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science MATHEMATICS GRAVITY LIGHT TOMORROW QUESTIONS AND ANSWERS Quantum theory
NUMBERS thaughts RESEARCH Brain Planets PLAZMA quantum earth PARTICLE PHYSICS
computer 2d metals nucleus GRAVITY kuiper belt golden ratio STANDARD MODEL RESEARCH
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1 Contents
Yo u m ay eve n
wonder what
exactly it means for
the copier to know the doc-
ument before hand! Think
of the machine as a general
purpose one which can print
and scan. Usually, in xerox-
ing the document is scanned
and then printed. First, think
of a machine which can
take an input file and make
copies of its contents. This is
»»p.5 what we would call perfect
Scienceteen
We have all won-
dered about the
mysterious twin-
kling stars in the night sky
at some point in our life.
Although, this curiosity about
these primary inhabitants of
the universe, diminishes for
most of us with passage of
time. Nevertheless, some
of us, namely the astrono-
mers, do study stars in order
to understand how they are
born and evolve with time.
»»p.23 The apparent brightness and
CONTENTS
Scienceteen
5 Cover story
A Quantum Dolly is an impossibbility! 05
8 Featured article
The Golden Ratio 09
13 teen Spectrum
»»p.15 Viju & Cheeru 13
Science Quiz 14
15 technoteens
The Techno Brain 15
16 Mystery
A new Periodic Table for 2D Elements 17
The Kuiper belt 18
16 Public Library
All Biology is Computational Biology 19
»»p.18
22 Your Articles
The theory which pedicted gravitational waves 21
Matter and fundamental particles 22
Life cycle of stars 23
30 insight
Ramanujan Shodh Sansthan News 25
31 testimonials
Appreciations and suggestions 28
»»p.17
Editors’s page
Scienceteen
We are glad to present the 6th issue of Scienceteen magazine. EDITOR
We regret that you have to wait for such a long time as we Prashant Kumar Sinha
could not publish during July to Novemberber due to some prashant@scienceteen.com
health issue of our members. Anyway, we are back again ASSOCIATE EDITOR
with you sharing our gathered knowledge to our readers. Rahul Aggrawal
Contributing to the development of science is the contri- rahulaggrawal@scienceteen.com
bution to the development of mankind and society. From WRITER
the stone age, man to the era of computing human race has Rohit Jha
evolved much far ahead of any other species and this is only rohitjha@scienceteen.com
due to the fact that the human brain cannot only perceive EDITORIAL ASSISTANT
the nature around us like the other species but it also thinks Vikash Kumar
of the laws governing the nature. This extraordinary capa- vikashkrpro@gmail.com
bility of the human brain has led to the subject of science. Our little efforts are also in CREATIVE HEAD
the same direction to make our readers aware of the recent discoveries in the field of Meenakshi Sinha
science and technology and enhance your knowledge. Let’s start with our latest issue. mickymeenakshi@gmail.com
The cover story is “A Quantum Dolly is an impossibility!” By Prof. N.D. Hari Dass PRODUCTION MANAGER
TIFR-TCIS, Hyderabad which explains that Xerox copying is a classical phenome- Prabhat Kumar Srivastava
non it can’t happen in the quantum world. We are very thankful to Prof. N.D. Hari prabhat@scienceteen.com
Dass for giving his valuable time and writing on such an advanced subject in such a
manner which could inspire the teenage students. It’s like a window to an entirely new
field to the students and researchers. The featured article is “The Golden Ratio” which
describes how the golden ratio and Fibonacci sequence is embedded in the nature and SE N D YOU R L E T T E R S
science of aesthetics. In the Mystery section, we have the article on 2D metals and its
new periodic table based on a new research and an article on the Kuiper belt a very If you have read somthing in Scienceteen mag-
mysterious part of our solar system by Mr. Rohit Jha. In the wisdom section, we have azine which has excited you then you can write
an article from public library “All biology is computational biology” which is based on your comments. We will be thankful for your
the coordination between the two sciences biology and computation and how computa- valuable comments.
tion has become the ultimate tool to do research in biological sciences. In your articles Email : prashant@scienceteen.com
section, we have an article by Mr. Rajeev Singh “The theory which predicted gravita- we welcome your letters, with right to edit
tional waves” which explains how Einstein’s general theory of relativity predicted the them for length and clarity in expression.You
existence of gravitational waves. Then we have the article “Lifecycle of stars” by Mr. can also send your own articles for publication
Anupam Bhardwaj which tells the story of a star from its birth to death it's different in our magazine or website:
phases and how the whole process is carried. It’s more of a learning experience. Then www.scienceteen.com
we have article “Matter and fundamental article” which is a short informative article
on particle physics and the standard model. We are thankful to Prof. N.D Hari Dass,
Mr. Rohit Jha, Mr. Rajeev Singh, Dr. Anupam Bhardwaj and Mr. Protick Mohanta for The ideas presented in Scienceteen mag-
writing such informative and creative articles in this issue. We are also thankful to all azine are the author’s own ideas. The
our readers for their appreciations and their creative articles. We will be thankful for author of the article is solely responsi-
your suggestions and support. ble for anything presented in the article.
