Huvepharma gut health training Oct 2018 Introduction

Welcome!

• Countries Participating
Albania Hungary
Huvepharma® Austria Ireland
Belgium Poland
Bulgaria Romania
Intestinal Health Workshop Cyprus Switzerland
Czech Republic Turkey
Ecuador UK
Germany
October 2018, Ghent Italy

Welcome!

Program – Wednesday
Morning
• Gut health management & introduction to coccidiosis
▪ Maja Marien, Huvepharma NV

• Gut health in turkeys

▪ Monita Vereecken, Huvepharma NV

• Diagnosis of coccidiosis & Aviapp

▪ Ben Dehaeck, Huvepharma NV

Afternoon

• Practical session
▪ Faculty of veterinary medicine – University of Ghent

1
Huvepharma gut health training Oct 2018 Introduction

Program - Thursday
Morning

• Controlling coccidiosis with coccidiostats

▪ Ben Dehaeck, Huvepharma NV

• Controlling coccidiosis with vaccines

▪ Monita Vereecken, Huvepharma NV Background and Global activities

EN_v07_0517

Huvepharma History
The beginning

2007

Acquisition of:
Merial Inc anticoccidial
range & production
2005-2006 site, St Louis, USA

Acquisition of : Establishment of:

1| Huvepharma History
Intervet’s FA business Huvepharma Russia
Balkanpharma, Razgrad Huvepharma Thailand
2000-02 Establishment of:
Huvepharma EU, Belgium
Privatization of:
1954-99 Huvepharma USA
Biovet Peshtera plant
Huvepharma Taiwan
Production companies with
Acquisition of: Huvepharma China
R&D established in Peshtera,
Razgrad and Botevgrad Biovet Botevgrad
Downstream processing plant for enzymes &
facilities and wastewater probiotics production
treatment plants built in
Biovet Peshtera & Razgrad
Tylosin production line
Razgrad approved by FDA
Biovet is ISO 9001 &
GMP compliance certified

Huvepharma History
The present

2016-2018
Acquisition of:
CORID® trademark from Merial
Inc
Agrilabs & Benchmark USA
Antelope

2| Organization
Animal Health of Neovia
2014-2015 T-HEXX® Animal Health of
Hydromer, Inc.
Acquisition of: Establishment of :
ADVENT® vaccine Huvepharma Mexico
ANC, Turkey Huvepharma Japan
Sanofi’s Garessio plant, Huvepharma South Africa
2009-2013 Italy
Products & production
New Fermentation
sites from Zoetis
plant (Monensin) in
Razgrad

Establishment of:
Huvepharma India
Huvepharma Brazil

Acquisition of:
OptiPhos portfolio

2
Huvepharma gut health training Oct 2018 Introduction

We invest in the Future Global Organization

Becoming an Industrial leader World Presence

Huvepharma EOOD is a private company owned by Domuschiev family, which

has also investments in other economic sectors:

Shipping business
Real estate and Construction
Energy production
Trading business including logistic centers
Machinery
Consumer goods
Port operations

RSA

Affiliate
Production site

Organization Huvepharma - Production

Structure Fermentation KNOW-HOW

HUVEPHARMA EOOD, Bulgaria

Sales and Marketing Production Fermentation

Huvepharma Biovet

Huvepharma NV
Huvepharma Inc.
Biovet Razgrad | Vet&Human
Huvepharma Taiwan, Branch of Huvepharma NV
Biovet Peshtera | Vet&Human
Huvepharma Beijing, Representative office
Huvepharma Polska Sp. z o.o.
Biovet Botevgrad | Enzymes EU Producer Formulation
Garessio, Italy |Chemical synthesis
Huvepharma (Thailand) Ltd.
St. Louis, USA | Formulation Facility
Huvepharma EOOD Representative Office in
Moscow Lincoln, USA| Vaccine production
Huvepharma (Pune) Private Limited Laurinburg, USA | Vaccine production
Huvepharma do Brasil Comércio e Importação Ltda Van Buren, USA | Formulation Facility
Huvepharma de México S.A. de C.V. Longmont, USA | Vet WSP production
Market Oriented
ANC Hayvan Beslenmesi ve Sağlığı Hizmetleri A.Ş.
Huvepharma Japan Inc

Production sites Production sites

EU USA

Production Facility Key Statistics Plants Production Facility Key Statistics Plants

Total Production Area: Three fermentation plants

c. 309,000 m2 Two chemical plants Total Production Area: Five blending lines
Peshtera Two formulation & packaging plant c.15,000 m2
Bulgaria Total Fermentation Waste water treatment plant St. Louis Annual Production Capacity:
Capacity: 2,700 m3
Missouri c. 13,600 tons

Total Production Area: Four fermentation plants Total Production Area: Three brooder houses
Razgrad c. 385,000 m2 Multipurpose chemical plant 530 m² Downstream plant
Bulgaria Formulation and downstream plant Lincoln
Total Fermentation Capacity: Waste water treatment plant Annual Production Capacity:
3,400 m3 Nebraska 1.56 billion doses

Total Production Area: Fermentation and downstream

Total Production Area: Four brooder houses
c. 34,000 m2 plant
Botevgrad Laurinburg 1333 m2 Downstream plant
Bulgaria Total Fermentation Capacity:
325 m3 North Carolina Annual Production Capacity:
2 billion doses
Total Production Area: Seven manufacturing buildings
c. 54,000 m2 Nine production lines for complex Total Production Area: Two vertical mixers
Garessio chemistry Van Buren c. 464 m2 Two packaging lines
Italy Total Chemical Synthesis
Capacity: 700 m3
Eight warehouses Arkansas Annual Production Capacity:
Thermo-oxidizer unit for exhausted air 5.76 million lbs.
Waste water treatment plant
Longmont Total Production Area: Three blending lines
Colorado c. 954 m2 Four packaging lines
Annual Production Capacity:
2 million lbs.

