Group no: 09

Extended release tablets

Tablet name and Buffer (Name, Apparatus Speed Time Q

Strength pH & Quantity) I/II
1 Nifedipine 0.05M Phosphate II 100rpm 1hour NMT 30%
30mg buffer,7.5, 4 hours 30%-55%
900ml 8 hours NLT 60%
12 hours NLT 80%
2 Acetaminophen Simulated gastric II 50rpm 15 minutes 45%-65%
650mg fluid(without 1 hour 60%-85%
enzyme), 3 hours NLT 85%
1.2, For gelatin
900mL coated
tablets
30 minutes 40%-60%
90 minutes 55%-85%
4 hours NLT 80%

3 Oxycodone Simulated gastric I 100rpm For 10mg,

Hydrochloride fluid (without 20mg and
10mg, 20mg, enzymes), 40mg
40mg,80mg 1.2, tablets
900 mL 1 hour 20%-40%
2 hours 35%-55%
4 hours 55%-75%
6 hours 70%-90%
8 hours NLT 80%
For 80mg
tablets
1 hour 25%-45%
2 hours 45%-65%
4 hours 65%-85%
6 hours NLT 80%

4 Metoprolol succinate 1M phosphate II 75rpm 1 hour NMT 20%

25mg, 50mg, 100mg, buffer, 4 hours 20%-40%
200mg 6.8, 8 hours 55%-85%
500 mL 20 hours NLT 80%

5 Chlorpheniramine Water I 100rpm 1.5 hour 15% - 40%

Meleate 4mg, 8mg, 500ml 6.0 hours 50% - 80%
12mg 10.0 hours NLT 70%
Simulated Gastric Fluid without enzyme (USP):
• • Sodium Chloride = 2.0g
• • Hydrochloric Acid = 7ml
• • Distilled Water Q.S 1000ml

Dissolve 2.0 g of sodium chloride in 7.0 mL of hydrochloric acid and sufficient water to make 1000
mL. This test solution has a pH of about 1.2.