PFT613 S1Q – Quiz 1

Problem 1
Given:
A sample of L-Serine contaminated with D-Serine rotates polarized
light beam at +10.0o.

Having the compound characteristics below:

L-Serine
(S)-2-amino-3-hydroxypropanoic acid
C3H7NO3 Mol.Wt.105.09
Specific rotation [α] 20/ D : +13.5 － +16.0° (average value +14.75o)

https://en.wikipedia.org/wiki/Serine#/media/File:Betain-Serin.png

1. Determine which of the structures on the image (right or left) is

L-Serine

2. Determine the purity of the sample of L-Serine

Problem 2
Determine which covalent compounds (see below) are polar and
which are not
Cl
F Cl
Cl Cl
H3C O O CH4 F Cl
3 4 5 Cl
F 6
1 OH 2
O
CH3
H3C
H3C CH3 H2C O H3C
7 8 OH
O 10
9

Put you answers in the Table

Number of 1 2 3 4 5 6 7 8 9 10
Compound

Polar:
Yes
Non-polar:
No
Problem 3
Which properties are typical for ionic compounds:

1 – liquid state at normal conditions

2 – Specific smell

3 – Crystal structure

4 – Conductivity in aqueous solutions

5 – Melting point below 0oC

6 – Acidic taste

7 - High melting point

8 – Are mostly inorganic compounds

9 – Are mostly organic compounds

10 – Alcohols

Put your answers in the Table

Number 1 2 3 4 5 6 7 8 9 10
of
Statement

True: T
False: F
Problem 4

Draw the products of reactions:

1 - acetic acid with ethylene glycol

2 – propanoic (propionic) acid with cyclohexylamine

(Scan your draw and attach it to the Quiz with respective numbers of
Problem and Reaction)

OH
OH
1 H3C + HO
O

O H2N
2 H3C
+
HO
Problem 5
Draw the products of the following reactions

1. oxidation of formaldehyde

2. formation of imine from butanal and ethylamine

(Scan your draw and attach it to the Quiz with respective numbers
of Problem and Reaction)

1 Oxidation
H

2
H3C O
+ H2N CH3
Problem 6
Determine which one of the three structures below is the product of
aldol condensation of ethylmethylketone

CH3
H3C

1 CH3
H3C
O
H3C Aldol condensation O
(3E)-3,4-dimethylhex-3-en-2-one
CH3
CH3
H3C

2
O CH3

(2E)-5-methylhept-2-en-4-one

CH3
H3C

3 CH3

O
(4E)-5-methylhept-4-en-3-one
Problem 7

What is similar and what is different in medicines manufactured by

brand name and generic pharmaceutical companies?

No Statement True False

1 Generic and brand name drugs with the same API are
identical

2 Generic and brand name drugs are for the same purposes

3 Generic and brand name drugs differ in API only

4 Generic and brand name drugs differ in excipients, not in API

5 Cost price of generic drug is usually higher than that of

brand name analog

6 Generic analog of a brand name drug can be brought to a

market after expiration of the brand name patent
Problem 8

Which of the listed below are dosage forms?

No Description True False

1 Tablets

2 Capsules

3 Sprays

4 Liquid solution or suspension

5 Drops

6 Inhaler

7 Ointment

8 All listed above