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Ex. Cushing
Dex suppression test (Dexsomethosone)
Give a synthetic agonist of cortisol to test the feedback loop
Should be able to suppress the secretion of cortisol, by suppressing the secretion of
ACTH.
Cortisol measured in saliva (filtrate of plasma)
o Pretty reliable method of measurement
o In adrenal hyperplasia, you should get a positive reaction to the dex
suppression test
o Not responsive means it’s probably a tumor
o Before a tumor becomes malignant, it will make its presence known,
which is the advantage of having an endocrine cancer
In animal studies, the andogenist cortisol is corticosterone, but squirrels have
cortisol which is the exception.
Depending on the results you get from the test you do more follow up.
Diabetes test:
Test status of patient’s islets capacity to produce insulin
C - peptide
Ovarian cancer:
Less common than breast cancer
Asymptomatic
Endocrinology lecture: Reproductive cancers Nov 28
How do you know you have ovarian cancer? It starts effecting other parts of the
body (Ovaries in open cavity easy for tumors to spread)
Screening is really tough
How is it detected?
TNBC:
Problem with breast cancer: estrogen can be metabolized into a promotor or initiator in
cancer
Ductal cytonoma:
Non-cancerous
Stomach cancer
H. plyori
Inflammation
Asbestos mesothelioma
Due to inflammation
Reproductive cancers:
Incidence of cancers in men and women is about the same.
Female
Breast (most common)
Cervix/uteri
o HPV (sexually transmitted)
Ovarian (do not notice the difference)
Endometrial
Male
Prostate (most common)
o Once you get up to about 90 years old, the incidence of prostate insitu is
almost 100%.
Testicular cancer (Lance Armstrong effect produces abundance of androgens)
o Makes presence known months or years before it’s dangerous.