1. Indicate how you could synthesis trans-chalcone.

Chalcones can be prepared by an aldol condensation between benzaldehyde and

acetophenone in the presence of sodium hydroxide as a catalyst. Preparation of
chalcone:

This reaction can be carried out without any solvent as a solid-state reaction. A
mixture of benzaldehyde derivatives and acetophenone derivatives was dissolved in
rectified spirit in a round‐bottomed flask equipped with a magnetic stirrer. Then
NaOH solution was added drop wise to the reaction mixture on vigorous stirring. The
reaction temperature was maintained between 20‐25 ˚C using a cold water bath on the
magnetic stirrer. After vigorous stirring for , the reaction mixture was left to stand for
overnight. The precipitate obtained was filtered, washed, dried in air and
recrystallized from ethanol.

REFERENCES

1. (2013) Donal L . Pavia ; Gary M. Lampman;George S Kriz;Randall G Engel ,

A microscaleapproach to organic laboratory techniques, fifth edition, published by
Belmont/Cole ,Cengage Learning

2. F. Steven, (2019, June 6), The Michael Reaction, Retrieved from

https://chem.libretexts.org/Bookshelves/Organic_Chemistry/Map%3A_Organic_Che
mistry_(Smith)/Chapter_24%3A_Carbonyl_Condensation_Reactions/24.8%3A_The_
Michael_Reaction

3. (2016) Aldol Reactions and Aldol-like Reactions, Retrieved from

http://www.chemgapedia.de/vsengine/vlu/vsc/en/ch/12/oc/vlu_organik/keto_enol/aldo
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