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Chapter 14
Biomolecules
Solutions (Set-1)
SECTION - A
School/Board Exam. Type Questions
Sol. 20.
Sol. Insulin.
8. What is mutarotation?
Sol. The spontaneous change of specific rotation of an optically active substance with time is called mutarotation.
10. Name the molecule which provides energy for all the activities of a cell.
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2 Biomolecules Solutions of Assignment (Set-1) (Level-I)
Sol. Tetrasaccharides give four molecules of same of different monosaccharides. For example, stachyrose on
hydrolysis gives one molecule of glucose, one of fructose and two of galactose.
Sol. -amino acids undergo condensation reaction between –NH2 group of one acid and –COOH group of the other
with elimination of H2O molecule.
Sol. They are building blocks of proteins which are essential for growth and maintenance of life.
Sol. van der Waals interactions, disulphide bridges, dipolar interactions (ionic) and hydrogen bonding.
Sol. An equimolar mixture of glucose and fructose obtained by hydrolysis of sucrose in presence of an acid such
as dil. HCl or enzyme invertase is called invert sugar.
Sol. Defective haemoglobin which is produced due to replacement of one amino acid i.e., glutamic acid by valikne.
Sol. The enzyme present in saliva is amylase. It converts starch into maltose.
Sol. An alternation in the base sequence of nucleic acid molecule is called mutation.
19. What are carbohydrates? Why they are generally optically active?
Sol. Hydrocarbons are the hydrates of carbon having general formula Cx(H2O)y. Carbohydrate molecules have one
or more asymmetric carbon atoms. Hence they are generally optically active.
Sol. Most of the reactions in living systems proceed at very high rates under physiological pH of 7.4 and
temperature of 37ºC under one atm pressure. All these reactions are catalysed by a group of biomolecules
called enzyme. Thus enzymes are biological catalysts, chemically almost all the enzymes are globular
proteins.
Sol. Carbohydrates which reduces Tollen’s reagent and Fehling solution are called reducing sugars. All
monosaccharides (aldose and ketose such as glucose, fructose, galactose, mannose etc.) and disaccharides
(such as maltose, lactose etc.) except sucrose are reducing sugars.
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Solutions of Assignment (Set-1) (Level-I) Biomolecules 3
22. What type of linkage holds together the monomers of DNA?
Sol. The monomers of DNA are polydeoxyribonucleotides. There are helds together by H-bond. There are three
H-bonds between guanine and cytosine (G C) and two between adenine and thymine (A T).
23. B-complex is often prescribed vitamin. What is complex about it and what is its usefulness?
Sol. It is a group of vitamins which contains vitamin B1, B2, B6, B12, biotin, pantothenic acid, folic acid, and nicotinic
acid. Since it is not a single vitamin, therefore it is called vitamin B-complex. It is required to release energy
from food and promote healthy skin and muscles. Its deficiency causes beri-beri (B1) and pericious anaemia
(B12).
Sol. During osazone formation reaction occur only at C1 and C2 while rest of the molecule remains intact. Since
glucose and fructose differ from each other only in arrangement of atoms at C1 and C2, therefore they give
same osazone.
CHO CH = NNHC6H5
3 C6H5NHNH2
CH – OH C = N – NH – C6H5
–C6H5NH2
(CHOH)3 –NH3 (CHOH)3
–2H2O
CH2OH CH2OH
(Glucose) (Glucosazone)
CH2 – OH CH = N – NH – C6H5
3 C6H5NH – NH2
C=O C = N – NH – C6H5
–C6H5NH2
(CHOH)3 –NH3 (CH – OH)3
–2H2O
CH2OH CH2 – OH
(Fructose) (Fructosazone)
25. Despite having an aldehyde group glucose does not give 2, 4-DNP test. What does this indicate? What is the
significance of D and (+) in -D-(+) Glucopyranose.
Sol. Glucose does not have open structure and hence it does not have a free –CHO group. Actually –CHO group
combines with C5 –OH to form an hemiacetal. Thus glucose largely exists in cyclic hemiacetal form along with
a very small amount (< 0.5 %) of the open chain structure. Since the concentration of open chain form is low
and its reaction with 2, 4-DNP is reversible, therefore formation of 2,4-DNP derivative can not disturb the
equilibrium to generate more of the open chain form from the cyclic hemiacetal form and hence it does not
react with 2, 4-DNP. The capital letter D in D-(+)-Glucopyranose indicates that the C-5 –OH group is oriented
towards right, while the sign (+) shows that glucopyranose is dextrorotatory.
