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INSTRUCTIONAL DESIGN
ON PRIMARY COMPLEX
(TUBERCULOSIS)
IN CHILDREN
Narrative Report
A primary (Ghon) complex is formed, consisting of a granuloma (inflammation), typically in the middle or
lower zones of the lung (primary or Ghon focus). The primary complex usually resolves within weeks or months,
leaving signs of fibrosis and calcification (calcium salts) detectable on chest X-ray. In general, the risk of disease
progression following primary infection is low, but young children and immunocompromised patients are at
increased risk.
In the Philippines, having TB is considered a major health problem and is actually the sixth leading cause of
death and illness in the country. It is estimated that 200,000 to 600,000 Filipinos have active Tuberculosis. This
condition makes the person sick and is very contagious to others. Active TB can occur on either in the first few
weeks after infection with the bacteria, or in a few years later. The danger of TB is real. According to a report in the
World Health Organizations (WHO), out of 196 countries, the Philippines has the distinction of being included in the
top 22 high-burden tuberculosis countries in the world -- being ranked as the 9th worldwide. TB prevalence is high
among the high risk groups such as the elderly, urban poor, smokers, and those with compromised immune
systems such as people living with HIV, malnutrition, and diabetes. It is estimated that 10 600 patients have multi-
drug resistant TB (MDR-TB) in 2011.
TB disease in children under 15 years of age (also called pediatric tuberculosis) is a public health problem of
special significance because it is a marker for recent transmission of TB. In addition to it being significant, infants
and young children are more likely to develop life-threatening forms of TB disease (e.g., disseminated TB, TB
meningitis) than older children and adults. Among children, the greatest numbers of TB cases are seen in those
less than 5 years of age. On the other hand, with concern to adolescents, TB cases is more common with those
older than 10 years of age. The most common route of infection is through inhalation. A person with active TB
coughs up the germ which can be inhaled by a healthy child. The TB then travels to the lungs of the child; following
with the immune system that kicks in and “quarantines” the germ at the local site and at the neighboring lymph
nodes (this forms the “walled-in” complex or also called as the primary complex). The child remains healthy and
usually does not exhibit any of the symptoms. They may remain free of symptoms until their immune system
declines and the disease becomes active.
People with TB disease of the lungs or throat can spread bacteria to others especially with those people that
they spend time every day. However, children are less likely to spread TB bacteria to others. This is because the
forms of TB disease most commonly seen in children are usually less infectious than the ones seen in adults. Many
children infected with M. tuberculosis never develop active TB and remain in the latent TB stage. TB bacteria is
spread through the air when an infected person coughs, sneezes, speaks, sings, or laughs. A child usually does
not become infected unless he or she has repeated contact with the bacteria. TB is not likely to be spread through
personal items, such as clothing, bedding, cups, eating utensils, a toilet, or other items that a person with TB has
touched. Good air flow is the most important way to prevent the spread of TB. To prevent primary complex
tuberculosis be sure to: avoid contact with people who have the active disease; use medicines as a preventive
measure in high-risk cases; maintain good living standards; wash hands well and often; sneeze or cough into a
tissue or on the elbow and not into the hands; and use separate towels, drinking glasses, and eating utensils rather
than sharing these items.
As most patients of this disease does not show noticeable symptoms, they only find out the presence of a
Primary Complex through a tuberculin skin test (also called a Mantoux test or PPD test). A small amount of purified
protein derivative (a.k.a. PPD) of the TB germ is injected superficially into the forearm. An itchy, raised, red reaction
past a certain size (this changes depending on other conditions) is considered positive. In 20% of cases, a PPD
test will be negative in patients with TB infection. Other times, children will have a falsely positive PPD test because
they had the BCG (Bacillus Calmette-Guerin) vaccine. If primary complex is left untreated, it may eventually evolve
into active tuberculosis. Drug treatment choices vary depending on the drug resistance to tuberculosis.
Symptoms of TB disease in other parts of the body depend on the area affected. Signs and symptoms of TB
disease in children includes: coughing for 3 weeks or longer, chest pain, feelings of sickness or weakness,
lethargy, and/or reduced playfulness; weight loss or failure to thrive; fever; poor growth, swollen glands, blood in
sputum and/or night sweat.
A pediatric TB expert should be involved in the treatment of TB in children and in the management of
infants, young children, and immunocompromised children who have been exposed to someone with infectious TB
disease. It is very important that children or anyone being treated for latent TB infection or TB disease finish the
medicine and take the drugs exactly as instructed. For Latent TB infection, treatment is recommended for children
to prevent them from developing TB disease. Infants, young children, and immunocompromised children with latent
TB infection or children in close contact with someone carrying infectious TB disease, require special consideration
because they are at an increased risk for acquiring the TB disease. Consultation with a pediatric TB expert is
recommended before treatment begins. Children over 2 years of age can be treated for latent TB infection with
once-weekly isoniazid-rifapentine within the course of 12 weeks. Alternative treatments for latent TB infection in
children include 4 months of daily rifampin or 9 months of daily isoniazid.
The treatment of TB disease is through taking several anti-TB medicines for 6 to 9 months. It is important to
note that if a child stops taking the drugs before completion, the child can become sick again. If drugs are not taken
correctly, the bacteria that are still alive may become resistant to the drugs. A Tuberculosis that is resistant to drugs
is harder and more expensive to treat, and with its treatment lasting for a much longer period of time (up to 18 to 24
months).
Evaluation:
Attachments:
References:
University of Rochester Medical Center Rochester. (2019). Retrieved from https://www.urmc.rochester.edu
Heemskerk D, Heemskerk Caws M, Marais B, et al (2017). Tuberculosis in Adults and Children. Chapter 3, Clinical
Manifestations. Retrieved from:
https://www.ncbi.nlm.nih.gov/books/NBK344404/?fbclid=IwAR0jv1LeKD5aqQJWxQxMWxisDywMmhFUhM9
7AS3iRd_yWITcFKc2r_GKXk4
Batra, B (April 2018). Pediatric Tuberculosis. Retrieved from (April 2018). Pediatric Tuberculosis. Retrieved from
https://emedicine.medscape.com/article/969401-overview#a5