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All ACS AF CAD Heart failure Hypertension Intervention Lipids Surgery

Key cardiology trials in evidence based medicine - click on a trial for more information or a topic above for a summary
Topic Therapy group Therapy Trial
Captopril ISIS-4
ACE inhibitors
Lisinopril GISSI-3

Aldosterone antagonists Eplerenone EPHESUS

Aspirin ISIS-2, CURRENT-OASIS-7

Clopidogrel CURE, COMMIT, CURRENT-OASIS-7

Anti-platelet therapy
Prasugrel TRITON-TIMI-38, TRILOGY-ACS, ACCOAST

Ticagrelor PLATO

Atenolol ISIS-1
Beta-blockers
Metoprolol COMMIT

Diabetic control Insulin DIGAMI, DIGAMI-2

Ezetimibe Added to statin IMPROVE-IT

Glycoprotein IIbIIIa inhibitors In PCI CADILLAC, HORIZONS-AMI

Fondaparinux OASIS-6, OASIS-5

Acute coronary syndromes Heparinoids
Heparin infusion ISIS-3, OASIS-6

Hirudin & Direct Thrombin Inhibitors Bivalirudin HORIZONS-AMI, HEAT-PPCI

GTN GISSI-3
Nitrates
ISMN (MR) ISIS-4

PCI post-thrombolysis NORDISTEMI

PCI (STEMI) PCI to non-culprit arteries PRAMI

Thrombus aspiration TAPAS

PCI (UA/NSTEMI) PCI TACTICS-TIMI-18, RITA-3

Atorvastatin PROVE-IT
Statins
Ezetimibe

Streptokinase ISIS-2
Thrombolysis
Streptokinase, rtPA, Alterplase ISIS-3

Factor Xa inhibitors Rivaroxaban ATLAS-ACS-2-TIMI-51

Paroxysmal AF APAF, ThermoCool-AF

Ablation
RFA (treatment naive) MANTRA-PAF

Apixiban ARISTOTLE

Aspirin SPAF, SPAF-II

Anticoagulation Dabigatran RE-LY

Atrial Fibrillation
Rivaroxaban ROCKET-AF

Warfarin SPAF, SPAF-II, SPAF-III

Dronedarone ATHENA, PALLAS

Rate & Rhythm control Lenient vs strict rate control RACE-II

Rate vs. rhythm control AFFIRM

Coronary heart disease ACE inhibitors Ramipril HOPE

ACE inhibitors & ARBs Ramipril & Telmisartan ONTARGET

Telmisartan ONTARGET
Angiotensin receptor blockers
Valsartan VALUE

Niacin AIM-HIGH

Lipid therapy Rosuvastatin SATURN

Simvastatin 4S

PCI 2-3 VD (vs. CABG) ASCERT

LMS/3VD (vs. CABG) SYNTAX

PCI (vs. medical therapy) COURAGE, FAME-2

 T2DM - vs OMT/CABG BARI-2D, FREEDOM

ACE inhibitors Enalapril CONSENSUS, SOLVD

Candesartan CHARM

ARBs Diastolic dysfunction CHARM, I-PRESERVE

Valsartan ValHeFT

Eplerenone (NYHA 2+) EMPHASIS-HF

Aldosterone antagonists
Spironolactone (NYHA 3+) RALES

Anticoagulation Warfarin WARCEF

Bisoprolol CIBIS-II
Heart failure Beta-blockers
Carvedilol COMET

CRT-D MADIT-CRT
Devices
ICD SCD-HeFT

Glycosides Digoxin DIG

If channel blockers Ivabradine BEAUTIFUL, SHIFT

Statins Rosuvastatin CORONA

Surgery CABG STITCH

Ultrafiltration Cardiorenal syndrome CARRESS-HF

Benazepril ACCOMPLISH

ACEi Lisinopril ALLHAT

Prev. CVA/TIA PROGRESS

Losartan LIFE
ARB
Valsartan VALUE

Alpha-blockers Doxazosin ALLHAT

Hypertension
Amlodipine ALLHAT, VALUE
CCB
Nitrendipine Syst-Eur

Diet DASH diet DASH

Renal denervation Renal denervation Symplicity HTN-2, Symplicity HTN-3

Chlorthalidone SHEP, ALLHAT

Thiazides
Hydrochlorothiazide ACCOMPLISH

Access Radial RIVAL

Antiplatelet cover Dual antiplatelet therapy PRODIGY

2-/3-VD (vs. CABG) ASCERT

3VD/LMS disease (vs. CABG) SYNTAX

CAD (stable) MVD in DM vs. CABG FREEDOM

PCI (vs. medical therapy) COURAGE, FAME-2

T2DM - PCI vs OMT/CABG BARI-2D

Renal denervation Resistant hypertension Symplicity HTN-2, Symplicity HTN-3

Intervention Drug-eluting stents (vs. bare-metal) HORIZONS-AMI

PCI post-thrombolysis NORDISTEMI

STEMI
PCI to non-culprit arteries PRAMI

Thrombus aspiration TAPAS

Drug-eluting stents (1st generation) RAVEL, TAXUS-IV, COMPARE

Stents
Drug-eluting stents (2nd generation) COMPARE

Non-surgical AS patients PARTNER

TAVI
Versus surgery in AS PARTNER

UA/NSTEMI PCI TACTICS-TIMI-18, RITA-3

Lipids Atorvastatin PROVE-IT

ACS
Ezetimibe IMPROVE-IT

Niacin AIM-HIGH

CAD (stable) Rosuvastatin SATURN

Simvastatin 4S

Heart failure Rosuvastatin CORONA

Ezetimibe ENHANCE

Primary prevention PCSK9

Rosuvastatin JUPITER
 Primary prevention (T2DM) CARDS CARDS

2-3 VD (vs. PCI) ASCERT

CCF STITCH

Surgery CABG LMS/3VD (vs. PCI) SYNTAX

MV disease in DM FREEDOM

T2DM - vs OMT & PCI BARI-2D

Testing intervention Testing trial

Test Testing therapy
Testing intervention2 Testing trial

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