26. In E.coli DNA, the (A + T)/(G + C) ratio is 0.93 if number of moles of adenine in DNA sample is 465,000 then
calculate number of moles of guanine present.
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4 Biomolecules Solutions of Assignment (Set-1) (Level-I)
Sol. Since number of moles of ademine must be equal to that of thymine, therefore
(A T)
Since 0.93
(G C)
930000
Therefore number of moles of C G = 10,00,000
0.93
1000000
Therefore number of moles of guanine (G) = 500000
2
SECTION - B
Model Test Paper
Very Short Answer Type Questions :
Sol. Amylase
Sol. Vitamin C
Sol. Vitamin B1
Non-reducing - Sucrose
Sol. Glycogen
Globular - Haemoglobin
Sol. D.N.A.
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Solutions of Assignment (Set-1) (Level-I) Biomolecules 5
Short Answer Type Questions :
Sol. Secondary structure is the conformation which a polypeptide chain assumes as a result of H-bonding.
Sol. Polypeptides are formed when several molecules of a-amino acids are joined together by peptide bonds.
e.g., Insulin.
Sol. The spontaneous change of specific rotation of an optically active substance with time is called mutarotation.
Sol. Zwitter ions are dipolar ion formed by neutralization of acidic and basic groups present within the molecule.
Sol. Amino acids are building blocks of proteins which are essential for growth and maintenance of life.
Sol. polysaccharides are those carbohydrate which on hydrolysis give a large number of molecules of
monosaccharides. e.g., Starch.
Sol. The covalent bond NH – CO formed between –NH2 group of one amino acid and –COOH group of the other
with the elimination of a molecule of water is called peptide bond or peptide linkage. Amino acids are joined
together, by peptide bonds.
Sol. The pH at which there is no net migration of the amino acid under the influence of an applied electric field is
called isoelectric point. For example isoelectric point of glycine is 6.1.
Sol. Excess intake of vitamins A and D causes hypervitaminoses while multiple deficiency caused by lack of more
than one vitamin is called avitaminoses.
Sol. -Helix structure of DNA is stabilized by intramolecular H-bonding between N – H of one amino acid residue
and C = O of the fourth amino acid residue in the polypeptide chain.
Sol. Amino acids which the body can not synthesize but are required for growth and maintenance of the life are
called essential amino acids. For example phenylalanine, valine, etc.
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6 Biomolecules Solutions of Assignment (Set-1) (Level-I)
21. An optically active compound having molecular formula C6H12O6 exists in two cyclic forms A and B. When
A and B are dissolved in water they show following equilibrium
A Equilibrium mixture B
()D = 111º 52.2º 19.2º
Sol. The optically active compound having molecular formulae C6H12O6 is called glucose. It exists in two
stereoisomeric forms A and B. These two isomers which differ in configuration only at the anomeric (first) carbon
are called anomers.
H C O
H C OH HO C H
H C OH
H C OH H C OH
HO C H O
O
HO C H
HO C H H C OH
H C OH
H C OH H C OH
H C H C
CH2OH
CH2OH CH2OH
Open chain
-D-(+)-Glucose -D-(+)-Glucose
-forms is less stable than -form therefore equilibrium mixture cartains 36% of -form [()D = 111º] and 64%
of B-form [()D = 19.2º]
Sol. Mutation : A mutation may be defined as a chemical change in the sequence of nitrogenous bases along the
DNA strands that can lead to the synthesis of protein with altered amino acid sequence. These changes may
either occur spontaneously or may be caused by exposure to X-ray or UV radiation, chemical agents viruses.
Most of the changes in DNA molecules are automatically repaired by special enzymes present in the cell.
However if changes can not be repaired by enzymes. Mutations are said to occur. As a result of mutation,
proteins with altered amino acid sequences will be obtained which may not have any biological acitivty leading
to the death of cell.
