[Nov-17]

[MPL-102T]
M. Pharmacy DEGREE EXAMINATION
Pharmacology
I SEMESTER
ADVANCED PHARMACOLOGY-I
(Effective from the admitted batch 2017–18)
Time: 3 Hours Max.Marks: 75
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Instructions: Each Unit carries 15 marks.
Answer all units choosing one question from each unit.
All parts of the unit must be answered in one place only.
Figures in the right hand margin indicate marks allotted.
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UNIT-I
1. a) Describe the concepts of linear and nonlinear compartment
models 8
b) Discuss the significance of protein binding 7
OR
2. a) Discuss briefly about G-protein coupled receptors 8
b) Write about the relationship between drug concentration and
effect 7
UNIT-II
3. a) Discuss in detail about neurohumoral transmission in CNS 8
b) Write about cholinergics drugs 7
OR
4. a) Write about agents affecting neuromuscular junction 8
b) Write in detail about neurotransmitters in ANS 7
UNIT-III
5. a) Classify the anti psychotics & write the pharmacological
actions of atypical anti psychotic drugs 8
b) Write about mania & discuss the pharmacology of anti
maniac drugs 7
 OR
6. a) Write about the neurodegenerative diseases 8
b) Write the pharmacology of anti anxiety drugs 7
UNIT-IV
7. a) Write about the hyperlipidemia & classify anti hyperlipidemic
drugs 8
b) Write about the pathophysiology of Ischemia & classify anti
ischemic drugs 7
OR
8. a) Write the pathophysiology of CHF 8
b) Write a note on ACE inhibitors 7
UNIT-V
9. Discuss about opioid autocoids 15
OR
10. a) Write the pharmacology of antihistaminics 8
b) Discuss about synthesis of autocoids 7

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