 02 /07

Melting point : 56-58 C

-4
Vapour pressure : 7 x 10 (exp ) Pa
Volatiles : Dissociation constant : pKa = 8.14 @ 200 C
Evaporation rate : Not applicable
Vapour density : Not applicable
Specific Gravity : Not evaluated
Flash Point : 2230 C (433.4o F) (Tag closed cup)
Auto Ignition Temperature : Not applicable
Flammable Limit : Not applicable
Other properties if Applicable : Not available

SECTION 4: HAZARD IDENTIFICATION

MOST IMPORTANT HAZARDS :

HMIS Hazard Classification: NFPA Hazard Classification:

Health 2 Health 2
Flammability 1 Flammability 1
Reactivity 0 Reactivity 0
Personal Protection E
Routes of Entry : Inhalation and dermal

Potential Health Effects : Very toxic to aquatic organisms. Target Organ effect : Animal
revealed the liver is a target organ at high doses; however, liver injury is not likely to
occur in humans because of the very low human exposure and the differences in liver
responses between some species and humans. The U.S. Food and Drug Administration
has concluded lower doses are safe for human consumption.

Carcinogenicity (NTP) : Not listed

Carcinogenicity (IARC) : Not listed
Carcinogenicity (OSHA) : Not listed

SECTION 5: FIRST AID MEASURES

Ingestion : If conscious, give plenty of water to drink. Get medical attention.

If unconscious, do not give anything to drink. Get immediate
medical attention.
Eye contact : Flush eyes with water for at least 15 minutes. Get medical
attention.
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Skin contact : Wash with mild soap and water. If irritation occurs, get medical
attention. If clothing is contaminated, remove and wash before
reuse
Inhalation : Remove to fresh air. Get medical attention.

SECTION 6: FIRE FIGHTING MEASURES

FLAMMABLE LIMITS
Flash Point: 2230 C (433.4o F) Method Used : ASTM D56 (Tag closed cup)
Flammable Limits in Air – Lower: Not Applicable
Flammable Limits in Air – Upper: Not Applicable
Auto-Ignition Temperature : : Not Applicable
Extinguishing Media: Carbon dioxide, dry chemical, foam, water.

Fire fighting instruction: Firefighters should wear self-contained breathing apparatus

and protective clothing.
Special hazards:
Fire and Explosion Hazards : No unusual hazards.
Hazardous Combustion Products : Burning may produce hydrogen chloride, chlorine and
oxides of carbon.

SECTION 7: ACCIDENTAL RELASE MEASURE

Leak / Spill : Prevent entry in to drains and surface water. Large releases to surface
waters may result in fish kills and require reporting to the local authorities.

SECTION 8: HANDLING AND STORAGE

Handling: Skin and eye irritation. Avoid contact with eyes, skin and clothing.

Storage: Keep container closed. Store in a cool place. For industrial use only.
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SECTION 9: EXPOSURE CONTROL AND PERSONAL PROTECTION

Exposure Limit
ACGIH/PPM OSHA/PPM
TWA STEL PEL % By Wt
None None None 100
Engineering Measures: Local exhaust recommended, mechanical exhaust acceptable

Emergency Response Protection : No additional specialized equipment should be

required.
Personal protection: Wear appropriate equipment to prevent probability of exposure and
personal contact. Deluge safety shower and eye wash should be located near work area.

Eye Protection : Wear side-shield safety glasses.

Skin Protection : Wear impervious gloves as a standard handling procedure.

Respiratory Protection : In cases where there is a likelihood of inhalation exposure to the

powder(dust), wear a dust respirator.

SECTION 10 : STABILITY AND REACTIVITY

Stability : Stable
Conditions to avoid : Direct sun light
Incompatibles : Avoid contact with chlorinating substances.
Decomposition Products: -
Hazardous polymerization: Will not occur

SECTION 11 : TOXICOLOGICAL INFORMATION

Toxicity Data :

Eye Irritation: (Rabbits) irritant

Skin Irritation: (Rabbits) irritant
3
Inhalation Toxicity : (Rats) LC50>140mg/m
Sensitization : In guinea pigs, not a dermal sensitizer by maximization tes or Buehler
(non-adjuvant) test
Photo toxicity (Humans) : Not photo toxic by dermal route.
Photo allergy (Humans) : Not a photo sensitizer by dermal route.
Acute Dermal Toxicity : Acute Dermal (Rabbits) LD50 > 6,000 mg/kg
Acute Oral effects : (Rats) LD50 > 5,000 mg/kg.
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Chronic: The primary target organ after oral dosing is the liver in rats and mice and the
kidney in hamsters. The NOEL in Rats is 52(males) and 67(females) mg/kg/d, and in
hamsters 75 mg/kg/d.

