1.

3: SOURCES AND CONTROL OF PREANALYTICAL VARIATION

Use the following key to answer questions 1 through 4.
a. 1,2, and 3 are correct
b. 1 and 3 are correct
c. 2 and 4 are correct
d. only 4 is correct
e. all are correct
1. Moderate levels of hemoglobin can cause methodological interference in which of the following analytical
procedures?
1. cholesterol
2. albumin
3. triglycerides
4. iron
2. The information on a chain of custody document includes:
1. subject name
2. person sending specimen
3. person receiving specimen
4. condition of seals
3. The purpose of a chain of custody document is to:
1. ensure that no tampering of the sample occurred
2. ensure that the specimen is derived from the appropriate individual
3. ensure that the reported results are correct for
the appropriate individual
4. ensure that quality control was performed
4. Which of the following patient variables can affect measured analyte concentrations?
1. diurnal variation
2. posture
3. stasis
4. height
5. All of the following are higher in the morning than the afternoon or evening (in persons with a normal wake:sleep
cycle) EXCEPT:
a. ACTH
b. Cortisol
c. Iron
d. Prolactin
e. Renin/aldosterone
6. Which of the following is typically decreased after meals?
a. Chloride
b. Gastrin
c. Growth hormone
d. Insulin
e. Triglycerides
7. EDTA contamination will decrease all of the following analytes EXCEPT:
a. Alkaline phosphatase
b. Calcium (spectrophotometric methods)
c. Creatine kinase
d. Magnesium (spectrophotometric methods)
e. Potassium
8. The mechanism of interference in hemolyzed samples is correctly matched with the test name in all of the following
combinations EXCEPT:
a. Bilirubin – release from red blood cells
b. Cholesterol – interference in assay

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 c. Creatine kinase – interference in assay
d. Lactate dehydrogenase – release from red blood cells
e. Magnesium – release from red blood cells.
9. Appropriate tests to use for delta checks, since they show low intra-individual variation, little day to day variation, but
higher inter-individual variation, include:
a. Alkaline phosphatase
b. Creatine kinase
c. Glucose
d. Lactate dehydrogenase
e. Phosphate
10. The percent intraindividual variation is highest for:
a. Albumin
b. Calcium
c. Creatinine
d. Sodium
e. Triglycerides
11. Regular aerobic exercise is associated with:
a. Decreased glucose
b. Decreased bilirubin
c. Decreased creatine kinase
d. Increased aspartate aminotransferase
e. Increased alanine aminotransferase
12. Short term, intensive exercise, such as running a marathon, is associated with:
a. Decreased potassium
b. Decreased uric acid
c. Decreased glucose
d. Decreased creatine kinase
e. Increased phosphate
13. All of the following increase after a meal EXCEPT:
a. Glucose
b. Insulin
c. Iron
d. Potassium
e. Triglycerides
14. Stress is associated with which of the following?
a. Decreased cortisol
b. Decreased catecholamines
c. Decreased cholesterol
d. Increased high density lipoprotein cholesterol
e. Increased TSH
15. All of the following are increased by upright posture EXCEPT:
a. Albumin
b. Calcium (total)
c. Cholesterol
d. Iron
e. Potassium
16. Which of the following statements regarding differences between arterial and venous blood is INCORRECT?
a. Arterial blood has higher concentrations of metabolites extracted by tissue, such as oxygen and glucose.
b. Arterial blood has lower concentrations of waste products, such as carbon dioxide and ammonia.
c. Capillary blood is more similar to arterial than to venous blood.
d. The difference between arterial and venous blood is increased with poor tissue perfusion.
e. The difference between arterial and venous blood glucose is similar in fasting and postprandial collections.

Answer:

Lawrence Kaplan & Amadeo Pesce 1/17/2020 1.3.2 CC-BY-NC-SA https://chem.libretexts.org/link?113850

 1. b (p. 73)
2. e (p. 73-74)
3. a (p. 74)
4. a (p. 66-68)
5. d (p. 69)
6. a (p. 69)
7. e (p. 71)
8. a (p. 73)
9. a (p. 80)
10. e (p. 67)
11. c (p. 67-68)
12. c (p. 67)
13. d (p. 69)
14. c (p. 68)
15. d (p. 68)
16. a (p. 70)

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