We are not responsible for any of the ideas
Your’s thankfully presented by the author of the articles.
-Prashant Kumar Sinha &
Image: Back cover: Credit: Reading Tom.
Rahul Aggrawal
Date: 25/02/2018
Source: https://www.flickr.com/pho-
www.scienceteen.com
Published by Prashant Kumar Sinha and Rahul Aggrawal on
tos/16801915@N06/
www.scienceteen.com
A Quantum Dolly
is an impossibility!
Prof. N.D. Hari Dass, TIFR-TCIS, Hyderabad
Why talk of a Dolly in the quantum world around us. But the laws governing these dynamical laws can be recast in
context? Dolly the sheep was a clone. such a macroscopic world were discov- vastly different(but physically equivalent)
Clones are supposed to be perfect copies ered first, for obvious reasons, and this is forms like Lagrangian or Hamiltonian
of their original. In the case of Dolly, the what one means by the classical world. forms. When there are many different par-
original is a living entity, hence all the That world, which included such magnif- ticles the state of the composite system, in
excitement! In the non-living context, we icent creations like Galileo’s inertia, classical theory, can be construed from the
are familiar with a Xerox Machine. An Newton’s laws, Maxwell’s electrodynam- states of the constituents. A concept
ideal Xerox machine would make perfect ics, and even Einstein’s special theory of crucial to our subject of focus is that of
copies of the original. It can also make an relativity went a long way in accounting measurements. In classical physics there
arbitrary number of copies. So, what is the for the world around us. Important to the are two central aspects to be remembered
big deal, you might ask. The big deal is dissection we wish to undertake is a clear i) no separate laws other than the dynami-
that in the quantum world, such copying delineation of the structures of the two cal principles are needed to describe mea-
is in general, impossible! This is a very theories. All theories start with the primi- surements, ii) there are certainly errors but
deep result that sets the quantum world in tive notion of states. In classical mechan- these can be controlled and compensated
deep contrast from its classical counter- ics, the state of a point particle is specified with the consequence that measurements
part. To appreciate the significance of it by its position and its momentum at the do not affect the state of the system mea-
requires a careful dissection of the classi- same instant. The other aspect of theories sured. For classical copying this leads to
cal and quantum world. As of today, the is Dynamics. This is the prescription by another subtle aspect; a perfect xerox
scientific consensus is that our world is which given the state of a system at one machine can make perfect copies whether
governed by quantum mechanics. What instant one can uniquely determine the or not the state(in this case the document
then do we mean by a classical world? The state at a later instant. In classical mechan- being copied) is known before hand or not.
point is that in an approximation to the ics, this dynamics is described by You may be puzzled as to why this appar-
quantum world one obtains the so-called Newton’s laws. For the purposes of this ently irrelevant detail has been brought in!
classical world which seems to govern article the detailed form of these laws is You will appreciate this when we turn to
pretty much most of the macroscopic not very relevant; nor is it important that quantum theory later on. You may even
wonder what exactly it means for the
Image: An example of classical copying in nature is the Giant Causway. All the stones seem to be a copy of each other The copier to know the document before hand!
only World Heritage Site in Northern Ireland, Giant’s Causeway is an area of about 38,000 interlocking basalt columns, Think of the machine as a general purpose
the result of a volcanic eruption 60 million years ago. The tops of the columns form stepping stones that lead from the cliff
foot and disappear under the sea. Most of the columns are hexagonal, although there are also some with four, five, seven, one which can print and scan. Usually, in
and eight sides. The tallest are about 39 ft high.
Source: http://www.geodiversite.net/media543, Author: geolman http://www.geodiversite.net/auteur5 xeroxing the document is scanned and
then printed. First, think of a machine
which can take an input file and make
copies of its contents. This is what we
would call perfect copying of a known
state. Now consider feeding to the machine
for which no such input file has been pro-
vided. We call that copying of an unknown
state. In the classical context, as we know
too well, this hardly makes any difference.
In the unknown state case, the machine
scans the unknown document and then
prints or copies it as a known document.