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Solutions of Assignment (Set-2) (Level-I) Biomolecules 7
Solutions (Set-2)
Objective Type Questions
(Carbohydrates)
1. Which of the following is a reducing sugar?
(1) Glycogen (2) Maltose (3) Sucrose (4) Starch
Sol. Answer (2)
The maltose is a reducing sugar.
CH2OH
H OH H O H
H
Hemiacetal linkage
OH H O OH H
OH OH This makes a molecule
reducing
H OH H OH
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8 Biomolecules Solutions of Assignment (Set-2) (Level-I)
6. Rice is deficient in
(1) Lysine (2) Leucine (3) Glycine (4) Alanine
Sol. Answer (1)
Rice does not have lysine.
10. Which of the following disaccharide in acidic medium is called invert sugar?
(1) Lactose (2) Maltose
(3) Sucrose (4) All of these
Sol. Answer (3)
Sucrose is called invert sugar in acidic medium .
Amylose Amylopectin
(water insoluble)
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Solutions of Assignment (Set-2) (Level-I) Biomolecules 9
13. Glucose when reacted with acetic anhydride forms
(1) Diacetate (2) Hexa-acetate (3) Pentacetate (4) Tetra-acetate
Sol. Answer (3)
CHO CHO
O O
H OH H OAC
HO H ACO H
H OH + 5 CH3 O CH3 H OAC
H OH H OAC
CH2OH CH2OAC
"penta derivative"
14. The best solvent for removing butter stain from cloth is
(1) CHCl3 (2) C2H5OH (3) C2H5OC2H5 (4) H2O
Sol. Answer (3)
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10 Biomolecules Solutions of Assignment (Set-2) (Level-I)
19. The two cyclic hemiacetal forms of glucose differing only in the configuration of the hydroxyl group at C-1 are
called
(1) Anomers (2) Enantiomers
(3) Epimers (4) Metamers
Sol. Answer (1)
CH2OH CH2OH
H OH H O OH
H H
OH H OH H
OH OH OH H
H OH H OH
-D glucose -D glucose
Anomers
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Solutions of Assignment (Set-2) (Level-I) Biomolecules 11
(Proteins and Enzymes)
25. Glycosidic linkage is present in
(1) Proteins (2) Lipids (3) Carbohydrates (4) Nucleic acids
Sol. Answer (3)
Glycosidic linkage is present in carbohydrates.
(Vitamins)
34. Deficiency of which of the vitamin causes rickets?
(1) Vitamin-D (2) Vitamin-C (3) Vitamin-B12 (4) Vitamin-E
Sol. Answer (1)
Vitamin-D causes rickets.
(Nucleic Acid)
37. Which of the following is an essential amino acid?
(1) Asparagine (2) Glutamine
(3) Histidine (4) Alanine
Sol. Answer (3)
Histidine is essential amino acid.
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Solutions of Assignment (Set-2) (Level-I) Biomolecules 13
40. Complementary bases present in DNA are
(1) Uracil & Adenine : Cytosine & Guanine (2) Thymine & Adenine : Guanine & Cytosine
(3) Adenine & Thymine : Guanine & Uracil (4) Adenine & Guanine : Thymine & Cytosine
Sol. Answer (2)
In DNA,
A=T
C G {Complementary bases}
45. The relation between nucleotide triplets and the amino acids is called as
(1) Gene (2) Nucleoside
(3) Genetic code (4) Gene pool
Sol. Answer (3)
The relation between nucleotide triplets and the amino acid is called genetic code.
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14 Biomolecules Solutions of Assignment (Set-2) (Level-I)
(Miscellaneous)
46. The acid which shows salt-like character in aqueous solution is
(1) Acetic acid (2) -aminoethanoic acid (3) Benzoic acid (4) Formic acid
Sol. Answer (2)
- Amino ethanoic acid
O O
–
CH2 – C – OH CH2 – C – O
47. The number of amino acids required to form three peptide bonds are
(1) Seven (2) Two (3) Six (4) Four
Sol. Answer (4)
For tripeptide formation, four aminoacids are required.
O
Peptide linkase ( – C – NH –)
AA AA AA AA
(1) (2) (3) (4)
49. In the double helix structure of DNA, the base pairs are
(1) Part of the backbone structure (2) Inside the helix
(3) Outside the helix (4) Bonded with covalent bond
Sol. Answer (2)
In double helix of DNA, the base pairing occurs inside the helix.
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