trypanosomiasis 8. Butolinum toxin inhibit the release of ACh 82. Etoposide - inhibits topoisomerase II and other - S/E Alopecia, neutrotransmitters by myelosuppression exocytocis. 17. Pilocarpine - TX Glaucoma - 0.5-4% solution 83. Vemurafenib TX Metastatic melanoma 18. Scopolamine Prophylactic agent for 84. Tacrolimus immunosuppressant short exposure to severe macrolide antibiotic motion produced by Streptomyces 21. Atropine TX Organophosporus anti- tsukabaensis Pralidoxime cholinesterase agent 98. Cyclosporine - peptide antibiotic intoxication - non-biologic DMARD 22. Edrophonium Diagnosis of Myasthenia 112. Vit B6 enhance extracerebral gravis metabolism of levodopa. 25. Dopamine - precursor of NE and EPI 114. Entacapone catechol-O- - important in the methyltransferase inhibitor regulation of movement. 117. Misoprostol - TX NSAID- induced ulcer 27. Isoproterenol potent, non selective Beta - Abortifacient drug receptor agonist with a 118. Alprostadil TX Erectile dysfunction very low affinity to alpha 119. Febuxosat -TX Gout, blocks xanthine receptors. Allopurinol oxidase, 28. Dobutamine short term TX Congestive -Decrease uric acid HF and Acute Myo production Infarction 120. Probenecid TX Gout, for urinary 29. Ritodrine - selective beta 2 agonist excretion of uric acid - uterine relaxant 121. Colchicine TX Gout, phagocytosis of 31. Methylphenidate -mild CNS stimulant uric acid crystals -TX for narcolepsy and 127. Tacrolimus - immunosuppressant drug ADHD - inhibits calcineurin 32. Yohimbine Alpha 2 selective 128. Methotrexate - chemotherapeutic drug antagonist - inhibits dihydrofolate 33. Metoprolol beta 1 selective antagonist reductase 34. Phenoxybenzamine TX for Pheochromocytoma 129. Cyclophosphamide Chemotherapy for solid 38. Flurazepam - hypnotic drug tumor malignancies - Benzodiazepine 134. Ocreotide TX Acromegaly derivative 135. Bromocriptine - Dopamine D2 receptor 39. Phenobarbital - hypnotic drug agonist - increase hepatic drug- - Tx Hyperprolactinemia metabolizing enzyme and Parkinson’s disease 43. Phenytoin MOA block high-frequency 136. Leuprolide - Gonadotropin-releasing firing of neurons through hormone the action on voltage- -Analog for ovarian gated Na Channels. suppression 45. Selegeline TX Parkinsonian disorder 137. Conivaptan - antagonist of vasopressin 46. Carbidopa MOA inhibition of beta V1a and V2 receptor decarboxylase enzyme - Tx Hyponatremia in 48. Tolcapone - cathecol-O- hospitalized methyltransferase inhibitor 138. Desmopressin - Agonist of vasopressin V2 - prolong action of receptor methyldopa - Tx Pituitary diabetes 50. Morphine - opioid analgesic. insipidus - strong muscarinic agonist 139. Atosiban Antagonist of oxytocin 51. Naloxone full antagonist of opioid receptor receptor 145. Methimazole Inhibit thyroid peroxidase 53. Aspirin non-narcotic agent. reaction, iodine salicylic acid derivative. organification, and 55. Atorvastatin - inhibits HMG-COA peripheral conversion of T4 reductase and T3. -reduces cholesterol 146. PropranoLOL - inhibition of beta receptor synthesis - inhibit conversion of T4 56. Dypiridamole - vasodilator also inhibits and T3. platelet function -Management of thyroid storm 61. Losartan - antagonize angiotensin II - decrease systemic 149. Fludrocortisone Management of adrenal vascular resistance insufficiency in Addison’s disease 62. Metoprolol reduce both resting and exercise heart rate, cardiac 150. Spironolactone - Antagonist of output, systolic & diastolic mineralocorticoid receptor BP and weak antagonist of androgen receptor. 63. CaptoPRIL ARBS - Angiotensin -S/E Gynecomastia Receptor Blocker 154. Benzodiazepine - binds to GABAa receptor 70. Filgastrim TX of neutropenia subunits to facilitate 78. Tincture of Iodine USP - 2% Iodine, 2.4% NaI chloride channel opening - most active antiseptic for and increase FREQUENCY. intact skin 155. Barbiturates - binds to GABAa receptor 79. Hexachlorophene - phenolic disinfectant site , facilitate fluoride - causes cerebral edema channel opening and and convulsions in increase DURATION. gram-positive cocci 156. Flumazenil - Antagonist at particularly vancomycin benzodiazepine site on resistant and MRSA. GABAa receptor 248. Amphotericin B Polyene antifungal agent 157. Ramelteon - activates MT1 and MT2 that binds to ergosterol in receptor fungal plasma membrane. -Sleep disorder 250. Methotrexate - Oldest and most studied 158. Buspirone Used for Generalized antineoplastic drug related anxiety to folic acid. 165. Acamprosate - NMDA glutamate receptor - Inhibits Dihydrofolate antagonist reductase -TX of alcoholism 252. Bromocriptine For parkinsonism. Binds to 166. Disulfiram - Aldehyde dehydrogenase dopamine receptor and inhb mimic the action of - TX alcoholics dopamine. 