Crucial to this is the possibility, both in
principle and nearly always in practice, of
scanning without mutilating the docu-
ment.You may be wondering what all this
information about the initial state either! state. Since only a single copy
It is only a large number of independent is available, no measurement
measurements on an equally large number scheme can be used to deter-
of identically prepared copies of the initial mine that state(though we only
state that we can ever hope to learn about showed how it works for Von
the initial state. For then, we can measure Neumann projective measure-
the probabilities of various outcomes and ments, one can show this for
that indeed contains information about the every type of quantum mea-
initial state. These are called ensemble surement conceivable). Thus
measurements. At this point, it is worth the analog of scanning in the
pointing out that since this formulation of classical xerox machine will
quantum measurements from the early not work. While we have
days, explicitly realized by the von heavily used ideas pertaining
Neumann model, a wide variety of new to quantum measurements to
schemes for quantum measurements have argue the case, the theorem as
come up notably the so-called weak mea- originally proved by Wootters
surements and weak value measurements, and Dieks, only used the rules
quantum non-demolition measurements f o r q u a n t u m
etc. But none them can really avoid the evolution(dynamics) to prove
inevitability of ensemble measurements. it. The proof is so elegant and
After this long, but essential elucidation straightforward, that I will
Image: An artist's imagination of an attempt to visualise the impossible
of quantum mechanics, we are now in a include its essentials here. cloning in action, here quantum states are represented by small cubes
position to address the main concern of Suppose we want to clone an
this article, namely, the impossibility of a unknown quantum state |u> into two iden- measurements to determine the state! But
quantum Dolly! I picked Dolly to drama- tical copies. The way to do it is to consider this goes against the crux of quantum
tize the issue but for the quantum context |u> along with a blank |0>(think of this as mechanics we stated earlier, namely, no
that may not be the best choice. For one the empty sheets of a classical xerox measurements on a single copy can yield
thing, Dolly’s case involved the cloning machine. Now let the quantum dynamical any information about it. Therefore there
of a living being(in fact much of the process be described by a unitary trans- can not be such universal cloning
excitement was on that front!), and living formation U(all quantum evolutions are machines. I end this article with a point
beings are very complex. Also, the ques- described by unitary transformations, that often confuses people when first con-
tion of whether the original was a known these are the technical aspects that you fronted with the no-cloning theorem. They
state or unknown state is also moot. One have to learn if you want to get a proper cite the laser as a possible counterexam-
can always argue that DNA and the genetic understanding of quantum mechanics). ple. In a laser starting with an initial
code make every living being a known This means we have the cloning transfor- photon injected into a cavity with popula-
state. Whether the original in the case of mation expressed by the equation U|u>|0> tion inversion, induced emission creates a
Dolly is a single copy or many copies is = |u>|u>. Since the original state is huge number of copies of the initial
also moot as in the body of the original unknown, the same U should clone any photon. Superficially it looks like the
there are numerous identical copies of state! Therefore, if |v> is another state, one initial photon has been cloned and the no-
cells and their genetic material. So we would have U|v>|0> = |v>|v>. Unitary cloning theorem has been violated! In a
shall play it safe and rephrase the impos- transformations maintain the inner product sense, the laser is a cloner, but it clones a
sibility we started with for the case of between two vectors(this is exactly like known state as the lasing device has to be
quantum states. Once again, if the quantum rotations maintaining angles). This imme- specifically chosen to match the initial
state is known, cloning or making an arbi- diately gives <v|u>=<v|u><v|u> which is state of the photon.
trary number of copies is no big deal and only possible if <v|u>=0 or 1. But |u>, |v> N.D. Hari Dass did his matriculation
works in spirit exactly as in the classical were arbitrary, so the only way out is that from Mahajana High School, Mysore,
case. Again, if a large enough ensemble no such cloning transformation U can his BSc(Hons) and MSc from Delhi Uni-
versity, and his Ph.D. from University of
of identically prepared states is given, exist.Though this proof makes no refer- California at Santa Barbara. After that he
there is no big deal either. One can make ence to quantum measurements, there is a worked at UCLA, Max Planck Inst. for
Physics at Munich (Werner-Heisenberg Institute), Niels
ensemble measurements to determine the peculiar inner consistency in the follow- Bohr Inst. at Copenhagen, Raman Research Inst. at Ban-
state(called tomography) and then use the ing sense. Suppose such universal cloning galore and National Inst. for High Energy Physics at Am-
knowledge of the state to make an arbi- machines could exist; by universal, we sterdam before joining IMSc in Chennai from where he
retired as a Senior Professor. He was then the DAE Raja
trary number of copies. The impossibility mean that U is the same for all input states. Ramanna Professor at IISc, Bangalore and Adjunct Pro-
statement, also called the no-cloning Then using such a cloning machine we can fessor at Chennai Mathematical Inst.. He is now a visiting
professor at TCIS. He is a fellow of the National Academy
theorem, states that it is impossible to produce an arbitrarily large number of of Sciences, Allahabad.
clone or make multiple perfect copies of copies of the unknown state. Then using Source: https://www.tifrh.res.in/~dass/
a single copy of an unknownquantum them we can make ensemble
Method Two
Make a square (small to conserve space),
Please note that the golden area is what
the rectangle will eventually look like.
