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DISORDERS
NAIL UNIT ANATOMY
The nail apparatus consists of nail plate and specialized epithelial tissues
(nail matrix, nail bed and nail folds)
1- Nail plate
• Fully keratinized, hard, flexible and semitransparent structure.
• Comprised of tightly packed corneocyte (onychocyte), arranged in layers.
• Results from keratinization of nail matrix epithelium.
• Resting on and firmly attached to nail bed which partially contributes to
its formation. It is less adherent proximally.
• Approximately ¼ of nail is covered by proximal nail fold, and a narrow
margin of its sides is occluded by the lateral nail folds.
• Toenails are usually thicker than fingernails.
• Men nails are thicker than women nails.
• Toenails 1.4 - 1.65 mm. Fingernail 0.5 - 0.6 mm.
2- Nail matrix
• Epithelium situated above the middle part of distal phalanx.
• Keratinizes without a granular layer.
• Generates > 90% of nail plate (≤ 1% from nail bed)
• Contains many melanocytes that are normally quiescent (inactive),
however, they may become activated.
• Proximal matrix: produce ~80% of nail plate → dorsal nail plate (outer).
• Distal matrix (lunula): visible as white half moon → Ventral plate (inner)
3- Nail fold
• Skin surrounding lateral and proximal aspects of
nail plate.
• proximal nail fold: a double layer of skin overlying
the matrix, protects this area from trauma, solvents and infectious agents.
Extends onto the proximal nail plate to form the cuticle. Its dorsal layer is
continuous with the skin of digit, while the ventral layer is continuous
with the nail matrix.
• lateral nail fold: a double layer of skin. Continuous with skin on the sides
of digit laterally, and medially they are joined by the nail bed.
• Capillary loops at tip of proximal nail fold are small and non apparent
(apparent in AICTD e.g. SLE).
4- Nail bed Epidermis
Nail bed epidermis: Dermis
• Thin epithelium (2-5 cell layers). Has no granular
layer, no melanocytes. Extend from distal margin of
lunula to hyponychium. So adherent to nail plate.
• Completely visible through the nail plate.
• Its keratinization produces thin horny layer, that add plate
to the undersurface of nail, thickening it and making
it densely adherent to the nail bed.
Dermis
• Their rete ridges has parallel longitudinal pattern:
o Interdigitate with the underling longitudinal dermal ridges.
o Small blood vessels run longitudinally at the base of these ridges,
explaining the linear pattern of nail bed hemorrhage (i.e. splinter).
Nail bed dermis: Devoid of fat. Contain numerous glomus bodies.
5- Hyponychium
The site where the nail plate detaches from nail
bed (between nail bed and distal groove).
NAIL EMBRYOLOGY
• 12th week nail primordium invaginates beneath the proximal nail fold.
• 15th week →Fully developed nail matrix + Nail plate production occurs
continuously until death.
• Nails grow continuously, but their growth rate decreases both with age
and with poor circulation.
• Nails take long time to grow from the matrix to the free edge:
o Fingernails take 3–6 months (2-3 mm/month).
o Toe nails take 12–18 m ( 1 mm/month).
Minor trauma
nail biting
NORMAL VARIATIONS
NAIL SIGNS
1-Beau’s Lines
• Transverse grooves on nail plate, that move distally with
nail growth. Often deeper in the center.
• Result from a temporary arrest of proximal nail matrix
proliferation (mitotic activity).
• Causes :
1. Local: Most commonly trauma (e.g. onychotillomania, manicures) OR
skin disease of proximal nail fold (e.g. eczema, chronic paronychia).
2. Systemic:
• Severe illness (e.g. erythroderma).
• Febrile illness (e.g. high fever, scarlet fever, measles, mumps, HFMD)
• Drugs (e.g. chemotherapy).
• Multiple digits involvement + presence of lines at same
level in all the involved nails suggests a systemic cause.
• Multiple lines in the same nail indicate repetitive insult.
• Self-limiting and requires no treatment.
2- Onychomadesis (nail shedding)
• Detachment of nail plate from the proximal nail fold.
• Result from a temporary arrest of proximal nail matrix
proliferation (mitotic activity).
• Causes: same as those for Beau’s lines + It may appear in
the setting of pemphigus vulgaris or SJS + In children often
relates to recent coxsackievirus infection (HFMD).
• Self-limiting and requires no treatment.
