ONCOLOGY

12. Which of the following is a strategy for primary prevention of cancer?

A. Paps smear
B. Digital rectal exam
A. Hepatitis B vaccination
B. Self-breast examination
13. Desired response to treatment if the goal of treatment is TO PALLIATE
A. Complete response
B. Partial response
C. Stable disease
D. Progressive disease
14. HER-2 neu is commonly expressed in which of the following malignancies?
A. Colonic Ca
B. Breast Ca
C. Bronchogenic Ca
D. Endometrial CA
15. The most common malignant cause of mortality in both sexes is
A. Cervical Ca
B. Bronchogenic Ca
C. Breast Ca
D. Colonic Ca
16. A 20 y/o male was noted to be oliguria 2 days after hazing in fraternity. Urine was described as
reddish in color. Extreme tenderness noted all over the body. The cause of reddish urine is
A. Hematuria
B. hemoglobinuria
C. myoglobinemia
D. porphyria
17. A 23y/o female complaining of 1 day duration of dysuria, with urgency & hesitancy, afebrile with
mild hypogastric tenderness. What is the most common uropathogen
A. E. coli
B. Staph saprophyticus
C. Proteus

C. Candida
18. A 35y/o F, w/ Type 1 DM since 11y/o had a consultation for generalized edema. Had hypertension
for 2 years & had laser therapy of both eyes
for retinopathy. Screa is 3.8 mg% Hgb=80. The stage of diabetic glomerulopathy is

A. Initial Hyperfunctioning stage

B. Incipient Glomerulopathy
C. Overt Glomerulopathy
D. Azotemia Glomerulopathy
E. End Stage Glomerulopathy
19. 60 y/o male, smoker, had consultation for gross hematuria on & off for
3 months & weight loss. There is a palpable mass on (L) flank. The

laboratory examination which will be very helpful to clinically stage

this disease is

A. renal UTZ
B. IVP
C. CT scan with contrast
D. Renal scan
20. The most common glomerulopathy worldwide
A. Acute post strep GN
B. Lupus Nephritis
C. IgA Nephropathy
D. Thin Basement Membrane Disease
21. The most common functioning pituitary adenoma
A. Prolactinoma
B. ACTH-secreting adenoma
C. TSH-secreting adenoma
D. Acromegaly
22. A 67 year old woman has just undergone near total thyroidectomy for
follicular thyroid carcinoma. Next step is

A. Chemotherapy with adriamycin

B. Radioactive iodine therapy
C. Levothyroxine replacement therapy
D. Observe and follow-up

23. Colon biopsy revealed adenocarcinoma. How does this condition produce pedal edema?
A. Congestive heart failure
B. Protein loss
C. Renal failure
D. Compression of the vena cava
24. Which of the following does NOT predispose to colon cancer?
A. Hyperplastic polyp
B. Ulcerative colitis
C. Polyposis coli
D. Adenomatous polyp

25. Colonic polyps will most likely become malignant if it is:

A. Sessile (flat-based)
B. 1.5 cm in size
C. Pedunculated (stalked)
D. Multiple

26. A definitive diagnosis of cancer is only made through:

A. Radiologic characteristics of the tumor
B. Elevated levels of tumor markers
C. Pathologic exam of tissue samples
D. Clinical manifestations of the disease

27. What is the importance of estimating a tumor’s doubling time?

A. It helps you choose the appropriate drug regimen for the case.
B. It gives you an estimate of a patient’s performance ability.
C. It determines how soon you need to initiate treatment.
D. It gives you an idea how a patient will develop drug toxicity.

28. Which of the following conditions is a contraindication to systemic chemotherapy?

A. Patients with age >60 years old
B. Patients with good performance status
C. White blood cell count of 5 000 cells/cu mm
D. Overwhelming systemic infection present

1. In the tumor cell cycle, the cells refractory to chemotherapy are the:
a. Cells in the G2 phase
b. Cells in the M phase
c. Cells in the G0 phase
d. Cells in the active S phase

2. Multiple osteolytic lesions, hypercalcemia and neurologic abnormalities are most often seen
in:
a. Prostatic CA
b. Non-Hodgkin’s lymphoma
c. Plasma cell myeloma
d. CNS tumors
3. Thrombocytopenia is not expected in:
a. SLE
b. G6PD deficiency
c. Acute Leukemia
d. Disseminated intravascular Coagulation (DIC)

4. This finding in Chronic Myelogenous Leukemia can differentiate it from leukemoid reaction:
a. decreased leukocyte alkaline phosphatase
b. increased WBC count
c. anemia
d. hypercellular marrow with increased granulocyte precursor

5. Lung cancer that is associated with significant progressive dyspnea and increasing
hypoxemia
a. Squamous cell carcinoma
b. Oat cell CA
c. Adenocarcinoma
d. Bronchoalveolar CA