Now, build another, congruent square
right next to the first one. Now we have a
rectangle with a width 1 and length 2 units
and build a square on top of this rectangle
such that square formed will have a side
of 2 units. Now we have a new rectangle
with width 2 and length 3. Let's continue Constructing a Golden Spiral
the process, building another square on
the right of our rectangle. This square will
have a side of 3. Now we have a rectangle
of width 3 and length 5. Again, let's build
upon this rectangle and construct a square
underneath, with a side of 5. The new
rectangle has a width of 5 and a length of
8. Let's continue to the left with a square line should look like a spiral. Here is an
with side 8. Have you noticed the pattern The golden ratio is expressed in spiraling example of what your spiral should look
yet? The new rectangle has a width of 8 shells. Through the opposite corners of like:
and a length of 13. Let's make one final each square, a quarter circle goes. The
square on top, with a side of 13. Our final spiral formed is not a true mathematical Fibonacci numbers in nature
rectangle has a width of 13 and a length spiral. We built our rectangle in a Look at any seed head, it looks like spiral
of 21. Notice that the constructed golden counterclockwise direction which leads us patterns curving out from the center left
rectangle using a square have side lengths into another interesting aspect of the and right. If you count these spirals to
from the Fibonacci sequence (1, 1, 2, 3, Golden Ratio. Look at the rectangle with the left and then the right you will notice
5, 8, 13, ...)! No wonder our rectangle is all of our construction lines drawn in and that these are two consecutive Fibonacci
golden! Each successive rectangle has concentrate on the squares that we drew, numbers. This can also be seen in pine-
a width and length same as consecutive starting with the two smallest ones. Let's cones, pineapples, cauliflower, and many
terms in the Fibonacci sequence. If we start with the one on the right. Connect the more!
divide the length by the width, we get the upper right corner to the lower left corner
Golden Ratio! Of course, our rectangle with an arc that is 1/4th of a circle.
is not "perfectly" golden but if we keep
on going the ratio becomes better, for
our purpose a length of 21 and a width
of 13 are sufficient. This rectangle should
seem very well proportioned to you, i.e.
it should be pleasing to the eye. If it isn't,
maybe you need your eyes checked!
i = Nosetip to chin Image: The Golden Spiral expressed in the human ear
j = Lips to chin The same applies to the side view of the Source: https://in.pinterest.com/pin/826129125372790476/
Author: Erica Hansen, http://ericahansen.net
k = Length of lips human head. The following lines define
l = Nosetip to lips the different golden sections:
Now find the following ratios: a/g , b/d ,
i/j , i/c, e/l, f/h, k/e Blue: in front of the head defines the posi-
tion of the ear opening, Yellow: neck,
The pupils and outside corners of the Green: back of the eye and the front of
mouth makes a perfect square depicted the eye and back of the nose and Magenta:
by the blue line. The golden section of mouth. Image: Golden ratio in index finger
these four blue lines defines the nose, the
tip of the nose, the inside of the nostrils, Divine Proportion is also reflected in the
the two rises of the upper lip and the inner face dimensions from top to bottom. The
points of the ear. The blue line also indi- positions of the eyebrow (blue), nose
cates the distance from the upper lip to (yellow) and mouth (green and magenta)
Image: Your hand shows Phi and the Fibonacci Series
the bottom of the chin. The yellow line, shows the same ratio. The Fibonacci spiral The ratio of your forearm to hand is Phi
a golden section of the blue line, defines is evident in the shape of the human ear. Source: https://www.goldennumber.net/human-hand-foot/
Fn = Fn-1 + Fn-2
Fibonacci’s rabbits
F1 = F2 = 1 In Fibonacci’s book Liber Abaci there is
a question involving the reproduction of a
F2 = 1 pair of rabbits. Suppose a newly born pair
of rabbits (a male and female) are put in a
By the above definition the Fibonacci field. The rabbits can mate at the minimum
numbers for n=1, 2 is 1 and the sequence age of one month so that at the end of
continues as 1, 1, 2, 3, 5, 8, 13, 21,… the second month a female can produce
another pair of rabbits. Assuming that the
Before Fibonacci, these numbers were rabbits never die and the female always
already investigated by Indian Scholars produces a new pair every month from the
in rhythmic patterns of syllables. The second month on. How many pairs will
ratio of successive Fibonacci numbers is there be in one year?
something you might be surprised by! As
n increases, the ratio of Fn / Fn-1 approaches Written by: Prashant Kumar Sinha
the golden ratio and is expressed as
References
science QUIZ
Rohit Jha
In movies and documentaries exploring then pops up to provide a structure’s name region’s connection to the rest of the brain.
the body and riding inside the veins and and details about the structure’s function. A drop-down menu provides easy navi-
seeing the complicated structures of the For example: Primary Visual Cortex: gation to particular structures and gives
nervous system is an awesome experi- It is the first part of the occipital lobe to more context for the brain’s anatomy. At
ence. Thanks to a new virtual model, you receive visual information. Each neuron in a glance, the menu outlines, for instance,
can journey through a three-dimensional the primary visual cortex receives infor- that the limbic system contains the ento-
brain. The website BrainFacts.org, spon- mation from both eyes working together rhinal cortex, amygdala, and hippocam-
sored by The Society for Neuroscience and to cover a specific portion of the visual pus. And the hippocampus is further com-
other organizations has recently launched field. Each side of the primary visual posed of the subiculum and dentate gyrus.
an interactive 3-D brain, which has basic cortex processes information from…It Long, sometimes tongue-twisting names
information about how the human brain also tells how a structure got its name — such as the glossopharyngeal nerve
functions. A translucent, light pink brain or how researchers knew what it’s func- — can be daunting. But the text boxes
initially rotates on the screen. With a click tions. Clicking and dragging your mouse are easy primers, most no more than 50
of a mouse or a tap of a finger on a mobile or finger allows you to rotate the brain. to 100 words. Make it through the names
device, you can highlight and isolate dif- You can zoom in to view areas in detail and you’ll learn interesting nuggets, like
ferent parts of the organ. A brief text box or back out to get a bigger picture of a that the glossopharyngeal nerve oversees
Image credit: Society for Neuroscience
swallowing muscles and relays information about taste and touch in the mouth. Anyone interested or fascinated by the anatomy
of the brain should visit through this interactive model a fun and informative journey.