168. Diazepam - BDZ receptor agonist 253. Amantadine For parkinsonism. Increase - PV and TX acute ethanol dopamine release and withdrawal syndrome reduces dopamine 169. Thiamine PV Wernicke Korsakoff reuptake. Syndrome 258. Thioamides Tx option for children, 170. Naltrexone Reduce risk of relapse in young adult and pregnant individuals with alcohol-use women for uncomplicated disorder Grave’s Disease. 171. Fomepizole Antidote for methanol and 259. Metyrapone Tx for Cushing Syndrome ethylene alcohol poisoning 262. Sulfonylureas Historical mainstay of 176. Ethosuximide TX absence seizure therapy in type 2 DM 184. Ketamine State of “dissociative 264. Curare Binds to Ach receptors thus anesthesia” preventing depolarization. 185. Dexmedetomidine Centrally acting alpha2 – 265. Physostigmine Blocks adrenergic agonist that has acetylcholinesterases. analgesic and hypnotic Prolongs action of actions of IV acetylcholine. 186. Thiopental Barbiturate; induction of 268. Phenoxybenzamine alpha antagonist (non- anesthesia and for short selective, irreversible) surgical procedure Tx of Pheochromocytoma 187. Tetracaine Long-acting local anesthetic 269. LabetaLOL - mixed alpha and beta 191. Neostigmine Reverse blockade brought antagonist drug about by non-depolarizing - used in hypertension during neuro-muscular blocker pregnancy. 192. Dantrolene TX malignant hyperthermia 270. PropranoLOL - beta non selective antagonist 199. Carbidopa Does not cross BBB drug In combination with - TX for angina, hypertension, levodopa for the cardiac dysrhythmias, anxiety, TX of Parkinsonism tremor and glaucoma. 200. Pramipexole Non-ergot. High affinity to 275. Varenicline - used for smoking cessation D3 receptor 277. Cimetidine Long term use S/E: Monotherapy for Mild galactorrhea and Parkinsonism gynecomastia in women, 221. Aliskerin Newer drug in reduced sperm count, and antihypertensive. Inhibits impotence in men. renin’s action on its 278. Sucralfate - inhibits pepsin-mediated substrate angiotensinogen. hydrolysis of mucosal proteins 230. Milrinone Phosphodiesterase that contributes to mucosal inhibitor erosion and ulceration. 233. Cromolyn Blocks mast cell 279. Ocreotide Inhibit severe secretory degranulation by diarrhea brought about by suppressing release of hormone secreting tumor of mediators of pancreas and GI tract bronchoconstriction and 280. Ondansetron - used for Chemotherapy- reduce eosinophilic induced emesis recruitment causing airway - 5 HT3 receptor antagonist inflammation. 281. Dronabinol Prophylactic agent in patient 236. Permethrin Mainstay for scabies. receiving cancer chemotherapy A topical scabicide. when other antiemetic 240. Tazobactam Beta lactamase inhibitor medications is not effective used in combination with 282. Quinine DOC for drug-resistant P. antibacterial drug falciparum malaria. Piperacillin. 283. Primaquine - primarily as terminal 243. Carbapenems Broadest spectrum beta- prophylaxis and radical cure of lactam antibiotics P. vivax and P. ovale malarias. 244. Aztreonam Monobactam antibiotic that - Prevent and cure for inhibits bacterial cell wall relapsing malaria synthesis and is resistant 286. Protamine Sulfate Antagonize the effect of to most beta lactamases. warfarin. 245. Vancomycin Glycopeptide antibiotic. 287. Dabigatran 1st oral direct thrombin Barteriostatic inhibitor approved by US-FDA. 246. Quinolones Broad-spectrum 288. Hirudin - irreversible thrombin inhibitor bactericidal antibiotics from leech saliva 247. Linezolid Oxazolidine derivative. Tx - Lepirudin – recombinant form of multidrug resistant 289. Acetazolamide Diuretic agent, used for glaucoma 290. (Natrixam®) Tx Hypertension amlodipine + indapamide 291. (Invokana®) Management for diabetes Canaglifozin Miletus 292. (Rapamune®) Prophylaxis in organ rejection Sirolimus in renal transplant 294. (Trump plus®) Tx Moderate/ severe pain Paracetamol + tramadol 296. Dengvaxia Newly marketed Live Attenuated Dengue Tetravalent vaccine developed by Sanofi-pasteur. 297. Promethazine H1 antagonist that possess an alpha-receptor blocking action. 299. Montelukast Leukotriene antagonist; for asthma
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