3- Pitting
• Small punctate depressions on nail plate surface.
• Result from foci of abnormal keratinization of
proximal nail matrix that result in clusters of
parakeratotic cells in dorsal nail plate, these
clusters are easily detached, leaving the pits.
• Seen in psoriasis, alopecia areata, eczema, fungal
infection or as normal variation.
Note… Large deep irregularly distributed pits in
psoriasis + atopic eczema. Small shallow regular
(rippled or arranged in longitudinal lines) in AA.
4- Onychorrhexis Onychorrhexis
• Multiple longitudinal ridges (raised line) and fissures
(groove) of nail plate.
• Often associated with nail thinning.
• Indicating severe nail matrix damage.
• Seen in lichen planus, trauma (frequent nail polish use)
chronic arterial insufficiency, systemic amyloidosis.
• D/D: the common age-related ridging.
age-related ridging
Proximal Subungual
10- Onychauxis and Onychogryphosis
Onychauxis
• Onychauxis: refer to thickening (Hypertrophy) of nail
plate in general, without deformity (curvature).
If neglected (not trimmed), the nail may grow to form
Onychogryphosis.
1- Apparent leukonychia
• The nail are pale white, due to nail bed discoloration, that fades with
pressure and does not move distally with nail growth.
• Often due to drugs (chemotherapy) OR
systemic diseases (e.g. Chronic renal and liver disease).
• 3 different types:
(i) Terry’s Nails: leukonychia affects the whole nail except for
1 to 2 mm distal normal band. common sign of liver cirrhosis
(80 % of pt). Also in chronic renal disease, adult-onset DM, Terry’s
also frequently seen in normal individuals.
2- Subungual hyperkeratosis
• Accumuloation of scales under the nail plate, as a result of excessive
proliferation of keratinocytes in nail bed and hyponychium.
• Nail plate appears thick.
• Commonly seen in psoriasis, PRP, atopic dermatitis,
subungual warts and distal subungual onychomycosis.
3- Onycholysis
• Detachment of nail plate from nail bed.
• Starting at distal margin and progressing proximally.
• Signs:
1. Detached nail looks yellow-white (b/c of air in subungual space) OR
discoloured (green-black in pseudomonas aeruginosa).
2. Subungual scales in case of Psoriasis, wart, onychomycosis.
Onycholysis
with 2ry
Pseudomonas
infection
• Causes of Onycholysis:
1-Environmental: The most common. Occur as a consequence of:
• Repetitive water immersion and exposure to irritant (most common).
• Trauma. e.g. manicure tools pushing beneath the nail.
• UV (photo-onycholysis) i.e. non-drug-induced-photo-onycholysis.
2-Skin disease affecting nail bed:
• Inflammatory: Psoriasis, Lichen Planus, Eczema.
• Infection: candida, dermatophyte, Pseudomonas, Herpes simplex, HPV.
• Neoplastic: SCC.
3- Drug. e.g. Tetracyclines, Retinoids.
4- Drug-induced-photo-onycholysis e.g. Psoralen, OCP, Griseofulvin,
tetracycline (demecycline > doxycycline > tetracycline > minocycline).
5- Subungual exostoses.
6- Pregnancy.
7- Internal diseases: iron deficiency anemia, DM, hyper- hypothyroidism.
4- Splinter hemorrhages
• Appear as thin longitudinal dark-red lines due to deposition of
haemoglobin on the undersurface of nail, which grows out.
• occur due to rupture of the longitudinally oriented nail bed capillaries,
either by trauma, vascular disease (e.g. lupus), or inflammatory nail dx
(e.g. psoriasis or onychomycosis)
5- Erythronychia
See later …
Onychopapilloma
Chromonychia (nail colour changes)
Diffuse red
Red spotted Red spotted with
(Psoriasis) Trachonychia
(AA)
2- Involve lunulae and nail plate:
Redness extent over the borders of lunula. Has 2 patterns;
i. Longitudinal erythronychia: linear red streak or band. Extending from
proximal nail to distal edge. It may:
• localized [i.e. single or paired (bifid) band in only 1 nail]: commonly
due to benign tumors (Onychopapilloma, glomus tumor) Or rarely
due to malignant (SCC, MM) or scarring of nail bed
• Multiples [i.e. multiple bands in many nails]: Characteristically
present in Dariers's disease. Other causes: LP, Amyloidosis, idiopathic.
ii. Diffuse erythronychia: SLE, CO poisoning, heart failure, liver cirrhosis
Band
Bifid
Onychopapilloma
5- Yellow chromonychia (Yellow nails)
causes;
i. Yellow-nail syndrome:
• Rare acquired condition.