T he Ku iper Belt
Rohit Jha
Image Credits: NASA| The Kuiper Belt
The issues surrounding the discovery of in January 2005
astrophysical objects can be complex. by a Palomar
Sometimes these objects get discov- Observatory-based
ered by chance and on other occasions, team led by Mike
their existence is inferred or predicted Brown. An inter-
by astronomers before their eventual dis- esting develop-
covery. A prediction was made in the year ment followed soon.
1943 by an Irish astronomer by the name The International
Kenneth Edgeworth who suggested that Astronomical Union,
a reservoir of comets and larger bodies in the year 2006
could exist beyond the planets. Eight years created a new class
later, another astronomer by the name of objects called
Gerard Kuiper came up with a somewhat dwarf planets. It
similar prediction. He believed that icy placed Pluto, Eris and the asteroid Ceres for some time to come. Luckily, Infrared
objects just might exist beyond the orbit of in this category. Pluto is no longer con- measurements from NASA's space-based
Neptune. They both turned out to be right. sidered a planet but it is probably the best telescope, Spitzer, have helped in the esti-
What is The Kuiper Belt? known large object in the Kuiper Belt. mation of the size of some of the large
According to NASA, the Kuiper Belt is “a Other large Kuiper Belt Objects include objects in the belt. This belt is believed
disc-shaped region beyond Neptune that Quaoar, Makemake, Haumea, Ixion and to be the point of origin for most of the
extends from about 30 to 55 astronomi- Varuna and they are often referred to as Comets. Probably the most famous of
cal units.” One Astronomical Unit (A.U.) Trans-Neptunian objects or TNOs.The these is the Halley’s Comet, which has
is the distance between the Sun and the well known interplanetary space probe been active for the past 16,000–200,000
Earth. This region consists of thousands named New Horizons launched by NASA years. Interestingly, astronomers have
of icy bodies and billions of comets. Most flew by Pluto in 2015. It surveyed a bunch found structures similar to our Kuiper
of these icy bodies are smaller than 100 of other Kuiper Belt objects as well. Belt around at least nine other stars. New
kilometers in size and they can be even as Formation of The Kuiper Belt: Horizons and Spitzer have collected a lot
small as a pebble. Comets from the Kuiper Structure Formation is one of the most of data regarding the Kuiper Belt but it
Belt usually take nearly 200 years to orbit intriguing areas in Modern Astrophysics. turns out that they’ve barely scratched
the sun. The most crowded section in the During the formation of the Solar System, the surface. We are dependent on just a
belt is between 42 and 48 A.U. much of the gas, dust, and rocks got pulled handful of organizations and techniques
Sedna, an object that is smaller than Pluto, together to form the sun and planets. The to collect data regarding the Solar System.
was discovered in the year 2004. Another planets then swept most of the remain- If more nations and organizations were to
object named Eris was discovered ing debris into the sun or out of the develop advanced space capabilities, more
solar system. But means of data collection can be arranged
bodies farther out that and hence more facts can be uncovered.
remained safe from These revelations would surely enhance
gravitational effects of among other things, our understanding of
planets. It is believed the formation of the Solar System - or any
that the Kuiper Belt structure for that matter. So it won’t be
objects are the rem- wrong to believe that a lot of great break-
nants of these bodies. throughs in Astrophysics that await us have
Exploration of the to do with Kuiper like belts. So Humanity
Kuiper Belt and the as a whole must aspire to develop greater
Future of Research: proficiency in Astronomical methods in
Kuiper Belt Objects order to nurture a new generation of Space
are very small and Researchers.