6. The most common form of Lung cancer arising in lifetime of a non smoker young women
a. Small cell carcinoma
b. Adenocarcinoma
c. Squamous cell carcinoma
d. Large cell carcinoma
MPL: 0.50 p: 507

7. Marantic endocarditis is commonly associated with this lung cancer:

a. Squamous cell
b. Large cell
c. Adenocarcinoma
d. Small cell
MPL: 0.25 p: 509

8. The most significant risk factor for cancer is:

a. Sex
b. Age
c. Nationality
d. Dietary factors
MPL: 0.50 p: 435

9. DNA synthesis phase

a. G1
b. G2
 c. G0
d. S
MPL: 0.333 p: 469

10. This is the most common local manifestation of lung cancer at presentation
a. Dyspnea
b. Cough
c. Hemoptysis
d. Chest pain
MPL: 0.50 p: 508

11. Most common site of pancreatic cancer:

A. head
B. body
C. tail
D. uncus
MPL: 0.25 p: 537

12. Most consistent risk factor in pancreatic cancer:

A. hypertension
B. alcoholism
C. cigarette smoking
D. obesity
MPL: 0.5 p: 537

13. Hereditable gastrointestinal syndromes that has least malignant potential:

A. gardner’s syndrome
B. turcot’s syndrome
C. lynch syndrome
D. juvenile polyposis
MPL: 0.333 p: 528

1. Majority (>50%) of all esophageal cancers are of which cell type?

A. adenocarcinoma

B. squamous cell carcinoma

C. lymphoma

D. sarcoma
 Page 542

2. Not considered as risk factor for the development of Pancreatic cancer?

A. smoking

B. cholelithiasis

C. long standing DM

D. obesity

Page 537

Choose the correct pair of tumor marker and cancer implicated:

A. Alphafetoprotein – colon cancer

B. CA-125 - ovarian cancer

C. Lactate dehydrogenase – myeloma

D. Carcinoembryonic antigen – hepatocellular carcinoma

Harrison’s Internal of Medicine, 16th ed. 439

82. The leading cause of cancer death in both men and women.

A. Lymphoma C. Lung CA

B. Nasopharyngeal CA D. Large cell CA

Harrison’s Internal of Medicine, 16th ed. 436, 506

83. The most common histologic subtype of lung cancer for the past 25 years.

A. Squamous or Epidermoid C. Small cell CA

B. Adenocarcinoma D. Large cell CA

Harrison’s Internal of Medicine, 16th ed. 506

84. Usually, these types of lung cancer have already spread at the time of

presentation and diagnosis, hence, surgery is unlikely to be curative. They are

 managed primarily by chemotherapy with or without radiotherapy.

A. Squamous or Epidermoid C. Small cell CA

B. Adenocarcinoma D. Large cell CA

Harrison’s Internal of Medicine, 16th ed. 506

CASE: Leo Garcia, 68-year old male came in to your clinic because of urgency,

hesitancy and bloody urine: (Questions 167-169).

85. Prostate cancer is highly entertained, and the first screening modality that you will

perform is:

A. Digital rectal exam

B. Assay for serum PSA (prostate specific antigen)

C. Ultrasound of bladder/prostate

D. Transrectal ultrasound guided biopsy

Harrison’s Internal of Medicine, 16th ed. 446

86. Examinations revealed prostate cancer. The most common site for its metastasis:

A. Lungs C. Colon

B. Liver D. Bone

Harrison’s Internal of Medicine, 16th ed.

87. Deregulation of molecular mechanics controlling cell cycle progression is a

hallmark of cancer. Which phase of the cell cycle is critical in the regulation of cell

proliferation.

A. M C. S
 B. G1 D. G2

Harrison’s Internal of Medicine, 16th ed. 453

88. Certain human malignancies are associated with viruses. Correct examples are

the following, EXCEPT:

A. Burkitt’s Lymphoma – Epstein Barr virus

B. Cervical cancer – Human Papilloma virus

C. Hepatocellular carcinoma – Hepatitis B virus

D. Colon cancer – Helicobacter pylori

Harrison’s Internal of Medicine, 16th ed. 442

89. A woman with the following characteristics, has a greater risk of developing breast

cancer:

A. Menarche at 12 y/o, Primigravida at 18, menopause at 45

B. Menarche at 12 y/o, Nulligravida, menopause at 52

C. Menarche at 12 y/o, Multigravida, menopause at 45

D. Menarche at 16 y/o, Primigravida at 25, surgical menopause at 40 because of

TAHBSO
 Harrison’s Internal of Medicine, 16th ed. 517

90. Tumor lysis syndrome is an oncologic emergency which may present as acute

renal failure. This is due to destruction of a large number of neoplastic cells

during chemotherapy. It is characterized by the following, EXCEPT:

A. Hyperuricemia C. Hypercalcemia

B. Hyperphosphatemia D. Hyperkalemia

Harrison’s Internal of Medicine, 16th ed. 581