• Defined by presence of yellow nails associated with
lymphedema and/or chronic respiratory diseases.
• Linear nail growth is arrested or greatly reduced.
• Nail are thick, diffuse yellow colored +/- Onycholysis.
• Associated with loss of both the cuticle and the lunula.
• In most pts, all 20 nail are involved.
• Treatment: not effective in all cases and must be prescribed for several
months; vitamin E 1200 IU/day + pulse itraconazole (400 mg daily for 1 wk
a month) or fluconazole (150 mg daily for 1 wk a month).
ii. Other : Onycholysis, Psoriasis, LP, tetracyclines(fluorescent lunula),
penicillamine. AIDS, RA, DM, Carotene.
6- Brown or black chromonychia (Melanonychia)
Melanonychia is the black-brown discoloration of nail due to deposition of
melanin. It has three Pattern:
1. Diffuse: chemotherapy, Antimalarial, Malnutrition, HIV.
2.Transverse black bands: chemotherapy, lichen planus.
3. Longitudinal.
Chemotherapy: Diffuse melanonychia
+ white bands (Muehrcke’s nail).
Longitudinal melanonychia:
• Longitudinal brown to black band extending from proximal nail fold to
distal margin. very commonly seen in darker-skinned (up to 90%).
• Due to deposition of melanin within nail plate. Single band may be a sign
of nail matrix nevi or melanoma. Multiple bands are usually due to
melanocyte activation. Causes:
1- Matrix melanocyte hyper/neoplasia: lentigo, nevi, melanoma.
2- Matrix melanocyte activation:
• Physiological: Racial, Pregnancy.
• Nail disorder: psoriasis, LP, amyloidosis, OM.
Note… OM due to T. rubrum (var. nigricans) and Scytalidium
dimidiatum can cause nail piment of nonmelanocytic origin
Congenital melanocytic nevus
• Drugs: chemotherapy (hydroxyurea, 5FU, cyclophosphamide),
antimalaria, zidovudine, psoralen, steroid, sulphonamide, minocycline,
MTX, azathioprine, phenytoin.
• Endocrine diseases: Addison’s disease, hyperthyroidism, acromegaly,
cushing syndrome.
• Nutritional: vitamin B12 or folate deficiency.
• Nonmelanocytic nail Tumors: Bowen’s disease
• ACTD: SLE, scleroderma.
• Trauma [manicure, nail biting, friction (primarily in toenails)
• Peutz-Jeghers syndrome
• AIDS.
NOTE (1) … An acquired single streak of dark pigmentation is a melanoma
until proved otherwise. The following features should be considered
indicative of possible malignant melanoma:
1. Only one digit affected
2. Periungual spread of the pigmentation (Hutchinson’s sign)
3. Change in appearance (for example, it may become wider or darker
over time with blurring of its border).
4. Age over 50 years.
NOTE (2) … Hutchinson’s sign
• Periungual extension of brown–black pigmentation from nail bed and
matrix to the proximal and lateral nail folds, hyponychium and cuticle.
• The development of periungual pigmentation in conjunction with
longitudinal melanonychia in adults is very suggestive of melanoma.
• Causes: • Melanoma, due to horizontal growth of the tumor.
• Racial (Skin type V and VI), Nail matrix nevi, Trauma,
malnutrition, Addison’s disease, Peutz-Jeghers syndrome,
Drug-induced, AIDS, Non melanoma tumor e.g. Bowen's disease.
Note… Pseudo Hutchinson's sign: The pigmentation can be observed
through the translucent cuticule.
Pseudo
Melanoma with Hutchinson's
Hutchinson sign sign
Nail changes due to cutaneous disorders
1- Darier’s Disease (Follicular Dyskeratosis)
• Nail changes in Darier are common, diagnostic and pathognomonic:
• Multiple red and white longitudinal streaks.
• The streaks often terminating in a V-shaped notching of distal margin.
• Wedge-shaped subungual hyperkeratosis.
• Similar changes may be seen in Hailey–Hailey disease.