since they are very far
References
from the Earth, spot- 1. https://space-facts.com/kuiper-belt/
ting them from any 2. https://solarsystem.nasa.gov/planets/kbos
ground-based obser- 3. https://www.space.com/16144-kuiper-belt-
objects.html
vatory is likely to
Credits: NASA | Artists rendering of the Kuiper Belt and Oort Cloud 4. https://www.universetoday.com/107598/what-
Image source: http://herschel.jpl.nasa.gov/solarSystem.shtml remain a challenge is-the-kuiper-belt/
RESEARCH MATTERS
Abstract
Here, I argue that computational thinking not the computer to biology,” writes
and techniques are so central to the quest Hallam Stevens in Life Out of Sequence
of understanding life that today all biology [2], his ethnographic and historical
is computational biology. Computational account of computational biology. He
biology brings order into our understand- explains: “Computers do not just scale up
ing of life, it makes biological concepts the old biology, they bring with them com-
rigorous and testable, and it provides a pletely new tools and questions, like sta-
reference map that holds together individ- tistics, simulation, and data management,
ual insights. The next modern synthesis that completely reshaped the way bio-
in biology will be driven by mathemati- logical research is being done.” One key
cal, statistical, and computational methods example of how computers reshaped bio-
being absorbed into mainstream biologi- logical research is the use of databases and
cal training, turning biology into a quan- ontologies. Biological knowledge today is
titative science. defined, organised, and accessed through
computation. If Carl von Linne´ (also
“How do people like you ever get last- known as Carl Linnaeus), the Swedish
author papers?” A leading cell biologist Fig 1. Carl von Linne´, the Swedish botanist and father
botanist and father of taxonomy, lived
asked me this question in 2008 during the of taxonomy, would be a computational biologist today. today, he would be a computational biol-
interview for my current job, implying I Image credit: Nationalmuseum Stockholm. ogist (Fig 1). As a botanist, he might take a
doi:10.1371/journal.pbio.2002050.g001
could never take a senior role in research leading role in a project like transPLANT
projects. I had been trained in mathemat- parasites” to describe computational (http://www.transplantdb.eu/) to organise
ics and machine learning but was now biologists making sense of published what we know about the genotypes and
interviewing for a computational biology data [1].Over the last 20 years, computa- phenotypes of crops and model plants. Or
job in a cancer research institute. My inter- tional methods have become a well-estab- he might work with the Gene Ontology
viewer wasn’t really sure what my con- lished part of biology, but the examples Consortium (http://www.geneontology.
tribution to biology could ever be. Aren’t above show that “old school” biologists org/) to create shared vocabularies that
computational folks just service provid- and clinicians—who make decisions on unify biological knowledge across organ-
ers? Handy to have, but without any real publications, funding, and careers—con- isms. Just like Linne´’s Systema Naturae,
scientific vision? She clearly worried tinue to be uncomfortable with people such databases are key intellectual contri-
about my ability to do independent bio- like me, who were trained in other dis- butions to our understanding of life. Every
logical research. And she was not the ciplines, pursue biological questions dif- other type of biological research builds on
last to worry. In 2012, with several last- ferent from their own, and use approaches these foundations.
author papers to my name, I was short- not covered in most biological training.
listed for an European Molecular Biology If even my colleagues in the life sciences Computational biology lets you see the
Organization Young Investigator fellow- do not see why computational research big picture
ship but did not get it. The feedback pro- matters, how will anybody else be able to
vided by the interview panel called my see its worth? In the following, I will argue Another way computers have reshaped
group a “mathematical service unit,” that computational thinking and computa- biology is by introducing statistics and
claimed “a lack of in-depth understand- tional methods are so central to the quest data analysis methods. A good example
ing of biology,” and decried “an overly of understanding life that today all biology is understanding how mutational pro-
strong reliance on collaborators.” Last is computational biology. cesses shape genomes [3]. Mutational
year, we finally saw how low the opinion processes—be it cigarette smoke, sun-
of computational work really can be in Computational biology brings order light, or defects in homologous recom-
the biomedical community, when the edi- into our understanding of life bination—are not visible in individual
tor-in-chief of the New England Journal mutations but only in their global pat-
of Medicine used the term “research “[B]iology adapted itself to the computer, terns. How often is a C turned into a T?
How does this frequency vary depending executing, and interpreting all focussed experimental techniques with mathemat-
on the neighbours of the mutated base? small-scale experiments that probe the ical theory and data analysis. And then,
How much of this frequency is explained uncharted areas and push out the bound- even "old school" biologists will view
by other features of the genome, like repli- aries of biological knowledge. computational biologists as one of their
cation timing? Answering these questions own.
helps us to understand basic properties of Computational biology turns ideas into
the mutational processes active in cells, hypotheses References
and it is only possible by statistical tech-
niques that identify patterns and correla- Finally, computers reshaped biology by 1. Longo D.L. and Drazen J.M.,
tions. These types of analyses need large making fuzzy concepts rigorous and test- Editorial Data Sharing, N Engl J Med
data collections, and thus the success of able. Here is one example from my own 2016; 374:276–277 doi: 10.1056/
computational biology is closely linked to research: for decades, cancer research- NEJMe1516564 PMID: 26789876
the success of large-scale efforts to gather ers have discussed the idea that genetic
genotypes and phenotypes of model heterogeneity between cells in the same 2. Stevens Hallam, Life Out of Sequence:
organisms and humans. One of the first tumour helps to make a cancer resistant to A Data-Driven History of Bioinformatics,
examples highlighting the power of com- therapy [6]. It is a simple idea: the more The University of Chicago Press; 2013
putational approaches was sequencing diverse the cell population is, the more
the human genome, which showed how likely it is that a subset of the cells is resis- 3. Alexandrov L. B. et al. Signatures of
efficiently computational alignment and tant to therapy and can regrow the tumour mutational processes in human cancers.