Carcinogenicity: Rat and hamster chronic studies did not reveal any pre-neoplastic or
neoplastic effects of oral dosing. A carcinogenicity study in mice fed at 10 up to 200
mg/kg/d revealed a significant incidence of tumors only in the liver of mice exposed to
30 mg/kg/d and higher. The NOEL of 10 mg/kg/d is over 600 times higher than relevant
human exposure levels and, according to the USFDA, provides sufficient margin of
safety for human use.

Reproductive Effect : Rat fertility and reproduction index values over two generations
were not adversely affected at 150 mg/kg/day, the highest dose given in the diet. For
offspring (F1 pups), the NOEL is 50 mg/kg/day based on increased (p<0.05) body
weight.
Mutagenicity : Not mutagenic in bacterial (Ames) assay and mouse lymphoma test (TK
locus). Not clastogenic in CHO cells in vitro.
Unscheduled DNA synthesis did not occur.
Negative in mouse micronucleus test in vivo.

Target organs : Liver

Effects of over exposure :

Skin contact : Irritation, prolonged contact may cause dermatitis.
Eye contact : Irritation, may cause temporary corneal damage.

SECTION 12: ECOLOGICAL INFORMATION

Mobility : Immiscible with water

Bioaccumulation : Relatively low BCF (Method : BCF fish study. Result 2.7-90)
Biodegradability : Not readily biodegradable. Aerobic soil showed primary
biodegradation with half-life of 17-35 days
Aquatic Toxicity : Harmful to aquatic organisms.
 PAGE : 06 /07

Taxonomic group End point Exposure Time Results (mg / L)

Days
Algae No data - -
Crustaceans EC50 immobility 2 0.39
Fish LC50 4 0.25
2 2.01

SECTION 13: DISPOSAL INFORMATION

Waste Disposal Method: Incinerate in a furnace where permitted under appropriate

federal, state and local regulation.
Container Disposal information: emptied container may contain product residue and
should not be reused.
Additional information: Do not discharge effluent containing this product into lakes,
steams, ponds, estuaries, oceans or public waters unless in accordance with the
requirements of local pollution control board permit and the permitting authority has been
notified in writing prior to discharge. Do not discharge effluent containing this product in
to sewer system without previously notifying the local sewage treatment plant authority.

SECTION 14: TRANSPORT INFORMATION

DOT : Not Regulated
IATA : Not Regulated
IMDG : Environmentally hazardous substance, Solid
Classification : Marine 9 Pollutant
UN Number : 3077
UN Packaging Code : 1H2 / Z 33 / S
Special instruction: Store in cool place.

SECTION 15: REGULATORY INFORMATION

a. Proposed classification: Irritant
Dangerous for the environment.
b. R Phrase : R 36/38, irritating to eyes and skin
R 50/53, very toxic to aquatic organisms, may cause
long term affects in the aquatic environment.

c. S- Phrase : S 26 in case of contact with eyes, rinse

Immediately with water and seek medical advice.
S 37/38 wear suitable gloves and eye / face
protection
 PAGE: 07 /07

S 61 avoid release to the environment. Refer to

special instruction / safety data sheet.

SECTION 16: OTHER INFORMATION

CAUTION! For manufacturing, processing, or repacking by trained Personnel.

The information and recommendations contain herein all based upon data believed to be
correct and complies with current FDA regulations for cosmetics and personal care
products. However, no guarantee or warranty of any kind expressed or implied is made
with respect to the information contained herein. The user assumes all liability for any
damage or injury resulting from abnormal use, from any failure to adhere to the
recommended practices. This Material Safety Data Sheet was prepared to comply with
the OSHA Hazard standard and with the Workplace Hazardous Materials Information
System ( WHIMIS).