NOTE … A single longitudinal erythronychia with distal subungual
hyperkeratosis is not sufficient for diagnosing Darier disease of nails, since
single bands may be due to a subungual benign tumor (e.g. glomus tumor,
onychopapilloma) and, less often, Bowen disease.
Darier’s Darier’s
2- Lichen Planus
• Nail changes present in 10% of patients. However, nail lichen planus is
most frequently seen in absence of skin, scalp or mucosal involvement.
• Clinical findings that are diagnostic include:
1. Nail thinning, longitudinal ridging and fissuring: Indicates nail
matrix involvement and the need for prompt treatment to avoid scarring.
2. Dorsal pterygium: Result from adhesion of proximal nail fold to nail
bed due to matrix destruction (scarring) and disappearance of nail plate.
• Other nonspecific nail changes: Red lunula. Nail bed lichen planus may
produces onycholysis, nail thickening, and yellow discoloration.
3- Psoriasis
• Most common dermatosis affecting the nail. Nail changes
seen in up to 50% of patients. Fingernails > toenails.
• Often associated with psoriatic arthropathy. patient with
nail Psoriasis has increased incidence of psoriatic arthritis.
• Koebner phenomenon worsen nail sign.
• It may affects:
(1) Nail folds: Typical psoriatic lesion.
(2) Nail Matrix:
• Pitting (most common): large, deep, irregularly scattered.
• Trachyonychia. • Longitudinal ridging • Thick yellow nail plat.
• Red spotted lunula. • Punctate leukonychia (pathognomonic)
• Nail Deformity: due to extensive involvement of nail matrix.
(3) Nail Bed
• Oil Spot (salmon patch): localized separation of nail plate. Cellular
debris and serum accumulate in this space giving brownish-yellow color.
• Onycholysis: The nail detaches in an irregular manner . Surrounded by
erythematous border. Nail plate turn yellow, simulating fungal infection
• Subungual hyperkeratosis: commonly mistaken for fungus infection.
• Splinter hemorrhage.
NOTE …
(1) Diagnostic signs of nail Psoriasis (fingernails only) are pitting, oil drop,
and onycholysis surrounded by an erythematous border.
(2) In toenails, psoriasis is usually clinically indistinguishable from OM.
(3) Nail psoriasis is often aggravated by sun exposure.
(4) Acrodermatitis continua of Hallopeau: A variant of localized type
Pustular Psoriasis (other variant is palmoplantar pustulosis). In most cases,
A single digit is involved + Nail involvement is a typical feature + It is not
associated with cutaneous plaques of psoriasis vulgaris. It presents with
recurrent episodes of acute painful inflammation with sterile pustules on
erythematous base around and under fingernail plate (less likely toenial) ,
followed by scaling and crust formation. Onycholysis may be seen.
4- Eczema
• Hand eczema is often associated with nail changes.
• In acute eczema, there are;
1. Vesicles and erythema of proximal nail fold and hyponychium.
2. Nail matrix damage produces irregular pitting and Beau’s Lines.
onychomadesis can occur in severe cases.
• Chronic eczema of hyponychium result in subungual hyperkeratosis,
onycholysis, and fissuring of hyponychium. Chronic eczema of
proximal nail fold can lead to chronic paronychia.
• In atopic dermatitis, the nail plate frequently shows irregular pits and
Beau’s lines.
• Controlling the skin disease results in gradual improvement of the nails.
5- Alopecia areata
• Nail abnormalities are present in ~20% of adults and 50% of children.
• Signs that are characteristic include geometric pitting and trachyonychia.
• The pits are small, superficial, and regularly distributed in a geometric
pattern (grid-like).
•Trachyonychia is more common in children and most frequently seen in
male patients with alopecia totalis or universalis.
• Additional nail abnormalities observed in alopecia areata include
punctate leukonychia, Mottled erythema of lunulae, and onychomadesis.
The nail and internal disease
1-Beau’s Lines 2-Yellow-nail syndrome 3-Terry’s Nails
4-Koilonychia 5-Clubbing
Clubbing
• Nail plate is enlarged and excessively curved +/-
enlargement of periungual soft tissue.
• The changes are permanent.
• There are 2 signs:
1.Schamroth sign: The normal diamond-shaped
window is obliterated.
2.Lovibond’s sign: The angle between proximal nail
fold and nail plate > 180° (normally = 160°).
• Causes: Idiopathic, hereditary–congenital, and
acquired. 80% of acquired are associated with
pulmonary disease. Other; CV disease, liver disease,
thyroid disease, inflammatory bowel disease, AIDS.