scaffolding methods were able to assem- after all other cells were killed.But how Nature 2013 Aug 22; 500 (7463): 415–
ble the DNA fragments produced during exactly can you measure “genetic hetero- 421. doi: 10.1038/nature12477 PMID:
shotgun sequencing [4], and modern Next geneity,” and how big is its influence on 23945592
Generation Sequencing techniques com- resistance development? To answer these
pletely rely on advances in computational questions, we had to turn the idea into 4. Weber J.L. and Myers E.W. Human
biology to analyse huge amounts of short a testable hypothesis. We used genomic whole-genome shotgun sequencing.
sequence reads [5]. DNA sequencing was approaches to measure changes in cancer Genome Res. 1997 May; 7 (5):401–9.
once a Nobel Prize–worthy development. genomes at different sites in a patient PMID: 9149936
Now, computational biology is leading and then defined quantitative measures
the way in turning it into a widely avail- of heterogeneity, which could be com- 5. Flicek P. and Birney E. Sense from
able and practical approach for both basic pared statistically to clinical informa- sequence reads: methods for align-
biology and medical research, which is tion on treatment resistance. And indeed, ment and assembly. Nat Methods. 2009
currently revolutionising what we know we found evidence supporting the initial Nov; 6(11 Suppl):S6–S12. doi: 10.1038/
about tissues and single cells. idea that heterogeneity determines resis- nmeth.1376 PMID: 19844229
tance [7]. This is just one of many exam-
Computational biology provides an ples in which a quantitative computational 6. Nowell P.C. The clonal evolution of
atlas of life approach was needed to turn a fuzzy idea tumor cell populations. Science. 1976 Oct
into a testable hypothesis. Computational 1; 194(4260):23–8. PMID: 959840
By combining large data collections biology excels at distilling huge amounts
with databases and statistics, computa- of complex data into something testable 7. Schwarz R.F. et al. Spatial and tem-
tional biology is providing a reference in the wet lab, thus, shaping and directing poral heterogeneity in high-grade serous
map for biology—an atlas of life that experimental follow-up. ovarian cancer: a phylogenetic analysis.
holds together individual insights. This PLoS Med. 2015 Feb 24; 12(2):e1001789.
map is not at the level of resolution pro- Rest in peace, computational biology doi: 10.1371/journal.pmed.1001789
vided by Google Street View, rather, it is PMID: 25710373
a map like the one used by Columbus, Pipette biologist. Microscopy biolo-
Magellan, or Vasco da Gama—intrepid gist. Cell culture biologist. Have you
explorers in search of adventure. The map ever heard any of those job titles? No, of
provides a general outline, but many areas course not. All are biologists, because it
are sketchy, and some PLOS Biology is the questions you address that matter,
| DOI:10.1371/journal.pbio.2002050 not the tools you use, and computational
March 9, 2017 2 / 4important parts might biologists are just biologists using a dif-
even be missing and waiting for discov- ferent tool. The next modern synthesis in
ery. “Here be dragons,” it just says. But biology will be driven by the absorption
even with all these shortcomings, the map of mathematical, statistical, and computa-
is still an indispensable guide: the atlas of tional methods into mainstream biological
life provided by computational biology training. It will look more and more like
forms the background for planning, training in physics and combine teaching
After publishing four groundbreak- experiments done in the world. space-time which marks the end of very
ing papers in 1905 which also includes Today’s physicists are trying to unify massive stars. It also predicted gravita-
“Special Theory of Relativity”, Albert quantum theory and general relativity to tional lensing which is due to the bending
Einstein was in a little distress about form a quantum theory of gravity. of light through space-time structure.
how to include gravity in his relativistic As the Einstein field equations are math- Gravitational Waves, the detection of
framework. It was said that he came up ematically nonlinear in nature, Albert which Nobel Prize of 2017 was awarded
with a simple thought experiment of an Einstein gave initial predictions by using were one of the important predictions
observer falling freely in an elevator when approximation methods. During 1916, an of the theory of gravity given by Albert
he was going to give one public lecture. Astrophysicist Karl Schwarzschild gave Einstein.
Then he started to work on the new theory the first non-trivial solution (exact) for the Einstein’s equations describe the relation-
of gravity which took eight long years Einstein Field Equations, which is called ship between the four-dimensional space-
and he presented in the year of 1915 at Schwarzschild metric. This exact solu- time geometry with the energy-momen-
the Prussian Academy of Sciences, and tion led the theory of gravitational col- tum contained in the space-time. There
what is now called as “Einstein Field lapse which we now call “Black Holes”. is no force of gravity as described in
Equations”. These field equations are The anomalous perihelion advance of Newtonian theory; instead, gravity is the
partial differential equations and specify the Mercury planet was shown by Albert change in the properties of space-time cur-
the geometrical nature of space and time Einstein with his theory of gravity in vature caused due to the energy-momen-
which got influenced by the matter and 1915 without using any extra or arbitrary tum of the matter which provides the pos-
radiation. This geometric theory of gravity parameters. General relativity’s predic- sible path which the object will follow.
