Classification of Anti-Hypertensive Agents Thiazides − Chlorothiazide

Drugs that alter − Diuretics − Hydrochlorothiazide

Sodium and Water − Chlorthalidone
Balance Potassium Sparing − Spironolactone
Drugs that Alter − Central Sympathoplegic Diuretics − Triamterene
Sympathetic Drugs − Amiloride
Nervous System − Ganglion Blocking Agents Loop Diuretics − Furosemide
function − Adrenergic Neuron − Bumetanide
Blocking Actions − Ethacrynic acid
− Adrenoceptor Antagonists: Other Diuretics − Indapamide
A and B − Metolazone
Vasodilator − Calcium Antagonist − Xipamide
− Drugs that activate Central Acting − Methyldopa (aldomet)
Potassium Channels Sympathoplegic − Clonidine (Catapres)
− Drugs that act via cyclic Drugs − Guanfacine
nucleotides − Guanbenz
− Cyclase Activation cGMP Ganglion Blocking − Trimethapan (Arfonad)
− Indirect acting Vasodilators Agents − Mecamylamine (Inversine)
Diuretics − Thiazides Adrenergic Neuron − Guanethidine (Ismelin)
− Loop diuretics Blocking Agent − Reserpine
− Potassium Sparing Alpha Adrenoceptor − Prazosin (Minipress)
Diuretics Antagonist − Doxazosin (Cardura)
− Others − Terazosin (Hytrin)
Non Selective Beta − Propranolol Beta Blocker with − Acebutolol
Blocker − Timolol (hydrophilic) Partial Agonist − Carteolol
− Pindolol Activity − Celiprozol
− Penbutolol − Labetalol
− Carteolol − Penbutolol
− Labetalol − pindolol
− Carvedilol Beta Blocker with − acebutolol
− Nadolol Local Anesthetic − labetalol
Beta 1 Selective − Metoprolol Effect − metoprolol
Blockers − Acebutolol − pinodolol
− Atenolol (hydrophilic) − propranolol
− Betaxolol Moderate Lipid − Carvedilol
− Bisoprolol Solubility − Metoprolol
− Esmolol − Pindolol
− Nebivolol − Timolol
Renally Cleared − Atenolol High Lipid Solubility − Penbutolol
Beta Blocker − Carteolol − propranolol
− Nadolol Release of Nitric − Nitroprusside
Renal and Hepatic − Acebutolol Oxide From Drug or − Hdralazine
Clearance Beta − Bisoprolol Endothelium − Nitrates
Blocker − Pindolol − Histamine
Beta Blocking and − Labetalol − Acetylcholine
− Carvedilol
Vasodilating Effect − Nebivolol Reduction of − Verapamil
Calcium Influx − Diltiazem − Nicardipine
− Nifedipine − Nifedipine
Hyperpolarization of − Minoxidil − Nisoldipine
smooth muscle − Nitrendipine
− Diazoxide
membrane through
opening of potassium Calcium Channel − Diltiazem (Benzodiazepine)
channels Antagonist − Verapamil
Activation of − Fenoldopam NON- (Phenylalkylamines)
Dopamine DIHYDROPYRIDINES
Receptors Indirect Acting Vasodilators
Direct Acting − Fenoldopam Inhibits − Clonidine
Vasodilators − Hyrdralazine Vasoconstriction − Methyldopa
Drugs that Activate − Minoxidil Drugs that Block − Propanolol
Potassium Channel − Cromakalim Renin Secretion
− Lemakalim Renin Inhibitor − Aliskiren
− Diazoxide Sulfhydryl- − Captopril
− Nicorandil Containing ACE − Fentiapril
Drugs that Act via − Sodium Nitroprusside Inhibitors − Pivalopril
Cyclic Nucleotides − Nitropress − Zofenopril
Cyclase Activation − Alacepril
CGMP Dicarboxyl- − Enalapril
Calcium Channel − Amlodipine Containing ACE − Lisonopril
Antagonist − Felodipine Inhibitors − Benazepril
DIHYDROPYRIDINES − Isradipine − Quinapril
 − Moexipril − Beta Blocker
− Ramipril Nitrites and Nitrates − Nitroglycerin
− Spirapril − Isosorbide Dinitrate
− Perindopril − Amyl Nitrite
− Pentopril − Pentaerytriol Tetranitrate
− Cilazapril (PETN)
Phosphorus Containing − Fosinopril REC 1 − Greater than or 60 years
ACE Inhibitor
− SBP: >=150
Angiotensin II − Candesartan − DBP: >=90
Receptor Blocker − Irbesartan
REC 2 − Less than 60 years
− Telmisartan
− DBP: >=90
− Valsartan
REC 3 − Less than 60 years
− Losartan
− SBP: >=140
− Olmesartan
REC 4 − >18 years with CKD
Drugs that Act via − NO
REC 5 − >18 years with DM
Cyclic Nucleotide − Nitrates
REC 6 − Thiazide diuretic
cGMP − Natriuretic Peptide
− CCB
Drugs that Act Via − Beta 2 agonists
− ACEI
Cyclic Nucleotide − Adenosine
− ARB
cAMP − PGI2
REC 8 − > 18 years with CKD
− ACEI or ARB
Drugs for Angina − Nitrites and Nitrates
Pectoris − Calcium Channel Blocker