Enlargement of
periungual soft tissue
HIV Infection
1- Onychomycosis: common (up to 25%). Dermatophyte is most commonly
responsible, but Candida is also often isolated:
• Proximal subungual onychomycosis: due to T. rubrum. considered as a
marker of immunosuppression.
• Candida onychomycosis: Candida does not invade the nail plate of
immunocompetent. It indicates immunosuppression or chronic
mucocutaneous candidiasis.
2- Longitudinal melanonychia: Usually, several nails are involved.
3- HPV-induced SCC: Longstanding periungual warts in HIV pts should
always raise the suspicion of SCC [HPV types 16 and 35].
Thickened
rounded nail fold
• Treatment:
1- avoid exposure to contact irritants.
2- keep proximal nail fold dry.
3- Controlling inflammation is the primary goal by Topical steroid creams
or tacrolimus ointment 0.1% twice daily for up to 3 weeks is more effective
than systemic antifungals.
4- Miconazole topical suspension at proximal nail fold to flow into the
space created by the absent cuticle, 2 or 3 times a day for weeks, until the
cuticle is re-formed.
5- Topical antiseptics (e.g. 4% thymol in 95% ethanol).
6- Cuticle may never re-form in pts with long standing inflammation. So
Fluconazole (150 mg/day) for 1-4 weeks may control chronic inflammation.
Powdery
patches Diffusely opaque
Discrete small
patches
Speckled patches
2. Transverse striate bands variant. • More likely caused by T. rubrum.
3. Origination from proximal nail fold. • The more invasive forms seen in
4. Deep variant (diffuse involvement of healthy children and
nail plate + presence of fungi in both immunocompromised pts.
superficial and intermediate layers). • Deep variant can also result from
NDM such as Fusarium, Aspergillus
Deep
Proximal Subungual Onychomycosis:
• The most common pattern seen in patients with AIDS.
• T. rubrum is the most common cause.
• Microorganisms enter the Proximal nail fold cuticle
area, migrate to the matrix, and finally invade the nail
plate from below.
• Infection occurs within the substance of nail plate, but
the surface remains intact (but it may involve the entire
thickness of proximal plat).
• Presents as an area of leukonychia in proximal nail
plate (Proximal leukonychia) that moves distally with
nail growth + subungual hyperkeratotic debris that may
cause proximal onycholysis.
• In the cases caused by molds, leukonychia is typically
associated with marked periungual inflammation with
purulent discharge.
Endonyx
Presents as a milky white discoloration of nail plate. Nail plate is smooth.
There is no subungual hyperkeratosis or onycholysis.
Total dystrophic onychomycosis:
• The most advanced form of any subtype. It involves the entire nail unit.
• The nail matrix may become permanently scarred, and the nail plate can
be completely destroyed.
• Start as a thickened, opaque, and yellow-brown nail, that finally
disappears leaving a thickened nail bed retaining keratotic nail debris.
• Differential Diagnosis:
1- Psoriasis: pitting is the single distinguishing feature of psoriasis. pitting
is not a feature of fungal infection.
2- Bacterial infection: especially Pseudomonas aeruginosa, which turns
the nail black or green.
3- Onychauxis and Onychogryphosis
4- True Leukonychia: White opaque discoloration of nail plate, that move
distally with growth. Nail plate has a normal surface.
5- Onycholysis.
6- Eczema and habitual picking of proximal nail fold: induces the nail
plate to be wavy and ridged, but its substance remains intact and hard.
• Laboratory Diagnosis:
KOH examination, culture, and occasionally nail biopsy.
• Fluconazole: 1st line therapy for candidal, but also active against
dermatophytes. Mycologic cure rate 47%.
150-450 mg each week for 9 months or until nails are clear in toenails
(6 months or until nails are clear in fingernail).
• Nonpharmacologic approaches include the following:
1. Laser treatment (Nd: YAG laser. Diode laser). 2. Photodynamic therapy.
3. Chemical or surgical nail avulsion:
• Surgical Nail Removal: for Painful or extremely infected nails
• Nonsurgical Avulsion of Nail Dystrophies: Painful or very thick nails
can be removed with 40% urea cream under occlusion. This technique
can be used to treat other hypertrophic nail conditions, such as psoriatic
nails. It is also facilitates treatment with topical antifungal agents.
