No Jenis Kelainan Bentuk Definisi
1 Döhle bodies Döhle bodies are variably
sized, variably shaped, light
blue to slate gray structures in
the cytoplasm of neutrophils.
These foci are clumps of
endoplasmic reticulum that are
usually degraded during
maturation, yet retained during
accelerated neutron- poiesis.
2 Diffuse Cytoplasmic The neutrophil cytoplasm
Basophilia stains basophilic (blue).
Diffuse basophilia occurs
when ribosomes remain
scattered throughout the
cytoplasm (as opposed
to being clumped into Döhle
bodies), instead of being
degraded during maturation.
Diffuse cytoplasmic
basophilia is graded as a mild,
moderate, or severe,
depending on the number of
neutrophils affected
and the severity of the
basophilia.
3 Foamy Cytoplasm Neutrophils containing foamy
appearing vacuoles within
their cytoplasm are considered
toxic. Toxic vacuolization
generally is recognized in
association with diffuse
cytoplasmic
basophilia, as the basophilic
background enhances the
ability to discern the vacuoles.
Kausa Gambar Tangan Gambar Literatur
Regardless of the number
of neutrophils containing
Döhle bodies, when
occurring alone without
other toxic changes, Döhle
bodies should never be
interpreted as meaning
anything more than a mild
toxic change in dogs. Döhle
bodies may occur in
clinically healthy cats and,
thus, are often not reported
as a toxic change in cats
unless these bodies are
numerous or present with
other toxic changes.
The presence of diffuse
cytoplasmic basophilia
indicates systemic
inflammation,
regardless of whether a
neutrophilia or a left shift
exists (although it usually is
associated with
both).
Toxic vacuolization occurs
secondary to systemic
inflammation or
artifactually.
4 Toxic granulation Neutrophils containing low to
high numbers of magenta-
staining cytoplasmic granules
are toxic. These are retained
primary granules, which are
not normally present in later
stages
of neutrophil development
(usually seen up to the
progranulocyte stage)
5 Giant neutrophil Giant (larger than normal)
neutrophils and bands are
considered a toxic change
that affects cell size.
6 Hyalinized nuclei Hyalinized nuclei have been
considered a toxic change but
may also represent
deterioration or autolysis
7 Asynchronous nuclear Nuclear lobes with dispersed
maturation chromatin (indicating
immaturity) that are connected
by very thin constrictions or
filaments (indicating
maturity). Lobulated nucleus
with an immature cromatin
pattern.
Toxic granulation indicates
systemic inflammation.
Skipped cell divisions
during accelerated
neutrophil production and
maturation
process may lead to the
formation of large
neutrophils and bands in
the peripheral blood. This
is generally associated with
other toxic changes.
Cellular degeneration,
cause by bacterial toxin,
and degeneration of bone
marrow
An indication of dysplasia.
Disorderly nuclear
maturation, it may
accompany resurgent
granulapoiesis, granulocyte
leukemia and myelo-
dysplastic syndrome.