Name of Drug Action Contraindicat Special Side Effects Drug Dosa Nursing

/ ions Concerns Interactio ge Considerat

a. Brand Name Kineti ns ion
cs
b. Generic Name

1. CALCIUM GLUCONATE
a. Phil Pharmawealth/ Harson Replac Calcium salts For CNS: Tingling sensation, The 2 tabs
are intravenou inotropic
Calcium Gluconate es syncope with rapid I.V. BID
contraindicated s use only. and toxic
calciu in patients with Subcutane injection.
b. Calcium Gluconate effects of
m and ventricular ous or cardiac
maintai fibrillation or intramuscu CV: mild drop in drop glycosides
ns hypercalcemia. lar injection pressure, vasodilatation, and calcium
calciu Intravenous may cause bradycardia, arrythmias, are
administration of severe cardiac arrest, with rapid I.V synergistic
m level calcium is necrosis
injection. and
contraindicated and arrhythmias
when serum sloughing. may occur if
calcium levels G.I: irritation, constipation,
these drugs
are above nausea, vomiting, thirst, abd. are given
normal. pain. together
(particularly
G.U: polyuria, renal calculi. when
Metabolic: hypercalcemia. calcium is
Skin: local reactions, given
including burning, necrosis, intravenousl
y).
tissue, sloughing, cellulities, Intravenous
soft tissue calcification with administrati
I.M use pain. on of
calcium
should be
avoided in
patients
receiving
cardiac
glycosides;
if
necessary,
calcium
should be
given slowly
in small
amounts.

Calcium
complexes
tetracycline
antibiotics
rendering
them
inactive.
The two
drugs
should not
be given at
the same
time orally
nor should
they be
mixed for
parenteral
administrati
on.

Calcium
gluconate
injection
has been
reported to
be
incompatibl
e with
intravenous
solutions
containing
various
drugs.
Published
data are too
varied
and/or
limited to
permit
generalizati
ons, and
specialized
 reference
should be
consulted
for specific
information.

2. ALLOPURINOL
a. Side effects of allopurinol are
Allohexal, Allosig, Milurit, Alloril,
Progout rare, though significant when
they occur. A small
b. Allopurinol
percentage of people develop
a rash and must discontinue
this drug. The most serious
adverse effect is a
hypersensitivity syndrome
consisting of fever, skin
rash, eosinophilia, hepatitis,
worsened renal function and,
in some cases, allopurinol
hypersensitivity syndrome.
Allopurinol is one of the
drugs commonly known to
cause Stevens-Johnson
syndrome (SJS) and toxic
epidermal necrolysis (TENS),
two life-
threatening dermatological co
nditions.
Allopurinol can cause
severe pancytopenia if given
with azathioprine or mercapto
purine, due to inhibition of
xanthine oxidase which
metabolizes these drugs. It
can also cause breast
enlargement in both males
and females.

Allopurinol can lower blood

pressure in mild hypertension.