Note… Pregnancy and lactation
• Terbinafine is category B, itraconazole and fluconazole are category C.
• Use of all these oral drugs should be avoided in pregnancy.
• All oral antifungals are excreted in breast milk, therefore C/I in lactation.
Note… Indications for topical monotherapy include:
1. Superficial white onychomycosis (SWO).
2. In children with thin, fast growing nails.
3. No matrix area involvement.
4. Involvement limited to distal 50 % of nail plate, 3 or 4 nails involvement.
5. As prophylaxis in patients at risk of recurrence.
6. Patients where oral therapy is inappropriate.
From Bolognia dermatology book 4th edition (2018)
Areas of nail
involvement >50%
Significant
lateral disease
Subungual
keratosis >2 mm
Total dystrophic
onychomycosis
Environmental nail disorders
1- Chronic paronychia
2- Brittle Nails
• Brittleness meaning that the nail easily break, split or
peel off. It is very common and usually affect women.
• It can manifest in different ways: Onychoschizia
II. Onychotillomania:
A . Nail picking:
• Uncontrollable desire to pick at, tries off, or
harmfully bite the nails. It may also affect
proximal nail fold.
• Often produces nail matrix damage with 2ry
nail plate abnormality, e.g. surface irregularity,
longitudinal melanonychia.
• Treatment: Topical preparations that taste
unpleasant and bandages. Serotonin reuptake
inhibitors (e.g. paroxetine).
B . Habit-tic deformity:
• Due to nervous habit of picking, rubbing and pushing back the
midportion of cuticle of thumb by index finger, causing injury to the
underlying nail matrix.
• The nail plate shows multiple midline Beau’s lines that resemble a
washboard (i.e. longitudinal band of horizontal grooves).
• The lunula is usually large.
• The proximal nail fold skin is often thickened, scaly or otherwise
abnormal reflecting manipulation of the skin (picking).
• When proximal nails and nail fold are covered with a tape continually,
normal nails regrew in 5 months.
2- Subungual Hematoma
•Collection of blood under nail plate. May caused by trauma, which cause
immediate bleeding and pain. Quantity of blood may be sufficient to cause
onycholysis. Compression of the matrix may cause 2ry nail plate dystrophy.
• Subungual hematomas migrate distally with nail growth.
• The color will change over time initially red to purple and later to dark
brown and black as the blood clots.
•D/D: some cases can be difficult to distinguish from subungual melanoma
by the naked eye, so Dermoscopy is useful in these cases.
• Treatment: If the hematoma is large and causing pain, drainage of blood
is required, by creating a hole through the nail plate, either by a red-hot
paperclip tip (the quickest and most effective+ painless) or with
hypodermic needle (painful).
This relieve the pressure and
give the patient immediate
pain relief.
3- Traumatic Toenail Abnormalities
Most commonly seen in women who wear high-heeled pointed shoes, but
can also be seen in athletes. They are often bilateral.
I. Traumatic onycholysis of the hallux: the most common
clinical presentation. Clipping of detached nail plate reveals
normal nail bed. The differential diagnosis includes onychomycosis, but
here the onycholysis is associated with subungual hyperkeratosis.
II. Transverse leukonychia of hallux: results from repeated
microtrauma by shoes to untrimmed, long, great toenails.
Multiple bands of true leukonychia move distally with nail growth.
III. Frictional melanonychia: affects the toenails of the fourth and/or fifth
digit of women. It is due to activation of nail matrix melanocyte by friction
from shoes or from the adjacent digit. It may be multiple and black color.
IV. Retronychia is caused by embedding of the nail into the proximal nail
fold following trauma and may present with inflammation of the proximal
nail fold.
4- Onychogryphosis
• Common in elderly persons and almost exclusively affects the toenails,
usually the hallux. The nail plate is grossly thickened, hard
and deformed (curved) either oyster-like or ram’s horn.
•It turned yellow–brown, with multiple transverse striations.
III. Retronychia: ingrowth of proximal nail plate into proximal nail fold,
with one to three nail plates misaligned beneath the uppermost nail plate.
There may be associated proximal periungual pyogenic granulomas.
Treatment of lateral ingrowing nail:
1- Ingrown nail without Inflammation: Separate distal anterior tip and
lateral edges of ingrown nail from the adjacent soft tissue with a wisp of
absorbent cotton coated with collodion. This gives immediate relief of pain
and provides a firm runway for further growth of nail. collodion fixes the
cotton in place. may need reinsertion in 3 to 6 weeks. Cotton without
collodion may be used, but it may have to be replaced frequently.
