Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Definition

Vitamin D is important for good overall health and strong and healthy bones. It’s
also an important factor in making sure your muscles, heart, lungs and brain
work well and that your body can fight infection.

Your body can make its own vitamin D from sunlight. You can also get vitamin
D from supplements and a very small amount comes from a few foods you eat

Long prescribed to prevent and treat bone-related disorders, supplemental vitamin D has been
viewed in recent years as a potential strategy for preventing cancer and cardiovascular
disease.

Application

Laboratory studies have shown the presence of vitamin D receptors in many tissues and have
suggested plausible vitamin D pathways that may be related to cancer and cardiovascular
disease, and observational studies have shown associations between low serum levels of 25-
hydroxyvitamin D and increased risks of cancer and cardiovascular disease.

Cons

The use of vitamin D did not lead to a significant difference in any of the secondary
cardiovascular end points or in the rate of death from any cause in the overall cohort or in
subgroups

Cons

Alternatively, because of volumetric dilution or decreased bioactivity of vitamin D, overweight

and obese persons may require higher doses to derive a benefit with respect to cancer.

Pro

vitamin D may inhibit carcinogenesis and slow tumor progres - sion, including promotion of cell
differentiation, inhibition of cancer-cell proliferation, and antiinflammatory,
immunomodulatory, proapoptotic, and antiangiogenic effects

pro

Vitamin D may decrease tumor invasiveness and the propensity to metastasize, leading to a
reduced rate of death from cancer

Issue in ec
Initial epidemiological research shows the incidence and mortality rates for some cancers lower in
individuals living in the southern latitudes, where the degrees of exposure to sunlight are high, than in
those living in latitudes from North. Since exposure to the ultraviolet rays of sunlight leads to the
production of vitamin D, to the hypothesis forms of the variation of the amount of vitamin D could be
responsible for this association

Opinion

It is not 100 percent proven that vitamin D prevents cancer or vascular diseases, but
studies and observational studies have suggested that people who take vitamin D
supplements may have a lower risk of many diseases.

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