3
Huvepharma gut health training Oct 2018 Introduction

Manufacturing complex products Emphasis on Quality

High-tech API manufacturing process
with fermentation steps

Huvepharma® masters in-house the complete complex production cycle:

GMP animal feed sector based on HACCP principles:
Biovet production sites
Huvepharma EOOD
Huvepharma NV

Biovet production sites are:

Compliant with EU GMP/Feed Chain Alliance Regulations
Approved by FDA for US-marketed products
Compliant with ISO standards for superior quality management and
environmental protection

Portfolio

Coccidiostats

Veterinary
3| Huvepharma Portfolio
Enzymes
Products

Feed
API Additives

Vaccines

Coccidiostats Enzymes
Feed Industry

•SACOX® •COXIRIL® / CLINACOX®

/SALINOPHARM® (diclazuril)
•OPTIPHOS® / •HOSTAZYM® X
(salinomycin) •STENOROL®
•HOSTAZYM® P (xylanase)
•COXIDIN® / POULCOX® (halofuginone)
(phytase)
(monensin) •COYDEN® WSP
•YUMAMYCIN® (clopidol) Liquid WSP
(maduramycin)
Ionophores Chemicals •AMPROL®(amprolium) Coated Liquid
•CORID®(amprolium) Granula Granular
r

Granula
Vaccine Combination Granular
r
•HUVEGUARD® MMAT Liquid
•HOSTAZYM® C / Liquid
•HUVEGUARD® NB •MONIMAX® /
MONICOX® •HOSTAZYM® suis •CELLUGAZ®
•ADVENT® (trichoderma
(monensin/nicarbazin) (glucanase)
•EIMERIAVAX 4M® longibrachiatum)
•INOVOCOX®

4
Huvepharma gut health training Oct 2018 Introduction

Enzymes Feed Additives

Huvematic® Growth Promoters & Nutraceuticals

Huvematic®
On-site and on-demand liquid enzyme production
•LIANOL® •MIYA-GOLD®
(fermented potato (clostridium butyricum)
Presents the opportunity to produce tailor protein) •B-ACT®
made liquid enzymes on demand. (bacillus licheniformis)
Uses highly concentrated instant water
soluble enzymes like Hostazym® X WSG and
OptiPhos® WSP
Replaces the need for liquid enzymes in IBC
containers.

•FLAVOMYCIN®
(flavophospholipol)
•BIO D® •ALBAC®
(25-hydroxyvitamin D3) (zinc bacitracin)
•BOBIOVET®
(monensin)

Veterinary Product Range Veterinary Product Range

Global Brands
Formulations

Feed mill industry Veterinarian

Oral Granules Pharmasin® / Tylovet® Tylosin tartrate &

Pack 1 kg

/Tylmasin ® tylosin phosphate

Rodotium® / Vetmulin® Tiamulin

Packages | 5, 20 kg

Water Soluble
Medicated
Premix Powder Tilmovet® Tilmicosin

HydroDoxx®/ Doxx-Sol® Doxycycline

Vial - 100,
250 ml

Injectable
Apravet ® Apramycin

Parofor ® Paromomycin
1000 ml
Bottle

Oral Solution Albiotic® / Lincocin® forte Lincomycin /

Neomycin

Veterinary Product Range API

Regional brands EUROPEAN API and ingredients producer

•TOBRAMYCIN family •ARTEMISINIC ACID

•FRAMYCETIN family •SEMI-SYNTHETIC
•OLEANDOMYCIN ARTEMISININ
Amphen® Florfenicol •PAROMOMYCIN •CORTISEVEN
•ERYTHROMYCIN •RAMIPrIL PREC.1
•ANDROSTENDIONE •THIOPHENE
Pigfen® Fenbendazole
•ANDROSTEDIENEDIONE
•ARTEMETHER Our
Bacivet® S Bacitracin
Our Human
•ARTESUNATE Human
•TIAPRIDE API Interme-
Doxx-Sol® Doxycycline
•SULPIRIDE diates
Combiotic® Benzylpenicillin /
Dihydrostreptomycin Toll Animal
•Anti-infectives Manufac- health •API for animal health
Paromomicina Huvepharma ® Paromomycin •Cosmetics turing API products
•Flavours
Gutal® Zinc oxide •Fragrance
•Sweeteners
•Enzymes for food & feed

5
Huvepharma gut health training Oct 2018 Introduction

Global Sales by Region

95 products | 90+ countries | 5 continents

4| Global Sales

*North America – includes sales figures of US & Canada only

*Latin America – includes South America + Mexico for the needs of Huvepharma sales region differentiation
(Mexico – 1,3%)

Data: 2017

Global AH Ranking 2017

Animal Pharm, April 2018

5| Conclusion

Huvepharma
A Global Business Partner

Marketing and Sales driven organization with:

EU based production

Over 60 years of Fermentation experience

Formulation Innovations

Market oriented

“Filled Pipeline” with innovations and new developments

Production:

Quality controlled through FDA, HACCP, GMP/Feed Chain

Alliance certification

R&D driven