Benign Tumors
1- Pyogenic granuloma (Botryomycoma)
• Commonly appear within the nail apparatus. It may be periungual or
subungual. Appears as a bleeding, friable, soft red papulonodule. When
subungual, it is associated with onycholysis.
• Causes: often follow penetrating trauma. Other include
ingrown toenails, systemic drugs (e.g. retinoids,
EGFR inhibitors), frictional onycholysis.
• Treatment is surgical.
• D/D: amelanotic melanoma.
2- Periungual Fibroma
• Benign fibrous tissue tumors that can be;
• Acquired; due to trauma, also in old age. Or
• Congenital; associated with tuberous sclerosis (referred to as Koenen
tumours) and Neurofibromatosis type I.
• Appear as pink or skin colored, fusiform-shaped , firm, protruding papule
or nodule, originating from the proximal nail fold. It may compress the
nail matrix and produce a longitudinal groove in nail plate.
• It may originate from nail bed and grow under the nail plate (Subungual
fibroma), producing longitudinal erythronychia or onycholysis.
NOTE… Koenen tumours; Multiple periungual fibromas, seen in 50% of
tuberous sclerosis patients.
fusiform
3- Acquired periungual fibrokeratoma (APF)
• Clinically and histologically identical to acquired digital fibrokeratoma.
• Rare tumor. Usually presents as;
• Solitary (Multiple APF is rare. May misdiagnosed as Koenen tumors).
• Firm, smooth, skin colored papules.
• Protruding on nail plate from beneath the cuticle (sometimes from
matrix or nail bed) with hyperkeratotic tip.
• May be surrounded by a collarette of raised skin.
• D/D of APF: Periungual fibroma (Koenen’s Tumor), Wart, keloid,
Pyogenic granulomas, cutaneous horn, exostosis.
APF
longitudinal leukonychia
Longitudinal erythronychia and
leukonychia with focal hemorrhage
8- Melanocytic nevi of nail matrix
•Uncommon cause of longitudinal melanonychia, especially in comparison
with melanocyte activation. Usually develop during childhood.
• Often involve the fingers, especially the thumb. The color, width, and
pigment distribution may vary considerably and it is not unusual to
observe fading or darkening of the pigmentation over time.
• pseudo-Hutchinson’s sign is also possible.
• The age at onset represents the most important clue to the diagnosis.
• Histologically, a junctional nevus is usually seen.
• Treatment: Optimal management of nail matrix nevi is still debated.
Subungual SCC
2-Bowen’s disease (SCC in situ)
• Bowen disease of nail is uncommon and is seen most often in middle-
aged men.
• Clinically, it may be difficult to differentiate it from warts. The affected
digit shows periungual or subungual verrucous lesions with onycholysis
and/or longitudinal melanonychia.
• Predisposing factors include HPV infection and chronic X-ray exposure.
5- Epidermolysis Bullosa
• Nail changes are common in all forms of EB. Deviated axis
• Nail signs: Beau’s lines
• Pachyonychia lateral ingrown toenail
• Partial or total anonychia.
• Subungual/ periungual blister.
dermoscopy of longitudinal
melanonychia
Dermoscopy of Longitudinal Melanonychia
Diagnostic algorithm
for nail pigmentations
of melanocytic origin
1. The background of the pigmented area of melanocytic origin
is brown homogenous color , with dots, and is due to melanin.
Journals
Indian journals of dermatology, venereology and leprosy;
• Singal A, Khanna D. Onychomycosis: Diagnosis and management. Indian J Dermatol Venereol Leprol
2011;77:659-72.
• Archana Singal, Rahul Arora. Nail as a window of systemic diseases. Indian J Dermatol Venereol Leprol
2015 Mar-Apr; 6(2): 67–74.
Journal of General Internal Medicine;
• Siwadon Pitukweerakul, Sree Pilla. Terry’s Nails and Lindsay’s Nails: Two Nail Abnormalities in Chronic
Systemic Diseases. J Gen Intern Med. 2016 Aug; 31(8): 970.
Journal of turkish dermatology;
• Yalçın Tüzün, Özge Karakuş. Leukonychia. Turk Acad Dermatol 2009; 3 (1): 93101r.