2/20/2011

Particle Sources & Control

Sources of Contamination Description Control Methods

Tighter exterior wall

construction, exterior
Infiltration through
zone pressurization,
doors, and cracks at
vestibules at main
windows, and walls
Outdoor air entrances, and seal
space penetrations.
Makeup air entering
External
through the air Multiple level filtrations
conditioning systems
Seal wall penetrations,
Infiltration through multiple level
Indoor transfer air doors, windows, and pressurizations &
between rooms wall penetrations for depressurizations to
pipes, ducts, etc. obtain proper airflow
directions
Largest source of
Garments, proper
internal particles: skin
People gowning procedures, air
scales, hair, textile
shower before entry
fibers
Work surface Rubbing one item Use cleanroom suitable
shedding against another or rated furniture
Process Spray, painting, Local filtration and
equipment welding, grinding exhaust
Equipment washing,
cleaning and
Internal Raw and semi-
During transport sterilization before
finished material
entry, use airlock &
pass-through
Liquids, During preparation,
pressurized gases processing and Local exhaust
used in process packaging
Chemicals used Use cleanroom suitable
Out-gassing to room
for cleaning or rated cleaners
Room Dust generated from Constructed with
construction wall, floor, ceiling, special building
materials door, fibrous insulation materials

Microbiological Contamination & Control

Unlike non- Control Methods

reproduce, microorganisms could reproduce at a
rapid speed if nutrition and environment are Physical:
favorable.
Heat
Microorganism can be classified as bacteria, Radiation
algae, fungi, protozoa and viruses. Some of Filtration
these are essential, useful and harmless, while
others are harmful and dangerous. Chemical:

Sterilization
Disinfection