is what we call today is “General Theory tion of deflection of star light was shown
of Relativity”, which is the current theory by Prof. Arthur Eddington during a solar
of gravity in modern physics. The theory eclipse in 1919 expedition which instantly
is mathematically beautiful and gives us makes Einstein renowned in the world.
the notion of geometric property of space- Yet the gravity theory was not in main-
time. Technically speaking, this curva- stream physics before 1960, but after
ture of space-time is linked directly to 1960 physicists began to know about the
the energy-momentum of matter present. concept of a black hole and to take into
Some of the predictions of general rel- account for the identification of quasars.
ativity which are different from classi- It also has important consequences like
cal physics are space-time geometry, free black holes, regions from where nothing
fall motion, gravitational lensing. These can escape out not even light because of
predictions are confirmed to date by the the complex distortion and structure of
Image Credit: Robert Sullivan
Gravitational Waves Eject a Black Hole from Its Central Home
This illustration shows how gravitational waves can propel a black hole from the center of a galaxy. The scenario begins in the first panel with the merger of two galaxies, each with
a central black hole. In the second panel, the two black holes in the newly merged galaxy settle into the center and begin whirling around each other. This energetic action produces
gravitational waves. As the two hefty objects continue to radiate away gravitational energy, they move closer to each other over time, as seen in the third panel. If the black holes do
not have the same mass and rotation rate, they emit gravitational waves more strongly in one direction, as shown by the bright area at upper left. The black holes finally merge in the
fourth panel, forming one giant black hole. The energy emitted by the merger propels the black hole away from the center in the opposite direction of the strongest gravitational waves.
Life-cycle of stars
Dr. Anupam Bhardwaj
The most remarkable discovery in all of about the enigmatic universe, one can ask: Hertzsprung-Russel diagram to understand
astronomy is that the stars are made of why do we need to study stars? Well, the the stellar evolution. In the Hertzsprung-
atoms of the same kind as those on the simplest answer would be that our life on Russel diagram, the luminosity of stars is
earth. earth is very much dependent on the Sun, plotted against its effective temperature.
a star. Sun is at the center of the solar- However, it is not possible to directly
Richard P. Feynman (1918-1988) system and is the fundamental source of measure the luminosity and temperature
energy for life on earth. The life-cycle of a star. We can only observe the apparent
We have all wondered about the mysterious of a star begins with the gravitational magnitude of a star which is dependent
twinkling stars in the night sky at some collapse of massive molecular clouds of on the distance. An intrinsically bright
point in our life. Although, this curiosity dust and gas (mainly hydrogen) which star may appear faint because it is far
about these primary inhabitants of the forms the regions of high matter density, away from us and on the other hand, a
universe, diminishes for most of us with the Nebulae, often called the stellar relatively faint star may appear bright as
passage of time. Nevertheless, some of us, nurseries or star-forming regions. These it is close to us. Similarly, the temperature
namely the astronomers, do study stars in high-density regions of Nebulae attract can be understood in terms of color of
order to understand how they are born and more dust and gas, thus heating the the stars, the blue color represents hotter
evolve with time. The apparent brightness denser regions and form Protostars. This temperature while the red represents cooler
and position of stars in the sky may seem is the first phase of stellar evolution and temperatures. Therefore, in practice, the
fixed to the naked eye but they indeed vary these baby-stars keep accreting gas and Hertzsprung-Russel diagram is replaced
from one class to another over their life- dust from the surrounding as pre-main- by the color-magnitude diagram.
span. Apart from the mankind's curiosity sequence stars. The astronomers use Main-sequence is the region where stars
spend most of their lifetime, as can be
Figure 1. Hertzsprung-Russel diagram displaying the evolution of stars. Source: NASA
seen in Figure 1. Roughly around 90%
of stars in our universe belong to the
main-sequence, including our Sun. The
evolution of a star from protostar phase is
dependent on its mass. If a protostar could
not gain enough mass to fuse hydrogen
in its core, it becomes a substellar object
called the Brown dwarf. On the other
hand, if the masses are sufficient to fuse
hydrogen into helium in its core, the
protostars form a main-sequence star.
The main-sequence stars can have masses
up to a couple of hundred solar masses
but we will consider only two cases,
low-mass (~upto 2 solar mass) and
high-mass (above 10 solar mass) stars. The
lifetime of a star on the main-sequence is
dependent on its mass. Higher mass stars
will have high temperatures inside their
core and therefore “burn” their material
faster. Therefore, lower is the mass, more
is the time spent on the main-sequence. So
our Sun will spend total 10 billion years
in the main-sequence phase. However, a
high-mass star may only spend a couple of
tens million years on the main-sequence.
A low-mass star like our Sun will stay on
the main-sequence as long it has hydrogen
in its core. Once all the hydrogen is fused,
helium core starts contracting, increasing
the temperature sufficient enough to fuse
Image: Students gathering for quiz competition on 22nd december 2017. Image: Mr. Rahul Aggrawal with his colleague and students organizing the quiz
Image: Rahul Aggrawal with his colleague and students organizing the quiz. Image: Students listening to the story of Ramanujan on 22nd December 2017.